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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:6121
Term: ketamine
Definition: A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Chemical ID: MESH:D007649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects expressionIEP 14995427RGDKetamine co-treated with xylazine inhibits the reaction [lipopolysaccharide increases expression of Tnf protein in serum and mucosa of stomach] 
Tnfdecreases expressionEXP 6480464CTDKetamine results in decreased expression of TNF mRNAPMID:15207037 PMID:15207038
Tnfincreases expressionEXP 6480464CTDKetamine results in increased expression of TNF proteinPMID:33536391
Tnfmultiple interactionsEXP 6480464CTDOzone inhibits the reaction [Ketamine results in decreased expression of TNF mRNA]; TRPV4 protein affects the reaction [Ketamine results in increased expression of TNF protein]PMID:15207037 PMID:33536391
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein]; Ketamine inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]PMID:19540866 PMID:22245128 PMID:37491939
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDKetamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:15720977
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