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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:6741
Term: meloxicam
Definition: A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
Chemical ID: MESH:C065757
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDMeloxicam inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]PMID:29484840
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDMeloxicam results in increased activity of CASP3 proteinPMID:19709125 PMID:35920412
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Meloxicam affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Meloxicam inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]PMID:24799355 PMID:29315975
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Meloxicam co-treated with Cilostazol] results in increased activity of CASP3 proteinPMID:35920412
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