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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDProgesterone results in increased expression of CCND1 mRNA

PMID:17170212
multiple interactionsEXP 6480464CTD[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 mRNA, [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 protein, [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 mRNA, [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 protein

PMID:20732338
decreases expressionISORGD:685566480464CTDProgesterone results in decreased expression of CCND1 mRNA

PMID:18070364, PMID:20864642
decreases expressionISORGD:685576480464CTDProgesterone results in decreased expression of CCND1 mRNA

PMID:16966611
increases expressionISORGD:685566480464CTDProgesterone results in increased expression of CCND1 mRNA

PMID:16888808
increases expressionISORGD:685576480464CTDProgesterone results in increased expression of CCND1 mRNA

PMID:19847363
multiple interactionsISORGD:685566480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of CCND1 mRNA

PMID:20660070
multiple interactionsISORGD:685576480464CTD[Estradiol co-treated with Progesterone] results in increased expression of CCND1 mRNA, Lithium Chloride inhibits the reaction [Progesterone inhibits the reaction [Estradiol affects the localization of CCND1 protein]], Progesterone inhibits the reaction [Estradiol affects the localization of CCND1 protein]

PMID:15845746, PMID:18556351
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.