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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1increases expressionEXP 6480464CTDParaquat results in increased expression of EDN1 mRNA; Paraquat results in increased expression of EDN1 proteinPMID:17235729
Edn1multiple interactionsEXP 6480464CTDgreen tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]; green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 protein]PMID:17235729
Edn1increases expressionISOEdn1 (Mus musculus)6480464CTDParaquat results in increased expression of EDN1 mRNAPMID:21765237
Edn1multiple interactionsISOEdn1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]; Dapsone inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]PMID:21765237
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