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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:80774
Term: tauroursodeoxycholic acid
Definition: A bile acid taurine conjugate derived from ursoodeoxycholic acid.
Chemical ID: MESH:C031655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2increases expressionEXP 6480464CTDursodoxicoltaurine results in increased expression of BCL2 mRNA; ursodoxicoltaurine results in increased expression of BCL2 proteinPMID:12721362 PMID:15255934
Bcl2multiple interactionsEXP 6480464CTDursodoxicoltaurine inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]PMID:35028790
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDursodoxicoltaurine inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]PMID:29751043
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [pachymic acid results in decreased expression of BCL2 mRNA]PMID:16923170 PMID:35524978
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