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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1increases expressionEXP 6480464CTDOzone results in increased expression of EDN1 mRNA; Ozone results in increased expression of EDN1 proteinPMID:16081523 PMID:16716893 PMID:16741034 PMID:17662977 PMID:20980218
Edn1multiple interactionsEXP 6480464CTD[Ozone co-treated with Oxygen] inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA]; [Ozone co-treated with Oxygen] inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDN1 protein]; [Particulate Matter co-treated with Ozone] results in increased expression of EDN1 mRNAPMID:16081523 PMID:26550192
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDOzone results in increased expression of EDN1 mRNAPMID:27206323
Edn1multiple interactionsISOEdn1 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of EDN1 mRNAPMID:34911549
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