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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDthymoquinone affects the reaction [Ethanol affects the expression of BCL2 mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]; thymoquinone inhibits the reaction [sodium arsenate results in decreased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]PMID:29085585 PMID:29710533 PMID:29923357 PMID:30558456 PMID:35437842
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDthymoquinone results in decreased expression of BCL2 proteinPMID:21609759 PMID:29981725 PMID:31298468 PMID:31433961
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDthymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]PMID:36193556
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of BCL2 mRNA; DDIT3 protein affects the reaction [thymoquinone results in decreased expression of BCL2 protein]PMID:24289642 PMID:29981725
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