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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2015
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl1affects expressionEXP 6480464CTDFenofibrate affects the expression of ACSL1 mRNAPMID:20801182
Acsl1decreases expressionEXP 6480464CTDFenofibrate results in decreased expression of ACSL1 proteinPMID:20118634
Acsl1increases expressionEXP 6480464CTDFenofibrate results in increased expression of ACSL1 mRNAPMID:10600944 PMID:25596134 PMID:32741897
Acsl1increases expressionISOACSL1 (Homo sapiens)6480464CTDFenofibrate results in increased expression of ACSL1 mRNA; Fenofibrate results in increased expression of ACSL1 proteinPMID:24752549 PMID:25596134
Acsl1increases expressionISOAcsl1 (Mus musculus)6480464CTDFenofibrate results in increased expression of ACSL1 mRNA; Fenofibrate results in increased expression of ACSL1 proteinPMID:17118139 PMID:24752549
Acsl1multiple interactionsISOACSL1 (Homo sapiens)6480464CTDPPARA protein promotes the reaction [Fenofibrate results in increased expression of ACSL1 protein]PMID:24752549
Acsl1multiple interactionsISOAcsl1 (Mus musculus)6480464CTDPPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 protein]PMID:24752549
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