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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat1increases expressionISOSTAT1 (Homo sapiens)6480464CTDPoly I-C results in increased expression of STAT1 mRNAPMID:31154625
Stat1increases phosphorylationISOStat1 (Mus musculus)6480464CTDPoly I-C results in increased phosphorylation of STAT1 proteinPMID:30726814
Stat1multiple interactionsISOSTAT1 (Homo sapiens)6480464CTDIRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]PMID:31154625
Stat1multiple interactionsISOStat1 (Mus musculus)6480464CTDsodium arsenite inhibits the reaction [Poly I-C results in increased phosphorylation of STAT1 protein]PMID:30726814
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