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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552578
Species: Mus musculus
RGD Object: Gene
Symbol: Chrm2
Name: cholinergic receptor, muscarinic 2, cardiac
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm2affects expressionISOChrm2 (Rattus norvegicus)6480464CTDStreptozocin affects the expression of CHRM2 mRNAPMID:17989502
Chrm2increases expressionISOChrm2 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of CHRM2 mRNA; Streptozocin results in increased expression of CHRM2 proteinPMID:18715473
Chrm2multiple interactionsISOChrm2 (Rattus norvegicus)6480464CTD1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM2 mRNA]; Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]; Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein]PMID:17989502 PMID:18715473
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