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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1affects expressionISOEdn1 (Mus musculus)6480464CTDTamoxifen affects the expression of EDN1 mRNAPMID:17555576
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDTamoxifen results in increased expression of EDN1 mRNAPMID:19943105
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTD[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA; [ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA; Estradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]PMID:19943105
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