Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of HIF1A mRNAPMID:21215274
Hif1aincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of HIF1A mRNAPMID:24475139 PMID:34747641
Hif1aaffects expressionISOHif1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of HIF1A mRNAPMID:18343893 PMID:21570461 PMID:24058054 PMID:24680724 PMID:28213091
Hif1aaffects expressionISOHIF1A (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of HIF1A mRNAPMID:22298810
Hif1aincreases expressionISOHif1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of HIF1A mRNAPMID:15328365 PMID:19465110 PMID:21041162
Hif1amultiple interactionsISOHif1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HIF1A gene]PMID:28213091
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTD[Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased stability of HIF1A proteinPMID:18072750
Go Back to source page   Continue to Ontology report