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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4affects response to substanceISOIl4 (Mus musculus)6480464CTDIL4 protein affects the susceptibility to BleomycinPMID:12574379
Il4decreases response to substanceISOIl4 (Mus musculus)6480464CTDIL4 gene mutant form results in decreased susceptibility to BleomycinPMID:15322207
Il4increases expressionISOIl4 (Mus musculus)6480464CTDBleomycin results in increased expression of IL4 mRNAPMID:11554783 PMID:30033591
Il4increases secretionISOIL4 (Homo sapiens)6480464CTDBleomycin results in increased secretion of IL4 proteinPMID:37898439
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTDCannabidiol analog inhibits the reaction [Bleomycin results in increased expression of IL4 mRNA]; IL4 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of IL4 mRNA]PMID:15322207 PMID:30033591
Il4multiple interactionsISOIL4 (Homo sapiens)6480464CTDyupingfeng inhibits the reaction [Bleomycin results in increased secretion of IL4 protein]PMID:37898439
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