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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1decreases expressionISOGPX1 (Homo sapiens)6480464CTDTretinoin results in decreased expression of GPX1 mRNAPMID:17218384 PMID:33167477
Gpx1increases expressionISOGPX1 (Homo sapiens)6480464CTDTretinoin results in increased expression of GPX1 mRNAPMID:15498508 PMID:17169568
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTD[bisphenol S co-treated with Tretinoin] results in decreased expression of GPX1 mRNAPMID:30951980
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