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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf1aaffects response to substanceISOTnfrsf1a (Mus musculus)6480464CTDTNFRSF1A protein affects the susceptibility to Hydrogen PeroxidePMID:20159942
Tnfrsf1aincreases cleavageISOTNFRSF1A (Homo sapiens)6480464CTDHydrogen Peroxide results in increased cleavage of TNFRSF1A proteinPMID:15550384
Tnfrsf1aincreases expressionISOTnfrsf1a (Mus musculus)6480464CTDHydrogen Peroxide results in increased expression of TNFRSF1A proteinPMID:27494022
Tnfrsf1aincreases expressionISOTNFRSF1A (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of TNFRSF1A proteinPMID:9870925
Tnfrsf1aincreases secretionISOTNFRSF1A (Homo sapiens)6480464CTDHydrogen Peroxide results in increased secretion of TNFRSF1A proteinPMID:33491125
Tnfrsf1amultiple interactionsISOTnfrsf1a (Mus musculus)6480464CTDPI103 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]PMID:27494022
Tnfrsf1amultiple interactionsISOTNFRSF1A (Homo sapiens)6480464CTD1,3-dimethylthiourea inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]; calphostin C inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]; CAT protein inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]; Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]; KB R8301 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]PMID:9870925
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