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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:5721
Term: hinokiflavone
Definition: A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic potential.
Chemical ID: MESH:C060299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDhinokiflavone results in decreased expression of MMP2 proteinPMID:29635122
Mmp2decreases expressionISOMmp2 (Mus musculus)6480464CTDhinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 proteinPMID:30575109
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