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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:6682
Term: mangiferin
Definition: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position.
Chemical ID: MESH:C013592
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTDmangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein]PMID:19201465
Mapk3decreases activityISOMapk3 (Mus musculus)6480464CTDmangiferin metabolite results in decreased activity of MAPK3 proteinPMID:22084399
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDmangiferin results in increased phosphorylation of MAPK3 proteinPMID:20683903
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDmangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]PMID:22465218
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDmangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]PMID:20683903 PMID:23451106 PMID:27474068
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