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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620625
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dusp4
Name: dual specificity phosphatase 4
Acc ID: CHEBI:31596
Term: febuxostat
Definition: A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.
Chemical ID: MESH:D000069465
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dusp4increases expressionISODUSP4 (Homo sapiens)6480464CTDFebuxostat results in increased expression of DUSP4 mRNAPMID:35866629
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