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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:28445
Term: vincristine
Definition: A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Chemical ID: MESH:D014750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6affects response to substanceEXP 6480464CTDIL6 protein affects the susceptibility to VincristinePMID:18270703
Il6increases expressionISOIl6 (Mus musculus)6480464CTDVincristine results in increased expression of IL6 mRNA; Vincristine results in increased expression of IL6 proteinPMID:18652822 PMID:34286406
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDVincristine results in increased expression of IL6 mRNAPMID:16001973 PMID:23649840
Il6increases secretionISOIl6 (Mus musculus)6480464CTDVincristine results in increased secretion of IL6 proteinPMID:34286406
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTDgap 27 peptide inhibits the reaction [Vincristine results in increased secretion of IL6 protein]; GJA1 protein promotes the reaction [Vincristine results in increased secretion of IL6 protein]; KN 93 inhibits the reaction [Vincristine results in increased expression of IL6 mRNA]PMID:34286406
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