GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ppargc1a | multiple interactions | EXP | | 6480464 | CTD | [Nitrites co-treated with Oxygen deficiency] results in increased expression of and results in decreased acetylation of PPARGC1A protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARGC1A mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARGC1A protein; [Oxygen deficiency co-treated with Oxygen] results in decreased expression of PPARGC1A protein; dorsomorphin inhibits the reaction [sappanone A inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of PPARGC1A protein]]; PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]; Rosiglitazone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARGC1A mRNA]; Rosiglitazone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARGC1A protein]; sappanone A inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of PPARGC1A protein]; splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] | PMID:22892143 PMID:24898700 PMID:34358556 | Ppargc1a | decreases expression | ISO | Ppargc1a (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in decreased expression of PPARGC1A mRNA; Oxygen deficiency results in decreased expression of PPARGC1A protein | PMID:21113404 | Ppargc1a | decreases expression | ISO | PPARGC1A (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in decreased expression of PPARGC1A protein | PMID:24503013 | Ppargc1a | increases expression | ISO | Ppargc1a (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of PPARGC1A mRNA | PMID:23539316 | Ppargc1a | multiple interactions | ISO | Ppargc1a (Mus musculus) | 6480464 | CTD | [Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein; genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]; rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A mRNA]; sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]] | PMID:21113404 PMID:28477916 | Ppargc1a | multiple interactions | ISO | PPARGC1A (Homo sapiens) | 6480464 | CTD | EPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A protein]; HIF1A gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A protein] | PMID:24503013 | | ||||||||||||||||||||||
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