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GENE - TERM ANNOTATION REPORT

RGD ID: 14051082
Species: Sus scrofa
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: DOID:684
Term: hepatocellular carcinoma
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma "DO" "DO", http://en.wikipedia.org/wiki/Hepatocellular_carcinoma "DO" "DO", http://www.omim.org/entry/114550 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2 ISOPtgs2 (Rattus norvegicus)9068941RGD PMID:18373278 REF_RGD_ID:2300283
PTGS2 ISOPTGS2 (Homo sapiens)9068941RGDmRNA,protein:decreased expression:liverPMID:24759835 REF_RGD_ID:14695011
PTGS2severityISOPTGS2 (Homo sapiens)9068941RGDprotein:increased expression:liver, cytosolPMID:15800977 REF_RGD_ID:14695012
PTGS2susceptibilityISOPTGS2 (Homo sapiens)9068941RGDDNA:SNP:promoter:-1195A>G (rs689466) (human)PMID:24720952 REF_RGD_ID:14695010
PTGS2treatmentISOPtgs2 (Rattus norvegicus)9068941RGD PMID:25999787 REF_RGD_ID:152177911
PTGS2 ISOPTGS2 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:11872629 PMID:12024111 PMID:14563831 PMID:16374840 PMID:17510421
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