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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfaffects expressionEXP 6480464CTDNicotine affects the expression of BDNF mRNAPMID:20426880
Bdnfincreases expressionEXP 6480464CTDNicotine results in increased expression of BDNF mRNAPMID:9503263 PMID:9832142
Bdnfaffects response to substanceISOBDNF (Homo sapiens)6480464CTDBDNF gene polymorphism affects the susceptibility to NicotinePMID:17186223
Bdnfincreases secretionISOBDNF (Homo sapiens)6480464CTDNicotine results in increased secretion of BDNF proteinPMID:16790237
Bdnfmultiple interactionsISOBdnf (Mus musculus)6480464CTD[Nicotine co-treated with Quartz] results in increased expression of BDNF proteinPMID:36868510
Bdnfmultiple interactionsISOBDNF (Homo sapiens)6480464CTDmethyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein]PMID:16790237
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