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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDCyclophosphamide results in increased activity of CASP3 proteinPMID:32197949
Casp3increases cleavageEXP 6480464CTDCyclophosphamide results in increased cleavage of CASP3 proteinPMID:35762198
Casp3increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of CASP3 proteinPMID:32456565
Casp3multiple interactionsEXP 6480464CTDCilostazol inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]; Cyclophosphamide results in increased expression of and results in increased activity of CASP3 protein; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP3 protein]]; Quercetin inhibits the reaction [Cyclophosphamide results in increased expression of and results in increased activity of CASP3 protein]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]PMID:32197949 PMID:32456565 PMID:35762198 PMID:37419146
Casp3decreases response to substanceISOCASP3 (Homo sapiens)6480464CTDCASP3 protein alternative form results in decreased susceptibility to CyclophosphamidePMID:17020986
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDCyclophosphamide results in increased expression of CASP3 proteinPMID:30506662
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDCyclophosphamide results in increased expression of CASP3 mRNAPMID:14503796
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]PMID:30506662
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Bortezomib co-treated with oblimersen co-treated with Cyclophosphamide] results in increased activity of CASP3 protein; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP3 proteinPMID:11723234 PMID:16675587 PMID:17898787
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