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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of EDN1 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Edn1increases expressionEXP 6480464CTDbisphenol A results in increased expression of EDN1 mRNAPMID:25181051
Edn1affects expressionISOEDN1 (Homo sapiens)6480464CTDbisphenol A affects the expression of EDN1 mRNAPMID:20170705
Edn1decreases expressionISOEdn1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of EDN1 mRNAPMID:30951980
Edn1decreases expressionISOEDN1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of EDN1 mRNAPMID:29275510 PMID:29718440
Edn1decreases secretionISOEDN1 (Homo sapiens)6480464CTDbisphenol A results in decreased secretion of EDN1 proteinPMID:27745655
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDbisphenol A analog results in increased expression of EDN1 mRNAPMID:32387340
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