nimesulide - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nimesulide	go back to main search page
Accession:	CHEBI:44445	browse the term
Definition:	An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Synonyms:	related_synonym:	4-NITRO-2-PHENOXYMETHANESULFONANILIDE; Formula=C13H12N2O5S; InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3; InChIKey=HYWYRSMBCFDLJT-UHFFFAOYSA-N; N-(4-nitro-2-phenoxyphenyl)methanesulfonamide; SMILES=CS(=O)(=O)Nc1ccc(cc1Oc1ccccc1)[N+]([O-])=O
	alt_id:	CHEBI:44440; CHEBI:7574
	xref:	Beilstein:2421175; CAS:51803-78-2; DrugBank:DB04743; Drug_Central:1935; KEGG:D01049; LINCS:LSM-3718
	xref_mesh:	MESH:C012655
	xref:	PDBeChem:NIM; PMID:18426087; Reaxys:2421175; VSDB:1893; Wikipedia:Nimesulide

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Genes (1254)

nimesulide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arylacetamide deacetylase

decreases expression

nimesulide results in decreased expression of AADAC mRNA

NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734

G

4-aminobutyrate aminotransferase

decreases expression

nimesulide results in decreased expression of ABAT mRNA

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

G

ATP binding cassette subfamily A member 1

decreases expression

nimesulide results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

decreases expression
increases expression

nimesulide results in decreased expression of ABCB1 protein
nimesulide results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 6

increases expression

nimesulide results in increased expression of ABCB6 mRNA

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily C member 1

increases expression

nimesulide results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases expression

nimesulide results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

nimesulide results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily E member 1

increases expression

nimesulide results in increased expression of ABCE1 mRNA

NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489

G

ATP binding cassette subfamily G member 2

decreases activity
decreases expression

nimesulide results in decreased activity of ABCG2 protein
nimesulide results in decreased expression of ABCG2 protein

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP-binding cassette, subfamily G (WHITE), member 3-like 2

decreases expression

nimesulide results in decreased expression of ABCG3L2 mRNA

NCBI chr14:4,493,259...4,538,264
Ensembl chr14:4,493,262...4,533,306

G

acetyl-CoA acyltransferase 1A

increases expression

nimesulide results in increased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA acyltransferase 2

increases expression

nimesulide results in increased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acetyl-CoA carboxylase alpha

decreases expression

nimesulide results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

angiotensin converting enzyme 2

decreases expression

nimesulide results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

ATP citrate lyase

decreases expression

nimesulide results in decreased expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

aconitase 1

increases expression

nimesulide results in increased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

increases expression

nimesulide results in increased expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA thioesterase 2

increases expression

nimesulide results in increased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 7

increases expression

nimesulide results in increased expression of ACOT7 mRNA

NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309

G

acyl-CoA oxidase 3, pristanoyl

decreases expression

nimesulide results in decreased expression of ACOX3 mRNA

NCBI chr14:75,133,986...75,176,767
Ensembl chr14:75,094,676...75,176,205

G

acyl-CoA synthetase family member 2

decreases expression

nimesulide results in decreased expression of ACSF2 mRNA

NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673

G

acyl-CoA synthetase long-chain family member 1

decreases expression

nimesulide results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 4

increases expression

nimesulide results in increased expression of ACSL4 mRNA

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase long-chain family member 5

decreases expression

nimesulide results in decreased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

ADAM metallopeptidase with thrombospondin type 1 motif, 7

decreases expression

nimesulide results in decreased expression of ADAMTS7 mRNA

NCBI chr 8:90,704,727...90,744,333
Ensembl chr 8:90,704,727...90,744,328

G

aarF domain containing kinase 5

increases expression

nimesulide results in increased expression of ADCK5 mRNA

NCBI chr 7:108,301,623...108,319,439
Ensembl chr 7:108,301,415...108,319,436

G

adducin 1

increases expression

nimesulide results in increased expression of ADD1 mRNA

NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182

G

adhesion G protein-coupled receptor L2

decreases expression

nimesulide results in decreased expression of ADGRL2 mRNA

NCBI chr 2:237,696,055...238,327,141
Ensembl chr 2:237,696,056...238,327,141

G

alcohol dehydrogenase, iron containing, 1

decreases expression

nimesulide results in decreased expression of ADHFE1 mRNA

NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517

G

adiponectin receptor 2

decreases expression

nimesulide results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent

increases expression

nimesulide results in increased expression of ADPRM mRNA

NCBI chr10:51,732,073...51,744,635
Ensembl chr10:51,731,993...51,744,635

G

ADRM1 26S proteasome ubiquitin receptor

increases expression

nimesulide results in increased expression of ADRM1 mRNA

NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195

G

adenylosuccinate lyase

increases expression

nimesulide results in increased expression of ADSL mRNA

NCBI chr 7:112,479,256...112,503,439
Ensembl chr 7:112,479,271...112,503,760

G

afamin

decreases expression

nimesulide results in decreased expression of AFM mRNA

NCBI chr14:17,531,022...17,563,868
Ensembl chr14:17,531,024...17,563,870

G

angiotensinogen

decreases activity

nimesulide results in decreased activity of AGT

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

alanine--glyoxylate aminotransferase

decreases expression

nimesulide results in decreased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

alanine-glyoxylate aminotransferase 2

decreases expression

nimesulide results in decreased expression of AGXT2 mRNA

NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926

G

activator of Hsp90 ATPase activity 1

increases expression

nimesulide results in increased expression of AHSA1 mRNA

NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345

G

allograft inflammatory factor 1

decreases expression

nimesulide results in decreased expression of AIF1 mRNA

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

androgen-induced 1

increases expression

nimesulide results in increased expression of AIG1 mRNA

NCBI chr 1:8,046,430...8,269,276
Ensembl chr 1:8,046,430...8,269,084

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

increases expression

nimesulide results in increased expression of AIMP2 mRNA

NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769

G

adenylate kinase 4

decreases expression

nimesulide results in decreased expression of AK4 mRNA

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 1 member A1

increases expression

nimesulide results in increased expression of AKR1A1 mRNA

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 7, member A2

increases expression

nimesulide results in increased expression of AKR7A2 mRNA

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

aldo-keto reductase family 7 member A3

increases expression

nimesulide results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

AKT1 substrate 1

increases expression

nimesulide results in increased expression of AKT1S1 mRNA

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

5'-aminolevulinate synthase 1

increases expression

nimesulide results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

activated leukocyte cell adhesion molecule

decreases expression

nimesulide results in decreased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

aldehyde dehydrogenase 1 family, member A1

increases expression

nimesulide results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

nimesulide results in decreased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

ALG12, alpha-1,6-mannosyltransferase

increases expression

nimesulide results in increased expression of ALG12 mRNA

NCBI chr 7:119,895,112...119,909,488
Ensembl chr 7:119,895,120...119,909,458

G

ALG14, UDP-N-acetylglucosaminyltransferase subunit

increases expression

nimesulide results in increased expression of ALG14 mRNA

NCBI chr 2:209,368,285...209,445,425
Ensembl chr 2:209,368,312...209,445,431

G

amylase alpha 1

decreases expression

nimesulide results in decreased expression of AMY1A mRNA

NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816

G

angiogenin

decreases expression

nimesulide results in decreased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

angiopoietin-like 3

decreases expression

nimesulide results in decreased expression of ANGPTL3 mRNA

NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957

G

angiopoietin-like 4

increases expression

nimesulide results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ANKH inorganic pyrophosphate transport regulator

decreases expression

nimesulide results in decreased expression of ANKH mRNA

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187

G

ankyrin repeat domain 24

increases expression

nimesulide results in increased expression of ANKRD24 mRNA

NCBI chr 7:8,061,634...8,081,142
Ensembl chr 7:8,061,953...8,081,142

G

ankyrin repeat domain 40

increases expression

nimesulide results in increased expression of TMPRSS2 mRNA

NCBI chr10:79,282,075...79,295,322
Ensembl chr10:79,282,075...79,295,320

G

alanyl aminopeptidase, membrane

decreases expression

nimesulide results in decreased expression of ANPEP mRNA

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

annexin A3

decreases expression

nimesulide results in decreased expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

annexin A4

increases expression

nimesulide results in increased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

annexin A5

decreases expression

nimesulide results in decreased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

annexin A7

increases expression

nimesulide results in increased expression of ANXA7 mRNA

NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385

G

aminopeptidase O

decreases expression

nimesulide results in decreased expression of AOPEP mRNA

NCBI chr17:1,811,281...2,127,316
Ensembl chr17:1,811,980...2,127,331

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

nimesulide results in increased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

amyloid beta precursor like protein 2

decreases expression

nimesulide results in decreased expression of APLP2 mRNA

NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855

G

adipocyte plasma membrane associated protein

decreases expression

nimesulide results in decreased expression of APMAP mRNA

NCBI chr 3:139,409,021...139,437,296
Ensembl chr 3:139,409,022...139,437,341

G

apolipoprotein A5

decreases expression

nimesulide results in decreased expression of APOA5 mRNA

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

apolipoprotein E

multiple interactions

nimesulide inhibits the reaction [APOE results in decreased expression of CCNA2 protein]; nimesulide inhibits the reaction [APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha]

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein L3, pseudogene 1

decreases expression

nimesulide results in decreased expression of APOL3 mRNA; nimesulide results in decreased expression of APOL7B mRNA

NCBI chr 7:109,156,746...109,175,642

G

adenine phosphoribosyl transferase

increases expression

nimesulide results in increased expression of APRT mRNA

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

aquaporin 8

increases expression

nimesulide results in increased expression of AQP8 mRNA

NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158

G

amphiregulin

multiple interactions

nimesulide inhibits the reaction [LHB results in increased expression of AREG mRNA]; nimesulide inhibits the reaction [LHB results in increased expression of AREG protein]

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

Rho GTPase activating protein 24

decreases expression

nimesulide results in decreased expression of ARHGAP24 mRNA

NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823

G

Rho GDP dissociation inhibitor beta

decreases expression

nimesulide results in decreased expression of ARHGDIB mRNA

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

Rho guanine nucleotide exchange factor 19

decreases expression

nimesulide results in decreased expression of ARHGEF19 mRNA

NCBI chr 5:153,536,038...153,554,203
Ensembl chr 5:153,536,013...153,554,203

G

actin related protein 2/3 complex, subunit 5-like

increases expression

nimesulide results in increased expression of ARPC5L mRNA

NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
Ensembl chr 9:22,759,876...22,767,538

G

actin-related protein 2/3 complex inhibitor

increases expression

nimesulide results in increased expression of ARPIN mRNA

NCBI chr 1:133,864,288...133,873,124
Ensembl chr 1:133,864,265...133,873,124

G

cAMP-regulated phosphoprotein 19

increases expression

nimesulide results in increased expression of ARPP19 mRNA

NCBI chr 8:75,779,640...75,802,474
Ensembl chr 8:75,779,523...75,802,452
Ensembl chr 8:75,779,523...75,802,452

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

decreases expression

nimesulide results in decreased expression of ASAP2 mRNA

NCBI chr 6:40,658,201...40,821,017
Ensembl chr 6:40,657,880...40,820,975

G

asialoglycoprotein receptor 2

decreases expression

nimesulide results in decreased expression of ASGR2 mRNA

NCBI chr10:54,821,407...54,834,624
Ensembl chr10:54,821,438...54,834,617

G

asparaginase

decreases expression

nimesulide results in decreased expression of ASPG mRNA

NCBI chr 6:131,176,727...131,196,268
Ensembl chr 6:131,176,874...131,196,268

G

activating transcription factor 4

increases expression

nimesulide results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

increases expression

nimesulide results in increased expression of ATIC mRNA

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

atlastin GTPase 2

increases expression

nimesulide results in increased expression of ATL2 mRNA

NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421

G

atos homolog A

decreases expression

nimesulide results in decreased expression of ATOSA mRNA

NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549

G

ATPase Na+/K+ transporting subunit beta 1

decreases expression

nimesulide results in decreased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATP synthase inhibitory factor subunit 1

increases expression

nimesulide results in increased expression of ATP5IF1 mRNA

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

ATP synthase membrane subunit c locus 1

increases expression

nimesulide results in increased expression of ATP5MC1 mRNA

NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124

G

ATPase H+ transporting accessory protein 2

increases expression

nimesulide results in increased expression of ATP6AP2 mRNA

NCBI chr X:10,183,983...10,210,948
Ensembl chr X:10,183,068...10,210,918

G

ATPase H+ transporting V0 subunit B

increases expression

nimesulide results in increased expression of ATP6V0B mRNA

NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401

G

ATPase H+ transporting V0 subunit e1

increases expression

nimesulide results in increased expression of ATP6V0E1 mRNA

NCBI chr10:16,479,656...16,502,732
Ensembl chr10:16,479,567...16,524,434

G

ATPase, H+ transporting V0 subunit e2

increases expression

nimesulide results in increased expression of ATP6V0E2 mRNA

NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777

G

ATPase H+ transporting V1 subunit F

increases expression

nimesulide results in increased expression of ATP6V1F mRNA

NCBI chr 4:58,067,666...58,070,628

G

ATPase H+ transporting V1 subunit G1

increases expression

nimesulide results in increased expression of ATP6V1G1 mRNA

NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463

G

attractin

decreases expression

nimesulide results in decreased expression of ATRN mRNA

NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322

G

AUP1, lipid droplet regulating VLDL assembly factor

increases expression

nimesulide results in increased expression of AUP1 mRNA

NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346

G

apoptosis and caspase activation inhibitor

increases expression

nimesulide results in increased expression of AVEN mRNA

NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634

G

arginine vasopressin receptor 1A

decreases expression

nimesulide results in decreased expression of AVPR1A mRNA

NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215

G

Axl receptor tyrosine kinase

decreases expression

nimesulide results in decreased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

beta-2 microglobulin

decreases expression

nimesulide results in decreased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BCL2-antagonist/killer 1

multiple interactions
decreases response to substance

nimesulide inhibits the reaction [Etoposide results in increased activity of BAK1 protein]
BAK1 results in decreased susceptibility to nimesulide

PMID:18349538 PMID:21745461

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BAF nuclear assembly factor 1

increases expression

nimesulide results in increased expression of BANF1 mRNA

NCBI chr 1:202,672,170...202,674,215
Ensembl chr 1:202,671,305...202,674,188

G

BCL2 associated X, apoptosis regulator

multiple interactions

nimesulide inhibits the reaction [Etoposide results in increased activity of and affects the localization of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

gamma-butyrobetaine hydroxylase 1

decreases expression

nimesulide results in decreased expression of BBOX1 mRNA

NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458

G

BCAR1 scaffold protein, Cas family member

decreases expression

nimesulide results in decreased expression of BCAR1 mRNA

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BRCA2 and CDKN1A interacting protein

increases expression

nimesulide results in increased expression of BCCIP mRNA

NCBI chr 1:188,512,544...188,524,957
Ensembl chr 1:188,512,367...188,524,958

G

BCL2, apoptosis regulator

decreases expression
affects localization

nimesulide results in decreased expression of BCL2 mRNA; nimesulide results in decreased expression of BCL2 protein
nimesulide affects the localization of BCL2 protein

PMID:18564172 PMID:19772912

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

increases expression

nimesulide results in increased expression of BCS1L mRNA

NCBI chr 9:76,164,925...76,168,940
Ensembl chr 9:76,164,932...76,168,938

G

3-hydroxybutyrate dehydrogenase 1

decreases expression

nimesulide results in decreased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

Bet1 golgi vesicular membrane trafficking protein

increases expression

nimesulide results in increased expression of BET1 mRNA

NCBI chr 4:32,116,232...32,126,592
Ensembl chr 4:32,116,235...32,126,617

G

biglycan

decreases expression

nimesulide results in decreased expression of BGN mRNA

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member e40

decreases expression

nimesulide results in decreased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

betaine-homocysteine S-methyltransferase

decreases expression

nimesulide results in decreased expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

betaine-homocysteine S-methyltransferase 2

decreases expression

nimesulide results in decreased expression of BHMT2 mRNA

NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:24,895,533...24,912,475

G

BH3 interacting domain death agonist

multiple interactions

benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [nimesulide results in increased cleavage of and results in increased activity of BID protein]; nimesulide results in increased cleavage of and results in increased activity of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

decreases expression
decreases expression

nimesulide results in decreased expression of BIRC5 protein
Nimesulide decreases expression of BIRC5 protein in esophagus squamous epithelium

CTD
RGD

PMID:16969492 PMID:25724470

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

biliverdin reductase B

increases expression

nimesulide results in increased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

bone morphogenetic protein 1

decreases expression

nimesulide results in decreased expression of BMP1 mRNA

NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776

G

bone morphogenetic protein 6

increases expression

nimesulide results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

BCL2 interacting protein 3

increases expression

nimesulide results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

increases expression

nimesulide results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

bolA family member 1

increases expression

nimesulide results in increased expression of BOLA1 mRNA

NCBI chr 2:183,758,515...183,771,445
Ensembl chr 2:183,758,441...183,781,576

G

bolA family member 2, pseudogene 4

increases expression

nimesulide results in increased expression of BOLA2-PS4 mRNA

NCBI chr 3:153,272,435...153,272,781

G

bolA family member 3

increases expression

nimesulide results in increased expression of BOLA3 mRNA

NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797

G

BOP1 ribosomal biogenesis factor

increases expression

nimesulide results in increased expression of BOP1 mRNA

NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931

G

BTG anti-proliferation factor 1

decreases expression

nimesulide results in decreased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

bystin-like

increases expression

nimesulide results in increased expression of BYSL mRNA

NCBI chr 9:13,382,806...13,392,557
Ensembl chr 9:13,382,557...13,394,339

G

similar to human chromosome 17 open reading frame 58

increases expression

nimesulide results in increased expression of C10H17ORF58 mRNA

NCBI chr10:91,972,938...91,977,606
Ensembl chr10:91,972,410...91,977,602

G

similar to human chromosome 5 open reading frame 15

increases expression

nimesulide results in increased expression of C10H5ORF15 mRNA

NCBI chr10:36,563,989...36,576,593
Ensembl chr10:36,563,958...36,576,590

G

similar to human chromosome 18 open reading frame 32

increases expression

nimesulide results in increased expression of C18H18ORF32 mRNA

NCBI chr18:68,586,278...68,594,851
Ensembl chr18:68,586,211...68,596,787

G

C1GALT1-specific chaperone 1

increases expression

nimesulide results in increased expression of C1GALT1C1 mRNA

NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787

G

complement C1q A chain

decreases expression

nimesulide results in decreased expression of C1QA mRNA

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

G

complement C1q B chain

multiple interactions
decreases expression

nimesulide inhibits the reaction [PTGS2 results in increased expression of C1QB mRNA]
nimesulide results in decreased expression of C1QB mRNA

PMID:11810182 PMID:24136188

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

G

complement C1q binding protein

increases expression

nimesulide results in increased expression of C1QBP mRNA

NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649

G

complement C1q C chain

decreases expression

nimesulide results in decreased expression of C1QC mRNA

NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017

G

complement C1s

decreases expression

nimesulide results in decreased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

similar to human chromosome 6 open reading frame 89

increases expression

nimesulide results in increased expression of C20H6ORF89 mRNA

NCBI chr20:7,322,483...7,362,054
Ensembl chr20:7,322,442...7,357,612

G

complement C6

decreases expression

nimesulide results in decreased expression of C6 mRNA

NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275

G

complement C8 alpha chain

decreases expression

nimesulide results in decreased expression of C8A mRNA

NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754

G

complement C8 beta chain

decreases expression

nimesulide results in decreased expression of C8B mRNA

NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565

G

similar to human chromosome 11 open reading frame 54

increases expression

nimesulide results in increased expression of C8H11ORF54 mRNA

NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473

G

complement C9

decreases expression

nimesulide results in decreased expression of C9 mRNA

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

calcyclin binding protein

increases expression

nimesulide results in increased expression of CACYBP mRNA

NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177

G

calmodulin 2

decreases expression

nimesulide results in decreased expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calnexin

increases expression

nimesulide results in increased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

cyclase associated actin cytoskeleton regulatory protein 1

decreases expression

nimesulide results in decreased expression of CAP1 mRNA

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

calpain 2

decreases expression

nimesulide results in decreased expression of CAPN2 mRNA

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

carbonic anhydrase 3

decreases expression

nimesulide results in decreased expression of CAR3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

carbonic anhydrase 8

increases expression

nimesulide results in increased expression of CAR8 mRNA

NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374

G

calcium regulated heat stable protein 1

decreases expression

nimesulide results in decreased expression of CARHSP1 mRNA

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

caspase 3

multiple interactions
increases expression
increases activity
increases cleavage
increases expression

benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [nimesulide results in increased cleavage of and results in increased activity of CASP3 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; nimesulide results in increased cleavage of and results in increased activity of CASP3 protein
nimesulide results in increased expression of CASP3 mRNA; nimesulide results in increased expression of CASP3 protein
[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased cleavage of CASP3 protein]; nimesulide inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Silymarin inhibits the reaction [nimesulide results in increased cleavage of CASP3 protein]
nimesulide results in increased activity of CASP3 protein
Nimesulide increases expression of CASP3 protein in esophagus squamous epithelium

CTD
RGD

PMID:11296547 PMID:19360361 PMID:19772912 PMID:21176579 PMID:21745461 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [nimesulide results in increased cleavage of and results in increased activity of CASP8 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP8 protein]; nimesulide results in increased activity of and results in increased cleavage of CASP8 protein

PMID:19360361 PMID:21745461

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity
increases cleavage

benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [nimesulide results in increased cleavage of and results in increased activity of CASP9 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; nimesulide results in increased cleavage of and results in increased activity of CASP9 protein
nimesulide results in increased activity of CASP9 protein
[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased cleavage of CASP9 protein]; Silymarin inhibits the reaction [nimesulide results in increased cleavage of CASP9 protein]

PMID:19360361 PMID:19772912 PMID:21745461 PMID:22509279

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression
multiple interactions
decreases activity

nimesulide results in decreased expression of CAT protein
nimesulide inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein]
nimesulide results in decreased activity of CAT; nimesulide results in decreased activity of CAT protein

PMID:17147060 PMID:17274466 PMID:18848576 PMID:20043943

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

nimesulide results in increased expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

caveolae associated protein 3

increases expression

nimesulide results in increased expression of CAVIN3 mRNA

NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161

G

carbonyl reductase 1

increases expression

nimesulide results in increased expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

coiled-coil domain containing 107

decreases expression

nimesulide results in decreased expression of CCDC107 mRNA

NCBI chr 5:57,749,502...57,752,920
Ensembl chr 5:57,748,999...57,752,918

G

coiled-coil domain containing 6

increases expression

nimesulide results in increased expression of CCDC6 mRNA

NCBI chr20:18,432,177...18,528,186
Ensembl chr20:18,433,695...18,528,658

G

coiled-coil domain containing 80

decreases expression

nimesulide results in decreased expression of CCDC80 mRNA

NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

nimesulide results in decreased expression of CCL2 protein
nimesulide inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein]
[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CCL2 mRNA

PMID:17380299 PMID:20039930 PMID:22561872

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 9

decreases expression

nimesulide results in decreased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cyclin A2

multiple interactions

nimesulide inhibits the reaction [APOE results in decreased expression of CCNA2 protein]

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B2

decreases expression

nimesulide results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

multiple interactions
decreases expression

nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]
nimesulide results in decreased expression of CCND1 mRNA

PMID:20043093 PMID:24136188

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

chaperonin containing TCP1 subunit 2

increases expression

nimesulide results in increased expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

chaperonin containing TCP1 subunit 3

increases expression

nimesulide results in increased expression of CCT3 mRNA

NCBI chr 2:173,765,701...173,790,353
Ensembl chr 2:173,765,698...173,790,757

G

chaperonin containing TCP1 subunit 4

increases expression

nimesulide results in increased expression of CCT4 mRNA

NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267

G

chaperonin containing TCP1 subunit 5

increases expression

nimesulide results in increased expression of CCT5 mRNA

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

chaperonin containing TCP1 subunit 6A

increases expression

nimesulide results in increased expression of CCT6A mRNA

NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337

G

chaperonin containing TCP1 subunit 7

increases expression

nimesulide results in increased expression of CCT7 mRNA

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

chaperonin containing TCP1 subunit 8

increases expression

nimesulide results in increased expression of CCT8 mRNA

NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079

G

CD14 molecule

decreases expression

nimesulide results in decreased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD164 molecule

decreases expression

nimesulide results in decreased expression of CD164 mRNA

NCBI chr20:45,024,051...45,035,628
Ensembl chr20:45,023,973...45,035,634

G

CD59b molecule

decreases expression

nimesulide results in decreased expression of CD59 mRNA

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

Cd5 molecule-like

decreases expression

nimesulide results in decreased expression of CD5L mRNA

NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753

G

Cd68 molecule

decreases expression

nimesulide results in decreased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

CD74 molecule

decreases expression

nimesulide results in decreased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

Cd81 molecule

decreases expression

nimesulide results in decreased expression of CD81 mRNA

NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660

G

Cd82 molecule

decreases expression

nimesulide results in decreased expression of CD82 mRNA

NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809

G

cell division cycle 20

decreases expression

nimesulide results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 5-like

decreases expression

nimesulide results in decreased expression of CDC5L mRNA

NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450

G

cadherin 17

increases expression

nimesulide results in increased expression of CDH17 mRNA

NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884

G

cadherin 2

decreases expression

nimesulide results in decreased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 1

decreases expression

nimesulide results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

nimesulide results in increased expression of CDKN1A mRNA; nimesulide results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nimesulide results in increased expression of CDKN1A mRNA]

PMID:14567460 PMID:16376453

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

nimesulide results in increased expression of CDKN1B; nimesulide results in increased expression of CDKN1B protein

PMID:12717830 PMID:14567460

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2C

multiple interactions

nimesulide inhibits the reaction [PTGS2 results in decreased expression of CDKN2C mRNA]

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

cyclin-dependent kinase inhibitor 3

decreases expression

nimesulide results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

cysteine dioxygenase type 1

decreases expression

nimesulide results in decreased expression of CDO1 mRNA

NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296

G

CEA cell adhesion molecule 1

decreases expression

nimesulide results in decreased expression of CEACAM1 mRNA

NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992

G

CEA cell adhesion molecule 4

decreases expression

nimesulide results in decreased expression of CEACAM10 mRNA

NCBI chr 1:80,376,667...80,382,943
Ensembl chr 1:80,376,648...80,382,915

G

CCAAT/enhancer binding protein alpha

multiple interactions

nimesulide promotes the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CEBPA protein]
nimesulide inhibits the reaction [Dietary Fats results in decreased expression of CEBPA mRNA]

PMID:19247274 PMID:22107987

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centrosomal protein 170

decreases expression

nimesulide results in decreased expression of CEP170 mRNA

NCBI chr13:88,669,672...88,754,011
Ensembl chr13:88,670,358...88,732,226

G

carboxylesterase 2H

increases expression

nimesulide results in increased expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

complement factor H

decreases expression

nimesulide results in decreased expression of CFH mRNA

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

cofilin 1

increases expression

nimesulide results in increased expression of CFL1 mRNA

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

cingulin

decreases expression

nimesulide results in decreased expression of CGN mRNA

NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645

G

cell growth regulator with ring finger domain 1

increases expression

nimesulide results in increased expression of CGRRF1 mRNA

NCBI chr15:20,088,564...20,109,042
Ensembl chr15:20,088,571...20,109,037

G

coiled-coil-helix-coiled-coil-helix domain containing 1

increases expression

nimesulide results in increased expression of CHCHD1 mRNA

NCBI chr15:3,592,719...3,593,901
Ensembl chr15:3,592,727...3,593,901

G

coiled-coil-helix-coiled-coil-helix domain containing 2

increases expression

nimesulide results in increased expression of CHCHD2 mRNA

NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755

G

coiled-coil-helix-coiled-coil-helix domain containing 6

increases expression

nimesulide results in increased expression of CHCHD6 mRNA

NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216

G

chitinase domain containing 1

increases expression

nimesulide results in increased expression of CHID1 mRNA

NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606

G

choline kinase alpha

decreases expression

nimesulide results in decreased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

cysteine and histidine rich domain containing 1

increases expression

nimesulide results in increased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

choline phosphotransferase 1

increases expression

nimesulide results in increased expression of CHPT1 mRNA

NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103

G

chromatin accessibility complex subunit 1

increases expression

nimesulide results in increased expression of CHRAC1 mRNA

NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136

G

component of inhibitor of nuclear factor kappa B kinase complex

increases expression

nimesulide results in increased expression of CHUK mRNA

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

churchill domain containing 1

increases expression

nimesulide results in increased expression of CHURC1 mRNA

NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586

G

cytosolic iron-sulfur assembly component 2A

increases expression

nimesulide results in increased expression of CIAO2A mRNA

NCBI chr 8:66,670,533...66,682,455
Ensembl chr 8:66,670,483...66,682,455

G

cytokine induced apoptosis inhibitor 1

increases expression

nimesulide results in increased expression of CIAPIN1 mRNA

NCBI chr19:10,179,963...10,195,511
Ensembl chr19:10,180,100...10,195,503

G

cell death-inducing DFFA-like effector a

increases expression

nimesulide results in increased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

CDGSH iron sulfur domain 2

increases expression

nimesulide results in increased expression of CISD2 mRNA

NCBI chr 2:223,828,937...223,853,768
Ensembl chr 2:223,828,937...223,868,946

G

CDGSH iron sulfur domain 3

increases expression

nimesulide results in increased expression of CISD3 mRNA

NCBI chr10:82,679,345...82,682,376
Ensembl chr10:82,679,196...82,682,550

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

nimesulide results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

CDC28 protein kinase regulatory subunit 1B

increases expression

nimesulide results in increased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

CDC28 protein kinase regulatory subunit 2

decreases expression

nimesulide results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

claudin domain containing 1

increases expression

nimesulide results in increased expression of CLDND1 mRNA

NCBI chr11:41,883,120...41,889,471
Ensembl chr11:41,883,134...41,889,354

G

C-type lectin domain family 4, member F

decreases expression

nimesulide results in decreased expression of CLEC4F mRNA

NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775

G

CAP-GLY domain containing linker protein 1

increases expression

nimesulide results in increased expression of CLIP1 mRNA

NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884

G

caseinolytic mitochondrial matrix peptidase proteolytic subunit

increases expression

nimesulide results in increased expression of CLPP mRNA

NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

decreases expression

nimesulide results in decreased expression of CLPX mRNA

NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082

G

clathrin, light chain B

increases expression

nimesulide results in increased expression of CLTB mRNA

NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169

G

carboxymethylenebutenolidase homolog

increases expression

nimesulide results in increased expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

G

CKLF-like MARVEL transmembrane domain containing 6

decreases expression

nimesulide results in decreased expression of CMTM6 mRNA

NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033

G

carnosine dipeptidase 2

increases expression

nimesulide results in increased expression of CNDP2 mRNA

NCBI chr18:78,039,924...78,057,030
Ensembl chr18:78,039,932...78,056,922

G

cornichon family member 4

increases expression

nimesulide results in increased expression of CNIH4 mRNA

NCBI chr13:92,910,315...92,926,428
Ensembl chr13:92,910,315...92,927,853

G

cannabinoid receptor 1

multiple interactions

[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased activity of nimesulide

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

collagen type XIV alpha 1 chain

decreases expression

nimesulide results in decreased expression of COL14A1 mRNA

NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214

G

collagen type XVIII alpha 1 chain

decreases expression

nimesulide results in decreased expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 2 chain

decreases expression

nimesulide results in decreased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

decreases expression

nimesulide results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type VI alpha 1 chain

decreases expression

nimesulide results in decreased expression of COL6A1 mRNA

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

COMM domain containing 5

increases expression

nimesulide results in increased expression of COMMD5 mRNA

NCBI chr 7:108,621,766...108,623,616
Ensembl chr 7:108,598,673...108,624,764

G

catechol-O-methyltransferase domain containing 1

increases expression

nimesulide results in increased expression of COMTD1 mRNA

NCBI chr15:2,459,783...2,462,895
Ensembl chr15:2,459,783...2,462,895

G

COP9 signalosome subunit 5

increases expression

nimesulide results in increased expression of COPS5 mRNA

NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731

G

coenzyme Q10A

decreases expression

nimesulide results in decreased expression of COQ10A mRNA

NCBI chr 7:792,089...798,392
Ensembl chr 7:792,089...800,161

G

coenzyme Q10B

increases expression

nimesulide results in increased expression of COQ10B mRNA

NCBI chr 9:56,553,751...56,573,671
Ensembl chr 9:56,553,758...56,573,663

G

coenzyme Q6 monooxygenase

increases expression

nimesulide results in increased expression of COQ6 mRNA

NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657

G

coenzyme Q8A

decreases expression

nimesulide results in decreased expression of COQ8A mRNA

NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431

G

coronin 1C

decreases expression

nimesulide results in decreased expression of CORO1C mRNA

NCBI chr12:42,713,024...42,785,179
Ensembl chr12:42,712,991...42,785,179

G

cytochrome c oxidase assembly factor COX14

increases expression

nimesulide results in increased expression of COX14 mRNA

NCBI chr 7:130,852,226...130,854,316

G

cytochrome c oxidase copper chaperone COX17

increases expression

nimesulide results in increased expression of COX17 mRNA

NCBI chr11:62,400,733...62,406,507

G

cytochrome c oxidase assembly factor COX19

increases expression

nimesulide results in increased expression of COX19 mRNA

NCBI chr12:15,303,535...15,313,014
Ensembl chr12:15,303,551...15,313,014

G

ceruloplasmin

decreases expression

nimesulide results in decreased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carboxypeptidase Q

decreases expression

nimesulide results in decreased expression of PGCP mRNA

NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546

G

carbamoyl-phosphate synthase 1

decreases expression

nimesulide results in decreased expression of CPS1 mRNA

NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033

G

carnitine palmitoyltransferase 1A

increases expression

nimesulide results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

increases expression

nimesulide results in increased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

carnitine O-acetyltransferase

increases expression

nimesulide results in increased expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

cellular repressor of E1A-stimulated genes 1

increases expression

nimesulide results in increased expression of CREG1 mRNA

NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308

G

cysteine-rich with EGF-like domains 1

increases expression

nimesulide results in increased expression of CRELD1 mRNA

NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499

G

cAMP responsive element modulator

decreases expression

nimesulide results in decreased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

carnitine O-octanoyltransferase

decreases expression

nimesulide results in decreased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

crystallin, lambda 1

increases expression

nimesulide results in increased expression of CRYL1 mRNA

NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997

G

cysteine sulfinic acid decarboxylase

decreases expression

nimesulide results in decreased expression of CSAD mRNA

NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615

G

colony stimulating factor 1 receptor

decreases expression

nimesulide results in decreased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cysteine and glycine-rich protein 1

decreases expression

nimesulide results in decreased expression of CSRP1 mRNA

NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384

G

cystathionine gamma-lyase

decreases expression

nimesulide results in decreased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin beta 1

affects localization
decreases expression

nimesulide affects the localization of CTNNB1 protein
nimesulide results in decreased expression of CTNNB1

PMID:15892897 PMID:16331303

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin H

decreases expression

nimesulide results in decreased expression of CTSH mRNA

NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824

G

cathepsin L

increases expression

nimesulide results in increased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cathepsin S

decreases expression

nimesulide results in decreased expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

C-X-C motif chemokine ligand 10

multiple interactions

[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

multiple interactions

[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 12

decreases expression

nimesulide results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 9

multiple interactions

[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

CXXC finger protein 5

decreases expression

nimesulide results in decreased expression of CXXC5 mRNA

NCBI chr18:27,427,591...27,458,579
Ensembl chr18:27,427,230...27,458,673

G

cytochrome b5 type A

increases expression

nimesulide results in increased expression of CYB5A mRNA

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome b5 type B

increases expression

nimesulide results in increased expression of CYB5B mRNA

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome b-245 beta chain

decreases expression

nimesulide results in decreased expression of CYBB mRNA

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity
multiple interactions
decreases expression

nimesulide analog results in decreased activity of CYP19A1 protein; nimesulide results in decreased activity of CYP19A1; nimesulide results in decreased activity of CYP19A1 protein
nimesulide analog results in decreased activity of and results in decreased expression of CYP19A1
nimesulide analog results in decreased expression of CYP19A1 mRNA; nimesulide results in decreased expression of CYP19A1 mRNA

PMID:15964185 PMID:17315855 PMID:20542113 PMID:23054057

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases glutathionylation
decreases expression

CYP1A2 protein results in increased glutathionylation of nimesulide
nimesulide results in decreased expression of CYP1A2 mRNA

PMID:24136188 PMID:26524229

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases glutathionylation

CYP1B1 protein results in increased glutathionylation of nimesulide

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 20, subfamily a, polypeptide 1

increases expression

nimesulide results in increased expression of CYP20A1 mRNA

NCBI chr 9:61,755,804...61,805,123
Ensembl chr 9:61,755,790...61,805,123

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

nimesulide results in decreased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily a, polypeptide 1

decreases expression

nimesulide results in decreased expression of CYP2A1 mRNA

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily a, polypeptide 2

decreases expression

nimesulide results in decreased expression of CYP2A2 mRNA

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily b, polypeptide 12

increases expression

nimesulide results in increased expression of CYP2B12 mRNA

NCBI chr 1:82,007,609...82,019,409
Ensembl chr 1:82,007,609...82,080,480

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases glutathionylation
decreases expression

CYP2B6 protein results in increased glutathionylation of nimesulide
nimesulide results in decreased expression of CYP2B3 mRNA

PMID:24136188 PMID:26524229

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases glutathionylation

CYP2C19 protein results in increased glutathionylation of nimesulide

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases glutathionylation

CYP2D6 protein results in increased glutathionylation of nimesulide

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily j, polypeptide 3

increases expression

nimesulide results in increased expression of CYP2J3 mRNA

NCBI chr 5:111,219,921...111,244,987
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 2, subfamily t, polypeptide 1

decreases expression

nimesulide results in decreased expression of CYP2T1 mRNA

NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:82,446,921...82,451,563

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases glutathionylation

nimesulide inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein]
CYP3A4 protein results in increased glutathionylation of nimesulide

PMID:18079364 PMID:26524229

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

nimesulide results in increased expression of CYP3A9 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

nimesulide results in increased expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 3

increases expression

nimesulide results in increased expression of CYP4A3 mRNA

NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases expression

nimesulide results in decreased expression of CYP4F1 mRNA

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450, family 4, subfamily f, polypeptide 6

decreases expression

nimesulide results in decreased expression of CYP4F6 mRNA

NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782

G

dishevelled associated activator of morphogenesis 1

decreases expression

nimesulide results in decreased expression of DAAM1 mRNA

NCBI chr 6:90,389,544...90,550,114
Ensembl chr 6:90,389,688...90,550,114

G

DAB adaptor protein 2

decreases expression

nimesulide results in decreased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

dystroglycan 1

decreases expression

nimesulide results in decreased expression of DAG1 mRNA

NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325

G

death associated protein kinase 1

decreases expression

nimesulide results in decreased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

DAZ associated protein 1

increases expression

nimesulide results in increased expression of DAZAP1 mRNA

NCBI chr 7:9,423,673...9,448,116
Ensembl chr 7:9,424,178...9,538,818

G

dopa decarboxylase

decreases expression

nimesulide results in decreased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DDHD domain containing 1

decreases expression

nimesulide results in decreased expression of DDHD1 mRNA

NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

nimesulide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DDIT3 protein]
nimesulide results in increased expression of DDIT3 mRNA

PMID:22940226 PMID:24136188

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

increases expression

nimesulide results in increased expression of DDOST mRNA

NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413

G

DEAD-box helicase 17

decreases expression

nimesulide results in decreased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

DExD-box helicase 39A

increases expression

nimesulide results in increased expression of DDX39A mRNA

NCBI chr19:24,418,743...24,427,422
Ensembl chr19:24,418,114...24,426,954

G

2,4-dienoyl-CoA reductase 1

increases expression

nimesulide results in increased expression of DECR1 mRNA

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018

G

2,4-dienoyl-CoA reductase 2

increases expression

nimesulide results in increased expression of DECR2 mRNA

NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479

G

derlin 1

increases expression

nimesulide results in increased expression of DERL1 mRNA

NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145

G

desumoylating isopeptidase 1

increases expression

nimesulide results in increased expression of DESI1 mRNA

NCBI chr 7:113,519,974...113,542,834
Ensembl chr 7:113,519,980...113,542,845

G

desumoylating isopeptidase 2

increases expression

nimesulide results in increased expression of DESI2 mRNA

NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416

G

diacylglycerol O-acyltransferase 2

decreases expression

nimesulide results in decreased expression of DGAT2 mRNA

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

dehydrodolichyl diphosphate synthase subunit

increases expression

nimesulide results in increased expression of DHDDS mRNA

NCBI chr 5:146,198,359...146,224,479
Ensembl chr 5:146,197,457...146,224,454

G

dihydrofolate reductase

decreases expression

nimesulide results in decreased expression of DHFR mRNA

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

dehydrogenase/reductase 4

increases expression

nimesulide results in increased expression of DHRS4 mRNA

NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127

G

dehydrogenase/reductase 7

increases expression

nimesulide results in increased expression of DHRS7 mRNA

NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892

G

dehydrogenase/reductase 7B

increases expression

nimesulide results in increased expression of DHRS7B mRNA

NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076

G

dimethylglycine dehydrogenase

decreases expression

nimesulide results in decreased expression of DMGDH mRNA

NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528

G

DnaJ heat shock protein family (Hsp40) member A3

increases expression

nimesulide results in increased expression of DNAJA3 mRNA

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

nimesulide results in increased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

nimesulide results in increased expression of DNAJB11 mRNA

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

nimesulide results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C15

increases expression

nimesulide results in increased expression of DNAJC15 mRNA

NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675

G

DNL-type zinc finger

increases expression

nimesulide results in increased expression of DNLZ mRNA

NCBI chr 3:9,169,948...9,171,727
Ensembl chr 3:9,169,793...9,180,551

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

increases expression

nimesulide results in increased expression of DNPH1 mRNA

NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022

G

diphthamide biosynthesis 3

increases expression

nimesulide results in increased expression of DPH3 mRNA

NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265

G

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

increases expression

nimesulide results in increased expression of DPM3 mRNA

NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668
Ensembl chr15:174,676,363...174,677,668

G

dpy-30 histone methyltransferase complex regulatory subunit

increases expression

nimesulide results in increased expression of DPY30 mRNA

NCBI chr 6:21,120,947...21,141,720
Ensembl chr 6:21,120,947...21,141,432

G

dihydropyrimidine dehydrogenase

decreases expression

nimesulide results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

dihydropyrimidinase

decreases expression

nimesulide results in decreased expression of DPYS mRNA

NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231

G

desmocollin 2

increases expression

nimesulide results in increased expression of DSC2 mRNA

NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392

G

D-aminoacyl-tRNA deacylase 1

increases expression

nimesulide results in increased expression of DTD1 mRNA

NCBI chr 3:131,995,870...132,158,646
Ensembl chr 3:131,995,861...132,158,659

G

dual specificity phosphatase 11

increases expression

nimesulide results in increased expression of DUSP11 mRNA

NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181

G

dynein light chain Tctex-type 3

decreases expression

nimesulide results in decreased expression of DYNLT3 mRNA

NCBI chr X:13,327,933...13,337,139
Ensembl chr X:13,327,892...13,337,139

G

EBNA1 binding protein 2

increases expression

nimesulide results in increased expression of EBNA1BP2 mRNA

NCBI chr 5:132,148,164...132,152,730
Ensembl chr 5:132,148,143...132,153,267

G

EBP like

increases expression

nimesulide results in increased expression of EBPL mRNA

NCBI chr15:35,508,074...35,531,472
Ensembl chr15:35,508,074...35,531,472

G

enoyl-CoA hydratase 1

increases expression

nimesulide results in increased expression of ECH1 mRNA

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

enoyl-CoA delta isomerase 1

increases expression

nimesulide results in increased expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

Ecm29 proteasome adaptor and scaffold

increases expression

nimesulide results in increased expression of ECPAS mRNA

NCBI chr 5:73,601,745...73,714,026
Ensembl chr 5:73,604,533...73,713,860

G

ER degradation enhancing alpha-mannosidase like protein 2

increases expression

nimesulide results in increased expression of EDEM2 mRNA

NCBI chr 3:144,201,604...144,227,423
Ensembl chr 3:144,201,605...144,227,485

G

endothelin 1

multiple interactions

nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type B

multiple interactions

nimesulide inhibits the reaction [IL1B results in increased activity of EDNRB]

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

eukaryotic translation elongation factor 1 beta 2

increases expression

nimesulide results in increased expression of EEF1B2 mRNA

NCBI chr 9:64,580,163...64,582,737
Ensembl chr 9:64,579,893...64,582,737

G

eukaryotic translation elongation factor 1 delta

increases expression

nimesulide results in increased expression of EEF1D mRNA

NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799

G

eukaryotic translation elongation factor 1 epsilon 1

increases expression

nimesulide results in increased expression of EEF1E1 mRNA

NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720

G

epidermal growth factor

decreases expression

nimesulide results in decreased expression of EGF mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

EH domain binding protein 1

decreases expression

nimesulide results in decreased expression of EHBP1 mRNA

NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332

G

EH-domain containing 3

decreases expression

nimesulide results in decreased expression of EHD3 mRNA

NCBI chr 6:21,640,861...21,665,601
Ensembl chr 6:21,639,290...21,665,236

G

eukaryotic translation initiation factor 2 alpha kinase 1

decreases expression

nimesulide results in decreased expression of EIF2AK1 mRNA

NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573

G

eukaryotic translation initiation factor 2 subunit alpha

increases expression

nimesulide results in increased expression of EIF2S1 mRNA

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 3, subunit B

increases expression

nimesulide results in increased expression of EIF3B mRNA

NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886

G

eukaryotic translation initiation factor 3, subunit I

increases expression

nimesulide results in increased expression of EIF3I mRNA

NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676

G

eukaryotic translation initiation factor 3, subunit M

increases expression

nimesulide results in increased expression of EIF3M mRNA

NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392

G

eukaryotic translation initiation factor 4A1

increases expression

nimesulide results in increased expression of EIF4A1 mRNA

NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression

nimesulide results in increased expression of EIF4EBP1 mRNA

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4 gamma 1

increases expression

nimesulide results in increased expression of EIF4G1 mRNA

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

eukaryotic translation initiation factor 5

increases expression

nimesulide results in increased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

eukaryotic translation initiation factor 5A

increases expression

nimesulide results in increased expression of EIF5A mRNA

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

elongin C

increases expression

nimesulide results in increased expression of ELOC mRNA

NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890

G

ELOVL fatty acid elongase 5

decreases expression

nimesulide results in decreased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

ELOVL fatty acid elongase 6

decreases expression

nimesulide results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

ER membrane protein complex subunit 10

increases expression

nimesulide results in increased expression of EMC10 mRNA

NCBI chr 1:94,980,260...94,988,847
Ensembl chr 1:94,943,587...94,988,847

G

ER membrane protein complex subunit 6

increases expression

nimesulide results in increased expression of EMC6 mRNA

NCBI chr10:57,794,072...57,795,671
Ensembl chr10:57,793,685...57,796,217

G

ER membrane protein complex subunit 7

increases expression

nimesulide results in increased expression of EMC7 mRNA

NCBI chr 3:99,263,933...99,274,365
Ensembl chr 3:99,263,980...99,274,360

G

ER membrane protein complex subunit 8

increases expression

nimesulide results in increased expression of EMC8 mRNA

NCBI chr19:48,708,304...48,721,626
Ensembl chr19:48,582,574...48,721,543

G

EMAP like 4

decreases expression

nimesulide results in decreased expression of EML4 mRNA

NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879

G

ectodermal-neural cortex 1

increases expression

nimesulide results in increased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

glutamyl aminopeptidase

decreases expression

nimesulide results in decreased expression of ENPEP mRNA

NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

nimesulide results in increased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleoside triphosphate diphosphohydrolase 5

increases expression

nimesulide results in increased expression of ENTPD5 mRNA

NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530

G

erythrocyte membrane protein band 4.1

increases expression

nimesulide results in increased expression of EPB41 mRNA

NCBI chr 5:144,110,010...144,264,037
Ensembl chr 5:144,111,906...144,237,821

G

epoxide hydrolase 1

decreases glutathionylation
increases expression

EPHX1 protein results in decreased glutathionylation of nimesulide
nimesulide results in increased expression of EPHX1 mRNA

PMID:24136188 PMID:26524229

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

glutamyl-prolyl-tRNA synthetase 1

increases expression

nimesulide results in increased expression of EPRS1 mRNA

NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966

G

epiregulin

multiple interactions
increases expression

nimesulide inhibits the reaction [LHB results in increased expression of EREG mRNA]
nimesulide results in increased expression of EREG mRNA

PMID:16888076 PMID:32816093

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endoplasmic reticulum protein 44

increases expression

nimesulide results in increased expression of ERP44 mRNA

NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761

G

esterase D

increases expression

nimesulide results in increased expression of ESD mRNA

NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144

G

exosome component 4

increases expression

nimesulide results in increased expression of EXOSC4 mRNA

NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573

G

exosome component 5

increases expression

nimesulide results in increased expression of EXOSC5 mRNA

NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265

G

exostosin glycosyltransferase 1

decreases expression

nimesulide results in decreased expression of EXT1 mRNA

NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357

G

coagulation factor X

decreases expression

nimesulide results in decreased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor II, thrombin

decreases activity
multiple interactions

nimesulide results in decreased activity of F2
nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]; nimesulide inhibits the reaction [F2 protein affects the localization of PRKCE protein]

PMID:17379757 PMID:21811393

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor III, tissue factor

multiple interactions

nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased expression of F3 mRNA]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid amide hydrolase

multiple interactions
decreases expression

[nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]
nimesulide results in decreased expression of FAAH mRNA

PMID:20702753 PMID:24136188

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

G

fatty acid binding protein 5

decreases expression

nimesulide results in decreased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

fatty acid desaturase 1

decreases expression

nimesulide results in decreased expression of FADS1 mRNA

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

G

fatty acid desaturase 2

decreases expression

nimesulide results in decreased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

FAM3 metabolism regulating signaling molecule A

increases expression

nimesulide results in increased expression of FAM3A mRNA

NCBI chr X:152,166,716...152,175,327
Ensembl chr X:152,165,535...152,175,362

G

phenylalanyl-tRNA synthetase subunit beta

increases expression

nimesulide results in increased expression of FARSB mRNA

NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045

G

fatty acid synthase

decreases expression

nimesulide results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillarin

increases expression

nimesulide results in increased expression of FBL mRNA

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

F-box protein 31

increases expression

nimesulide results in increased expression of FBXO31 mRNA

NCBI chr19:49,624,813...49,656,052
Ensembl chr19:49,627,686...49,656,010

G

Fc gamma receptor 2A

decreases expression

nimesulide results in decreased expression of FCGR2A mRNA

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

FCH and double SH3 domains 2

decreases expression

nimesulide results in decreased expression of FCHSD2 mRNA

NCBI chr 1:155,444,471...155,685,350
Ensembl chr 1:155,444,460...155,685,539

G

ferredoxin 2

increases expression

nimesulide results in increased expression of FDX2 mRNA

NCBI chr 8:19,604,916...19,609,832
Ensembl chr 8:19,604,916...19,609,849

G

ferrochelatase

increases expression

nimesulide results in increased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

fibrinogen alpha chain

decreases expression

nimesulide results in decreased expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fat storage-inducing transmembrane protein 2

increases expression

nimesulide results in increased expression of FITM2 mRNA

NCBI chr 3:152,141,346...152,147,858
Ensembl chr 3:152,141,346...152,147,858

G

FKBP prolyl isomerase 11

increases expression

nimesulide results in increased expression of FKBP11 mRNA

NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303

G

FKBP prolyl isomerase 3

increases expression

nimesulide results in increased expression of FKBP3 mRNA

NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011

G

flavin containing dimethylaniline monoxygenase 1

decreases expression

nimesulide results in decreased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

fibronectin 1

decreases expression

nimesulide results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

forkhead box N3

decreases expression

nimesulide results in decreased expression of FOXN3 mRNA

NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401

G

folylpolyglutamate synthase

increases expression

nimesulide results in increased expression of FPGS mRNA

NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563

G

follistatin-like 1

decreases expression

nimesulide results in decreased expression of FSTL1 mRNA

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

formimidoyltransferase cyclodeaminase

increases expression

nimesulide results in increased expression of FTCD mRNA

NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735

G

ferritin light chain 1

increases expression

nimesulide results in increased expression of FTL1 mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

alpha-L-fucosidase 1

decreases expression

nimesulide results in decreased expression of FUCA1 mRNA

NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972

G

frataxin

increases expression

nimesulide results in increased expression of FXN mRNA

NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540

G

frizzled class receptor 8

decreases expression

nimesulide results in decreased expression of FZD8 mRNA

NCBI chr17:57,312,924...57,320,551
Ensembl chr17:57,314,450...57,320,650

G

alpha glucosidase

increases expression

nimesulide results in increased expression of GAA mRNA

NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836

G

growth arrest and DNA-damage-inducible, alpha

increases expression

nimesulide results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, gamma

decreases expression

nimesulide results in decreased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

galactokinase 1

increases expression

nimesulide results in increased expression of GALK1 mRNA

NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337

G

galactose mutarotase

decreases expression

nimesulide results in decreased expression of GALM mRNA

NCBI chr 6:14,837,540...14,889,484
Ensembl chr 6:14,837,548...14,889,310

G

growth arrest specific 6

decreases expression

nimesulide results in decreased expression of GAS6 mRNA

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

GATA binding protein 6

decreases expression

nimesulide results in decreased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

GC, vitamin D binding protein

decreases expression

nimesulide results in decreased expression of GC mRNA

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glycine C-acetyltransferase

decreases expression

nimesulide results in decreased expression of GCAT mRNA

NCBI chr 7:110,595,126...110,601,474
Ensembl chr 7:110,595,091...110,601,473

G

GTP cyclohydrolase 1

increases expression

nimesulide results in increased expression of GCH1 mRNA

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

glucokinase regulator

decreases expression

nimesulide results in decreased expression of GCKR mRNA

NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654

G

glutamate-cysteine ligase, catalytic subunit

increases expression

nimesulide results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

nimesulide results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

guanine deaminase

increases expression

nimesulide results in increased expression of GDA mRNA

NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416

G

glycerophosphodiester phosphodiesterase 1

increases expression

nimesulide results in increased expression of GDE1 mRNA

NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429

G

gamma-glutamyl cyclotransferase

increases expression

nimesulide results in increased expression of GGCT mRNA

NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277

G

gamma-glutamyl hydrolase

increases expression

nimesulide results in increased expression of GGH mRNA

NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787

G

growth hormone inducible transmembrane protein

increases expression

nimesulide results in increased expression of GHITM mRNA

NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879

G

growth hormone receptor

decreases expression

nimesulide results in decreased expression of GHR mRNA

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

glycerol kinase

decreases expression

nimesulide results in decreased expression of GK mRNA

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

glycine decarboxylase

decreases expression

nimesulide results in decreased expression of GLDC mRNA

NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097

G

glutaredoxin 2

increases expression

nimesulide results in increased expression of GLRX2 mRNA

NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831

G

glutaminase 2

decreases expression

nimesulide results in decreased expression of GLS2 mRNA

NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426

G

glutamate dehydrogenase 1

decreases expression

nimesulide results in decreased expression of GLUD1 mRNA

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

glutamate-ammonia ligase

decreases expression

nimesulide results in decreased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glycine-N-acyltransferase

increases expression

nimesulide results in increased expression of GLYAT mRNA

NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942

G

ganglioside GM2 activator

decreases expression

nimesulide results in decreased expression of GM2A mRNA

NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757

G

GDP-mannose pyrophosphorylase A

increases expression

nimesulide results in increased expression of GMPPA mRNA

NCBI chr 9:76,926,724...76,934,274
Ensembl chr 9:76,926,739...76,934,269

G

guanosine monophosphate reductase 2

increases expression

nimesulide results in increased expression of GMPR2 mRNA

NCBI chr15:29,165,421...29,175,933
Ensembl chr15:29,165,783...29,174,935

G

guanine monophosphate synthase

increases expression

nimesulide results in increased expression of GMPS mRNA

NCBI chr 2:148,441,369...148,491,908
Ensembl chr 2:148,435,643...148,485,875

G

GNAS complex locus

decreases expression

nimesulide results in decreased expression of GNAS mRNA

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

decreases expression

nimesulide results in decreased expression of GNE mRNA

NCBI chr 5:58,267,189...58,307,396
Ensembl chr 5:58,267,210...58,307,499

G

G protein nucleolar 3

increases expression

nimesulide results in increased expression of GNL3 mRNA

NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392

G

glycine N-methyltransferase

decreases expression

nimesulide results in decreased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

glucosamine (N-acetyl)-6-sulfatase

decreases expression

nimesulide results in decreased expression of GNS mRNA

NCBI chr 7:56,889,148...56,923,173
Ensembl chr 7:56,889,232...56,923,151

G

golgi transport 1A

increases expression

nimesulide results in increased expression of GOLT1A mRNA

NCBI chr13:44,760,356...44,773,123
Ensembl chr13:44,760,380...44,773,122

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

nimesulide results in decreased expression of GPAM mRNA

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

glycerol-3-phosphate acyltransferase 4

increases expression

nimesulide results in increased expression of GPAT4 mRNA

NCBI chr16:68,819,031...68,852,903
Ensembl chr16:68,819,079...68,852,901

G

glycosylphosphatidylinositol specific phospholipase D1

decreases expression

nimesulide results in decreased expression of GPLD1 mRNA

NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939

G

glutamic--pyruvic transaminase

increases expression

nimesulide results in increased expression of GPT mRNA

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamic--pyruvic transaminase 2

decreases expression

nimesulide results in decreased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione peroxidase 1

decreases expression
multiple interactions

nimesulide results in decreased expression of GPX1 protein
nimesulide results in decreased expression of GPX1 mRNA
[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of GPX1 mRNA]; Silymarin inhibits the reaction [nimesulide results in decreased expression of GPX1 mRNA]

PMID:18848576 PMID:22509279 PMID:24136188

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

granulin precursor

decreases expression

nimesulide results in decreased expression of GRN mRNA

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glycogen synthase kinase 3 beta

decreases activity

nimesulide results in decreased activity of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

increases expression
multiple interactions
decreases expression
decreases activity

nimesulide results in increased expression of GSR mRNA
[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased activity of GSR protein]; [camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of GSR mRNA]; Silymarin inhibits the reaction [nimesulide results in decreased activity of GSR protein]; Silymarin inhibits the reaction [nimesulide results in decreased expression of GSR mRNA]

PMID:22509279 PMID:24136188

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases expression

nimesulide results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 2

increases expression

nimesulide results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

increases expression

nimesulide results in increased expression of GSTA3 mRNA

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 4

increases expression

nimesulide results in increased expression of GSTA4 mRNA

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase mu 1

increases expression

nimesulide results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 4

increases expression

nimesulide results in increased expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase pi 1

increases expression

nimesulide results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase pi 3

decreases expression

nimesulide results in decreased expression of GSTP3 mRNA

NCBI chr 1:201,355,682...201,358,216
Ensembl chr 1:201,355,682...201,358,330

G

glutathione S-transferase zeta 1

decreases expression

nimesulide results in decreased expression of GSTZ1 mRNA

NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284

G

general transcription factor IIH subunit 1

increases expression

nimesulide results in increased expression of GTF2H1 mRNA

NCBI chr 1:97,321,417...97,349,455
Ensembl chr 1:97,321,394...97,349,455

G

general transcription factor III A

increases expression

nimesulide results in increased expression of GTF3A mRNA

NCBI chr12:8,136,746...8,144,690
Ensembl chr12:8,136,747...8,144,690

G

guanylate cyclase 1 soluble subunit alpha 1

decreases expression

nimesulide results in decreased expression of GUCY1A1 mRNA

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

G

guanylate kinase 1

increases expression

nimesulide results in increased expression of GUK1 mRNA

NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107

G

H1.0 linker histone

decreases expression

nimesulide results in decreased expression of H1F0 mRNA

NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694

G

H2A.X variant histone

multiple interactions

nimesulide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

2-hydroxyacyl-CoA lyase 1

increases expression

nimesulide results in increased expression of HACL1 mRNA

NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

nimesulide results in increased expression of HADHB mRNA

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histidine ammonia lyase

decreases expression

nimesulide results in decreased expression of HAL mRNA

NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701

G

hydroxyacid oxidase 1

decreases expression

nimesulide results in decreased expression of HAO1 mRNA

NCBI chr 3:121,757,400...121,828,721
Ensembl chr 3:121,771,836...121,828,721

G

histidyl-tRNA synthetase 1

increases expression

nimesulide results in increased expression of HARS1 mRNA

NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740

G

hemoglobin alpha, adult chain 1

decreases expression

nimesulide results in decreased expression of HBA-A1 mRNA

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin alpha, adult chain 2

decreases expression

nimesulide results in decreased expression of HBA1 mRNA

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392

G

histone deacetylase 2

decreases expression

nimesulide results in decreased expression of HDAC2 mRNA

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

heparin binding growth factor

increases expression

nimesulide results in increased expression of HDGF mRNA

NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

nimesulide results in increased expression of HERPUD1 mRNA

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hes family bHLH transcription factor 6

decreases expression

nimesulide results in decreased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

hematopoietically expressed homeobox

decreases expression

nimesulide results in decreased expression of HHEX mRNA

NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042

G

3-hydroxyisobutyryl-CoA hydrolase

increases expression

nimesulide results in increased expression of HIBCH mRNA

NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

nimesulide results in increased expression of HIGD1A mRNA

NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443

G

HIG1 hypoxia inducible domain family, member 2A

increases expression

nimesulide results in increased expression of HIGD2A mRNA

NCBI chr17:10,021,853...10,022,777
Ensembl chr17:10,021,859...10,022,796

G

heat shock protein nuclear import factor hikeshi

increases expression

nimesulide results in increased expression of HIKESHI mRNA

NCBI chr 1:143,825,399...143,849,361
Ensembl chr 1:143,825,923...143,849,363

G

histidine triad nucleotide binding protein 2

increases expression

nimesulide results in increased expression of HINT2 mRNA

NCBI chr 5:57,904,613...57,906,868
Ensembl chr 5:57,904,614...57,907,097

G

histone cluster 1 H4 family member B

decreases expression

nimesulide results in decreased expression of HIST1H4B mRNA

NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370

G

high mobility group box 2

decreases expression

nimesulide results in decreased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

nimesulide results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

high mobility group nucleosome binding domain 1

increases expression

nimesulide results in increased expression of HMGN1 mRNA

NCBI chr11:35,422,328...35,428,247
Ensembl chr11:35,422,328...35,428,254

G

heme oxygenase 1

increases expression

nimesulide results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

4-hydroxy-2-oxoglutarate aldolase 1

decreases expression

nimesulide results in decreased expression of HOGA1 mRNA

NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568

G

hook microtubule-tethering protein 3

decreases expression

nimesulide results in decreased expression of HOOK3 mRNA

NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338

G

hypoxanthine phosphoribosyltransferase 1

increases expression

nimesulide results in increased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

multiple interactions

nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

nimesulide results in increased expression of HSD17B12 mRNA

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

hydroxysteroid (17-beta) dehydrogenase 13

decreases expression

nimesulide results in decreased expression of HSD17B13 mRNA

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166

G

hydroxysteroid (17-beta) dehydrogenase 4

increases expression

nimesulide results in increased expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxysteroid dehydrogenase like 2

increases expression

nimesulide results in increased expression of HSDL2 mRNA

NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839

G

heat shock transcription factor 1

increases activity

nimesulide results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class A member 1

increases expression

nimesulide results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

increases expression

nimesulide results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 13

increases expression

nimesulide results in increased expression of HSPA13 mRNA

NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895

G

heat shock protein family A (Hsp70) member 8

increases expression

nimesulide results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

increases expression

nimesulide results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 8

increases expression

nimesulide results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

HSPA (Hsp70) binding protein 1

increases expression

nimesulide results in increased expression of HSPBP1 mRNA

NCBI chr 1:69,165,394...69,189,062
Ensembl chr 1:69,165,572...69,244,593

G

heat shock protein family D (Hsp60) member 1

increases expression

nimesulide results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

increases expression

nimesulide results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heat shock protein family H (Hsp110) member 1

increases expression

nimesulide results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

HIV-1 Tat interactive protein 2

increases expression

nimesulide results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

HtrA serine peptidase 1

decreases expression

nimesulide results in decreased expression of HTRA1 mRNA

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

hyaluronidase 3

decreases expression

nimesulide results in decreased expression of HYAL3 mRNA

NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647

G

hyccin PI4KA lipid kinase complex subunit 2

increases expression

nimesulide results in increased expression of HYCC2 mRNA

NCBI chr 9:60,056,883...60,129,176
Ensembl chr 9:60,056,890...60,093,007

G

hypoxia up-regulated 1

increases expression

nimesulide results in increased expression of HYOU1 mRNA

NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186

G

iron-sulfur cluster assembly factor IBA57

increases expression

nimesulide results in increased expression of IBA57 mRNA

NCBI chr10:43,942,017...43,950,807
Ensembl chr10:43,942,017...43,950,807

G

intercellular adhesion molecule 1

multiple interactions

[Ketotifen co-treated with nimesulide] results in decreased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 4

decreases expression

nimesulide results in decreased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

nimesulide results in decreased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon induced transmembrane protein 1

decreases expression

nimesulide results in decreased expression of IFITM1 mRNA

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

interferon beta 1

multiple interactions

[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IFNB1 mRNA

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions
decreases expression

nimesulide inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to nimesulide
[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IFNG mRNA
nimesulide results in decreased expression of IFNG

PMID:12911628 PMID:19362101 PMID:22561872 PMID:24136188

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon-related developmental regulator 1

increases expression

nimesulide results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

interferon-related developmental regulator 2

increases expression

nimesulide results in increased expression of IFRD2 mRNA

NCBI chr 8:108,260,969...108,266,191
Ensembl chr 8:108,260,969...108,266,194

G

insulin-like growth factor 1

decreases expression

nimesulide results in decreased expression of IGF1 mRNA

PMID:23142791 PMID:24136188

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

nimesulide results in decreased expression of IGFALS mRNA

NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677

G

insulin-like growth factor binding protein 3

decreases expression

nimesulide results in decreased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 7

decreases expression

nimesulide results in decreased expression of IGFBP7 mRNA

NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314

G

interleukin 10

multiple interactions

[Lipopolysaccharides co-treated with nimesulide] results in decreased expression of IL10

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

multiple interactions

[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to nimesulide

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression

[Ketotifen co-treated with nimesulide] results in decreased expression of IL1B protein; nimesulide inhibits the reaction [IL1B results in increased activity of EDNRB]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL1B protein]; nimesulide inhibits the reaction [Zymosan analog results in increased expression of IL1B protein]
nimesulide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B mRNA]
nimesulide results in increased expression of IL1B
nimesulide results in decreased expression of IL1B mRNA

PMID:12121561 PMID:12126971 PMID:12946449 PMID:22940226 PMID:24136188 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 23 subunit alpha

multiple interactions

[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 24

increases expression

nimesulide results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 4 receptor

decreases expression

nimesulide results in decreased expression of IL4RA mRNA

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

multiple interactions

nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL6 protein]; nimesulide inhibits the reaction [Zymosan analog results in increased expression of IL6 protein]
nimesulide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
nimesulide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IL6 mRNA]

PMID:12946449 PMID:19931610 PMID:22940226

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

IMP U3 small nucleolar ribonucleoprotein 3

increases expression

nimesulide results in increased expression of IMP3 mRNA

NCBI chr 8:57,339,528...57,340,416
Ensembl chr 8:57,339,496...57,340,414

G

IMP U3 small nucleolar ribonucleoprotein 4

increases expression

nimesulide results in increased expression of IMP4 mRNA

NCBI chr 9:36,654,127...36,659,265
Ensembl chr 9:36,654,401...36,660,075

G

inosine monophosphate dehydrogenase 2

increases expression

nimesulide results in increased expression of IMPDH2 mRNA

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

inhibin subunit beta A

decreases expression

nimesulide results in decreased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

inhibin subunit beta C

decreases expression

nimesulide results in decreased expression of INHBC mRNA

NCBI chr 7:63,184,141...63,197,630
Ensembl chr 7:63,184,142...63,197,630

G

inhibin subunit beta E

decreases expression

nimesulide results in decreased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

inhibitor of carbonic anhydrase

decreases expression

nimesulide results in decreased expression of INHCA mRNA

NCBI chr 8:103,836,846...103,874,980
Ensembl chr 8:103,823,196...103,874,985

G

insulin 1

multiple interactions

nimesulide inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of INS1]

PMID:19247274 PMID:20039930

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

importin 4

increases expression

nimesulide results in increased expression of IPO4 mRNA

NCBI chr15:29,117,365...29,127,382
Ensembl chr15:29,117,365...29,127,285

G

importin 5

increases expression

nimesulide results in increased expression of IPO5 mRNA

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

importin 7

increases expression

nimesulide results in increased expression of IPO7 mRNA

NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938

G

interleukin-1 receptor-associated kinase 1

increases expression

nimesulide results in increased expression of IRAK1 mRNA

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

interferon regulatory factor 1

decreases expression

nimesulide results in decreased expression of IRF1 mRNA

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

interferon regulatory factor 6

decreases expression

nimesulide results in decreased expression of IRF6 mRNA

NCBI chr13:104,672,179...104,691,386
Ensembl chr13:104,672,179...104,691,386

G

inositol-3-phosphate synthase 1

increases expression

nimesulide results in increased expression of ISYNA1 mRNA

NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979

G

inter-alpha trypsin inhibitor, heavy chain 1

decreases expression

nimesulide results in decreased expression of ITIH1 mRNA

NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363

G

inter-alpha-trypsin inhibitor heavy chain 2

decreases expression

nimesulide results in decreased expression of ITIH2 mRNA

NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841

G

isovaleryl-CoA dehydrogenase

decreases expression

nimesulide results in decreased expression of IVD mRNA

NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575

G

iodotyrosine deiodinase

decreases expression

nimesulide results in decreased expression of IYD mRNA

NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319

G

jagunal homolog 1

increases expression

nimesulide results in increased expression of JAGN1 mRNA

NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288

G

Janus kinase 1

decreases expression

nimesulide results in decreased expression of JAK1 mRNA

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

decreases phosphorylation

Nimesulide decreases phoshphorylation of JAK2 in esophagus squamous epithelium

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jupiter microtubule associated homolog 2

increases expression

nimesulide results in increased expression of JPT2 mRNA

NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170

G

junction plakoglobin

decreases expression

nimesulide results in decreased expression of JUP mRNA

NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057

G

potassium channel modulatory factor 1

increases expression

nimesulide results in increased expression of KCMF1 mRNA

NCBI chr 4:104,888,452...104,950,234
Ensembl chr 4:104,889,847...104,950,234

G

potassium voltage-gated channel subfamily H member 2

decreases activity

nimesulide results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium channel tetramerization domain containing 5

increases expression

nimesulide results in increased expression of KCTD5 mRNA

NCBI chr10:13,079,216...13,105,197
Ensembl chr10:13,079,214...13,105,209

G

ketohexokinase

decreases expression

nimesulide results in decreased expression of KHK mRNA

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

G

KLF transcription factor 4

multiple interactions

nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of KLF4 mRNA]

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kallikrein B1

increases response to substance
multiple interactions

KLKB1 gene mutant form results in increased susceptibility to nimesulide
nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased expression of F3 mRNA]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of KLF4 mRNA]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of SIRT1 mRNA]

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

kynurenine 3-monooxygenase

decreases expression

nimesulide results in decreased expression of KMO mRNA

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

kininogen 1

multiple interactions

nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]; nimesulide inhibits the reaction [KNG1 protein affects the localization of PRKCE protein]

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

kininogen 2

decreases expression

nimesulide results in decreased expression of KNG2 mRNA

NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971

G

keratin 10

multiple interactions

[[(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

G

keratin 8

increases expression

nimesulide results in increased expression of KRT8 mRNA

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

KxDL motif containing 1

increases expression

nimesulide results in increased expression of KXD1 mRNA

NCBI chr16:18,895,343...18,916,266
Ensembl chr16:18,900,616...18,920,807

G

kynurenine aminotransferase 1

increases expression

nimesulide results in increased expression of KYAT1 mRNA

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

kynureninase

decreases expression

nimesulide results in decreased expression of KYNU mRNA

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

increases expression

nimesulide results in increased expression of LAMTOR1 mRNA

NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

increases expression

nimesulide results in increased expression of LAMTOR2 mRNA

NCBI chr 2:174,008,556...174,011,950
Ensembl chr 2:174,008,548...174,013,013

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

increases expression

nimesulide results in increased expression of LAMTOR4 mRNA

NCBI chr12:17,258,656...17,262,478
Ensembl chr12:17,258,623...17,262,480

G

leucine aminopeptidase 3

decreases expression

nimesulide results in decreased expression of LAP3 mRNA

NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359

G

lysosomal protein transmembrane 4 alpha

increases expression

nimesulide results in increased expression of LAPTM4A mRNA

NCBI chr 6:31,719,287...31,737,023
Ensembl chr 6:31,718,976...31,737,020

G

lysosomal protein transmembrane 4 beta

decreases expression

nimesulide results in decreased expression of LAPTM4B mRNA

NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383

G

leucine carboxyl methyltransferase 1

decreases expression

nimesulide results in decreased expression of LCMT1 mRNA

NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112

G

lymphocyte cytosolic protein 1

decreases expression

nimesulide results in decreased expression of LCP1 mRNA

NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680

G

lactase

affects activity
decreases activity
multiple interactions
increases activity

nimesulide affects the activity of LCT protein
nimesulide results in decreased activity of LCT protein
[nimesulide results in decreased activity of LCT protein] which results in decreased transport of Glucose
nimesulide results in increased activity of LCT; nimesulide results in increased activity of LCT protein

PMID:16382204 PMID:16855794 PMID:17147060 PMID:18604318

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

leukocyte cell-derived chemotaxin 2

decreases expression

nimesulide results in decreased expression of LECT2 mRNA

NCBI chr17:8,044,759...8,050,983
Ensembl chr17:8,044,759...8,050,983

G

leptin receptor overlapping transcript-like 1

increases expression

nimesulide results in increased expression of LEPROTL1 mRNA

NCBI chr16:58,040,934...58,053,602
Ensembl chr16:58,040,960...58,053,593

G

galectin-like

decreases expression

nimesulide results in decreased expression of LGALSL mRNA

NCBI chr14:94,996,991...95,004,499
Ensembl chr14:94,996,990...95,004,980

G

legumain

decreases expression

nimesulide results in decreased expression of LGMN mRNA

NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480

G

luteinizing hormone subunit beta

multiple interactions

nimesulide inhibits the reaction [LHB results in increased expression of AREG mRNA]; nimesulide inhibits the reaction [LHB results in increased expression of AREG protein]; nimesulide inhibits the reaction [LHB results in increased expression of EREG mRNA]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

decreases expression

nimesulide results in decreased expression of LHPP mRNA

NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578

G

lipase C, hepatic type

decreases expression

nimesulide results in decreased expression of LIPC mRNA

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

G

lecithin retinol acyltransferase

decreases expression

nimesulide results in decreased expression of LRAT mRNA

NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619

G

LDL receptor related protein 5

decreases expression

nimesulide results in decreased expression of LRP5 mRNA

NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581

G

leucine rich repeat containing 28

increases expression

nimesulide results in increased expression of LRRC28 mRNA

NCBI chr 1:121,116,833...121,245,805
Ensembl chr 1:121,127,733...121,245,784

G

leukotriene A4 hydrolase

decreases expression

nimesulide results in decreased expression of LTA4H mRNA

NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600

G

lymphotoxin beta receptor

increases expression

nimesulide results in increased expression of LTBR mRNA

NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539

G

LUC7-like 2 pre-mRNA splicing factor

decreases expression

nimesulide results in decreased expression of LUC7L2 mRNA

NCBI chr 4:67,287,593...67,347,986
Ensembl chr 4:67,287,640...67,347,964

G

lymphocyte antigen 6 family member E

decreases expression

nimesulide results in decreased expression of LY6E mRNA

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

lymphatic vessel endothelial hyaluronan receptor 1

decreases expression

nimesulide results in decreased expression of LYVE1 mRNA

NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309

G

lysozyme 2

decreases expression

nimesulide results in decreased expression of LYZ2 mRNA

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

G

mono-ADP ribosylhydrolase 1

decreases expression

nimesulide results in decreased expression of MACROD1 mRNA

NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716

G

mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, pseudogene 1

increases expression

nimesulide results in increased expression of MAGMAS-PS1 mRNA

NCBI chr10:88,602,379...88,602,899

G

mago homolog, exon junction complex subunit

increases expression

nimesulide results in increased expression of MAGOH mRNA

NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617

G

mitochondrial assembly of ribosomal large subunit 1

increases expression

nimesulide results in increased expression of MALSU1 mRNA

NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905

G

mannosidase, alpha, class 2B, member 1

decreases expression

nimesulide results in decreased expression of MAN2B1 mRNA

NCBI chr19:23,055,092...23,074,398
Ensembl chr19:23,055,097...23,074,389

G

mesencephalic astrocyte-derived neurotrophic factor

increases expression

nimesulide results in increased expression of MANF mRNA

NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438

G

microtubule-associated protein 1 light chain 3 beta

increases expression

nimesulide results in increased expression of MAP1LC3B mRNA

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 3

increases expression

nimesulide results in increased expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nimesulide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nimesulide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 9

decreases expression

nimesulide results in decreased expression of MAPK9 mRNA

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MAPK activated protein kinase 2

decreases expression

nimesulide results in decreased expression of MAPKAPK2 mRNA

NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457

G

membrane associated ring-CH-type finger 5

increases expression

nimesulide results in increased expression of MARCHF5 mRNA

NCBI chr 1:234,931,137...234,953,849
Ensembl chr 1:234,931,271...234,952,632

G

membrane associated ring-CH-type finger 6

increases expression

nimesulide results in increased expression of MARCHF6 mRNA

NCBI chr 2:82,455,686...82,532,917
Ensembl chr 2:82,455,689...82,532,910

G

MARCKS-like 1

decreases expression

nimesulide results in decreased expression of MARCKSL1 mRNA

NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817

G

MBL associated serine protease 1

decreases expression

nimesulide results in decreased expression of MASP1 mRNA

NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974

G

methyl-CpG binding domain protein 3

increases expression

nimesulide results in increased expression of MBD3 mRNA

NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165

G

mannose binding lectin 2

decreases expression

nimesulide results in decreased expression of MBL2 mRNA

NCBI chr 1:228,016,439...228,024,736

G

mbt domain containing 1

decreases expression

nimesulide results in decreased expression of MBTD1 mRNA

NCBI chr10:78,839,140...78,895,413
Ensembl chr10:78,839,036...78,893,720

G

methylcrotonyl-CoA carboxylase subunit 2

decreases expression

nimesulide results in decreased expression of MCCC2 mRNA

NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972

G

minichromosome maintenance complex component 4

increases expression

nimesulide results in increased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 6

increases expression

nimesulide results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

minichromosome maintenance complex component 7

increases expression

nimesulide results in increased expression of MCM7 mRNA

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

G

mucolipin TRP cation channel 1

increases expression

nimesulide results in increased expression of MCOLN1 mRNA

NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252

G

MDM2 proto-oncogene

increases expression

nimesulide results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mediator complex subunit 29

increases expression

nimesulide results in increased expression of MED29 mRNA

NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

nimesulide results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

milk fat globule EGF and factor V/VIII domain containing

decreases expression

nimesulide results in decreased expression of MFGE8 mRNA

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

decreases expression

nimesulide results in decreased expression of MGAT4B mRNA

NCBI chr10:34,548,918...34,559,229
Ensembl chr10:34,549,433...34,559,229

G

monoglyceride lipase

increases expression

nimesulide results in increased expression of MGLL mRNA

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

G

microsomal glutathione S-transferase 2

increases expression

nimesulide results in increased expression of MGST2 mRNA

NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828

G

microsomal glutathione S-transferase 3

decreases expression

nimesulide results in decreased expression of MGST3 mRNA

NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411

G

MIA SH3 domain ER export factor 3

increases expression

nimesulide results in increased expression of MIA3 mRNA

NCBI chr13:94,970,421...95,012,071
Ensembl chr13:94,970,424...95,011,972

G

MID1 interacting protein 1

decreases expression

nimesulide results in decreased expression of MID1IP1 mRNA

NCBI chr X:12,060,993...12,063,318
Ensembl chr X:12,060,883...12,065,774

G

mitochondrial matrix import factor 23

increases expression

nimesulide results in increased expression of MIX23 mRNA

NCBI chr11:64,660,711...64,681,000
Ensembl chr11:64,660,711...64,681,000

G

marker of proliferation Ki-67

multiple interactions

nimesulide inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

malectin

increases expression

nimesulide results in increased expression of MLEC mRNA

NCBI chr12:41,458,234...41,468,710
Ensembl chr12:41,458,231...41,468,708

G

malonyl-CoA decarboxylase

increases expression

nimesulide results in increased expression of MLYCD mRNA

NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793

G

membrane magnesium transporter 1

increases expression

nimesulide results in increased expression of MMGT1 mRNA

NCBI chr X:134,408,463...134,420,798
Ensembl chr X:134,408,466...134,420,729

G

matrix metallopeptidase 9

decreases expression

nimesulide results in decreased expression of MMP9 mRNA; nimesulide results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

molybdenum cofactor synthesis 2

increases expression

nimesulide results in increased expression of MOCS2 mRNA

NCBI chr 2:46,504,588...46,516,327
Ensembl chr 2:46,504,588...46,516,324

G

mannosyl-oligosaccharide glucosidase

increases expression

nimesulide results in increased expression of MOGS mRNA

NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032

G

mitochondrial pyruvate carrier 2

increases expression

nimesulide results in increased expression of MPC2 mRNA

NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664

G

myeloperoxidase

decreases activity
multiple interactions

nimesulide results in decreased activity of MPO
[[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of nimesulide metabolite] which results in increased chemical synthesis of nimesulide metabolite; [[MPO protein co-treated with Hypochlorous Acid] results in increased oxidation of nimesulide metabolite] which results in increased chemical synthesis of nimesulide metabolite; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of and affects the activity of nimesulide metabolite; [MPO protein co-treated with Hypochlorous Acid] results in increased oxidation of and affects the activity of nimesulide metabolite
nimesulide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:11137876 PMID:11996850 PMID:20939553

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MAGUK p55 scaffold protein 1

decreases expression

nimesulide results in decreased expression of MPP1 mRNA

G

mannose receptor, C type 1

decreases expression

nimesulide results in decreased expression of MRC1 mRNA

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

mitochondrial ribosomal protein L12

increases expression

nimesulide results in increased expression of MRPL12 mRNA

NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913

G

mitochondrial ribosomal protein L14

increases expression

nimesulide results in increased expression of MRPL14 mRNA

NCBI chr 9:15,302,840...15,315,195
Ensembl chr 9:15,302,427...15,315,267

G

mitochondrial ribosomal protein L17

increases expression

nimesulide results in increased expression of MRPL17 mRNA

NCBI chr 1:160,162,181...160,163,870
Ensembl chr 1:160,158,807...160,163,815

G

mitochondrial ribosomal protein L18

increases expression

nimesulide results in increased expression of MRPL18 mRNA

NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987

G

mitochondrial ribosomal protein L19

increases expression

nimesulide results in increased expression of MRPL19 mRNA

NCBI chr 4:114,521,824...114,526,053
Ensembl chr 4:114,521,824...114,526,053

G

mitochondrial ribosomal protein L20

increases expression

nimesulide results in increased expression of MRPL20 mRNA

NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492

G

mitochondrial ribosomal protein L22

increases expression

nimesulide results in increased expression of MRPL22 mRNA

NCBI chr10:42,345,446...42,355,779
Ensembl chr10:42,342,776...42,355,779

G

mitochondrial ribosomal protein L23

increases expression

nimesulide results in increased expression of MRPL23 mRNA

NCBI chr 1:197,687,452...197,695,222
Ensembl chr 1:197,687,347...197,695,222

G

mitochondrial ribosomal protein L24

increases expression

nimesulide results in increased expression of MRPL24 mRNA

NCBI chr 2:173,383,062...173,389,249
Ensembl chr 2:173,383,224...173,389,248

G

mitochondrial ribosomal protein L34

increases expression

nimesulide results in increased expression of MRPL34 mRNA

NCBI chr16:18,152,470...18,153,205
Ensembl chr16:18,151,342...18,153,208

G

mitochondrial ribosomal protein L38

increases expression

nimesulide results in increased expression of MRPL38 mRNA

NCBI chr10:101,365,353...101,372,159
Ensembl chr10:101,365,353...101,372,171

G

mitochondrial ribosomal protein L49

increases expression

nimesulide results in increased expression of MRPL49 mRNA

NCBI chr 1:203,346,068...203,350,040
Ensembl chr 1:203,332,481...203,350,049

G

mitochondrial ribosomal protein L50

increases expression

nimesulide results in increased expression of MRPL50 mRNA

NCBI chr 5:63,867,437...63,872,591

G

mitochondrial ribosomal protein L53

increases expression

nimesulide results in increased expression of MRPL53 mRNA

NCBI chr 4:115,615,329...115,616,219

G

mitochondrial ribosomal protein L55

increases expression

nimesulide results in increased expression of MRPL55 mRNA

NCBI chr10:43,988,676...43,991,841
Ensembl chr10:43,988,683...43,991,841

G

mitochondrial ribosomal protein S14

increases expression

nimesulide results in increased expression of MRPS14 mRNA

NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915

G

mitochondrial ribosomal protein S18B

increases expression

nimesulide results in increased expression of MRPS18B mRNA

NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260

G

mitochondrial ribosomal protein S18C

increases expression

nimesulide results in increased expression of MRPS18C mRNA

NCBI chr14:8,812,301...8,818,538
Ensembl chr14:8,791,330...8,818,516

G

mitochondrial ribosomal protein S27

increases expression

nimesulide results in increased expression of MRPS27 mRNA

NCBI chr 2:30,740,007...30,808,577
Ensembl chr 2:30,740,033...30,808,577

G

mitochondrial ribosomal protein S33

increases expression

nimesulide results in increased expression of MRPS33 mRNA

NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:68,596,729...68,605,428

G

mitochondrial ribosomal protein S34

increases expression

nimesulide results in increased expression of MRPS34 mRNA

NCBI chr10:13,916,024...13,917,155
Ensembl chr10:13,916,026...13,918,406

G

mitochondrial ribosomal protein S35

increases expression

nimesulide results in increased expression of MRPS35 mRNA

NCBI chr 4:179,958,067...179,988,752
Ensembl chr 4:179,958,083...179,987,710

G

mitochondrial ribosomal protein S7

increases expression

nimesulide results in increased expression of MRPS7 mRNA

NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129

G

MRT4 homolog, ribosome maturation factor

increases expression

nimesulide results in increased expression of MRTO4 mRNA

NCBI chr 5:151,601,780...151,608,533
Ensembl chr 5:151,601,780...151,608,287

G

mitochondrially encoded cytochrome c oxidase II

decreases expression

Nimesulide decreases expression of MT-CO2 mRNA and protein in esophagus squamous epithelium

RGD

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mitochondrial amidoxime reducing component 1

decreases expression

nimesulide results in decreased expression of MTARC1 mRNA

NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796

G

Metaxin 1

increases expression

nimesulide results in increased expression of MTX1 mRNA

NCBI chr 2:174,615,460...174,621,383
Ensembl chr 2:174,615,461...174,620,982

G

murinoglobulin 1

decreases expression

nimesulide results in decreased expression of MUG1 mRNA

NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051

G

myeloid-derived growth factor

increases expression

nimesulide results in increased expression of MYDGF mRNA

NCBI chr 9:999,659...1,008,804
Ensembl chr 9:1,000,722...1,008,822

G

myosin, heavy chain 9

decreases expression

nimesulide results in decreased expression of MYH9 mRNA

NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457

G

myosin Ib

decreases expression

nimesulide results in decreased expression of MYO1B mRNA

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

myosin ID

decreases expression

nimesulide results in decreased expression of MYO1D mRNA

NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349

G

myosin IG

increases expression

nimesulide results in increased expression of MYO1G mRNA

NCBI chr14:81,386,701...81,401,843
Ensembl chr14:81,386,701...81,401,843

G

N(alpha)-acetyltransferase 20, NatB catalytic subunit

increases expression

nimesulide results in increased expression of NAA20 mRNA

NCBI chr 3:133,322,036...133,336,843
Ensembl chr 3:133,322,064...133,337,009

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

increases expression

nimesulide results in increased expression of NAA38 mRNA

NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494

G

N(alpha)-acetyltransferase 50, NatE catalytic subunit

increases expression

nimesulide results in increased expression of NAA50 mRNA

NCBI chr11:56,538,366...56,560,842
Ensembl chr11:56,538,366...56,560,842

G

nicotinamide phosphoribosyltransferase

increases expression

nimesulide results in increased expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

nucleosome assembly protein 1-like 1

increases expression

nimesulide results in increased expression of NAP1L1 mRNA

NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593

G

N-acetyltransferase 8

increases expression

nimesulide results in increased expression of NAT8 mRNA

NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763

G

NDRG family member 2

decreases expression

nimesulide results in decreased expression of NDRG2 mRNA

NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626

G

NADH:ubiquinone oxidoreductase subunit A5

increases expression

nimesulide results in increased expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598

G

NADH:ubiquinone oxidoreductase subunit A7

increases expression

nimesulide results in increased expression of NDUFA7 mRNA

NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976

G

NADH:ubiquinone oxidoreductase subunit AB1

increases expression

nimesulide results in increased expression of NDUFAB1 mRNA

NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099

G

NADH:ubiquinone oxidoreductase complex assembly factor 4

increases expression

nimesulide results in increased expression of NDUFAF4 mRNA

NCBI chr 5:38,605,169...38,610,341
Ensembl chr 5:38,605,153...38,610,336

G

NADH:ubiquinone oxidoreductase subunit C2

increases expression

nimesulide results in increased expression of NDUFC2 mRNA

NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189

G

nectin cell adhesion molecule 3

decreases expression

nimesulide results in decreased expression of NECTIN3 mRNA

NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519

G

NEDD8 ubiquitin like modifier

increases expression

nimesulide results in increased expression of NEDD8 mRNA

NCBI chr15:29,153,556...29,165,575
Ensembl chr15:29,153,556...29,166,160

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization
decreases expression

Sulfaphenazole affects the reaction [nimesulide affects the localization of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [nimesulide results in increased expression of NQO1]
nimesulide results in decreased expression of NFE2L2 mRNA

PMID:20405857 PMID:24136188

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor I/A

decreases expression

nimesulide results in decreased expression of NFIA mRNA

NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885

G

nuclear factor I/B

decreases expression

nimesulide results in decreased expression of NFIB mRNA

NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479

G

nuclear factor, interleukin 3 regulated

decreases expression

nimesulide results in decreased expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

nerve growth factor

multiple interactions

nimesulide inhibits the reaction [NGF protein results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [NGF protein results in increased secretion of TAC1 protein]; nimesulide inhibits the reaction [NGF results in increased expression of TAC1 mRNA]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

NHP2 ribonucleoprotein

increases expression

nimesulide results in increased expression of NHP2 mRNA

NCBI chr10:35,877,057...35,880,399
Ensembl chr10:35,877,054...35,882,545

G

nidogen 1

decreases expression

nimesulide results in decreased expression of NID1 mRNA

NCBI chr17:86,085,133...86,158,272
Ensembl chr17:86,085,077...86,158,267

G

nucleolar protein interacting with the FHA domain of MKI67

increases expression

nimesulide results in increased expression of NIFK mRNA

NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896

G

nitrilase family, member 2

decreases expression

nimesulide results in decreased expression of NIT2 mRNA

NCBI chr11:43,363,839...43,378,713
Ensembl chr11:43,363,985...43,375,024

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

nimesulide results in increased expression of NME1 mRNA

NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408

G

nicotinamide nucleotide transhydrogenase

decreases expression

nimesulide results in decreased expression of NNT mRNA

NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823

G

Nodal modulator 1

increases expression

nimesulide results in increased expression of NOMO1 mRNA

NCBI chr 1:96,505,460...96,556,280
Ensembl chr 1:96,505,484...96,556,279

G

NOP56 ribonucleoprotein

increases expression

nimesulide results in increased expression of NOP56 mRNA

NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841

G

nitric oxide synthase 2

multiple interactions
decreases expression
increases expression

nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]; nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; nimesulide inhibits the reaction [bepafant inhibits the reaction [[Mycoplasma arthritidis mitogen results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]]
[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased expression of NOS2 mRNA]; [camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased expression of NOS2 protein]; nimesulide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]; Silymarin inhibits the reaction [nimesulide results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [nimesulide results in increased expression of NOS2 protein]
nimesulide results in decreased expression of NOS2
nimesulide results in increased expression of NOS2 mRNA; nimesulide results in increased expression of NOS2 protein

PMID:15135310 PMID:15242784 PMID:15892897 PMID:22107987 PMID:22509279 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 2

decreases expression

nimesulide results in decreased expression of NOTCH2 mRNA

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

NPC intracellular cholesterol transporter 2

decreases expression

nimesulide results in decreased expression of NPC2 mRNA

NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155

G

aminopeptidase-like 1

increases expression

nimesulide results in increased expression of NPEPL1 mRNA

NCBI chr 3:162,893,932...162,906,491
Ensembl chr 3:162,893,943...162,906,492

G

nephrocystin 1

increases expression

nimesulide results in increased expression of NPHP1 mRNA

NCBI chr 3:114,960,650...115,016,234
Ensembl chr 3:114,960,650...115,016,234

G

NPL4 homolog, ubiquitin recognition factor

increases expression

nimesulide results in increased expression of NPLOC4 mRNA

NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

NFE2L2 mutant form inhibits the reaction [nimesulide results in increased expression of NQO1]
nimesulide results in increased expression of NQO1 mRNA

PMID:20405857 PMID:24136188

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group D, member 2

increases expression

nimesulide results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

nimesulide results in decreased expression of NR1H4 mRNA

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

nimesulide results in decreased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neuronal regeneration related protein

decreases expression

nimesulide results in decreased expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

NAD(P) dependent steroid dehydrogenase-like

decreases expression

nimesulide results in decreased expression of NSDHL mRNA

NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142

G

NSE1 homolog, SMC5-SMC6 complex component

increases expression

nimesulide results in increased expression of NSMCE1 mRNA

NCBI chr 1:180,030,355...180,058,541
Ensembl chr 1:180,030,160...180,058,417

G

NOP2/Sun RNA methyltransferase 2

increases expression

nimesulide results in increased expression of NSUN2 mRNA

NCBI chr 1:33,662,139...33,685,887
Ensembl chr 1:33,662,139...33,685,862

G

5' nucleotidase, ecto

decreases expression
multiple interactions

nimesulide results in decreased expression of NT5E mRNA
NT5E protein affects the reaction [nimesulide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of Nitrites]]

PMID:24136188 PMID:27188793

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

NUBP iron-sulfur cluster assembly factor 2

increases expression

nimesulide results in increased expression of NUBP2 mRNA

NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969

G

nuclear distribution C, dynein complex regulator

increases expression

nimesulide results in increased expression of NUDC mRNA

NCBI chr 5:145,758,006...145,771,390
Ensembl chr 5:145,758,002...145,771,425

G

nudix hydrolase 4

increases expression

nimesulide results in increased expression of NUDT4 mRNA

NCBI chr 7:30,188,100...30,204,615
Ensembl chr 7:30,188,100...30,204,615

G

nudix hydrolase 7

increases expression

nimesulide results in increased expression of NUDT7 mRNA

NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081

G

NUS1 dehydrodolichyl diphosphate synthase subunit

increases expression

nimesulide results in increased expression of NUS1 mRNA

NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561

G

nuclear transport factor 2

increases expression

nimesulide results in increased expression of NUTF2 mRNA

NCBI chr19:33,752,319...33,773,595
Ensembl chr19:33,752,291...33,773,591

G

out at first homolog

decreases expression

nimesulide results in decreased expression of OAF mRNA

NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334

G

ornithine aminotransferase

decreases expression

nimesulide results in decreased expression of OAT mRNA

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

alpha-2u globulin PGCL4

increases expression

nimesulide results in increased expression of OBP3 mRNA

NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757

G

ornithine decarboxylase 1

increases expression

nimesulide results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

8-oxoguanine DNA glycosylase

increases expression
multiple interactions

nimesulide results in increased expression of OGG1 protein
[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased expression of OGG1 protein]; Silymarin inhibits the reaction [nimesulide results in increased expression of OGG1 protein]

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

orosomucoid 1

increases expression

nimesulide results in increased expression of ORM1 mRNA

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

oxysterol binding protein-like 11

decreases expression

nimesulide results in decreased expression of OSBPL11 mRNA

NCBI chr11:67,533,669...67,616,795
Ensembl chr11:67,533,672...67,596,444

G

oligosaccharyltransferase complex non-catalytic subunit

increases expression

nimesulide results in increased expression of OSTC mRNA

NCBI chr 2:219,250,549...219,266,076
Ensembl chr 2:219,236,952...219,266,107

G

ornithine transcarbamylase

decreases expression

nimesulide results in decreased expression of OTC mRNA

NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918

G

OTU deubiquitinase, ubiquitin aldehyde binding 1

increases expression

nimesulide results in increased expression of OTUB1 mRNA

NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483

G

OVCA2 serine hydrolase domain containing

increases expression

nimesulide results in increased expression of OVCA2 mRNA

NCBI chr10:60,026,048...60,029,211
Ensembl chr10:60,026,048...60,039,850

G

oxidoreductase NAD-binding domain containing 1

increases expression

nimesulide results in increased expression of OXNAD1 mRNA

NCBI chr16:7,293,470...7,322,540
Ensembl chr16:7,293,470...7,322,540

G

proliferation-associated 2G4

increases expression

nimesulide results in increased expression of PA2G4 mRNA

NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331

G

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

increases expression

nimesulide results in increased expression of PAICS mRNA

NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635

G

phosphatase domain containing, paladin 1

increases expression

nimesulide results in increased expression of PALD1 mRNA

NCBI chr20:29,269,814...29,334,850
Ensembl chr20:29,270,193...29,334,858

G

palmdelphin

decreases expression

nimesulide results in decreased expression of PALMD mRNA

NCBI chr 2:204,889,526...204,941,355
Ensembl chr 2:204,889,533...204,941,519

G

peptidylglycine alpha-amidating monooxygenase

decreases expression

nimesulide results in decreased expression of PAM mRNA

NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965

G

polyamine oxidase

increases expression

nimesulide results in increased expression of PAOX mRNA

NCBI chr 1:194,919,655...194,928,498
Ensembl chr 1:194,903,273...194,928,504

G

3'-phosphoadenosine 5'-phosphosulfate synthase 2

decreases expression

nimesulide results in decreased expression of PAPSS2 mRNA

NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331

G

progestin and adipoQ receptor family member 9

decreases expression

nimesulide results in decreased expression of PAQR9 mRNA

NCBI chr 8:96,114,249...96,116,546

G

poly (ADP-ribose) polymerase 1

increases cleavage
increases expression

nimesulide results in increased cleavage of PARP1 protein
nimesulide results in increased expression of PARP1 mRNA

PMID:19360361 PMID:24136188

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pro-apoptotic WT1 regulator

increases expression

nimesulide results in increased expression of PAWR mRNA

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028

G

phenazine biosynthesis-like protein domain containing 1

increases expression

nimesulide results in increased expression of PBLD1 mRNA

NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614

G

PBX homeobox interacting protein 1

decreases expression

nimesulide results in decreased expression of PBXIP1 mRNA

NCBI chr 2:174,856,339...174,868,922
Ensembl chr 2:174,856,397...174,868,919

G

pyruvate carboxylase

decreases expression

nimesulide results in decreased expression of PC mRNA

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1

decreases expression

nimesulide results in decreased expression of PCMTD1 mRNA

NCBI chr 5:12,284,711...12,355,680
Ensembl chr 5:12,284,711...12,354,899

G

proliferating cell nuclear antigen

increases expression

nimesulide results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

pecanex 1

decreases expression

nimesulide results in decreased expression of PCNX1 mRNA

NCBI chr 6:101,565,461...101,702,339
Ensembl chr 6:101,565,580...101,702,271

G

programmed cell death 4

decreases expression

nimesulide results in decreased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

phosphodiesterase 4B

decreases expression

nimesulide results in decreased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

protein disulfide isomerase family A, member 4

increases expression

nimesulide results in increased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

pyruvate dehydrogenase kinase 2

decreases expression

nimesulide results in decreased expression of PDK2 mRNA

NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085

G

PDZ and LIM domain 1

decreases expression

nimesulide results in decreased expression of PDLIM1 mRNA

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

G

peroxisomal trans-2-enoyl-CoA reductase

increases expression

nimesulide results in increased expression of PECR mRNA

NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511

G

penta-EF hand domain containing 1

increases expression

nimesulide results in increased expression of PEF1 mRNA

NCBI chr 5:142,451,791...142,475,061
Ensembl chr 5:142,451,778...142,475,067

G

pelota mRNA surveillance and ribosome rescue factor

increases expression

nimesulide results in increased expression of PELO mRNA

NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746

G

phosphatidylethanolamine N-methyltransferase

decreases expression

nimesulide results in decreased expression of PEMT mRNA

NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013

G

peroxisomal biogenesis factor 11 alpha

increases expression

nimesulide results in increased expression of PEX11A mRNA

NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172

G

peroxisomal biogenesis factor 7

increases expression

nimesulide results in increased expression of PEX7 mRNA

NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748

G

prefoldin subunit 5

increases expression

nimesulide results in increased expression of PFDN5 mRNA

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

progesterone receptor membrane component 1

increases expression

nimesulide results in increased expression of PGRMC1 mRNA

NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682

G

prohibitin 1

increases expression

nimesulide results in increased expression of PHB1 mRNA

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

PHD finger protein 20-like 1

decreases expression

nimesulide results in decreased expression of PHF20L1 mRNA

NCBI chr 7:98,330,580...98,396,526
Ensembl chr 7:98,330,580...98,396,526

G

PHD finger protein 5A

increases expression

nimesulide results in increased expression of PHF5A mRNA

NCBI chr 7:113,378,469...113,385,035
Ensembl chr 7:113,378,471...113,385,460

G

pleckstrin homology-like domain, family B, member 2

decreases expression

nimesulide results in decreased expression of PHLDB2 mRNA

NCBI chr11:54,859,173...55,078,212
Ensembl chr11:54,859,135...55,078,467

G

phosphatidylinositol 4-kinase type 2 beta

increases expression

nimesulide results in increased expression of PI4K2B mRNA

NCBI chr14:58,221,790...58,248,716
Ensembl chr14:58,220,437...58,248,673

G

phosphatidylinositol glycan anchor biosynthesis, class X

increases expression

nimesulide results in increased expression of PIGX mRNA

NCBI chr11:68,687,126...68,703,067
Ensembl chr11:68,687,093...68,703,472

G

Pim-3 proto-oncogene, serine/threonine kinase

increases expression

nimesulide results in increased expression of PIM3 mRNA

NCBI chr 7:119,953,377...119,956,587
Ensembl chr 7:119,953,175...119,956,587

G

pirin

increases expression

nimesulide results in increased expression of PIR mRNA

NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218

G

PITH domain containing 1

increases expression

nimesulide results in increased expression of PITHD1 mRNA

NCBI chr 5:148,205,995...148,216,490
Ensembl chr 5:148,205,998...148,217,080

G

protein kinase domain containing, cytoplasmic

decreases expression

nimesulide results in decreased expression of PKDCC mRNA

NCBI chr 6:11,455,686...11,465,002
Ensembl chr 6:11,455,686...11,465,556

G

pyruvate kinase L/R

decreases expression

nimesulide results in decreased expression of PKLR mRNA

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

phospholipase A2, group XIIA

increases expression

nimesulide results in increased expression of PLA2G12A mRNA

NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740

G

phospholipase A2, activating protein

increases expression

nimesulide results in increased expression of PLAA mRNA

NCBI chr 5:109,428,600...109,460,373
Ensembl chr 5:109,428,265...109,460,282

G

phospholipase A and acyltransferase 3

decreases expression

nimesulide results in decreased expression of PLAAT3 mRNA

NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667

G

phospholipase B domain containing 1

decreases expression

nimesulide results in decreased expression of PLBD1 mRNA

NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277

G

perilipin 2

increases expression

nimesulide results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

phospholipid phosphatase 2

increases expression

nimesulide results in increased expression of PLPP2 mRNA

NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071

G

phospholipid phosphatase 3

decreases expression

nimesulide results in decreased expression of PLPP3 mRNA

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

phospholipid phosphatase 5

increases expression

nimesulide results in increased expression of PLPP5 mRNA

NCBI chr16:66,349,483...66,353,887
Ensembl chr16:66,349,502...66,464,797

G

phospholipid transfer protein

decreases expression

nimesulide results in decreased expression of PLTP mRNA

NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647

G

plexin A2

decreases expression

nimesulide results in decreased expression of PLXNA2 mRNA

NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979

G

PNN interacting serine and arginine rich protein

decreases expression

nimesulide results in decreased expression of PNISR mRNA

NCBI chr 5:35,395,965...35,422,852
Ensembl chr 5:35,395,965...35,422,844

G

patatin-like phospholipase domain containing 2

increases expression

nimesulide results in increased expression of PNPLA2 mRNA

NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805

G

patatin-like phospholipase domain containing 7

increases expression

nimesulide results in increased expression of PNPLA7 mRNA

NCBI chr 3:7,782,572...7,861,504
Ensembl chr 3:7,782,572...7,861,497

G

patatin-like phospholipase domain containing 8

increases expression

nimesulide results in increased expression of PNPLA8 mRNA

NCBI chr 6:61,329,810...61,391,736
Ensembl chr 6:61,329,810...61,391,734

G

proline-rich nuclear receptor coactivator 1

decreases expression

nimesulide results in decreased expression of PNRC1 mRNA

NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161

G

DNA polymerase delta 4, accessory subunit

increases expression

nimesulide results in increased expression of POLD4 mRNA

NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401

G

DNA polymerase epsilon 3, accessory subunit

increases expression

nimesulide results in increased expression of POLE3 mRNA

NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231
Ensembl chr 7:75,974,717...75,977,231

G

DNA polymerase epsilon 4, accessory subunit

increases expression

nimesulide results in increased expression of POLE4 mRNA

NCBI chr 4:115,165,285...115,171,097
Ensembl chr 4:115,165,285...115,171,097

G

RNA polymerase II subunit G

increases expression

nimesulide results in increased expression of POLR2G mRNA

NCBI chr 1:205,689,160...205,692,537
Ensembl chr 1:205,689,160...205,692,686

G

RNA polymerase II subunit I

increases expression

nimesulide results in increased expression of POLR2I mRNA

NCBI chr 1:85,483,515...85,484,952
Ensembl chr 1:85,483,515...85,484,952

G

proteasome maturation protein

increases expression

nimesulide results in increased expression of POMP mRNA

NCBI chr12:7,162,098...7,174,737
Ensembl chr12:7,160,714...7,174,715

G

paraoxonase 3

decreases expression

nimesulide results in decreased expression of PON3 mRNA

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

POP5 homolog, ribonuclease P/MRP subunit

increases expression

nimesulide results in increased expression of POP5 mRNA

NCBI chr12:41,376,755...41,384,882
Ensembl chr12:41,376,755...41,381,336

G

cytochrome p450 oxidoreductase

increases expression

nimesulide results in increased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

inorganic pyrophosphatase 1

increases expression

nimesulide results in increased expression of PPA1 mRNA

NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215

G

inorganic pyrophosphatase 2

decreases expression

nimesulide results in decreased expression of PPA2 mRNA

NCBI chr 2:221,800,791...221,878,079
Ensembl chr 2:221,800,842...221,878,081

G

peter pan homolog

increases expression

nimesulide results in increased expression of PPAN mRNA

NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression
increases expression

nimesulide inhibits the reaction [ciglitazone promotes the reaction [PPARA protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [ciglitazone results in increased expression of PPARA mRNA]; nimesulide inhibits the reaction [pirinixic acid promotes the reaction [PPARA protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]
nimesulide results in decreased expression of PPARA mRNA
nimesulide results in increased expression of PPARA mRNA; nimesulide results in increased expression of PPARA protein

PMID:11840453 PMID:19415698

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

increases expression
increases response to substance
multiple interactions

nimesulide results in increased expression of PPARD mRNA; nimesulide results in increased expression of PPARD protein
PPARD results in increased susceptibility to nimesulide
[[(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA; [[nimesulide results in decreased activity of PTGS2 protein] co-treated with [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone; nimesulide results in increased activity of and results in increased expression of PPARD; PPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]

PMID:19415698 PMID:19748995 PMID:21159610

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

multiple interactions
decreases expression
increases expression

2-chloro-5-nitrobenzanilide inhibits the reaction [nimesulide promotes the reaction [PPARG binds to PPARG promoter]]; [nimesulide co-treated with Doxorubicin] results in increased expression of PPARG; nimesulide inhibits the reaction [ciglitazone promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [ciglitazone results in increased expression of PPARG mRNA]; nimesulide inhibits the reaction [pirinixic acid promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [pirinixic acid results in increased expression of PPARG mRNA]; nimesulide promotes the reaction [PPARG binds to PPARG promoter]; PPARG mutant form inhibits the reaction [nimesulide results in increased expression of PPARG mRNA]
nimesulide results in decreased expression of PPARG mRNA
nimesulide results in increased expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [nimesulide results in increased expression of PPARG mRNA]
nimesulide inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]

PMID:11840453 PMID:14567645 PMID:14977856 PMID:15705899 PMID:19247274

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

phosphopantothenoylcysteine synthetase

increases expression

nimesulide results in increased expression of PPCS mRNA

NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933

G

pancreatic progenitor cell differentiation and proliferation factor

decreases expression

nimesulide results in decreased expression of PPDPF mRNA

NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:168,299,791...168,301,036

G

PPFIA binding protein 2

decreases expression

nimesulide results in decreased expression of PPFIBP2 mRNA

NCBI chr 1:161,504,774...161,687,339
Ensembl chr 1:161,504,890...161,655,212

G

peptidylprolyl isomerase D

increases expression

nimesulide results in increased expression of PPID mRNA

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

peptidylprolyl isomerase like 3

increases expression

nimesulide results in increased expression of PPIL3 mRNA

NCBI chr 9:59,966,405...59,980,147
Ensembl chr 9:59,964,919...59,979,886

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

increases expression

nimesulide results in increased expression of PPM1K mRNA

NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152

G

protein phosphatase 1 catalytic subunit beta

increases expression

nimesulide results in increased expression of PPP1CB mRNA

NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

increases expression

nimesulide results in increased expression of PPP1R14B mRNA

NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319

G

protein phosphatase 1, regulatory subunit 21

decreases expression

nimesulide results in decreased expression of PPP1R21 mRNA

NCBI chr 6:5,901,518...5,970,684
Ensembl chr 6:5,901,518...5,970,684

G

protein phosphatase 1, regulatory subunit 3B

decreases expression

nimesulide results in decreased expression of PPP1R3B mRNA

NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406

G

protein phosphatase 1, regulatory subunit 3C

decreases expression

nimesulide results in decreased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

protein phosphatase 2, regulatory subunit B', alpha

decreases expression

nimesulide results in decreased expression of PPP2R5A mRNA

NCBI chr13:102,931,264...102,975,661
Ensembl chr13:102,931,264...102,975,661

G

protein phosphatase 4, regulatory subunit 3B

decreases expression

nimesulide results in decreased expression of PPP4R3B mRNA

NCBI chr14:102,917,043...102,965,210
Ensembl chr14:102,917,443...103,068,192

G

PR/SET domain 15

decreases expression

nimesulide results in decreased expression of PRDM15 mRNA

NCBI chr11:37,164,608...37,225,172
Ensembl chr11:37,165,575...37,222,207

G

peroxiredoxin 1

increases expression

nimesulide results in increased expression of PRDX1 mRNA

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 3

increases expression

nimesulide results in increased expression of PRDX3 mRNA

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

peroxiredoxin 5

increases expression

nimesulide results in increased expression of PRDX5 mRNA

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

peroxiredoxin 6

increases expression

nimesulide results in increased expression of PRDX6 mRNA

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

prolactin regulatory element binding

increases expression

nimesulide results in increased expression of PREB mRNA

NCBI chr 6:25,418,805...25,422,594
Ensembl chr 6:25,418,776...25,422,590

G

PRELI domain containing 3B

increases expression

nimesulide results in increased expression of PRELID3B mRNA

NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181

G

protein kinase AMP-activated non-catalytic subunit beta 1

decreases expression

nimesulide results in decreased expression of PRKAB1 mRNA

NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661

G

protein kinase cAMP-dependent type I regulatory subunit alpha

increases expression

nimesulide results in increased expression of PRKAR1A mRNA

NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041

G

protein kinase C, epsilon

multiple interactions

nimesulide inhibits the reaction [F2 protein affects the localization of PRKCE protein]; nimesulide inhibits the reaction [KNG1 protein affects the localization of PRKCE protein]

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein arginine methyltransferase 1

increases expression

nimesulide results in increased expression of PRMT1 mRNA

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

proline dehydrogenase

decreases expression

nimesulide results in decreased expression of PRODH mRNA

NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305

G

phosphoribosyl pyrophosphate synthetase 1

increases expression

nimesulide results in increased expression of PRPS1 mRNA

NCBI chr X:104,132,139...104,154,191
Ensembl chr X:104,132,141...104,154,187

G

proline rich 13

decreases expression

nimesulide results in decreased expression of PRR13 mRNA

NCBI chr 7:133,592,511...133,595,817
Ensembl chr 7:133,592,490...133,601,005

G

serine protease 23

decreases expression

nimesulide results in decreased expression of PRSS23 mRNA

NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091

G

presenilin 2

decreases activity

nimesulide results in decreased activity of PSEN2 protein mutant form

NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174

G

presenilin enhancer gamma secretase subunit

increases expression

nimesulide results in increased expression of PSENEN mRNA

NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192

G

proteasome 20S subunit alpha 1

increases expression

nimesulide results in increased expression of PSMA1 mRNA

NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472

G

proteasome 20S subunit alpha 2

increases expression

nimesulide results in increased expression of PSMA2 mRNA

NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938

G

proteasome 20S subunit alpha 3

increases expression

nimesulide results in increased expression of PSMA3 mRNA

NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965

G

proteasome 20S subunit alpha 4

increases expression

nimesulide results in increased expression of PSMA4 mRNA

NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890

G

proteasome 20S subunit alpha 5

increases expression

nimesulide results in increased expression of PSMA5 mRNA

NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731

G

proteasome 20S subunit alpha 6

increases expression

nimesulide results in increased expression of PSMA6 mRNA

NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554

G

proteasome 20S subunit alpha 7

increases expression

nimesulide results in increased expression of PSMA7 mRNA

NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672

G

proteasome 20S subunit beta 1

increases expression

nimesulide results in increased expression of PSMB1 mRNA

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

G

proteasome 20S subunit beta 2

increases expression

nimesulide results in increased expression of PSMB2 mRNA

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

G

proteasome 20S subunit beta 3

increases expression

nimesulide results in increased expression of PSMB3 mRNA

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

G

proteasome 20S subunit beta 4

increases expression

nimesulide results in increased expression of PSMB4 mRNA

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

proteasome 20S subunit beta 5

increases expression

nimesulide results in increased expression of PSMB5 mRNA

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

G

proteasome 20S subunit beta 6

increases expression

nimesulide results in increased expression of PSMB6 mRNA

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

proteasome 20S subunit beta 7

increases expression

nimesulide results in increased expression of PSMB7 mRNA

NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937

G

proteasome 20S subunit beta 8

decreases expression

nimesulide results in decreased expression of PSMB8 mRNA

NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283

G

proteasome 20S subunit beta 9

decreases expression

nimesulide results in decreased expression of PSMB9 mRNA

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

proteasome 26S subunit, ATPase 3

increases expression

nimesulide results in increased expression of PSMC3 mRNA

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

proteasome 26S subunit, ATPase 4

increases expression

nimesulide results in increased expression of PSMC4 mRNA

NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494

G

proteasome 26S subunit, ATPase 5

increases expression

nimesulide results in increased expression of PSMC5 mRNA

NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135

G

proteasome 26S subunit, non-ATPase 1

increases expression

nimesulide results in increased expression of PSMD1 mRNA

NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211

G

proteasome 26S subunit, non-ATPase 13

increases expression

nimesulide results in increased expression of PSMD13 mRNA

NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905

G

proteasome 26S subunit, non-ATPase 14

increases expression

nimesulide results in increased expression of PSMD14 mRNA

NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 2

increases expression

nimesulide results in increased expression of PSMD2 mRNA

NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

increases expression

nimesulide results in increased expression of PSMD4 mRNA

NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194

G

proteasome 26S subunit, non-ATPase 5

increases expression

nimesulide results in increased expression of PSMD5 mRNA

NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029

G

proteasome 26S subunit, non-ATPase 6

increases expression

nimesulide results in increased expression of PSMD6 mRNA

NCBI chr15:11,102,174...11,112,180
Ensembl chr15:11,102,180...11,205,620

G

proteasome 26S subunit, non-ATPase 8

increases expression

nimesulide results in increased expression of PSMD8 mRNA

NCBI chr 1:84,474,377...84,481,209
Ensembl chr 1:84,474,378...84,481,209

G

proteasome activator subunit 3

increases expression

nimesulide results in increased expression of PSME3 mRNA

NCBI chr10:86,257,672...86,265,458
Ensembl chr10:86,257,668...86,333,804

G

proteasome activator subunit 4

increases expression

nimesulide results in increased expression of PSME4 mRNA

NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408

G

proteasome assembly chaperone 2

increases expression

nimesulide results in increased expression of PSMG2 mRNA

NCBI chr18:61,208,669...61,227,671
Ensembl chr18:61,208,678...61,259,816

G

phosphatidylserine synthase 2

increases expression

nimesulide results in increased expression of PTDSS2 mRNA

NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685

G

prostaglandin E synthase

decreases expression

nimesulide results in decreased expression of PTGES protein

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin E synthase 3-like 1

increases expression

nimesulide results in increased expression of PTGES3L1 mRNA

NCBI chr X:42,215,200...42,224,472
Ensembl chr X:42,214,756...42,225,047

G

prostaglandin reductase 1

affects activity
increases expression

nimesulide affects the activity of PTGR1 protein
nimesulide results in increased expression of PTGR1 mRNA

PMID:24136188 PMID:25619643

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

prostaglandin-endoperoxide synthase 1

increases expression
multiple interactions
decreases expression

nimesulide results in increased expression of PTGS1 protein
nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA]
nimesulide results in decreased expression of PTGS1 protein

PMID:15482327 PMID:19782545 PMID:22107987

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions
decreases expression
increases expression
decreases activity

nimesulide affects the expression of PTGS2 mRNA
[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [ciglitazone promotes the reaction [PPARA protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [ciglitazone promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [ciglitazone results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [ciglitazone results in increased expression of PTGS2 protein]; nimesulide inhibits the reaction [pirinixic acid promotes the reaction [PPARA protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [pirinixic acid promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [pirinixic acid results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [pirinixic acid results in increased expression of PTGS2 protein]; nimesulide inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; nimesulide inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; nimesulide inhibits the reaction [PTGS2 results in decreased expression of CDKN2C mRNA]; nimesulide inhibits the reaction [PTGS2 results in increased expression of C1QB mRNA]
nimesulide results in decreased expression of PTGS2 mRNA; nimesulide results in decreased expression of PTGS2 protein
[[(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA; [[nimesulide results in decreased activity of PTGS2 protein] co-treated with [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone; [nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CCL2 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL10 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL11 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL9 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IFNB1 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IFNG mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IL23A mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of TNFSF11 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of XCL1 mRNA; [nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]; [nimesulide results in decreased expression of PTGS2] which results in increased abundance of Arachidonic Acid; nimesulide binds to and results in decreased activity of PTGS2 protein; nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein]; nimesulide inhibits the reaction [[soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; nimesulide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA]; PPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PTGS2 affects the reaction [nimesulide results in decreased expression of VEGFA protein]; PTGS2 inhibits the reaction [nimesulide results in increased uptake of Hexoses]
[nimesulide results in decreased activity of PTGS2 protein] which results in increased susceptibility to Morphine; [nimesulide results in decreased expression of PTGS2 protein] which results in decreased abundance of Dinoprostone; [nimesulide results in decreased expression of PTGS2] which results in increased activity of anandamide; nimesulide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PTGS2 protein]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of PTGS2]; nimesulide promotes the reaction [Carrageenan results in increased expression of PTGS2 protein]
nimesulide results in decreased expression of PTGS2; nimesulide results in decreased expression of PTGS2 protein
nimesulide results in increased expression of PTGS2 mRNA; nimesulide results in increased expression of PTGS2 protein

PMID:9233713 PMID:11810182 PMID:11840453 PMID:11961048 PMID:12417326 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathymosin

decreases expression

nimesulide results in decreased expression of PTMS mRNA

NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009

G

protein tyrosine phosphatase 4A1

increases expression

nimesulide results in increased expression of PTP4A1 mRNA

NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964

G

protein tyrosine phosphatase, receptor type, B

decreases expression

nimesulide results in decreased expression of PTPRB mRNA

NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748

G

protein tyrosine phosphatase, receptor type, D

decreases expression

nimesulide results in decreased expression of PTPRD mRNA

NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396

G

protein tyrosine phosphatase, receptor type, F

decreases expression

nimesulide results in decreased expression of PTPRF mRNA

NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023

G

PTTG1 regulator of sister chromatid separation, securin

decreases expression

nimesulide results in decreased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

pseudouridine synthase 1

increases expression

nimesulide results in increased expression of PUS1 mRNA

NCBI chr12:45,880,364...45,889,196
Ensembl chr12:45,880,440...45,889,196

G

glycogen phosphorylase L

decreases expression

nimesulide results in decreased expression of PYGL mRNA

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

R3H domain containing 2

decreases expression

nimesulide results in decreased expression of R3HDM2 mRNA

NCBI chr 7:63,212,519...63,340,574
Ensembl chr 7:63,232,346...63,340,540

G

RAB11a, member RAS oncogene family

increases expression

nimesulide results in increased expression of RAB11A mRNA

NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525

G

RAB28, member RAS oncogene family

increases expression

nimesulide results in increased expression of RAB28 mRNA

NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967

G

RAB29, member RAS oncogene family

decreases expression

nimesulide results in decreased expression of RAB29 mRNA

NCBI chr13:43,307,757...43,313,420
Ensembl chr13:43,307,775...43,313,417

G

RAB2A, member RAS oncogene family

increases expression

nimesulide results in increased expression of RAB2A mRNA

NCBI chr 5:21,676,017...21,740,035
Ensembl chr 5:21,676,129...21,739,899

G

RAB34, member RAS oncogene family

increases expression

nimesulide results in increased expression of RAB34 mRNA

NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538

G

RAB38, member RAS oncogene family

decreases expression

nimesulide results in decreased expression of RAB38 mRNA

NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924

G

RAB5 interacting factor

increases expression

nimesulide results in increased expression of RAB5IF mRNA

NCBI chr 3:145,357,990...145,368,012
Ensembl chr 3:145,357,861...145,368,012

G

Rab acceptor 1

increases expression

nimesulide results in increased expression of RABAC1 mRNA

NCBI chr 1:80,564,029...80,567,164
Ensembl chr 1:80,564,033...80,567,163

G

rabaptin, RAB GTPase binding effector protein 1

decreases expression

nimesulide results in decreased expression of RABEP1 mRNA

NCBI chr10:55,566,156...55,667,595
Ensembl chr10:55,566,185...55,665,973

G

Rac family small GTPase 2

decreases expression

nimesulide results in decreased expression of RAC2 mRNA

NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720

G

receptor for activated C kinase 1

increases expression

nimesulide results in increased expression of RACK1 mRNA

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RAN, member RAS oncogene family

increases expression

nimesulide results in increased expression of RAN mRNA

NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276

G

RAN guanine nucleotide release factor

increases expression

nimesulide results in increased expression of RANGRF mRNA

NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840

G

Rap guanine nucleotide exchange factor 4

increases expression

nimesulide results in increased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

retinoic acid receptor, beta

decreases expression

nimesulide results in decreased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RB transcriptional corepressor 1

decreases expression

nimesulide results in decreased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

ribosome binding factor A

decreases expression

nimesulide results in decreased expression of RBFA mRNA

NCBI chr18:73,639,264...73,648,914
Ensembl chr18:73,639,260...73,648,915

G

ribosomal biogenesis factor

increases expression

nimesulide results in increased expression of RBIS mRNA

NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339

G

RNA binding motif protein 26

decreases expression

nimesulide results in decreased expression of RBM26 mRNA

NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118

G

RNA binding motif protein 39

decreases expression

nimesulide results in decreased expression of RBM39 mRNA

NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213

G

RNA binding motif protein 5

decreases expression

nimesulide results in decreased expression of RBM5 mRNA

NCBI chr 8:108,420,220...108,449,481
Ensembl chr 8:108,420,222...108,449,430

G

retinol binding protein 1

decreases expression

nimesulide results in decreased expression of RBP1 mRNA

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

ring-box 1

increases expression

nimesulide results in increased expression of RBX1 mRNA

NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051

G

regulator of calcineurin 1

decreases expression

nimesulide results in decreased expression of RCAN1 mRNA

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045

G

retinol dehydrogenase 11

decreases expression

nimesulide results in decreased expression of RDH11 mRNA

NCBI chr 6:97,979,377...97,995,252
Ensembl chr 6:97,979,378...97,995,252

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

nimesulide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reelin

decreases expression

nimesulide results in decreased expression of RELN mRNA

NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211

G

RNA exonuclease 2

increases expression

nimesulide results in increased expression of REXO2 mRNA

NCBI chr 8:48,811,900...48,823,622
Ensembl chr 8:48,811,900...48,823,622

G

replication factor C subunit 2

increases expression

nimesulide results in increased expression of RFC2 mRNA

NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557

G

regucalcin

decreases expression

nimesulide results in decreased expression of RGN mRNA

NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450

G

rhomboid domain containing 2

increases expression

nimesulide results in increased expression of RHBDD2 mRNA

NCBI chr12:21,043,605...21,054,305
Ensembl chr12:21,043,608...21,054,289

G

ras homolog family member U

decreases expression

nimesulide results in decreased expression of RHOU mRNA

NCBI chr19:51,641,476...51,651,249
Ensembl chr19:51,641,227...51,650,552

G

RNA sensor RIG-1

decreases expression

nimesulide results in decreased expression of RIGI mRNA

NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819

G

Ras and Rab interactor 2

decreases expression

nimesulide results in decreased expression of RIN2 mRNA

NCBI chr 3:133,086,858...133,303,604
Ensembl chr 3:133,086,749...133,303,604

G

regulator of microtubule dynamics 2

decreases expression

nimesulide results in decreased expression of RMDN2 mRNA

NCBI chr 6:15,372,569...15,443,000
Ensembl chr 6:15,375,496...15,441,480

G

ribonuclease A family member 4

decreases expression

nimesulide results in decreased expression of RNASE4 mRNA

NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117

G

ring finger protein 125

decreases expression

nimesulide results in decreased expression of RNF125 mRNA

NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983

G

ring finger protein 128

decreases expression

nimesulide results in decreased expression of RNF128 mRNA

NCBI chr X:103,183,643...103,298,431
Ensembl chr X:103,183,831...103,298,423

G

ring finger protein 139

increases expression

nimesulide results in increased expression of RNF139 mRNA

NCBI chr 7:90,439,726...90,450,911
Ensembl chr 7:90,436,621...90,488,009

G

ring finger protein 149

increases expression

nimesulide results in increased expression of RNF149 mRNA

NCBI chr 9:41,826,825...41,854,381
Ensembl chr 9:41,830,233...41,854,279

G

ring finger protein 187

increases expression

nimesulide results in increased expression of RNF187 mRNA

NCBI chr10:43,709,493...43,715,392
Ensembl chr10:43,702,357...43,716,157

G

ring finger protein 26

decreases expression

nimesulide results in decreased expression of RNF26 mRNA

NCBI chr 8:44,454,551...44,456,745
Ensembl chr 8:44,454,292...44,457,331

G

ring finger protein 7

increases expression

nimesulide results in increased expression of RNF7 mRNA

NCBI chr 8:97,038,845...97,048,080
Ensembl chr 8:97,038,840...97,047,824

G

RAR-related orphan receptor C

decreases expression

nimesulide results in decreased expression of RORC mRNA

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

G

replication protein A1

decreases expression

nimesulide results in decreased expression of RPA1 mRNA

NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949

G

ribosomal protein L10A

increases expression

nimesulide results in increased expression of RPL10A mRNA

NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357

G

ribosomal protein L13

increases expression

nimesulide results in increased expression of RPL13 mRNA

NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014

G

ribosomal protein L13A

increases expression

nimesulide results in increased expression of RPL13A mRNA

NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463

G

ribosomal protein L15

increases expression

nimesulide results in increased expression of RPL15 mRNA

NCBI chr15:7,503,883...7,507,166
Ensembl chr15:7,503,883...7,507,165

G

ribosomal protein L17

increases expression

nimesulide results in increased expression of RPL17 mRNA

NCBI chr18:68,581,141...68,584,253
Ensembl chr18:68,581,098...68,584,253

G

ribosomal protein L18

increases expression

nimesulide results in increased expression of RPL18 mRNA

NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452

G

ribosomal protein L18A

increases expression

nimesulide results in increased expression of RPL18A mRNA

NCBI chr16:18,542,555...18,544,578
Ensembl chr16:18,542,566...18,545,546

G

ribosomal protein L22 like 1

increases expression

nimesulide results in increased expression of RPL22L1 mRNA

NCBI chr 2:111,754,687...111,756,623
Ensembl chr 2:111,754,687...111,756,625

G

ribosomal protein L23

increases expression

nimesulide results in increased expression of RPL23 mRNA

NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870

G

ribosomal protein L27

increases expression

nimesulide results in increased expression of RPL27 mRNA

NCBI chr10:86,375,511...86,379,210
Ensembl chr10:86,375,454...86,379,193

G

ribosomal protein L34

increases expression

nimesulide results in increased expression of RPL34 mRNA

NCBI chr 2:219,284,373...219,288,108
Ensembl chr 2:219,284,382...219,288,111

G

ribosomal protein L35A

increases expression

nimesulide results in increased expression of RPL35A mRNA

NCBI chr11:67,726,031...67,729,953
Ensembl chr11:67,726,032...67,729,942
Ensembl chr 5:67,726,032...67,729,942

G

ribosomal protein L36A

increases expression

nimesulide results in increased expression of RPL36A mRNA

NCBI chr X:97,766,179...97,768,892
Ensembl chr X:97,766,179...97,768,892

G

ribosomal protein L37

increases expression

nimesulide results in increased expression of RPL37 mRNA

NCBI chr 2:54,215,469...54,217,429
Ensembl chr 2:54,215,469...54,217,442

G

ribosomal protein L38 like 1

increases expression

nimesulide results in increased expression of RPL38L1 mRNA

NCBI chr 4:60,296,358...60,296,687
Ensembl chr 4:60,296,410...60,296,622

G

ribosomal protein L9

increases expression

nimesulide results in increased expression of RPL9 mRNA

NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136
Ensembl chr 3:42,893,942...42,897,136

G

ribosomal protein lateral stalk subunit P0

increases expression

nimesulide results in increased expression of RPLP0 mRNA

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

ribosomal protein lateral stalk subunit P1

increases expression

nimesulide results in increased expression of RPLP1 mRNA

NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339

G

ribophorin I

increases expression

nimesulide results in increased expression of RPN1 mRNA

NCBI chr 4:120,543,667...120,565,069
Ensembl chr 4:120,543,667...120,565,069

G

ribosomal protein S11

increases expression

nimesulide results in increased expression of RPS11 mRNA

NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874

G

ribosomal protein S12

increases expression

nimesulide results in increased expression of RPS12 mRNA

NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014

G

ribosomal protein S13

increases expression

nimesulide results in increased expression of RPS13 mRNA

NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
Ensembl chr 3:170,572,921...170,575,355

G

ribosomal protein S14

increases expression

nimesulide results in increased expression of RPS14 mRNA

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166

G

ribosomal protein S15

increases expression

nimesulide results in increased expression of RPS15 mRNA

NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450

G

ribosomal protein S15a

increases expression

nimesulide results in increased expression of RPS15A mRNA

NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995

G

ribosomal protein S16

increases expression

nimesulide results in increased expression of RPS16 mRNA

NCBI chr 1:83,643,066...83,646,056
Ensembl chr 1:83,643,130...83,646,206

G

ribosomal protein S17

increases expression

nimesulide results in increased expression of RPS17 mRNA

NCBI chr 1:135,295,920...135,298,506
Ensembl chr 1:135,295,919...135,298,535
Ensembl chr 8:135,295,919...135,298,535

G

ribosomal protein S19

increases expression

nimesulide results in increased expression of RPS19 mRNA

NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508

G

ribosomal protein S2

increases expression

nimesulide results in increased expression of RPS2 mRNA

NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163

G

ribosomal protein S20

increases expression

nimesulide results in increased expression of RPS20 mRNA

NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475

G

ribosomal protein S21, pseudogene 1

increases expression

nimesulide results in increased expression of RPS21 mRNA

NCBI chr 5:153,387,133...153,387,476
Ensembl chr 5:153,387,176...153,387,427

G

ribosomal protein S27a

increases expression

nimesulide results in increased expression of RPS27A mRNA

NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

ribosomal protein S3

increases expression

nimesulide results in increased expression of RPS3 mRNA

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

ribosomal protein S3a

increases expression

nimesulide results in increased expression of RPS3A mRNA

NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055

G

ribosomal protein S5

increases expression

nimesulide results in increased expression of RPS5 mRNA

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073

G

ribosomal protein S9

increases expression

nimesulide results in increased expression of RPS9 mRNA

NCBI chr 1:65,511,723...65,515,076
Ensembl chr 1:65,511,723...65,515,123

G

ribosomal protein SA

increases expression

nimesulide results in increased expression of RPSA mRNA

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

ras responsive element binding protein 1

decreases expression

nimesulide results in decreased expression of RREB1 mRNA

NCBI chr17:26,876,687...27,002,554
Ensembl chr17:26,876,697...27,002,615

G

ribonucleotide reductase regulatory subunit M2

decreases expression

nimesulide results in decreased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

arginine and serine rich coiled-coil 2

decreases expression

nimesulide results in decreased expression of RSRC2 mRNA

NCBI chr12:32,839,840...32,859,820
Ensembl chr12:32,839,809...32,859,799

G

RT1 class II, locus Ba

decreases expression

nimesulide results in decreased expression of RT1-BA mRNA

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Da

decreases expression

nimesulide results in decreased expression of RT1-DA mRNA

NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455

G

RT1 class II, locus DMb

decreases expression

nimesulide results in decreased expression of HLA-DMB mRNA

NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340

G

RT1 class Ib, locus S3

decreases expression

nimesulide results in decreased expression of RT1-S3 mRNA

NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411

G

RWD domain containing 4

increases expression

nimesulide results in increased expression of RWDD4 mRNA

NCBI chr16:44,714,698...44,733,090
Ensembl chr16:44,714,699...44,733,098

G

retinoid X receptor gamma

decreases expression

nimesulide results in decreased expression of RXRG mRNA

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

sphingosine-1-phosphate receptor 1

decreases expression

nimesulide results in decreased expression of S1PR1 mRNA

NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681

G

Sin3A associated protein 18

increases expression

nimesulide results in increased expression of SAP18 mRNA

NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038
Ensembl chr10:31,943,230...31,950,038

G

secretion associated, Ras related GTPase 1B

increases expression

nimesulide results in increased expression of SAR1B mRNA

NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066

G

store-operated calcium entry-associated regulatory factor

increases expression

nimesulide results in increased expression of SARAF mRNA

NCBI chr16:58,017,231...58,035,481
Ensembl chr16:58,017,231...58,035,545

G

sarcosine dehydrogenase

decreases expression

nimesulide results in decreased expression of SARDH mRNA

NCBI chr 3:10,510,553...10,575,342
Ensembl chr 3:10,510,553...10,573,874

G

spermidine/spermine N1-acetyl transferase 1

decreases expression

nimesulide results in decreased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

secretory carrier membrane protein 1

increases expression

nimesulide results in increased expression of SCAMP1 mRNA

NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673

G

secretory carrier membrane protein 4

increases expression

nimesulide results in increased expression of SCAMP4 mRNA

NCBI chr 7:9,101,504...9,113,929
Ensembl chr 7:9,101,489...9,113,967

G

scavenger receptor class B, member 2

increases expression

nimesulide results in increased expression of SCARB2 mRNA

NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813

G

stearoyl-CoA desaturase

decreases expression

nimesulide results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

sodium voltage-gated channel alpha subunit 5

decreases activity

nimesulide results in decreased activity of SCN5A protein

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

G

syndecan 1

decreases expression

nimesulide results in decreased expression of SDC1 mRNA

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

syndecan 2

decreases expression

nimesulide results in decreased expression of SDC2 mRNA

NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081

G

stromal cell-derived factor 2-like 1

increases expression

nimesulide results in increased expression of SDF2L1 mRNA

NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902

G

succinate dehydrogenase complex subunit C

increases expression

nimesulide results in increased expression of SDHC mRNA

NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253

G

serine dehydratase

decreases expression

nimesulide results in decreased expression of SDS mRNA

NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203

G

SEC11 homolog A, signal peptidase complex subunit

increases expression

nimesulide results in increased expression of SEC11A mRNA

NCBI chr 1:134,881,448...134,909,427
Ensembl chr 1:134,875,265...134,915,069

G

SEC11 homolog C, signal peptidase complex subunit

increases expression

nimesulide results in increased expression of SEC11C mRNA

NCBI chr18:59,320,932...59,337,272
Ensembl chr18:59,320,884...59,337,364

G

SEC61 translocon subunit alpha 1

increases expression

nimesulide results in increased expression of SEC61A1 mRNA

NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925

G

SEC63 homolog, protein translocation regulator

decreases expression

nimesulide results in decreased expression of SEC63 mRNA

NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055

G

SECIS binding protein 2-like

decreases expression

nimesulide results in decreased expression of SECISBP2L mRNA

NCBI chr 3:112,989,613...113,036,060
Ensembl chr 3:112,991,908...113,035,884

G

selectin E

multiple interactions

[Ketotifen co-treated with nimesulide] results in decreased expression of SELE protein

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

selenoprotein K

increases expression

nimesulide results in increased expression of SELENOK mRNA

NCBI chr16:5,152,066...5,160,648
Ensembl chr16:5,152,066...5,159,188

G

selectin L

decreases expression

nimesulide results in decreased expression of SELL protein

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

septin 7

decreases expression

nimesulide results in decreased expression of SEPTIN7 mRNA

NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243

G

stress-associated endoplasmic reticulum protein 1

increases expression

nimesulide results in increased expression of SERP1 mRNA

NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116

G

serpin family A member 6

decreases expression

nimesulide results in decreased expression of SERPINA6 mRNA

NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349

G

serpin family D member 1

decreases expression

nimesulide results in decreased expression of SERPIND1 mRNA

NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519

G

sestrin 2

decreases expression

nimesulide results in decreased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

Set nuclear proto-oncogene

increases expression

nimesulide results in increased expression of SET mRNA

NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567

G

SET domain containing 4

increases expression

nimesulide results in increased expression of SETD4 mRNA

NCBI chr11:32,829,509...32,859,162
Ensembl chr11:32,838,063...32,858,243

G

seizure related 6 homolog

decreases expression

nimesulide results in decreased expression of SEZ6 mRNA

NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671

G

splicing factor 3b, subunit 5

increases expression

nimesulide results in increased expression of SF3B5 mRNA

NCBI chr 1:7,357,040...7,357,752
Ensembl chr 1:7,350,731...7,357,839

G

splicing factor proline and glutamine rich

decreases expression

nimesulide results in decreased expression of SFPQ mRNA

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

serum/glucocorticoid regulated kinase 1

decreases expression

nimesulide results in decreased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sphingosine-1-phosphate phosphatase 1

increases expression

nimesulide results in increased expression of SGPP1 mRNA

NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534

G

SH2 domain containing 4A

decreases expression

nimesulide results in decreased expression of SH2D4A mRNA

NCBI chr16:21,339,010...21,409,360
Ensembl chr16:21,340,015...21,409,260

G

SH3 domain binding glutamate rich protein like 1

decreases expression

nimesulide results in decreased expression of SH3BGRL mRNA

NCBI chr X:74,167,029...74,263,783
Ensembl chr X:74,166,871...74,263,783

G

SH3 domain binding glutamate-rich protein like 3

decreases expression

nimesulide results in decreased expression of SH3BGRL3 mRNA

NCBI chr 5:146,354,152...146,355,525
Ensembl chr 5:146,354,152...146,355,331

G

sedoheptulokinase

decreases expression

nimesulide results in decreased expression of SHPK mRNA

NCBI chr10:57,817,551...57,841,981
Ensembl chr10:57,817,629...57,841,980

G

sucrase-isomaltase

affects activity

nimesulide affects the activity of SI protein

NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260

G

sialic acid acetylesterase

decreases expression

nimesulide results in decreased expression of SIAE mRNA

NCBI chr 8:37,318,724...37,354,004
Ensembl chr 8:37,318,747...37,353,996

G

single Ig and TIR domain containing

increases expression

nimesulide results in increased expression of SIGIRR mRNA

NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:196,199,462...196,202,269

G

sirtuin 1

multiple interactions

nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of SIRT1 mRNA]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

Ski proto-oncogene

decreases expression

nimesulide results in decreased expression of SKI mRNA

NCBI chr 5:165,713,525...165,782,134
Ensembl chr 5:165,714,093...165,782,733

G

S-phase kinase-associated protein 1

increases expression

nimesulide results in increased expression of SKP1 mRNA

NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388

G

solute carrier family 10 member 1

decreases expression

nimesulide results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 12 member 2

increases expression

nimesulide results in increased expression of SLC12A2 mRNA

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 17 member 1

increases expression

nimesulide results in increased expression of SLC17A1 mRNA

NCBI chr17:41,219,461...41,255,199
Ensembl chr17:41,222,049...41,253,304

G

solute carrier family 17, member 2

decreases expression

nimesulide results in decreased expression of SLC17A2 mRNA

NCBI chr17:41,318,312...41,339,012
Ensembl chr17:41,319,701...41,336,325

G

solute carrier family 17 member 3

increases expression

nimesulide results in increased expression of SLC17A3 mRNA

NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256

G

solute carrier family 18 member B1

increases expression

nimesulide results in increased expression of SLC18B1 mRNA

NCBI chr 1:21,628,235...21,670,807
Ensembl chr 1:21,628,237...21,670,684

G

solute carrier family 19 member 2

decreases expression

nimesulide results in decreased expression of SLC19A2 mRNA

NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172

G

solute carrier family 22 member 1

increases expression

nimesulide results in increased expression of SLC22A1 mRNA

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 8

decreases expression

nimesulide results in decreased expression of SLC22A8 mRNA

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 25 member 20

increases expression

nimesulide results in increased expression of SLC25A20 mRNA

NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512

G

solute carrier family 25 member 23

decreases expression

nimesulide results in decreased expression of SLC25A23 mRNA

NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561

G

solute carrier family 25 member 25

decreases expression

nimesulide results in decreased expression of SLC25A25 mRNA

NCBI chr 3:15,708,702...15,742,195
Ensembl chr 3:15,708,703...15,742,216

G

solute carrier family 25, member 38

increases expression

nimesulide results in increased expression of SLC25A38 mRNA

NCBI chr 8:119,835,546...119,848,334
Ensembl chr 8:119,835,634...119,848,332

G

solute carrier family 27 member 5

decreases expression

nimesulide results in decreased expression of SLC27A5 mRNA

NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172

G

solute carrier family 28 member 2

decreases expression

nimesulide results in decreased expression of SLC28A2 mRNA

NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702

G

solute carrier family 2 member 1

multiple interactions

SLC2A1 inhibits the reaction [nimesulide results in increased uptake of Hexoses]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 2

decreases expression

nimesulide results in decreased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 4

increases expression
multiple interactions

nimesulide results in increased expression of SLC2A4 mRNA; nimesulide results in increased expression of SLC2A4 protein
[nimesulide results in increased expression of SLC2A4 protein] which results in increased uptake of Hexoses

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 30 member 5

increases expression

nimesulide results in increased expression of SLC30A5 mRNA

NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934

G

solute carrier family 33 member 1

increases expression

nimesulide results in increased expression of SLC33A1 mRNA

NCBI chr 2:148,415,660...148,438,182
Ensembl chr 2:148,415,666...148,437,758

G

solute carrier family 34 member 1

increases expression

nimesulide results in increased expression of SLC34A1 mRNA

NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852

G

solute carrier family 34 member 2

decreases expression

nimesulide results in decreased expression of SLC34A2 mRNA

NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436

G

solute carrier family 35, member B1

increases expression

nimesulide results in increased expression of SLC35B1 mRNA

NCBI chr10:80,327,921...80,335,279
Ensembl chr10:80,327,945...80,335,274

G

solute carrier family 35 member B4

increases expression

nimesulide results in increased expression of SLC35B4 mRNA

NCBI chr 4:62,776,993...62,799,013
Ensembl chr 4:62,776,993...62,799,003

G

solute carrier family 35, member E3

increases expression

nimesulide results in increased expression of SLC35E3 mRNA

NCBI chr 7:53,337,091...53,350,152
Ensembl chr 7:53,337,095...53,350,165

G

solute carrier family 39 member 4

increases expression

nimesulide results in increased expression of SLC39A4 mRNA

NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553

G

solute carrier family 39 member 8

decreases expression

nimesulide results in decreased expression of SLC39A8 mRNA

NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129

G

solute carrier family 3 member 2

increases expression

nimesulide results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 48 member 1

increases expression

nimesulide results in increased expression of SLC48A1 mRNA

NCBI chr 7:128,915,136...128,923,929
Ensembl chr 7:128,915,195...128,923,024

G

solute carrier family 6 member 9

increases expression

nimesulide results in increased expression of SLC6A9 mRNA

NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728

G

solute carrier organic anion transporter family member 1B2

decreases expression

nimesulide results in decreased expression of SLCO1B2 mRNA

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 2a1

decreases expression

nimesulide results in decreased expression of SLCO2A1 mRNA

NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546

G

secretory leukocyte peptidase inhibitor

increases expression

nimesulide results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

decreases expression

nimesulide results in decreased expression of SMARCE1 mRNA

NCBI chr10:84,159,270...84,180,547
Ensembl chr10:84,159,275...84,179,989

G

structural maintenance of chromosomes 6

decreases expression

nimesulide results in decreased expression of SMC6 mRNA

NCBI chr 6:33,978,730...34,033,201
Ensembl chr 6:33,978,716...34,031,746

G

small integral membrane protein 14

increases expression

nimesulide results in increased expression of SMIM14 mRNA

NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760

G

small integral membrane protein 26

increases expression

nimesulide results in increased expression of SMIM26 mRNA

NCBI chr 3:131,990,147...131,991,779
Ensembl chr 3:131,990,291...131,992,132

G

SPARC related modular calcium binding 1

decreases expression

nimesulide results in decreased expression of SMOC1 mRNA

NCBI chr 6:100,701,330...100,897,441
Ensembl chr 6:100,701,346...100,862,699

G

small nuclear ribonucleoprotein D3 polypeptide

increases expression

nimesulide results in increased expression of SNRPD3 mRNA

NCBI chr20:13,130,112...13,145,947
Ensembl chr20:13,130,119...13,145,978

G

small nuclear ribonucleoprotein polypeptide G

increases expression

nimesulide results in increased expression of SNRPG mRNA

NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826

G

small nuclear ribonucleoprotein 13

increases expression

nimesulide results in increased expression of SNU13 mRNA

NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872
Ensembl chr 1:113,565,295...113,570,872

G

sorting nexin 24

decreases expression

nimesulide results in decreased expression of SNX24 mRNA

NCBI chr18:46,670,987...46,826,070
Ensembl chr18:46,671,443...46,826,068

G

sorting nexin 9

decreases expression

nimesulide results in decreased expression of SNX9 mRNA

NCBI chr 1:46,424,897...46,510,096
Ensembl chr 1:46,423,553...46,509,036

G

superoxide dismutase 1

multiple interactions
decreases expression

[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of SOD1 mRNA]; Silymarin inhibits the reaction [nimesulide results in decreased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression
increases expression
multiple interactions

nimesulide results in decreased expression of SOD2 protein
nimesulide results in increased expression of SOD2 mRNA
nimesulide results in decreased expression of SOD2 mRNA; nimesulide results in decreased expression of SOD2 protein
[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of SOD2 mRNA]; [camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of SOD2 protein]; Silymarin inhibits the reaction [nimesulide results in decreased expression of SOD2 mRNA]; Silymarin inhibits the reaction [nimesulide results in decreased expression of SOD2 protein]

PMID:16969492 PMID:18848576 PMID:22509279 PMID:24136188

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

decreases expression

nimesulide results in decreased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

sorbin and SH3 domain containing 2

decreases expression

nimesulide results in decreased expression of SORBS2 mRNA

NCBI chr16:46,435,220...46,748,743
Ensembl chr16:46,435,237...46,626,514

G

secreted protein acidic and cysteine rich

decreases expression

nimesulide results in decreased expression of SPARC mRNA

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

signal peptidase complex subunit 2

increases expression

nimesulide results in increased expression of SPCS2 mRNA

NCBI chr 1:154,163,724...154,183,152
Ensembl chr 1:154,163,724...154,183,186

G

signal peptidase complex subunit 3

increases expression

nimesulide results in increased expression of SPCS3 mRNA

NCBI chr16:37,305,358...37,310,792
Ensembl chr16:37,305,305...37,331,746

G

serine peptidase inhibitor, Kazal type 1

decreases expression

nimesulide results in decreased expression of SPINK1 mRNA

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

SPRY domain containing 7

increases expression

nimesulide results in increased expression of SPRYD7 mRNA

NCBI chr15:35,707,185...35,727,704
Ensembl chr15:35,707,060...35,727,509

G

sequestosome 1

increases expression

nimesulide results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroid 5 alpha-reductase 1

decreases expression

nimesulide results in decreased expression of SRD5A1 mRNA

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

sterol regulatory element binding transcription factor 1

decreases expression

nimesulide results in decreased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

serglycin

decreases expression

nimesulide results in decreased expression of SRGN mRNA

NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406

G

spermidine synthase

increases expression

nimesulide results in increased expression of SRM mRNA

NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405

G

serine racemase

decreases expression

nimesulide results in decreased expression of SRR mRNA

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

serine and arginine rich splicing factor 4

increases expression

nimesulide results in increased expression of SRSF4 mRNA

NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229

G

sulfiredoxin 1

increases expression

nimesulide results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

SS18 like 2

increases expression

nimesulide results in increased expression of SS18L2 mRNA

NCBI chr 8:121,375,263...121,377,877
Ensembl chr 8:121,375,308...121,377,877

G

signal sequence receptor subunit 1

increases expression

nimesulide results in increased expression of SSR1 mRNA

NCBI chr17:26,833,720...26,861,821
Ensembl chr17:26,833,741...26,861,821

G

signal sequence receptor subunit 2

increases expression

nimesulide results in increased expression of SSR2 mRNA

NCBI chr 2:174,048,291...174,057,043
Ensembl chr 2:174,048,460...174,057,042

G

signal sequence receptor subunit 3

increases expression

nimesulide results in increased expression of SSR3 mRNA

NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132

G

signal sequence receptor subunit 4

increases expression

nimesulide results in increased expression of SSR4 mRNA

NCBI chr X:151,524,191...151,528,218
Ensembl chr X:151,524,009...151,528,202

G

SSX family member 2 interacting protein

decreases expression

nimesulide results in decreased expression of SSX2IP mRNA

NCBI chr 2:235,298,012...235,330,750
Ensembl chr 2:235,298,088...235,330,745

G

ST13, Hsp70 interacting protein

increases expression

nimesulide results in increased expression of ST13 mRNA

NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

decreases expression

nimesulide results in decreased expression of ST3GAL6 mRNA

NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

decreases expression

nimesulide results in decreased expression of ST6GAL1 mRNA

NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310

G

SH3 and cysteine rich domain 3

decreases expression

nimesulide results in decreased expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

STAG1 cohesin complex component

decreases expression

nimesulide results in decreased expression of STAG1 mRNA

NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677

G

STARD3 N-terminal like

increases expression

nimesulide results in increased expression of STARD3NL mRNA

NCBI chr17:45,583,278...45,617,226
Ensembl chr17:45,583,266...45,617,226

G

signal transducer and activator of transcription 3

decreases phosphorylation

Nimesulide decreases phoshphorylation of STAT3 in esophagus squamous epithelium

RGD

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

starch binding domain 1

increases expression

nimesulide results in increased expression of STBD1 mRNA

NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443

G

STEAP3 metalloreductase

decreases expression

nimesulide results in decreased expression of STEAP3 mRNA

NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519

G

STEAP4 metalloreductase

decreases expression

nimesulide results in decreased expression of STEAP4 mRNA

NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859

G

stress-induced phosphoprotein 1

increases expression

nimesulide results in increased expression of STIP1 mRNA

NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476

G

serine/threonine kinase 24

increases expression

nimesulide results in increased expression of STK24 mRNA

NCBI chr15:98,363,707...98,458,940
Ensembl chr15:98,365,791...98,460,553

G

stomatin like 2

increases expression

nimesulide results in increased expression of STOML2 mRNA

NCBI chr 5:57,256,227...57,259,824
Ensembl chr 5:57,256,220...57,259,920

G

steroid sulfatase

increases expression

nimesulide results in increased expression of STS mRNA

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

sulfotransferase family 1A member 1

decreases activity

nimesulide results in decreased activity of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1C member 2A

decreases expression

nimesulide results in decreased expression of SULT1C2A mRNA

NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734

G

sulfotransferase family 1C member 3

decreases expression

nimesulide results in decreased expression of SULT1C3 mRNA

NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030

G

small ubiquitin-like modifier 2

increases expression

nimesulide results in increased expression of SUMO2 mRNA

NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513

G

sulfite oxidase

decreases expression

nimesulide results in decreased expression of SUOX mRNA

NCBI chr 7:1,103,149...1,107,156
Ensembl chr 7:1,103,151...1,107,038

G

SPT20 homolog, SAGA complex component

decreases expression

nimesulide results in decreased expression of SUPT20 mRNA

NCBI chr 2:138,897,316...138,930,493
Ensembl chr 2:138,897,416...138,930,495

G

supervillin

decreases expression

nimesulide results in decreased expression of SVIL mRNA

NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404

G

SWI5 homologous recombination repair protein

increases expression

nimesulide results in increased expression of SWI5 mRNA

NCBI chr 3:15,574,687...15,583,760
Ensembl chr 3:15,564,715...15,583,805

G

synaptojanin 2 binding protein

decreases expression

nimesulide results in decreased expression of SYNJ2BP mRNA

NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:101,189,714...101,227,406

G

tachykinin, precursor 1

multiple interactions
decreases expression

nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]; nimesulide inhibits the reaction [NGF protein results in increased secretion of TAC1 protein]; nimesulide inhibits the reaction [NGF results in increased expression of TAC1 mRNA]
nimesulide results in decreased expression of TAC1 mRNA

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

TATA-box binding protein associated factor 13

increases expression

nimesulide results in increased expression of TAF13 mRNA

NCBI chr 2:196,205,219...196,215,882
Ensembl chr 2:196,205,243...196,215,878

G

transgelin 2

decreases expression

nimesulide results in decreased expression of TAGLN2 mRNA

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

TAR DNA binding protein

increases expression

nimesulide results in increased expression of TARDBP mRNA

NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055

G

tyrosine aminotransferase

decreases expression

nimesulide results in decreased expression of TAT mRNA

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

TatD DNase domain containing 2

increases expression

nimesulide results in increased expression of TATDN2 mRNA

NCBI chr 4:146,845,156...146,865,708
Ensembl chr 4:146,845,156...146,860,897

G

tubulin folding cofactor B

increases expression

nimesulide results in increased expression of TBCB mRNA

NCBI chr 1:85,477,639...85,483,488
Ensembl chr 1:85,477,640...85,483,488

G

tubulin folding cofactor E

increases expression

nimesulide results in increased expression of TBCE mRNA

NCBI chr17:51,290,143...51,336,090
Ensembl chr17:51,290,202...51,336,089

G

thromboxane A2 receptor

increases response to substance

TBXA2R results in increased susceptibility to nimesulide

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

G

t-complex 1

increases expression

nimesulide results in increased expression of TCP1 mRNA

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

trans-2,3-enoyl-CoA reductase

decreases expression

nimesulide results in decreased expression of TECR mRNA

NCBI chr19:24,526,700...24,568,168
Ensembl chr19:24,541,615...24,568,168

G

TEF transcription factor, PAR bZIP family member

increases expression

nimesulide results in increased expression of TEF mRNA

NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783

G

terminal nucleotidyltransferase 2

decreases expression

nimesulide results in decreased expression of TENT2 mRNA

NCBI chr 2:24,380,135...24,432,099
Ensembl chr 2:24,380,225...24,432,099

G

testis expressed 2

increases expression

nimesulide results in increased expression of TEX2 mRNA

NCBI chr10:91,436,629...91,546,240
Ensembl chr10:91,436,694...91,546,270

G

testis expressed 261

increases expression

nimesulide results in increased expression of TEX261 mRNA

NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253

G

transcription factor A, mitochondrial

increases expression

nimesulide results in increased expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transcription factor B2, mitochondrial

increases expression

nimesulide results in increased expression of TFB2M mRNA

NCBI chr13:91,278,889...91,296,709
Ensembl chr13:91,278,898...91,296,657

G

transferrin receptor

increases expression

nimesulide results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta induced

decreases expression

nimesulide results in decreased expression of TGFBI mRNA

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

transglutaminase 2

decreases expression

nimesulide results in decreased expression of TGM2 mRNA

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

thyroid hormone responsive

decreases expression

nimesulide results in decreased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

translocase of inner mitochondrial membrane 10

increases expression

nimesulide results in increased expression of TIMM10 mRNA

NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940

G

translocase of inner mitochondrial membrane 10B

increases expression

nimesulide results in increased expression of TIMM10B mRNA

NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642

G

translocase of inner mitochondrial membrane 13

increases expression

nimesulide results in increased expression of TIMM13 mRNA

NCBI chr 7:8,809,069...8,810,172
Ensembl chr 7:8,809,058...8,809,910

G

translocase of inner mitochondrial membrane 17A

increases expression

nimesulide results in increased expression of TIMM17A mRNA

NCBI chr13:46,731,117...46,742,604
Ensembl chr13:46,730,660...46,742,655

G

translocase of inner mitochondrial membrane 29

increases expression

nimesulide results in increased expression of TIMM29 mRNA

NCBI chr 8:20,145,264...20,148,233

G

translocase of inner mitochondrial membrane 8A1

increases expression

nimesulide results in increased expression of TIMM8A1 mRNA

NCBI chr X:97,717,932...97,722,170
Ensembl chr X:97,717,920...97,721,960

G

translocase of inner mitochondrial membrane 8 homolog B

increases expression

nimesulide results in increased expression of TIMM8B mRNA

NCBI chr 8:50,954,350...50,955,730
Ensembl chr 8:50,954,342...50,955,729

G

TERF1 interacting nuclear factor 2

increases expression

nimesulide results in increased expression of TINF2 mRNA

NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984

G

TLE family member 5, transcriptional modulator

decreases expression

nimesulide results in decreased expression of TLE5 mRNA

NCBI chr 7:8,143,357...8,150,295
Ensembl chr 7:8,143,357...8,150,113

G

TM2 domain containing 1

increases expression

nimesulide results in increased expression of TM2D1 mRNA

NCBI chr 5:113,020,793...113,062,134
Ensembl chr 5:113,020,760...113,050,933

G

TM2 domain containing 2

increases expression

nimesulide results in increased expression of TM2D2 mRNA

NCBI chr16:67,016,683...67,022,206
Ensembl chr16:67,012,675...67,022,226

G

TM2 domain containing 3

increases expression

nimesulide results in increased expression of TM2D3 mRNA

NCBI chr 1:119,267,194...119,277,094
Ensembl chr 1:119,264,576...119,277,099

G

transmembrane 7 superfamily member 2

decreases expression

nimesulide results in decreased expression of TM7SF2 mRNA

NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270

G

transmembrane 9 superfamily member 3

increases expression

nimesulide results in increased expression of TM9SF3 mRNA

NCBI chr 1:240,032,060...240,085,125
Ensembl chr 1:240,035,003...240,084,776

G

transmembrane p24 trafficking protein 2

increases expression

nimesulide results in increased expression of TMED2 mRNA

NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903

G

transmembrane p24 trafficking protein 3

increases expression

nimesulide results in increased expression of TMED3 mRNA

NCBI chr 8:90,241,516...90,249,429
Ensembl chr 8:90,241,516...90,249,346

G

transmembrane p24 trafficking protein 7

increases expression

nimesulide results in increased expression of TMED7 mRNA

NCBI chr18:39,318,564...39,325,640
Ensembl chr18:39,297,351...39,325,640

G

transmembrane p24 trafficking protein 9

increases expression

nimesulide results in increased expression of TMED9 mRNA

NCBI chr17:9,029,646...9,034,160
Ensembl chr17:9,029,646...9,034,176

G

transmembrane protein 106B

increases expression

nimesulide results in increased expression of TMEM106B mRNA

NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619

G

transmembrane protein 126A

increases expression

nimesulide results in increased expression of TMEM126A mRNA

NCBI chr 1:144,424,481...144,430,730
Ensembl chr 1:144,422,703...144,430,628

G

transmembrane protein 140

decreases expression

nimesulide results in decreased expression of TMEM140 mRNA

NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455

G

transmembrane protein 147

increases expression

nimesulide results in increased expression of TMEM147 mRNA

NCBI chr 1:85,977,028...85,978,848
Ensembl chr 1:85,977,025...85,978,868

G

transmembrane protein 14C

increases expression

nimesulide results in increased expression of TMEM14C mRNA

NCBI chr17:23,733,769...23,739,906
Ensembl chr17:23,733,894...23,753,320

G

transmembrane protein 150A

increases expression

nimesulide results in increased expression of TMEM150A mRNA

NCBI chr 4:104,410,271...104,414,630
Ensembl chr 4:104,410,516...104,429,349

G

transmembrane protein 205

increases expression

nimesulide results in increased expression of TMEM205 mRNA

NCBI chr 8:20,452,092...20,458,011
Ensembl chr 8:20,452,092...20,457,828

G

transmembrane protein 208

increases expression

nimesulide results in increased expression of TMEM208 mRNA

NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183

G

transmembrane protein 248

increases expression

nimesulide results in increased expression of TMEM248 mRNA

NCBI chr12:26,430,775...26,457,105
Ensembl chr12:26,432,953...26,457,105

G

transmembrane protein 258

increases expression

nimesulide results in increased expression of TMEM258 mRNA

NCBI chr 1:206,849,723...206,853,623

G

transmembrane protein 259

increases expression

nimesulide results in increased expression of TMEM259 mRNA

NCBI chr 7:9,724,196...9,730,932
Ensembl chr 7:9,722,485...9,730,932

G

transmembrane protein 33

increases expression

nimesulide results in increased expression of TMEM33 mRNA

NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715

G

transmembrane protein 38B

increases expression

nimesulide results in increased expression of TMEM38B mRNA

NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025

G

transmembrane protein 41a

increases expression

nimesulide results in increased expression of TMEM41A mRNA

NCBI chr11:79,084,005...79,090,613
Ensembl chr11:79,084,001...79,090,613

G

transmembrane protein 50A

increases expression

nimesulide results in increased expression of TMEM50A mRNA

NCBI chr 5:147,123,670...147,138,859
Ensembl chr 5:147,123,688...147,138,849

G

transmembrane protein 60

increases expression

nimesulide results in increased expression of TMEM60 mRNA

NCBI chr 4:14,210,029...14,214,884
Ensembl chr 4:14,210,029...14,215,063

G

transmembrane protein 62

increases expression

nimesulide results in increased expression of TMEM62 mRNA

NCBI chr 3:107,921,940...107,961,830
Ensembl chr 3:107,927,307...107,961,795

G

transmembrane protein 69

increases expression

nimesulide results in increased expression of TMEM69 mRNA

NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655

G

transmembrane protein 97

increases expression

nimesulide results in increased expression of TMEM97 mRNA

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

TMEM9 domain family, member B

increases expression

nimesulide results in increased expression of TMEM9B mRNA

NCBI chr 1:163,755,307...163,783,880
Ensembl chr 1:163,764,433...163,783,278

G

thymosin beta 4, X-linked

decreases expression

nimesulide results in decreased expression of TMSB4X mRNA

NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667

G

thioredoxin-related transmembrane protein 1

increases expression

nimesulide results in increased expression of TMX1 mRNA

NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301

G

tumor necrosis factor

multiple interactions
decreases expression
decreases activity
increases expression

[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to nimesulide; [Ketotifen co-treated with nimesulide] results in decreased expression of TNF protein
nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; nimesulide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
nimesulide results in decreased expression of TNF protein
nimesulide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; nimesulide inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]
nimesulide results in decreased activity of TNF
nimesulide results in increased expression of TNF mRNA

PMID:12121561 PMID:15086448 PMID:15135310 PMID:17377112 PMID:17878525 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases expression

nimesulide results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 11

multiple interactions

[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

translocase of outer mitochondrial membrane 20

increases expression

nimesulide results in increased expression of TOMM20 mRNA

NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198

G

translocase of outer mitochondrial membrane 40

increases expression

nimesulide results in increased expression of TOMM40 mRNA

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

G

translocase of outer mitochondrial membrane 5

increases expression

nimesulide results in increased expression of TOMM5 mRNA

NCBI chr 5:59,362,360...59,365,191
Ensembl chr 5:59,362,240...59,365,269

G

translocase of outer mitochondrial membrane 6

increases expression

nimesulide results in increased expression of TOMM6 mRNA

NCBI chr 9:13,304,269...13,305,637

G

torsin family 1, member A

increases expression

nimesulide results in increased expression of TOR1A mRNA

NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691

G

tumor protein p53 inducible protein 3

decreases expression

nimesulide results in decreased expression of TP53I3 mRNA

NCBI chr 6:27,818,327...27,825,753

G

triosephosphate isomerase 1

increases expression

nimesulide results in increased expression of TPI1 mRNA

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

tropomyosin 1

increases expression

nimesulide results in increased expression of TPM1 mRNA

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

tropomyosin 4

decreases expression

nimesulide results in decreased expression of TPM4 mRNA

NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984

G

tumor protein p63 regulated 1-like

increases expression

nimesulide results in increased expression of TPRG1L mRNA

NCBI chr 5:164,722,151...164,725,358
Ensembl chr 5:164,710,285...164,725,425

G

tyrosylprotein sulfotransferase 2

decreases expression

nimesulide results in decreased expression of TPST2 mRNA

NCBI chr12:44,321,875...44,363,892
Ensembl chr12:44,321,875...44,362,329

G

TraB domain containing

increases expression

nimesulide results in increased expression of TRABD mRNA

NCBI chr 7:120,155,042...120,166,015
Ensembl chr 7:120,155,042...120,166,015

G

Tnf receptor associated factor 4

increases expression

nimesulide results in increased expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

TNF receptor-associated protein 1

decreases expression

nimesulide results in decreased expression of TRAP1 mRNA

NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981

G

trafficking protein particle complex subunit 2L

increases expression

nimesulide results in increased expression of TRAPPC2L mRNA

NCBI chr19:50,662,507...50,666,193
Ensembl chr19:50,662,507...50,666,192

G

tribbles pseudokinase 3

increases expression

nimesulide results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 5

decreases expression

nimesulide results in decreased expression of TRIM5 mRNA

NCBI chr 1:158,720,407...158,737,393
Ensembl chr 1:158,720,410...158,814,012

G

tRNA methyltransferase activator subunit 11-2

increases expression

nimesulide results in increased expression of TRMT112 mRNA

NCBI chr 1:204,103,298...204,104,151

G

tetraspanin 7

decreases expression

nimesulide results in decreased expression of TSPAN7 mRNA

NCBI chr X:12,208,783...12,306,092
Ensembl chr X:12,208,783...12,306,131

G

tweety family member 2

decreases expression

nimesulide results in decreased expression of TTYH2 mRNA

NCBI chr10:99,709,063...99,753,449
Ensembl chr10:99,709,007...99,753,444

G

tubulin, beta 2A class IIa

decreases expression

nimesulide results in decreased expression of TUBB2A mRNA

NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714

G

terminal uridylyl transferase 7

decreases expression

nimesulide results in decreased expression of TUT7 mRNA

NCBI chr17:4,849,287...4,903,542
Ensembl chr17:4,849,283...4,903,169

G

trans-golgi network vesicle protein 23 homolog B

increases expression

nimesulide results in increased expression of TVP23B mRNA

NCBI chr10:47,553,789...47,565,203
Ensembl chr10:47,553,831...47,565,203

G

thioredoxin 1

increases expression

nimesulide results in increased expression of TXN1 mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin-like 1

increases expression

nimesulide results in increased expression of TXNL1 mRNA

NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266

G

thioredoxin reductase 1

increases expression

nimesulide results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

tyrosinase

decreases expression

nimesulide results in decreased expression of TYR mRNA; nimesulide results in decreased expression of TYR protein

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

ubiquitin-conjugating enzyme E2C

decreases expression

nimesulide results in decreased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin-conjugating enzyme E2E 3

decreases expression

nimesulide results in decreased expression of UBE2E3 mRNA

NCBI chr 3:63,786,976...63,851,400
Ensembl chr 3:63,786,650...63,843,237

G

ubiquitin-conjugating enzyme E2I

increases expression

nimesulide results in increased expression of UBE2I mRNA

NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443

G

ubiquitin-conjugating enzyme E2K

increases expression

nimesulide results in increased expression of UBE2K mRNA

NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630

G

ubiquitin-conjugating enzyme E2N

increases expression

nimesulide results in increased expression of UBE2N mRNA

NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355

G

ubiquitin protein ligase E3C

increases expression

nimesulide results in increased expression of UBE3C mRNA

NCBI chr 4:5,648,932...5,749,922
Ensembl chr 4:5,648,690...5,750,011

G

UBX domain protein 4

increases expression

nimesulide results in increased expression of UBXN4 mRNA

NCBI chr13:39,740,064...39,772,493
Ensembl chr13:39,740,107...39,772,491

G

ubiquitin C-terminal hydrolase L3, pseudogene 1

increases expression

nimesulide results in increased expression of UCHL3-PS1 mRNA

NCBI chr 3:161,856,954...161,857,835

G

ubiquitin C-terminal hydrolase L5

increases expression

nimesulide results in increased expression of UCHL5 mRNA

NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502

G

ubiquitin recognition factor in ER associated degradation 1

increases expression

nimesulide results in increased expression of UFD1 mRNA

NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087

G

ubiquitin-fold modifier 1

increases expression

nimesulide results in increased expression of UFM1 mRNA

NCBI chr 2:137,969,476...137,977,620
Ensembl chr 2:137,966,678...137,978,089
Ensembl chr 2:137,966,678...137,978,089

G

UDP-glucose 6-dehydrogenase

increases expression

nimesulide results in increased expression of UGDH mRNA

NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354

G

UDP-glucose glycoprotein glucosyltransferase 1

increases expression

nimesulide results in increased expression of UGGT1 mRNA

NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467

G

UDP glucuronosyltransferase family 1 member A6

increases expression

nimesulide results in increased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

nimesulide results in increased expression of UGT2B17 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

uridine monophosphate synthetase

increases expression

nimesulide results in increased expression of UMPS mRNA

NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903

G

uracil-DNA glycosylase

increases expression

nimesulide results in increased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

beta-ureidopropionase 1

decreases expression

nimesulide results in decreased expression of UPB1 mRNA

NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590

G

ubiquinol-cytochrome c reductase complex assembly factor 2

increases expression

nimesulide results in increased expression of UQCC2 mRNA

NCBI chr20:5,202,837...5,214,541
Ensembl chr20:5,202,837...5,214,164

G

URI1, prefoldin-like chaperone

increases expression

nimesulide results in increased expression of URI1 mRNA

NCBI chr 1:90,646,392...90,704,811
Ensembl chr 1:90,646,393...90,709,026

G

ubiquitin specific peptidase 10

increases expression

nimesulide results in increased expression of USP10 mRNA

NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897

G

ubiquitin specific peptidase 14

increases expression

nimesulide results in increased expression of USP14 mRNA

NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519

G

ubiquitin specific peptidase 39

increases expression

nimesulide results in increased expression of USP39 mRNA

NCBI chr 4:104,373,948...104,406,359
Ensembl chr 4:104,373,955...104,406,359

G

ubiquitin specific peptidase 5

increases expression

nimesulide results in increased expression of USP5 mRNA

NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711

G

integral membrane transport protein UST4r

decreases expression

nimesulide results in decreased expression of UST4R mRNA

NCBI chr 1:205,072,204...205,142,718
Ensembl chr 1:205,072,296...205,142,691

G

vesicle-associated membrane protein 7

increases expression

nimesulide results in increased expression of VAMP7 mRNA

NCBI chr12:16,728,486...16,764,261
Ensembl chr12:16,728,524...16,764,097

G

vav guanine nucleotide exchange factor 2

increases expression

nimesulide results in increased expression of VAV2 mRNA

NCBI chr 3:10,584,688...10,754,128
Ensembl chr 3:10,584,688...10,754,052

G

vascular cell adhesion molecule 1

multiple interactions

[Ketotifen co-treated with nimesulide] results in decreased expression of VCAM1 protein

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

affects secretion
multiple interactions
decreases expression
increases expression

nimesulide affects the secretion of VEGFA protein
[nimesulide co-treated with Doxorubicin] results in decreased expression of VEGFA protein
nimesulide results in decreased expression of VEGFA protein
nimesulide results in increased expression of VEGFA protein
PTGS2 affects the reaction [nimesulide results in decreased expression of VEGFA protein]

PMID:15705899 PMID:17380299 PMID:17431384

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor C

decreases expression

nimesulide results in decreased expression of VEGFC mRNA; nimesulide results in decreased expression of VEGFC protein

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

G

vimentin

decreases expression

nimesulide results in decreased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

vasoactive intestinal peptide receptor 1

decreases expression

nimesulide results in decreased expression of VIPR1 mRNA

NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585

G

vitamin K epoxide reductase complex, subunit 1-like 1

increases expression

nimesulide results in increased expression of VKORC1L1 mRNA

NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225

G

vanin 1

increases expression

nimesulide results in increased expression of VNN1 mRNA

NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395

G

VPS26 retromer complex component A

increases expression

nimesulide results in increased expression of VPS26A mRNA

NCBI chr20:30,404,320...30,434,266
Ensembl chr20:30,404,325...30,434,131

G

VPS29 retromer complex component

increases expression

nimesulide results in increased expression of VPS29 mRNA

NCBI chr12:34,208,911...34,217,977
Ensembl chr12:34,207,263...34,217,964

G

von Willebrand factor A domain containing 8

increases expression

nimesulide results in increased expression of VWA8 mRNA

NCBI chr15:54,252,703...54,576,871
Ensembl chr15:54,252,584...54,576,870

G

WASH complex subunit 4

increases expression

nimesulide results in increased expression of WASHC4 mRNA

NCBI chr 7:20,187,905...20,240,228
Ensembl chr 7:20,187,922...20,240,226

G

WD repeat domain 36

increases expression

nimesulide results in increased expression of WDR36 mRNA

NCBI chr18:24,473,657...24,501,773
Ensembl chr18:24,473,663...24,508,092

G

WD repeat domain 45

increases expression

nimesulide results in increased expression of WDR45 mRNA

NCBI chr X:14,776,280...14,782,202
Ensembl chr X:14,776,293...14,782,202

G

WD repeat and SOCS box-containing 1

decreases expression

nimesulide results in decreased expression of WSB1 mRNA

NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019

G

WD repeat and SOCS box-containing 2

increases expression

nimesulide results in increased expression of WSB2 mRNA

NCBI chr12:39,217,645...39,238,634
Ensembl chr12:39,217,648...39,238,640

G

WWC family member 3

increases expression

nimesulide results in increased expression of WWC3 mRNA

NCBI chr X:23,584,204...23,701,864
Ensembl chr X:23,584,424...23,700,513

G

X-C motif chemokine ligand 1

multiple interactions

[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of XCL1 mRNA

NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

nimesulide results in decreased expression of XPC mRNA

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

X-prolyl aminopeptidase 2

decreases expression

nimesulide results in decreased expression of XPNPEP2 mRNA

NCBI chr X:127,287,765...127,317,036
Ensembl chr X:127,287,979...127,317,223

G

exportin 1

increases expression

nimesulide results in increased expression of XPO1 mRNA

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

exportin for tRNA

increases expression

nimesulide results in increased expression of XPOT mRNA

NCBI chr 7:57,111,536...57,152,013
Ensembl chr 7:57,111,536...57,152,099

G

Yip1 interacting factor homolog A, membrane trafficking protein

increases expression

nimesulide results in increased expression of YIF1A mRNA

NCBI chr 1:202,394,923...202,399,125
Ensembl chr 1:202,394,897...202,399,427

G

Yip1 domain family, member 5

increases expression

nimesulide results in increased expression of YIPF5 mRNA

NCBI chr18:32,123,814...32,136,947
Ensembl chr18:32,123,842...32,157,642

G

yippee-like 5

increases expression

nimesulide results in increased expression of YPEL5 mRNA

NCBI chr 6:22,656,284...22,671,741
Ensembl chr 6:22,656,285...22,671,691

G

zinc finger protein 110

decreases expression

nimesulide results in decreased expression of ZFP110 mRNA

NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086

G

zinc finger protein 36, C3H type-like 1

decreases expression

nimesulide results in decreased expression of ZFP36L1 mRNA

NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748

G

zinc finger protein 386 (Kruppel-like)

decreases expression

nimesulide results in decreased expression of ZFP386 mRNA

NCBI chr 6:136,966,547...136,984,013
Ensembl chr 6:136,966,586...136,983,441

G

zinc finger with KRAB and SCAN domains 3

decreases expression

nimesulide results in decreased expression of ZKSCAN3 mRNA

NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827

G

ZPR1 zinc finger

increases expression

nimesulide results in increased expression of ZPR1 mRNA

NCBI chr 8:46,564,898...46,574,719
Ensembl chr 8:46,565,146...46,574,719

G

ZW10 interacting kinetochore protein

increases expression

nimesulide results in increased expression of ZWINT mRNA

NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19831
role	19807
application	19650
anti-inflammatory agent	16605
anti-inflammatory drug	14947
non-steroidal anti-inflammatory drug	14262
nimesulide	1254
Path 2
Term	Annotations
CHEBI ontology	19831
subatomic particle	19829
composite particle	19829
hadron	19829
baryon	19829
nucleon	19829
atomic nucleus	19829
atom	19829
main group element atom	19779
p-block element atom	19779
carbon group element atom	19728
carbon atom	19724
organic molecular entity	19724
organic molecule	19677
organic cyclic compound	19490
carbocyclic compound	18582
benzenoid aromatic compound	18000
benzenes	17863
nitrobenzenes	1819
nitrobenzene	1257
nimesulide	1254

paths to the root