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GENE - TERM ANNOTATION REPORT

RGD ID: 3729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snca
Name: synuclein alpha
Acc ID: DOID:12217
Term: Lewy body dementia
Definition: A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Dementia_with_Lewy_bodies "DO" "DO", http://www.mayoclinic.org/diseases-conditions/lewy-body-dementia/basics/definition/CON-20025038 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Snca ISOSNCA (Homo sapiens)6478704RGD  
Snca ISOSNCA (Homo sapiens)6478792RGDprotein:increased expression:cerebrospinal fluid 
Snca ISOSNCA (Homo sapiens)6480095RGDprotein:increased expression:hippocampus 
Snca ISOSNCA (Homo sapiens)6480103RGD  
Snca ISOSNCA (Homo sapiens)13506723RGDprotein:decreased expression:cerebral spinal fluid: 
Snca ISOSNCA (Homo sapiens)7240710OMIM  
Snca ISOSNCA (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:16141792 PMID:19628769
Snca ISOSNCA (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Lewy Body Disease | ClinVar Annotator: match by term: Lewy body dementiaPMID:10417297 PMID:11261505 PMID:11376188 PMID:12062037 PMID:14593171 PMID:14755719 PMID:14755720 PMID:15144854 PMID:15451224 PMID:15451225 PMID:15498564 PMID:15632170 PMID:16001411 PMID:16199547 PMID:16358335 PMID:17251522 PMID:17489854 PMID:17576681 PMID:17625105 PMID:18195271 PMID:18413475 PMID:18704525 PMID:18852445 PMID:18852448 PMID:18852449 PMID:19139307 PMID:19632874 PMID:19833540 PMID:20340137 PMID:21252228 PMID:21559878 PMID:23427326 PMID:23457019 PMID:23674501 PMID:23880019 PMID:24047453 PMID:24313877 PMID:24552873 PMID:24746362 PMID:24752924 PMID:24936070 PMID:25003242 PMID:25268550 PMID:25393002 PMID:25741868 PMID:25892596 PMID:26341711 PMID:26799529 PMID:26858591 PMID:27066564 PMID:27393118 PMID:28492532 PMID:28666710 PMID:29398121 PMID:29771508 PMID:30528390 PMID:30598256 PMID:32786148 PMID:33617693 PMID:9197268 PMID:9499430 PMID:9506559 PMID:9536098 PMID:9827625
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