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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects localizationEXP 6480464CTDtert-Butylhydroperoxide affects the localization of BCL2 proteinPMID:19772912
Bcl2decreases expressionEXP 6480464CTDtert-Butylhydroperoxide results in decreased expression of BCL2 mRNA; tert-Butylhydroperoxide results in decreased expression of BCL2 proteinPMID:15569404 PMID:19772912 PMID:22659508 PMID:26989860
Bcl2multiple interactionsEXP 6480464CTDacadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide affects the localization of BCL2 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Silymarin inhibits the reaction [tert-Butylhydroperoxide affects the localization of BCL2 protein]; Silymarin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]PMID:15569404 PMID:19772912 PMID:26989860
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDtert-Butylhydroperoxide results in decreased expression of BCL2 proteinPMID:20510348
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased expression of BCL2 proteinPMID:12782109 PMID:15288519 PMID:17419000 PMID:23994092 PMID:25522270 PMID:27050144 PMID:29111459 PMID:29128606
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; 3,4-dihydroxyphenyllactic acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in decreased expression of BCL2 mRNA; Genistein inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; LY96 protein affects the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in decreased expression of BCL2 mRNA]; Peptides inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]PMID:15288519 PMID:23994092 PMID:27050144 PMID:29111459 PMID:29128606 PMID:35690295
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