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GENE - TERM ANNOTATION REPORT

RGD ID: 2513
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnm2
Name: dynamin 2
Acc ID: GO:0006898
Term: receptor-mediated endocytosis
Definition: An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
Definition Source(s): GOC:mah, ISBN:0716731363
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnm2 IDA 728683RGD  
Dnm2involved_inISODNM2 (Homo sapiens)1624291RGD PMID:15731758 PMID:19623537 PMID:36445308

PMID:15731758 PMID:19623537 PMID:36445308
Dnm2involved_inIMP 10047197UniProtPMID:19995918

 
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