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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3932
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ucp2
Name: uncoupling protein 2
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp2increases expressionEXP 6480464CTDFenofibrate results in increased expression of UCP2 mRNAPMID:16595124 PMID:32741897
Ucp2multiple interactionsEXP 6480464CTD[Fenofibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of UCP2 mRNAPMID:11341955 PMID:21999347
Ucp2increases expressionISOUCP2 (Homo sapiens)6480464CTDFenofibrate results in increased expression of UCP2 mRNA; Fenofibrate results in increased expression of UCP2 proteinPMID:24752549
Ucp2increases expressionISOUcp2 (Mus musculus)6480464CTDFenofibrate results in increased expression of UCP2 mRNA; Fenofibrate results in increased expression of UCP2 proteinPMID:24752549
Ucp2multiple interactionsISOUCP2 (Homo sapiens)6480464CTDPPARA protein promotes the reaction [Fenofibrate results in increased expression of UCP2 protein]PMID:24752549
Ucp2multiple interactionsISOUcp2 (Mus musculus)6480464CTDPPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 protein]PMID:24752549
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