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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621315
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
Acc ID: CHEBI:37943
Term: colistin
Definition: A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Chemical ID: MESH:D003091
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map1lc3bincreases expressionEXP 6480464CTDColistin results in increased expression of MAP1LC3B mRNA; Colistin results in increased expression of MAP1LC3B proteinPMID:30273961 PMID:30318960
Map1lc3bmultiple interactionsEXP 6480464CTDchrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]PMID:30273961 PMID:30318960
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