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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552629
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:50867
Term: ciprofibrate
Definition: A cyclopropane that has formula C13H14Cl2O3.
Chemical ID: MESH:C019304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3affects localizationEXP 6480464CTDciprofibrate affects the localization of NR1I3 proteinPMID:17962186
Nr1i3increases activityEXP 6480464CTDciprofibrate results in increased activity of NR1I3 proteinPMID:30203046
Nr1i3increases expressionEXP 6480464CTDciprofibrate results in increased expression of NR1I3 mRNAPMID:25949234
Nr1i3multiple interactionsEXP 6480464CTDciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]PMID:17962186
Nr1i3increases expressionISONr1i3 (Rattus norvegicus)6480464CTDciprofibrate results in increased expression of NR1I3 mRNA; ciprofibrate results in increased expression of NR1I3 proteinPMID:20208394
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