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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2multiple interactionsEXP 6480464CTDnimesulide inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein]PMID:20039930
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDnimesulide results in decreased expression of CCL2 proteinPMID:17380299
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTD[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CCL2 mRNAPMID:22561872
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