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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1615151
Species: Mus musculus
RGD Object: Gene
Symbol: Cd40lg
Name: CD40 ligand
Acc ID: CHEBI:37941
Term: clopidogrel
Definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
Chemical ID: MESH:C055162
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd40lgdecreases expressionEXP 6480464CTDclopidogrel results in decreased expression of CD40LG proteinPMID:19155974
Cd40lgmultiple interactionsEXP 6480464CTDClopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD40LG protein]PMID:17043144 PMID:30537341
Cd40lgmultiple interactionsISOCD40LG (Homo sapiens)6480464CTDclopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]PMID:11297035
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