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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of PTEN proteinPMID:35110471
Ptenmultiple interactionsEXP 6480464CTDferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein]]PMID:35110471
Ptenincreases abundanceISOPten (Mus musculus)6480464CTDPTEN gene mutant form results in increased abundance of LipopolysaccharidesPMID:27022031
Ptenincreases expressionISOPTEN (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of PTEN mRNAPMID:35953652
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]]; Anti-Bacterial Agents inhibits the reaction [PTEN gene mutant form results in increased abundance of Lipopolysaccharides]; Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]; PTEN gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; PTEN gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; PTEN gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; PTEN gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:27022031
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