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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619571
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:7596
Term: nitroprusside
Definition: An iron coordination entity that has formula C5FeN6O.
Chemical ID: MESH:D009599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3affects response to substanceISOMapk3 (Rattus norvegicus)6480464CTDMAPK3 protein affects the susceptibility to NitroprussidePMID:20132804
Mapk3decreases expressionISOMapk3 (Rattus norvegicus)6480464CTDNitroprusside results in decreased expression of MAPK3 protein modified formPMID:20132804
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDNitroprusside results in decreased phosphorylation of MAPK3 proteinPMID:15486966 PMID:31066958
Mapk3increases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDNitroprusside results in increased phosphorylation of MAPK3 proteinPMID:16439612
Mapk3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTDMAPK3 protein affects the susceptibility to [Nitroprusside results in decreased expression of BCL2L1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nitroprusside results in increased phosphorylation of MAPK3 protein]; Nitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]PMID:16389725 PMID:16439612 PMID:20132804
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Deferoxamine inhibits the reaction [Nitroprusside results in decreased phosphorylation of MAPK3 protein]; GOSR1 protein affects the reaction [Deferoxamine inhibits the reaction [Nitroprusside results in decreased phosphorylation of MAPK3 protein]]; MAPK3 protein affects the reaction [GOSR1 protein affects the reaction [Nitroprusside results in decreased expression of NFE2L2 protein]]PMID:21332719 PMID:31066958
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