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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:9144
Term: silibinin
Definition: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Chemical ID: MESH:C440975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDSilybin results in decreased expression of CCND1 proteinPMID:18435416
Ccnd1decreases expressionISOCcnd1 (Mus musculus)6480464CTDSilybin results in decreased expression of CCND1 proteinPMID:16788158
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTD[Silybin co-treated with Arsenic] results in decreased expression of CCND1 proteinPMID:25868784
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTDSilybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCND1 protein]PMID:25559859
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