GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hif1a | affects response to substance | ISO | Hif1a (Mus musculus) | 6480464 | CTD | HIF1A protein affects the susceptibility to nickel chloride | PMID:12839937 | Hif1a | increases expression | ISO | Hif1a (Mus musculus) | 6480464 | CTD | nickel chloride results in increased expression of HIF1A protein | PMID:14729612 PMID:24577088 | Hif1a | increases expression | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | nickel chloride results in increased expression of HIF1A protein | PMID:10646848 PMID:18792914 PMID:22648416 PMID:28552779 PMID:29355601 | Hif1a | increases stability | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | nickel chloride results in increased stability of HIF1A protein | PMID:23566959 | Hif1a | multiple interactions | ISO | Hif1a (Mus musculus) | 6480464 | CTD | AKT1 protein affects the reaction [nickel chloride results in increased expression of HIF1A protein]; HIF1A affects the reaction [nickel chloride results in increased expression of AK4 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ALDOA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ARNT mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of BNIP3 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of CCNG2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of E2F1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of EGLN1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ERO1A mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GPI1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GPR137B mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of HK2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of IER3 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of LDHA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of MKNK1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of P4HA2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PFKL mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PGK1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PKM mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PTK2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of SLC2A1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of TPI1 mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of GBE1 mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA] | PMID:10646848 PMID:12426141 PMID:12729255 PMID:14729612 PMID:15094311 | Hif1a | multiple interactions | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]; 2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of HIF1A protein]; [nickel chloride co-treated with Tretinoin] results in increased expression of HIF1A protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of and results in decreased hydroxylation of HIF1A protein; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]; Cycloheximide promotes the reaction [nickel chloride results in increased expression of HIF1A protein]; HIF1A mutant form inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; HIF1A mutant form inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; HIF1A protein affects the reaction [nickel chloride results in increased secretion of IL6 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of BNIP3 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CA9 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1A protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1B protein]; nickel chloride inhibits the reaction [HIF1A protein binds to HSP90AB1 protein]; nickel chloride inhibits the reaction [VHL protein binds to HIF1A protein]; nickel chloride promotes the reaction [HIF1A protein binds to ARNT protein]; nickel chloride promotes the reaction [HIF1A protein binds to CDH1 promoter]; nickel chloride results in increased expression of and affects the localization of HIF1A protein; nickel chloride results in increased expression of and results in increased activity of HIF1A protein; nickel chloride results in increased expression of and results in increased stability of HIF1A protein; nickel chloride results in increased stability of and affects the localization of HIF1A protein; nickel chloride results in increased stability of and results in increased expression of HIF1A protein; Rotenone inhibits the reaction [nickel chloride results in increased expression of HIF1A protein] | PMID:16649251 PMID:17312168 PMID:21828359 PMID:22648416 PMID:24497960 PMID:25614230 PMID:28552779 PMID:29355601 PMID:33596451 PMID:35504338 | | ||||||||||||||||||||||
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