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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionEXP 6480464CTDQuercetin affects the expression of BCL2 proteinPMID:22000973
Bcl2decreases expressionEXP 6480464CTDQuercetin analog results in decreased expression of BCL2 protein; Quercetin results in decreased expression of BCL2 proteinPMID:23281070 PMID:23907460
Bcl2increases expressionEXP 6480464CTDQuercetin results in increased expression of BCL2 mRNAPMID:23281070
Bcl2multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]]; [1-Methyl-4-phenylpyridinium co-treated with Quercetin] results in increased expression of BCL2 mRNA; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Quercetin analog results in decreased expression of BCL2 protein]; Quercetin affects the reaction [Glucose affects the expression of BCL2 protein]; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [aluminum lactate affects the localization of BCL2 protein]; Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of BCL2 mRNA]; Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of BCL2 protein]; Quercetin inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [cypermethrin results in decreased expression of BCL2 mRNA]; Quercetin inhibits the reaction [cypermethrin results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Quercetin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BCL2 mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of BCL2 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Levetiracetam results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Thioacetamide affects the expression of BCL2 protein modified form]; Quercetin inhibits the reaction [triptolide affects the expression of BCL2 protein]; Quercetin inhibits the reaction [Vincristine results in decreased expression of BCL2 mRNA]PMID:14505808 PMID:19466539 PMID:21803128 PMID:21885874 PMID:22524206 PMID:23281070 PMID:23907460 PMID:24316378 PMID:24902966 PMID:26277538 PMID:26476374 PMID:26944603 PMID:27389774 PMID:28000380 PMID:30990955 PMID:32810592 PMID:33038355 PMID:35876585 PMID:37098359
Bcl2affects expressionISOBCL2 (Homo sapiens)6480464CTDQuercetin affects the expression of BCL2 proteinPMID:15975156
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDQuercetin results in decreased expression of BCL2; Quercetin results in decreased expression of BCL2 mRNA; Quercetin results in decreased expression of BCL2 proteinPMID:15538571 PMID:17039455 PMID:18586010 PMID:24275163 PMID:25543474
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDQuercetin analog results in decreased expression of BCL2 protein; Quercetin metabolite results in decreased expression of BCL2 protein; Quercetin results in decreased expression of BCL2; Quercetin results in decreased expression of BCL2 mRNA; Quercetin results in decreased expression of BCL2 proteinPMID:10437144 PMID:14688022 PMID:15741050 PMID:16049707 PMID:16082193 PMID:16280456 PMID:16898267 PMID:18787224 PMID:19623560 PMID:20386985 PMID:20438634 PMID:20803121 PMID:21867607 PMID:22200874 PMID:22222411 PMID:22431435 PMID:22447039 PMID:22555976 PMID:22983795 PMID:24612139 PMID:25289772 PMID:25293876 PMID:25339540 PMID:25481090 PMID:25830055 PMID:25896339 PMID:28811126 PMID:30152185 PMID:30639267 PMID:33070227
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDQuercetin results in increased expression of BCL2 mRNAPMID:23727915
Bcl2increases phosphorylationISOBCL2 (Homo sapiens)6480464CTDQuercetin results in increased phosphorylation of BCL2 proteinPMID:16059641
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Quercetin results in decreased expression of BCL2 mRNA]; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; [Quercetin results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; [Quercetin results in decreased phosphorylation of CREB1 protein] which results in decreased expression of BCL2 mRNA; Doxorubicin inhibits the reaction [Quercetin results in decreased expression of BCL2 protein]; Quercetin affects the reaction [Catechin affects the expression of BCL2 mRNA]; Quercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Quercetin inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]; Quercetin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Quercetin results in decreased expression of BCL2 protein]PMID:15538571 PMID:17135264 PMID:26363153 PMID:27260466 PMID:28681665 PMID:34726822
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein; [Quercetin analog co-treated with Nickel] results in decreased expression of BCL2 protein; [Quercetin results in increased susceptibility to Cisplatin] which results in decreased expression of BCL2 protein; AKT1 protein inhibits the reaction [Quercetin results in decreased expression of BCL2 protein]; BCL2 protein inhibits the reaction [[Arsenic Trioxide co-treated with Quercetin] results in increased cleavage of and results in increased activity of CASP8 protein]; Emulsions promotes the reaction [Quercetin inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]]; NFE2L2 protein inhibits the reaction [Quercetin results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Isoniazid results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Quercetin inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; Quercetin inhibits the reaction [squamosamide inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Quercetin promotes the reaction [TNFSF10 protein results in decreased expression of BCL2 protein]; RELA protein affects the reaction [[pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein]PMID:11597122 PMID:12672908 PMID:16082193 PMID:16619537 PMID:18359480 PMID:18852136 PMID:19557821 PMID:20386985 PMID:20577783 PMID:21295016 PMID:23711929 PMID:25108166 PMID:25896339 PMID:27050144 PMID:27132804 PMID:27470402 PMID:31332904 PMID:32527420
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