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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3130
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:68534
Term: enzalutamide
Definition: A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer.
Chemical ID: MESH:C540278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycaffects expressionISOMYC (Homo sapiens)6480464CTDenzalutamide affects the expression of MYC mRNAPMID:30940724
Mycdecreases activityISOMyc (Mus musculus)6480464CTDenzalutamide results in decreased activity of MYC proteinPMID:37777120
Mycdecreases expressionISOMYC (Homo sapiens)6480464CTDenzalutamide results in decreased expression of MYC proteinPMID:32184358
Mycmultiple interactionsISOMyc (Mus musculus)6480464CTDenzalutamide promotes the reaction [lupeol results in decreased activity of MYC protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of MYC protein]PMID:37777120
Mycmultiple interactionsISOMYC (Homo sapiens)6480464CTD[enzalutamide co-treated with NVP-BHG712] results in decreased expression of MYC protein; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC mRNA]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC protein]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MYC protein]PMID:24759320 PMID:25970160 PMID:32184358
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