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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1increases expressionEXP 6480464CTDProgesterone results in increased expression of CCND1 mRNAPMID:17170212
Ccnd1multiple interactionsEXP 6480464CTD[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 proteinPMID:20732338
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDProgesterone results in decreased expression of CCND1 mRNAPMID:18070364 PMID:20864642
Ccnd1decreases expressionISOCcnd1 (Mus musculus)6480464CTDProgesterone results in decreased expression of CCND1 mRNAPMID:16966611
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDProgesterone results in increased expression of CCND1 mRNAPMID:16888808
Ccnd1increases expressionISOCcnd1 (Mus musculus)6480464CTDProgesterone results in increased expression of CCND1 mRNAPMID:19847363
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of CCND1 mRNAPMID:20660070
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of CCND1 mRNA; Lithium Chloride inhibits the reaction [Progesterone inhibits the reaction [Estradiol affects the localization of CCND1 protein]]; Progesterone inhibits the reaction [Estradiol affects the localization of CCND1 protein]PMID:15845746 PMID:18556351
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