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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CYP7A1 mRNAPMID:25331106
Cyp7a1multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Isoniazid] results in increased expression of CYP7A1 mRNAPMID:25331106
Cyp7a1increases expressionISOCYP7A1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CYP7A1 mRNAPMID:35811015
Cyp7a1multiple interactionsISOCyp7a1 (Mus musculus)6480464CTD[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein]PMID:36328986
Cyp7a1multiple interactionsISOCYP7A1 (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CYP7A1 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of CYP7A1 mRNA; [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 mRNAPMID:22777745 PMID:35811015
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