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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:hepatocellular carcinoma
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Accession:DOID:684 term browser browse the term
Definition:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. (DO)
Synonyms:exact_synonym: Childhood Hepatocellular Carcinoma;   HCC;   Hepatocellular Cancer;   Hepatocellular Carcinoma, Childhood Type, Somatic;   LCC;   adult liver cancer;   adult liver cancers;   hepatocellular cancers;   hepatocellular carcinomas;   hepatoma;   hepatomas;   liver cell carcinoma;   liver cell carcinomas
 narrow_synonym: HEPATOBLASTOMA;   HEPATOBLASTOMA CAUSED BY SOMATIC MUTATION;   hepatitis B virus induced hepatocellular carcinoma;   hepatitis C virus induced hepatocellular carcinoma;   hepatitis virus-related hepatocellular carcinoma
 primary_id: MESH:D006528
 alt_id: OMIM:114550
 xref: EFO:0000182;   EFO:0000189;   EFO:0008503;   EFO:0008504;   EFO:0008505;   ICD-O:M8170/3;   NCI:C129298;   NCI:C24029;   NCI:C3099;   NCI:C38756;   NCI:C60416;   ORDO:88673
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
hepatocellular carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO CTD Direct Evidence: marker/mechanism
mRNA,protein:increased expression:liver:		 CTD
RGD		 PMID:15509519 RGD:1358261 NCBI chr 5:62,406,928...62,483,690
Ensembl chr 5:62,440,810...62,483,678 		JBrowse link
G AADAT aminoadipate aminotransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:19,768,816...19,792,254
Ensembl chr14:19,768,776...19,792,256 		JBrowse link
G ABCA1 ATP binding cassette subfamily A member 1 severity ISO mRNA:decreased expression:liver (human) RGD PMID:16941710 PMID:30580964 RGD:1598532 RGD:24922199 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492 		JBrowse link
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 susceptibility ISO DNA:polymorphism: : c.1465C > T(human)
DNA:polymorphism: :c.3751G>A(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17510421 PMID:23488625 PMID:24175826 PMID:25625052 RGD:11041138 RGD:14700904 RGD:14700905 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 ISO CTD Direct Evidence: marker/mechanism
OMIM:114550		 CTD
MouseDO		 PMID:22022477 NCBI chr 9:93,171,371...93,262,124 JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO mRNA:increased expression:liver RGD PMID:25842354 RGD:11535155 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,978,363 		JBrowse link
G ABCE1 ATP binding cassette subfamily E member 1 ISO mRNA:increased expression:liver (human) RGD PMID:21932399 RGD:11041873 NCBI chr 8:83,302,055...83,353,208
Ensembl chr 8:83,299,322...83,353,109 		JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO RGD PMID:32171747 RGD:126907997 NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr12:38,580,916...38,875,067
Ensembl chr12:38,581,457...38,824,712 		JBrowse link
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 susceptibility ISO CTD Direct Evidence: therapeutic
DNA:insertion/deletion:intron 16:		 CTD
RGD		 PMID:16328049 PMID:25208933 RGD:11343535 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G ACER3 alkaline ceramidase 3 disease_progression ISO RGD PMID:30097213 RGD:35673325 NCBI chr 9:10,985,078...11,167,386
Ensembl chr 9:10,967,857...11,162,502 		JBrowse link
G ACLY ATP citrate lyase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr12:20,796,678...20,841,301
Ensembl chr12:20,796,749...20,841,298 		JBrowse link
G ACO2 aconitase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 5:7,014,383...7,071,023
Ensembl chr 5:7,008,719...7,071,025 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12771043 PMID:15565109 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546 		JBrowse link
G ACSL4 acyl-CoA synthetase long chain family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr  X:89,760,863...89,838,103
Ensembl chr  X:89,760,866...89,806,274 		JBrowse link
G ACTB actin beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 PMID:21472284 NCBI chr 3:4,084,275...4,090,383
Ensembl chr 3:4,082,216...4,090,356 		JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19514085 NCBI chr13:190,277,175...190,285,957
Ensembl chr13:190,276,430...190,286,214 		JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:273,022,014...273,066,916
Ensembl chr 1:273,024,009...273,056,039 		JBrowse link
G ADD1 adducin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr 8:1,627,146...1,710,653
Ensembl chr 8:1,627,062...1,710,650 		JBrowse link
G ADGRG7 adhesion G protein-coupled receptor G7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:158,334,535...158,402,752
Ensembl chr13:158,338,849...158,408,525 		JBrowse link
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:121,225,485...121,259,262
NCBI chr  X:98,582,002...98,583,002
Ensembl chr 8:121,225,656...121,261,746 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing susceptibility ISO DNA:SNP:intron:+276T>G (rs1501299) (human) RGD PMID:23740135 RGD:14401720 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G ADRA1A adrenoceptor alpha 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:10,623,391...10,733,378
Ensembl chr14:10,626,293...10,733,068 		JBrowse link
G ADRA2B adrenoceptor alpha 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:45,760,966...45,762,306
Ensembl chr 3:45,760,541...45,764,175 		JBrowse link
G AFP alpha fetoprotein severity
treatment
disease_progression		 ISO protein:increased expression:serum (human)
CTD Direct Evidence: marker/mechanism
associated with hepatitis B		 RGD
CTD		 PMID:9029167 PMID:15276417 PMID:22147961 PMID:22392353 PMID:24012840 More... RGD:125097525 RGD:126790579 RGD:126790583 RGD:14401581 RGD:152177911 NCBI chr 8:69,677,690...69,698,864
Ensembl chr 8:69,677,690...69,698,864 		JBrowse link
G AICDA activation induced cytidine deaminase ISO RGD PMID:18997814 RGD:127285629 NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,369 		JBrowse link
G AK3 adenylate kinase 3 ISO protein:decreased expression:liver RGD PMID:17203974 RGD:13842477 NCBI chr 1:217,236,561...217,263,144
Ensembl chr 1:217,236,482...217,261,367 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32805337 NCBI chr 6:165,811,245...165,825,168
Ensembl chr 6:165,811,247...165,824,896 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B ISO protein:increased expression:liver (human)
protein:increased expression:liver (rat)		 RGD PMID:19422879 PMID:21683810 RGD:5509919 RGD:8548685 NCBI chr18:14,593,516...14,752,316
Ensembl chr18:14,684,036...14,752,310 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 treatment ISO ClinVar Annotator: match by term: Hepatocellular cancer RGD
ClinVar		 PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More... RGD:151893509 RGD:152177911
G AKT2 AKT serine/threonine kinase 2 ISO protein:increased phosphorylation:liver cancer cell (rat)
protein:increased phosphorylation:liver (mouse)		 RGD PMID:19309364 PMID:28100771 RGD:127285675 RGD:2313299 NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,795...48,587,919 		JBrowse link
G ALB albumin susceptibility ISO associated with hepatitis C;protein:decreased expression:serum
protein:decreased expression:serum (human)		 RGD PMID:22392353 PMID:23892757 PMID:29040987 RGD:11035269 RGD:125097525 RGD:14694841 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member no_association
severity
susceptibility		 ISO DNA:missense mutation:exon 12: (human)
mRNA, protein:decreased expression:liver (human)
associated with hepatitis B;DNA;missense mutation, haplotype:cds: (rs671) (human)
DNA:missense mutation:cds: (rs671) (human)
protein:decreased expression: liver (human)
associated with alcohol use disorder;DNA:missense mutation:cds: (human)
associated with alcoholic liver cirrhosis;DNA:missense mutation:cds:p.E487K (human)
associated with hepatitis C:DNA:SNP:exon 12 (human)
DNA:missense mutation:cds, exon 12:p.E487K (human)		 RGD PMID:1916152 PMID:10737710 PMID:12940444 PMID:18439068 PMID:25778454 More... RGD:11054822 RGD:14696699 RGD:14696778 RGD:14696779 RGD:14700899 RGD:15036809 RGD:15042857 RGD:15042859 RGD:15042862 NCBI chr14:39,902,317...39,933,113
Ensembl chr14:39,896,565...39,933,124 		JBrowse link
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 severity ISO mRNA:altered expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705 		JBrowse link
G ALDOC aldolase, fructose-bisphosphate C ISO mRNA:increased expression:liver RGD PMID:3830170 RGD:2301136 NCBI chr12:44,823,376...44,827,273
Ensembl chr12:44,822,780...44,827,597 		JBrowse link
G ALX4 ALX homeobox 4 ameliorates ISO mRNA, protein:decreased expression:liver RGD PMID:28081728 PMID:31132711 RGD:153323329 RGD:153323330 NCBI chr 2:18,070,726...18,085,685
Ensembl chr 2:18,037,401...18,085,683 		JBrowse link
G ANGPTL6 angiopoietin like 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:68,947,067...68,958,820
Ensembl chr 2:68,947,071...68,958,766 		JBrowse link
G ANK3 ankyrin 3 ISO protein:decreased expression:liver RGD PMID:26652480 RGD:153344559 NCBI chr14:63,416,154...63,809,220 JBrowse link
G ANLN anillin, actin binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr18:37,647,952...37,710,939
Ensembl chr18:37,647,961...37,708,575 		JBrowse link
G ANTXR1 ANTXR cell adhesion molecule 1 treatment ISO RGD PMID:20650339 RGD:9684932 NCBI chr 3:73,157,744...73,398,379
Ensembl chr 3:73,157,747...73,398,379 		JBrowse link
G ANXA10 annexin A10 disease_progression ISO mRNA:decreased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr14:21,249,020...21,315,260
Ensembl chr14:21,248,531...21,315,190 		JBrowse link
G ANXA2 annexin A2 ISO mRNA, protein:increased expression:liver (human) RGD PMID:33675609 RGD:152999436 NCBI chr 1:111,588,721...111,635,064
Ensembl chr 1:111,588,306...111,635,059 		JBrowse link
G ANXA4 annexin A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 3:72,623,311...72,654,591
Ensembl chr 3:72,622,358...72,694,212 		JBrowse link
G ANXA6 annexin A6 disease_progression ISO associated with tumor vascularization; protein:decreased expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr16:71,857,229...71,913,723
Ensembl chr16:71,857,258...71,913,723 		JBrowse link
G APC APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma OMIM
ClinVar		 PMID:1316610 PMID:8381579 PMID:8381580 PMID:9536098 PMID:9824584 More... NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,887 		JBrowse link
G APCS amyloid P component, serum ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr 4:90,900,585...90,901,854
Ensembl chr 4:90,898,689...90,901,874 		JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:25109342 PMID:33841550 RGD:152998960 NCBI chr 7:78,451,845...78,454,938
Ensembl chr 7:78,451,851...78,454,938 		JBrowse link
G APLN apelin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr  X:106,236,746...106,246,563
Ensembl chr  X:106,236,749...106,246,377 		JBrowse link
G APOA1 apolipoprotein A1 disease_progression ISO CTD Direct Evidence: marker/mechanism
associated with hepatitis B;
protein:decreased expression:plasma (human)		 CTD
RGD		 PMID:21472284 PMID:23935864 PMID:31211449 RGD:153350082 RGD:25671438 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G APOA2 apolipoprotein A2 ISO associated with hepatitis B; mRNA:increased expression:liver RGD PMID:31211449 RGD:153350082 NCBI chr 4:89,237,514...89,239,126
Ensembl chr 4:89,237,511...89,240,319 		JBrowse link
G APOA4 apolipoprotein A4 disease_progression ISO associated with hepatitis B; RGD PMID:31211449 RGD:153350082 NCBI chr 9:44,201,587...44,204,072
Ensembl chr 9:44,201,508...44,204,206 		JBrowse link
G APOC2 apolipoprotein C2 ISO associated with hepatitis B; mRNA:increased expression:liver RGD PMID:31211449 RGD:153350082 NCBI chr 6:51,404,219...51,406,302 JBrowse link
G APOC3 apolipoprotein C3 susceptibility
disease_progression		 ISO associated with Chronic Hepatitis B;DNA:SNP: :rs2854116(human)
associated with hepatitis B;		 RGD PMID:27547913 PMID:31211449 RGD:153344620 RGD:153350082 NCBI chr 9:44,211,171...44,213,538
Ensembl chr 9:44,211,194...44,213,533 		JBrowse link
G APOC4 apolipoprotein C4 disease_progression ISO associated with hepatitis B; RGD PMID:31211449 RGD:153350082 NCBI chr 6:51,400,909...51,403,719
Ensembl chr 6:51,400,931...51,405,169 		JBrowse link
G APOE apolipoprotein E ISO protein:increased expression:liver, serum (mouse) RGD PMID:21644509 RGD:6903288 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G APOF apolipoprotein F ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:21,759,670...21,760,753
Ensembl chr 5:21,759,475...21,760,815 		JBrowse link
G APRT adenine phosphoribosyltransferase ISO protein:increased activity:hepatoma (rat) RGD PMID:6327016 RGD:5135035 NCBI chr 6:890,272...893,278
Ensembl chr 6:890,831...893,276 		JBrowse link
G AR androgen receptor ISO CTD Direct Evidence: therapeutic CTD PMID:18639551 NCBI chr  X:53,609,113...53,806,778
Ensembl chr  X:53,609,176...53,800,677 		JBrowse link
G ARG1 arginase 1 disease_progression ISO associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) RGD PMID:17210712 PMID:30901224 RGD:152995286 RGD:4140476 NCBI chr 1:32,006,035...32,028,983
Ensembl chr 1:32,006,046...32,028,988 		JBrowse link
G ARHGAP11A Rho GTPase activating protein 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:136,497,436...136,522,355 JBrowse link
G ARHGAP44 Rho GTPase activating protein 44 exacerbates ISO protein:decreased expression:liver (human) RGD PMID:31136984 RGD:401901276 NCBI chr12:57,049,900...57,206,706
Ensembl chr12:57,049,895...57,206,889 		JBrowse link
G ARHGEF39 Rho guanine nucleotide exchange factor 39 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:236,383,684...236,387,705
Ensembl chr 1:236,383,925...236,387,667 		JBrowse link
G ARID1A AT-rich interaction domain 1A treatment
exacerbates		 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver (human)
mRNA, protein:decreased expression:liver (human)
human gene in mouse model
associated with non-alcoholic steatohepatitis 		RGD
CTD		 PMID:22561517 PMID:22634756 PMID:22922871 PMID:25975202 PMID:26569409 More... RGD:11344640 RGD:125097485 RGD:125097495 RGD:125097519 RGD:126790634 NCBI chr 6:84,049,729...84,124,302
Ensembl chr 6:84,049,087...84,123,349 		JBrowse link
G ARID1B AT-rich interaction domain 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:22634756 NCBI chr 1:9,791,627...10,227,381
Ensembl chr 1:9,791,633...10,227,502 		JBrowse link
G ARID2 AT-rich interaction domain 2 exacerbates
disease_progression		 ISO CTD Direct Evidence: marker/mechanism
associated with hepatitis B;protein:decreased expression:liver		 RGD
CTD		 PMID:21822264 PMID:22634756 PMID:25701229 PMID:27351279 PMID:28498550 More... RGD:150340708 RGD:150340711 RGD:150340712 RGD:150429631 NCBI chr 5:76,637,385...76,800,155
Ensembl chr 5:76,636,967...76,797,043 		JBrowse link
G ARID3A AT-rich interaction domain 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:35179300 NCBI chr 2:77,428,618...77,464,916
Ensembl chr 2:77,431,087...77,464,628 		JBrowse link
G ARRB2 arrestin beta 2 treatment ISO RGD PMID:33841550 RGD:152998960 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342 		JBrowse link
G ASF1B anti-silencing function 1B histone chaperone ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:65,063,186...65,072,681
Ensembl chr 2:65,062,766...65,072,679 		JBrowse link
G ASL argininosuccinate lyase disease_progression ISO associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr 3:16,637,481...16,646,869
Ensembl chr 3:16,637,481...16,646,867 		JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) ISO protein:increased activity:serum (rat) RGD PMID:10081 RGD:2316006 NCBI chr 9:77,318,341...77,336,290
Ensembl chr 9:77,318,213...77,343,035 		JBrowse link
G ASPG asparaginase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560
G ASPM assembly factor for spindle microtubules disease_progression ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:18676753 PMID:28284560 RGD:13439743 NCBI chr10:19,971,516...20,039,680
Ensembl chr10:19,975,192...20,039,623 		JBrowse link
G ASS1 argininosuccinate synthase 1 disease_progression ISO associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) RGD PMID:12359751 PMID:30901224 RGD:152995286 RGD:4140479 NCBI chr 1:270,531,434...270,586,364
Ensembl chr 1:270,531,589...270,586,364 		JBrowse link
G ATG101 autophagy related 101 disease_progression ISO RGD PMID:35592424 RGD:153350091 NCBI chr 5:17,418,085...17,425,770
Ensembl chr 5:17,418,121...17,425,624 		JBrowse link
G ATG7 autophagy related 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29191453 NCBI chr13:67,301,756...67,699,141
Ensembl chr13:67,417,938...67,707,654 		JBrowse link
G ATM ATM serine/threonine kinase exacerbates ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)		 CTD
RGD		 PMID:12866955 PMID:19919837 RGD:126781750 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552 		JBrowse link
G ATP5PB ATP synthase peripheral stalk-membrane subunit b ISO associated with hepatitis C RGD PMID:18932288 RGD:14696822 NCBI chr 4:108,896,063...108,907,626
Ensembl chr 4:108,896,057...108,907,805 		JBrowse link
G ATP5PD ATP synthase peripheral stalk subunit d ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr12:6,241,467...6,247,344 JBrowse link
G ATP7B ATPase copper transporting beta onset ISO RGD PMID:8291609 RGD:15036817 NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064 		JBrowse link
G AURKA aurora kinase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:56,954,838...56,972,435 JBrowse link
G AURKB aurora kinase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:53,410,833...53,426,165
Ensembl chr12:53,410,177...53,423,225 		JBrowse link
G AXIN1 axin 1 disease_progression ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
protein:decreased expression:liver (human)
associated with Hepatitis B, Chronic,DNA:SNP, haplotype:exon:(rs1805105) T>C (human)		 OMIM
ClinVar
RGD		 PMID:10700176 PMID:25741868 PMID:25741905 PMID:26968103 PMID:28492532 More... RGD:14402039 RGD:150530482 NCBI chr 3:41,344,908...41,393,999
Ensembl chr 3:41,337,071...41,393,997 		JBrowse link
G AXIN2 axin 2 ISO protein:increased expression:liver: RGD PMID:11809809 RGD:151356508 NCBI chr12:12,311,293...12,343,207
Ensembl chr12:12,311,298...12,343,200 		JBrowse link
G AZGP1 alpha-2-glycoprotein 1, zinc-binding disease_progression ISO mRNA:decreased expression:liver
associated with hepatitis B;mRNA:decreased expression:liver		 RGD PMID:22625427 PMID:26902423 PMID:27993894 RGD:153350130 RGD:153350132 RGD:153350133 NCBI chr 3:7,867,521...7,874,857 JBrowse link
G AZIN1 antizyme inhibitor 1 disease_progression ISO RNA:increased editing:liver RGD PMID:23291631 RGD:14700705 NCBI chr 4:34,221,368...34,257,261
Ensembl chr 4:34,234,679...34,257,134 		JBrowse link
G BANF1 BAF nuclear assembly factor 1 treatment ISO mRNA, protein:increased expression:liver (human)
mRNA, protein:increased expression:liver (rat)		 RGD PMID:29059470 RGD:155791679 NCBI chr 2:6,333,451...6,335,326
Ensembl chr 2:6,333,453...6,334,839 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:33841550 RGD:152998960 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO mRNA:increased expression:liver (mouse) RGD PMID:28100771 PMID:33841550 RGD:127285675 RGD:152998960 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G BCL2L1 BCL2 like 1 treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:liver (mouse)		 CTD
RGD		 PMID:10629087 PMID:11509945 PMID:28100771 PMID:33841550 RGD:127285675 RGD:152998960 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G BCO2 beta-carotene oxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:39,864,136...39,916,491
Ensembl chr 9:39,872,645...39,917,263 		JBrowse link
G BCORL1 BCL6 corepressor like 1 disease_progression ISO RGD PMID:26879601 PMID:29679906 RGD:11556159 RGD:150340705 NCBI chr  X:106,547,754...106,613,130
Ensembl chr  X:106,549,139...106,612,894 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase disease_progression ISO associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr 2:87,911,093...87,935,252
Ensembl chr 2:87,910,603...87,935,252 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 severity ISO mRNA:altered expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr 2:87,866,631...87,882,623
Ensembl chr 2:87,866,621...87,882,716 		JBrowse link
G BID BH3 interacting domain death agonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:15289866 NCBI chr 5:69,849,007...69,874,647
Ensembl chr 5:69,849,002...69,875,853 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 exacerbates
treatment
ameliorates		 ISO associated with hepatitis B;mRNA, protein:increased expression:liver (human)
human cell line in a mouse model		 RGD PMID:22682366 PMID:22820591 PMID:30210622 PMID:30368883 PMID:33310033 RGD:152998937 RGD:152998984 RGD:152998986 RGD:152998988 RGD:152999010 NCBI chr 9:33,003,570...33,020,252
Ensembl chr 9:33,003,276...33,020,242 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 disease_progression ISO CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:liver (human)		 CTD
RGD		 PMID:16086872 PMID:20514400 PMID:31964418 RGD:153344516 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 exacerbates ISO mRNA:increased expression:liver (human) RGD PMID:31964418 RGD:153344516 NCBI chr17:62,351,663...62,356,220 JBrowse link
G BLZF1 basic leucine zipper nuclear factor 1 disease_progression ISO RGD PMID:26342799 RGD:14398326 NCBI chr 4:81,597,312...81,639,788
Ensembl chr 4:81,571,300...81,639,577 		JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger treatment ISO RGD PMID:26919246 RGD:14928318 NCBI chr10:52,586,089...52,596,154
Ensembl chr10:52,586,509...52,596,564 		JBrowse link
G BMPER BMP binding endothelial regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr18:39,417,830...39,664,010
Ensembl chr18:39,412,838...39,663,592 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27222248 NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553 		JBrowse link
G BSG basigin ISO CTD Direct Evidence: marker/mechanism CTD PMID:36574092 NCBI chr 2:77,735,586...77,743,451 JBrowse link
G BTG2 BTG anti-proliferation factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18393292 NCBI chr 9:64,033,853...64,037,795
Ensembl chr 9:64,031,832...64,035,837 		JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:45,585,188...45,623,240
Ensembl chr 3:45,585,226...45,624,543 		JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:131,093,026...131,143,840
Ensembl chr 1:131,092,958...131,143,794 		JBrowse link
G C3 complement C3 ISO RGD PMID:23245919 RGD:11040806 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C9 complement C9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 PMID:28284560 NCBI chr16:24,521,318...24,575,939
Ensembl chr16:24,520,634...24,590,338 		JBrowse link
G CA12 carbonic anhydrase 12 disease_progression
ameliorates		 ISO mRNA:altered expression:liver RGD PMID:29900055 PMID:31934040 PMID:35362480 RGD:153352325 RGD:153352328 RGD:155226869 NCBI chr 1:108,649,277...108,710,658
Ensembl chr 1:108,649,271...108,710,651 		JBrowse link
G CA2 carbonic anhydrase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 4:51,194,686...51,211,436
Ensembl chr 4:51,193,756...51,211,259 		JBrowse link
G CA9 carbonic anhydrase 9 ISO mRNA:altered expression:liver RGD PMID:29900055 RGD:155226869 NCBI chr 1:236,393,727...236,400,994
Ensembl chr 1:236,394,306...236,400,822 		JBrowse link
G CAB39 calcium binding protein 39 disease_progression ISO RGD PMID:28605041 RGD:14398832 NCBI chr15:131,492,575...131,584,963
Ensembl chr15:131,492,578...131,584,962 		JBrowse link
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO DNA:amplification:cds (rat)
mRNA:increased expression:liver		 RGD PMID:2888462 PMID:2914957 PMID:7053379 RGD:10755426 RGD:2303530 RGD:5132587 NCBI chr 3:111,887,017...111,914,511
Ensembl chr 3:111,887,020...111,914,492 		JBrowse link
G CADM1 cell adhesion molecule 1 ISO DNA, mRNA, protein:hypermethylation, decreased expression:promoter:liver RGD PMID:17428255 RGD:2289095 NCBI chr 9:42,644,487...42,984,934
Ensembl chr 9:42,644,429...42,985,017 		JBrowse link
G CADM2 cell adhesion molecule 2 disease_progression ISO mRNA, protein:decreased expression:liver RGD PMID:24240726 RGD:15092075 NCBI chr13:169,681,947...170,753,114
Ensembl chr13:169,688,958...170,014,005 		JBrowse link
G CALR calreticulin exacerbates
treatment		 ISO protein:increased expression:liver (human)
human cells and recombinant gene in a mouse model		 RGD PMID:12096119 PMID:24997628 PMID:27055635 RGD:150521681 RGD:150521690 RGD:150521691 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132 		JBrowse link
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO RGD PMID:23651211 RGD:18337283 NCBI chr 6:78,730,204...78,734,232
Ensembl chr 6:78,730,206...78,733,740 		JBrowse link
G CAP2 cyclase associated actin cytoskeleton regulatory protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:13,211,110...13,350,966
Ensembl chr 7:13,211,574...13,350,961 		JBrowse link
G CAPN3 calpain 3 ISO mRNA:decreased expression:skeletal muscle RGD PMID:10806331 RGD:1600777 NCBI chr 1:128,960,117...129,013,508
Ensembl chr 1:128,960,118...129,013,546 		JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 ISO mRNA,protein:increased expression:liver: RGD PMID:23912631 RGD:9586718 NCBI chr 2:69,602,121...69,644,862
Ensembl chr 2:69,602,136...69,644,854 		JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:29133031 PMID:33841550 RGD:13782296 RGD:152998960 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP8 caspase 8 treatment
severity		 ISO associated with hepatitis B;DNA:insertion/deletion:promoter: (rs3834129) (human) OMIM
RGD		 PMID:28643196 PMID:29133031 RGD:13782296 RGD:14695027 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468 		JBrowse link
G CASP9 caspase 9 treatment ISO RGD PMID:29133031 RGD:13782296 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007 		JBrowse link
G CAT catalase disease_progression ISO associated with liver cirrhosis with Hepatitis C;DNA:SNP:promoter:-262T>C (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:21907168 PMID:33010264 RGD:27095879 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CBFB core-binding factor subunit beta ISO mRNA:decreased expression:liver RGD PMID:17094378 RGD:126775147 NCBI chr 6:27,684,320...27,750,856
Ensembl chr 6:27,684,030...27,750,852 		JBrowse link
G CBL Cbl proto-oncogene disease_progression ISO RGD PMID:26474280 RGD:11536137 NCBI chr 9:46,416,937...46,512,855
Ensembl chr 9:46,416,938...46,512,834 		JBrowse link
G CBX2 chromobox 2 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr12:2,570,841...2,580,336
Ensembl chr12:2,570,851...2,580,337 		JBrowse link
G CBX4 chromobox 4 disease_progression ISO protein:increased expression:cytoplasm: RGD PMID:23943028 PMID:24838576 RGD:9586738 RGD:9586739 NCBI chr12:2,520,913...2,527,245
Ensembl chr12:2,521,027...2,527,241 		JBrowse link
G CBX7 chromobox 7 ISO mRNA:decreased expression:liver RGD PMID:22041561 RGD:9587355 NCBI chr 5:9,070,312...9,090,467
Ensembl chr 5:9,070,353...9,087,634 		JBrowse link
G CCBE1 collagen and calcium binding EGF domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:161,320,627...161,556,539
Ensembl chr 1:161,321,273...161,556,537 		JBrowse link
G CCL1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:liver (mouse) RGD PMID:26569409 RGD:11344640 NCBI chr12:40,728,014...40,731,411
Ensembl chr12:40,728,014...40,731,411 		JBrowse link
G CCL14 C-C motif chemokine ligand 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:39,611,887...39,616,050
Ensembl chr12:39,611,868...39,616,159 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 treatment ISO RNA:increased expression:liver RGD PMID:12679798 PMID:22402625 PMID:27980102 RGD:14995459 RGD:14995468 RGD:14995927 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCL3L1 chemokine (C-C motif) ligand 3-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16284949 NCBI chr12:39,491,999...39,493,345
Ensembl chr12:39,491,914...39,493,774 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 susceptibility
treatment		 ISO DNA:polymorphisms:promoter:-403G>A,-28C>G (human)
associated with alcoholic liver cirrhosis;DNA:SNP:promoter:-403G>A(human)		 RGD PMID:21610221 PMID:22374185 PMID:28011329 RGD:14995306 RGD:14995333 RGD:14995338 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CCN1 cellular communication network factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17699798 NCBI chr 4:130,392,404...130,395,179
Ensembl chr 4:130,392,407...130,395,150 		JBrowse link
G CCNA1 cyclin A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12029619 NCBI chr11:12,396,149...12,405,357
Ensembl chr11:12,396,301...12,405,350 		JBrowse link
G CCNB1 cyclin B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377 		JBrowse link
G CCNB2 cyclin B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:112,907,047...112,942,218
Ensembl chr 1:112,907,047...112,942,235 		JBrowse link
G CCND1 cyclin D1 susceptibility ISO associated with Hepatitis B, Chronic;DNA:SNP:splice-site mutation:870G>A (human)
mRNA:increased expression:liver (mouse)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12029619 PMID:19919837 PMID:22649188 PMID:25822088 PMID:25851350 More... RGD:127285675 RGD:14401586 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CCND2 cyclin D2 disease_progression
susceptibility
severity		 ISO associated with hepatitis B
associated with Chronic Hepatitis C;DNA:SNP: :rs1049606(human)
DNA:hypermethylation:CpG site		 RGD PMID:22004425 PMID:31059558 PMID:33320844 RGD:151664743 RGD:151665109 RGD:151665169 NCBI chr 5:66,092,483...66,114,575
Ensembl chr 5:66,087,379...66,114,571 		JBrowse link
G CCNE1 cyclin E1 ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12029619 PMID:17196522 PMID:22634754 PMID:28100771 PMID:29551768 RGD:127285675 RGD:153297807 RGD:2289277 NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,363 		JBrowse link
G CCNF cyclin F ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:39,585,597...39,603,088
Ensembl chr 3:39,585,607...39,603,079 		JBrowse link
G CCNG1 cyclin G1 severity
treatment
disease_progression		 ISO protein:decreased expression:liver (human)
human cells in mouse model
protein:increased expression:liver (human)		 RGD PMID:19584283 PMID:22835824 PMID:23804702 PMID:24034575 PMID:25431954 More... RGD:151356922 RGD:151356932 RGD:151356933 RGD:151356967 RGD:151356970 RGD:151356981 RGD:151361198 RGD:151361200 NCBI chr16:60,349,255...60,356,737
Ensembl chr16:60,349,258...60,356,738 		JBrowse link
G CCNG2 cyclin G2 ISO RGD PMID:27982046 RGD:151361200 NCBI chr 8:72,790,394...72,800,553
Ensembl chr 8:72,791,703...72,800,551 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16284949 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960 		JBrowse link
G CD163 CD163 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498 		JBrowse link
G CD274 CD274 molecule disease_progression ISO CTD Direct Evidence: marker/mechanism
associated with hepatitis B
associated with hepatitis B		 CTD
RGD		 PMID:21912640 PMID:22396772 PMID:30267213 RGD:40818240 RGD:41410800 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724 		JBrowse link
G CD276 CD276 molecule ISO CTD Direct Evidence: therapeutic CTD PMID:16217749 NCBI chr 7:59,703,283...59,733,910
Ensembl chr 7:59,703,289...59,733,777 		JBrowse link
G CD34 CD34 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:134,912,793...134,937,763
Ensembl chr 9:134,913,121...134,937,762 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:19016771 RGD:2313413 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
G CD5L CD5 molecule like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 4:92,394,535...92,412,146 JBrowse link
G CD68 CD68 molecule severity ISO protein:increased expression:liver (human) RGD PMID:28656201 RGD:40924686 NCBI chr12:52,874,754...52,877,256
Ensembl chr12:52,874,785...52,877,695 		JBrowse link
G CDC20 cell division cycle 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:167,886,266...167,890,587
Ensembl chr 6:167,886,270...167,890,583 		JBrowse link
G CDC25C cell division cycle 25C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:140,289,156...140,323,696
Ensembl chr 2:140,289,115...140,324,425 		JBrowse link
G CDC27 cell division cycle 27 ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar NCBI chr12:16,810,868...16,882,271
Ensembl chr12:16,810,910...16,882,269 		JBrowse link
G CDC45 cell division cycle 45 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:51,133,111...51,158,604
Ensembl chr14:51,133,408...51,158,606 		JBrowse link
G CDC6 cell division cycle 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:22,101,281...22,118,441
Ensembl chr12:22,101,282...22,118,593 		JBrowse link
G CDCA2 cell division cycle associated 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:9,517,763...9,571,303
Ensembl chr14:9,518,201...9,566,588 		JBrowse link
G CDCA3 cell division cycle associated 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:63,858,905...63,861,902
Ensembl chr 5:63,859,541...63,864,269 		JBrowse link
G CDCA5 cell division cycle associated 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:7,103,648...7,112,772
Ensembl chr 2:7,103,673...7,113,202 		JBrowse link
G CDCA8 cell division cycle associated 8 disease_progression ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)		 CTD
RGD		 PMID:28284560 PMID:35693827 RGD:153344586 NCBI chr 6:93,750,694...93,764,845
Ensembl chr 6:93,750,689...93,764,836 		JBrowse link
G CDH1 cadherin 1 severity ISO DNA:hypermethylation
protein:decreased expression:liver
mRNA:increased expression:liver		 RGD PMID:17295234 PMID:18837082 PMID:24840851 PMID:30697077 RGD:14402045 RGD:14402046 RGD:14402047 RGD:2289638 NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986 		JBrowse link
G CDH13 cadherin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18425332 PMID:18553387 PMID:28284560 NCBI chr 6:4,809,752...5,832,188
Ensembl chr 6:4,808,255...5,832,415 		JBrowse link
G CDK1 cyclin dependent kinase 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)		 CTD
RGD		 PMID:19136513 PMID:28284560 RGD:2316317 NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197 		JBrowse link
G CDK12 cyclin dependent kinase 12 exacerbates ISO mRNA, protein:increased expression:liver (human) RGD PMID:31519701 RGD:151361172 NCBI chr12:22,755,365...22,831,397
Ensembl chr12:22,775,226...22,831,333 		JBrowse link
G CDK13 cyclin dependent kinase 13 onset ISO DNA:amplification: : RGD PMID:22912832 RGD:155641228 NCBI chr18:54,310,311...54,430,060
Ensembl chr18:54,310,324...54,430,786 		JBrowse link
G CDK14 cyclin dependent kinase 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22922871 NCBI chr 9:70,678,012...71,310,253
Ensembl chr 9:70,499,873...71,310,250 		JBrowse link
G CDK4 cyclin dependent kinase 4 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:26189965 PMID:33841550 RGD:152998960 NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO OMIM:114550 MouseDO NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:20698225 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831 		JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C severity ISO protein:decreased expression:liver (human) RGD PMID:26606000 RGD:11354707 NCBI chr 2:2,019,391...2,022,092
Ensembl chr 2:2,019,830...2,021,853 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A severity ISO Protein:decreased expression:liver
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA		 RGD
ClinVar		 PMID:7780957 PMID:8521414 PMID:9185756 PMID:9324288 PMID:10491434 More... RGD:1600816 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:33010264 NCBI chr 1:200,666,250...200,770,880
Ensembl chr 1:200,761,004...200,766,056 		JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:161,160,290...161,166,681
Ensembl chr 6:161,160,297...161,166,529 		JBrowse link
G CDKN3 cyclin dependent kinase inhibitor 3 treatment
severity		 ISO associated with alcoholism; protein:increased expression:liver
mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism
protein:decreased expression:liver		 RGD
CTD		 PMID:22390936 PMID:23292002 PMID:27314282 PMID:28284560 RGD:15090800 RGD:15090801 RGD:15090802 NCBI chr 1:183,792,606...183,809,178
Ensembl chr 1:183,792,688...183,809,174 		JBrowse link
G CDT1 chromatin licensing and DNA replication factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:893,377...897,706
Ensembl chr 6:893,381...897,934 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16288022 PMID:21785164 NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,207...43,085,836 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)		 CTD
RGD		 PMID:14563831 PMID:30659195 RGD:40903042 NCBI chr17:51,722,633...51,723,673
Ensembl chr17:51,722,426...51,724,305 		JBrowse link
G CEBPD CCAAT enhancer binding protein delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:14563831 NCBI chr 4:79,872,863...79,874,481
Ensembl chr 4:79,872,939...79,874,477 		JBrowse link
G CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:31,331,563...31,357,374
Ensembl chr13:31,331,574...31,357,469 		JBrowse link
G CENPA centromere protein A ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)		 CTD
RGD		 PMID:21956590 PMID:28284560 RGD:36947377 NCBI chr 3:112,263,912...112,272,638
Ensembl chr 3:112,263,915...112,272,621 		JBrowse link
G CENPE centromere protein E ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:117,888,968...117,965,325
Ensembl chr 8:117,888,970...117,965,252 		JBrowse link
G CENPF centromere protein F ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:128,948,386...129,012,241
Ensembl chr 9:128,948,498...129,012,218 		JBrowse link
G CENPM centromere protein M ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:6,677,607...6,690,322
Ensembl chr 5:6,677,717...6,690,308 		JBrowse link
G CENPU centromere protein U ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:45,818,562...45,851,461
Ensembl chr15:45,818,951...45,851,441 		JBrowse link
G CENPW centromere protein W ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:36,405,693...36,695,989
Ensembl chr 1:36,685,265...36,695,955 		JBrowse link
G CEP131 centrosomal protein 131 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:1,537,900...1,556,931
Ensembl chr12:1,538,326...1,556,929 		JBrowse link
G CEP164 centrosomal protein 164 susceptibility ISO associated with Chronic Hepatitis C;DNA:SNP: :rs573455 (human) RGD PMID:22004425 RGD:151665169 NCBI chr 9:44,670,857...44,752,477
Ensembl chr 9:44,670,874...44,752,469 		JBrowse link
G CEP55 centrosomal protein 55 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:104,957,256...104,980,690
Ensembl chr14:104,957,311...104,980,689 		JBrowse link
G CFP complement factor properdin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr  X:42,145,754...42,152,879
Ensembl chr  X:42,143,697...42,152,868 		JBrowse link
G CHAF1B chromatin assembly factor 1 subunit B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:200,048,096...200,074,902
Ensembl chr13:200,048,149...200,072,556 		JBrowse link
G CHD4 chromodomain helicase DNA binding protein 4 exacerbates ISO mRNA:increased expression:liver (human)
protein:increased expression:liver (human)		 RGD PMID:26095183 PMID:28486105 PMID:32070428 RGD:11571740 RGD:153323299 RGD:153323308 NCBI chr 5:64,071,627...64,105,212
Ensembl chr 5:64,065,992...64,105,173 		JBrowse link
G CHD5 chromodomain helicase DNA binding protein 5 ISO mRNA:decreased expression:liver RGD PMID:26517514 RGD:11537550 NCBI chr 6:67,017,410...67,086,685
Ensembl chr 6:67,017,417...67,086,711 		JBrowse link
G CKAP2L cytoskeleton associated protein 2 like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:43,736,526...43,772,995
Ensembl chr 3:43,736,744...43,772,974 		JBrowse link
G CKAP4 cytoskeleton associated protein 4 disease_progression ISO associated with tumor vascularization; mRNA,protein:increased expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr 5:14,021,131...14,031,196
Ensembl chr 5:14,021,131...14,030,039 		JBrowse link
G CLDN1 claudin 1 severity ISO protein:increased expression:liver (human)
associated with liver cirrhosis;protein:increased expression:liver (human)
protein:decreased expression:liver (human)		 RGD PMID:17270214 PMID:24696415 PMID:24815833 RGD:26884345 RGD:26884348 RGD:26884352 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G CLEC1B C-type lectin domain family 1 member B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:61,889,874...61,896,964
Ensembl chr 5:61,889,930...61,946,340 		JBrowse link
G CLEC4G C-type lectin domain family 4 member G ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:71,433,406...71,436,570
Ensembl chr 2:71,433,421...71,436,567 		JBrowse link
G CLPTM1L CLPTM1 like susceptibility
disease_progression		 ISO DNA:SNPs::rs401681(human)
DNA:SNP: :rs401681(human)		 RGD PMID:25339005 PMID:29042796 RGD:150530496 RGD:150537100 NCBI chr16:79,237,000...79,248,503
Ensembl chr16:79,237,061...79,248,500 		JBrowse link
G CLTRN collectrin, amino acid transport regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr  X:12,183,793...12,215,474
Ensembl chr  X:12,183,796...12,224,964 		JBrowse link
G CNDP1 carnosine dipeptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:149,523,983...149,564,728
Ensembl chr 1:149,521,510...149,562,623 		JBrowse link
G CNOT9 CCR4-NOT transcription complex subunit 9 ISO ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar PMID:26619011 NCBI chr15:120,590,354...120,622,203
Ensembl chr15:120,590,641...120,623,898 		JBrowse link
G CNTNAP4 contactin associated protein family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:11,316,534...11,589,628
Ensembl chr 6:11,317,848...11,589,300 		JBrowse link
G COL15A1 collagen type XV alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:240,718,128...240,829,188
Ensembl chr 1:240,709,086...240,829,185 		JBrowse link
G COL18A1 collagen type XVIII alpha 1 chain severity ISO Protein:increased expression RGD PMID:15739185 RGD:1600906 NCBI chr13:207,907,835...207,984,082
Ensembl chr13:207,940,948...207,982,938 		JBrowse link
G COLEC10 collectin subfamily member 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 4:19,692,990...20,143,740
Ensembl chr 4:19,692,830...19,744,135 		JBrowse link
G COMT catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15341023 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
G COPS5 COP9 signalosome subunit 5 severity ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)		 CTD
RGD		 PMID:20698225 PMID:26606000 RGD:11354707 NCBI chr 4:67,740,528...67,758,153
Ensembl chr 4:67,739,251...67,758,150 		JBrowse link
G CP ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19229483 NCBI chr13:89,396,713...89,463,540
Ensembl chr13:89,396,708...89,463,476 		JBrowse link
G CPEB3 cytoplasmic polyadenylation element binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:103,675,164...103,871,245
Ensembl chr14:103,675,175...103,871,227 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 disease_progression ISO associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr15:113,210,038...113,339,086
Ensembl chr15:113,150,157...113,339,078 		JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:89,257,603...89,480,414
Ensembl chr 5:89,267,944...89,479,712 		JBrowse link
G CREBBP CREB binding protein ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: LIVER CELL CARCINOMA ClinVar PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More... NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224 		JBrowse link
G CRHBP corticotropin releasing hormone binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:85,814,399...85,830,598
Ensembl chr 2:85,816,816...85,831,179 		JBrowse link
G CRP C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G CSF1R colony stimulating factor 1 receptor severity
exacerbates		 ISO DNA:hypomethylation:promoter (human)
mRNA:increased expression:liver (human)
protein:increased expression: liver (human)
protein:increased expression:liver (human)		 RGD PMID:11412385 PMID:14969845 PMID:20551429 PMID:32724427 PMID:32760707 RGD:150524279 RGD:150524282 RGD:150524286 RGD:150524301 RGD:150524302 NCBI chr 2:151,102,138...151,130,311
Ensembl chr 2:151,102,147...151,147,633 		JBrowse link
G CSF2 colony stimulating factor 2 treatment ISO RGD PMID:12731087 RGD:10450243 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155 		JBrowse link
G CSK C-terminal Src kinase ISO protein:decreased expression:liver RGD PMID:9918913 RGD:5134372 NCBI chr 7:58,736,473...58,755,034
Ensembl chr 7:58,736,531...58,755,260 		JBrowse link
G CSMD1 CUB and Sushi multiple domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:34,361,722...36,243,762
Ensembl chr15:34,363,758...35,023,152 		JBrowse link
G CSPG4 chondroitin sulfate proteoglycan 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:57,949,182...57,988,602
Ensembl chr 7:57,949,455...57,988,335 		JBrowse link
G CSRNP1 cysteine and serine rich nuclear protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:23,833,130...23,845,198
Ensembl chr13:23,833,134...23,845,204 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 susceptibility ISO DNA:SNPs: :rs231775,rs231725(human)
protein:increased expression:CD4+ and CD8+ T cells:		 RGD PMID:23432218 PMID:28648905 RGD:14398741 RGD:14398742 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103 		JBrowse link
G CTNNB1 catenin beta 1 exacerbates
susceptibility
severity		 ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA
DNA:missense mutations:exon 3:multiple (human)
associated with Hepatitis B, Chronic,DNA:SNP, haplotype: :rs3864004 (human)
DNA:Mutations:exon:
associated with hepatitis B;DNA:SNPs: :rs3864004,rs11564475(human)		 OMIM
ClinVar
RGD		 PMID:9065402 PMID:9065403 PMID:9294210 PMID:9500465 PMID:9927029 More... RGD:14402039 RGD:14402040 RGD:14402052 RGD:150429592 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G CTSB cathepsin B ISO RGD PMID:15641152 RGD:2315605 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,033,877 		JBrowse link
G CTSD cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 2:1,188,548...1,197,642
Ensembl chr 2:1,188,549...1,197,643 		JBrowse link
G CTSL cathepsin L ISO RGD PMID:15641152 RGD:2315605 NCBI chr10:27,668,523...27,674,705
Ensembl chr10:27,668,264...27,674,618 		JBrowse link
G CUnH14orf180 chromosome Un C14orf180 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560
G CUX1 cut like homeobox 1 ISO mRNA:increased expression:liver (human) RGD PMID:30561038 RGD:152985541 NCBI chr 3:9,317,145...9,669,999
Ensembl chr 3:9,317,140...9,669,998 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 disease_progression
treatment		 ISO RGD PMID:27245433 PMID:28592115 PMID:28638480 RGD:27095889 RGD:27095898 RGD:27095899 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 ISO mRNA:increased expression:liver (mouse) RGD PMID:26569409 RGD:11344640 NCBI chr 8:71,713,790...71,725,669
Ensembl chr 8:71,713,803...71,725,674 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 PMID:28284560 NCBI chr14:91,516,383...91,543,857
Ensembl chr14:91,516,431...91,552,752 		JBrowse link
G CXCL14 C-X-C motif chemokine ligand 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:137,803,988...137,813,118
Ensembl chr 2:137,803,992...137,813,118 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 disease_progression
susceptibility		 ISO protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:liver (human)
DNA:SNPs, haplotype:multiple		 RGD
CTD		 PMID:12432545 PMID:24381110 PMID:26078356 PMID:30523154 PMID:35776891 RGD:11526468 RGD:26884364 RGD:26884366 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 severity
treatment		 ISO protein:increased expression:liver (human)
human cells in mouse model		 RGD PMID:30034941 PMID:33574707 RGD:151665327 RGD:151665331 NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,232 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21109933 NCBI chr 6:34,058,091...34,121,939
Ensembl chr 6:34,059,081...34,121,264 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15341023 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15341023 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100 		JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr 3:70,573,551...70,593,416
Ensembl chr 3:70,572,197...70,593,408 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP2C49 cytochrome P450 2C49 susceptibility ISO associated with hepatitis C; DNA:polymorphisms: : RGD PMID:11021356 RGD:124713413 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO associated with alcohol dependence
DNA, mRNA:SNP, Decreased expression:liver: rs2031920 (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:15162526 PMID:20364586 PMID:29765251 RGD:14700882 RGD:14700899 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G CYP39A1 cytochrome P450 family 39 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:41,345,011...41,425,854
Ensembl chr 7:41,344,804...41,425,997 		JBrowse link
G DAB2IP DAB2 interacting protein severity ISO mRNA:decreased expression:liver (human)
protein:decreased expression:liver (human)		 RGD PMID:22168621 PMID:31176165 RGD:151665110 RGD:151665148 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,660...261,859,022 		JBrowse link
G DBH dopamine beta-hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:273,204,407...273,225,562
Ensembl chr 1:273,204,175...273,225,552 		JBrowse link
G DCN decorin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:91,678,601...91,713,925
Ensembl chr 5:91,682,658...91,714,235 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 severity ISO mRNA:increased expression:liver (human) RGD PMID:33173221 RGD:151347691 NCBI chr 7:23,371,358...23,391,585
Ensembl chr 7:23,373,845...23,391,584 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 disease_progression
treatment		 ISO RGD PMID:26362312 PMID:33969575 RGD:11086753 RGD:150429748 NCBI chr 4:87,749,738...87,911,818
Ensembl chr 4:87,756,168...87,911,296 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked exacerbates
sexual_dimorphism 		ISO associated with hepatitis B; mRNA,protein:decreased expression:liver (human) RGD PMID:16301996 PMID:30297359 RGD:151356499 RGD:151356660 NCBI chr  X:36,988,031...37,005,496
Ensembl chr  X:36,988,031...37,018,202 		JBrowse link
G DEPDC1 DEP domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:144,157,569...144,183,977
Ensembl chr 6:144,157,588...144,185,963 		JBrowse link
G DEPDC1B DEP domain containing 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr16:39,466,496...39,558,750
Ensembl chr16:39,466,497...39,557,840 		JBrowse link
G DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:21725309 NCBI chr14:48,421,788...48,523,530
Ensembl chr14:48,421,880...48,523,593 		JBrowse link
G DHFR dihydrofolate reductase ISO ClinVar Annotator: match by term: Hepatocellular cancer ClinVar PMID:28492532 NCBI chr 2:89,230,660...89,255,830 JBrowse link
G DICER1 dicer 1, ribonuclease III susceptibility ISO associated with hepatitis B; DNA:SNP: :rs1057035 T>C (human) RGD PMID:23868705 RGD:149735346 NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,365,802...116,411,224 		JBrowse link
G DIPK2B divergent protein kinase domain 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr  X:40,179,289...40,223,011
Ensembl chr  X:40,178,969...40,222,542 		JBrowse link
G DIRAS3 DIRAS family GTPase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:144,576,342...144,578,820
Ensembl chr 6:144,576,342...144,578,818 		JBrowse link
G DLGAP5 DLG associated protein 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:184,500,791...184,550,028
Ensembl chr 1:184,501,182...184,549,993 		JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 ISO mRNA:increased expression:liver (mouse) RGD PMID:26569409 RGD:11344640 NCBI chr 7:121,565,844...121,577,493
Ensembl chr 7:121,565,854...121,576,654 		JBrowse link
G DMGDH dimethylglycine dehydrogenase disease_progression ISO associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr 2:87,791,827...87,867,189
Ensembl chr 2:87,791,943...87,866,679 		JBrowse link
G DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:146,990,115...147,161,010
Ensembl chr 6:146,989,351...147,155,131 		JBrowse link
G DNASE1L3 deoxyribonuclease 1L3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:39,958,384...39,976,114
Ensembl chr13:39,958,387...39,975,946 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO mRNA, protein:increased expression:liver RGD PMID:11844796 RGD:2289670 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO mRNA, protein:increased expression:liver
protein:increased expression:liver:		 RGD PMID:11844796 PMID:15885882 RGD:2289670 RGD:9588598 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO mRNA:increased expression:liver:
mRNA, protein:increased expression:liver		 RGD PMID:11844796 PMID:15885882 RGD:2289670 RGD:9588598 NCBI chr17:36,345,715...36,386,076
Ensembl chr17:36,345,816...36,386,072 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18019677 NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,414...120,712,459 		JBrowse link
G DSN1 DSN1 component of MIS12 kinetochore complex disease_progression ISO RGD PMID:30136646 RGD:27372884 NCBI chr17:39,992,769...40,017,388
Ensembl chr17:39,990,624...40,017,365 		JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:131,225,840...131,275,426
Ensembl chr 9:131,227,705...131,275,451 		JBrowse link
G DYNLRB1 dynein light chain roadblock-type 1 ISO RGD PMID:11750132 RGD:13208527 NCBI chr17:37,923,451...37,941,851
Ensembl chr17:37,923,475...37,945,880 		JBrowse link
G DYNLRB2 dynein light chain roadblock-type 2 ISO RGD PMID:11750132 RGD:13208527 NCBI chr 6:7,650,444...7,661,380
Ensembl chr 6:7,649,699...7,661,308 		JBrowse link
G E2F1 E2F transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12029619 PMID:15565109 PMID:28284560 NCBI chr17:37,178,587...37,190,118
Ensembl chr17:37,178,599...37,189,883 		JBrowse link
G E2F8 E2F transcription factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:40,178,182...40,194,932
Ensembl chr 2:40,178,177...40,194,935 		JBrowse link
G EAF2 ELL associated factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20564326 NCBI chr13:138,632,541...138,681,607
Ensembl chr13:138,648,270...138,681,613 		JBrowse link
G ECM1 extracellular matrix protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 4:98,615,776...98,633,081
Ensembl chr 4:98,615,778...98,621,836 		JBrowse link
G ECT2 epithelial cell transforming 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:111,248,215...111,310,746
Ensembl chr13:111,248,131...111,314,828 		JBrowse link
G EEF2 eukaryotic translation elongation factor 2 exacerbates ISO protein:increased expression, increased phosphorylation:liver (human) RGD PMID:28060762 RGD:153298915 NCBI chr 2:74,746,541...74,756,687
Ensembl chr 2:74,747,080...74,756,680 		JBrowse link
G EFEMP1 EGF containing fibulin extracellular matrix protein 1 disease_progression ISO protein:decreased expression:liver: RGD PMID:23936443 RGD:10401793 NCBI chr 3:85,407,677...85,473,251
Ensembl chr 3:85,407,677...85,473,252 		JBrowse link
G EFTUD2 elongation factor Tu GTP binding domain containing 2 severity
ameliorates		 ISO RGD PMID:34282556 RGD:155791664 NCBI chr12:18,474,367...18,514,993
Ensembl chr12:18,474,097...18,517,479 		JBrowse link
G EGF epidermal growth factor susceptibility ISO associated with hepatitis B;DNA:SNP:exon: (rs11569017) (human)
associated with liver cirrhosis;DNA:SNP:5'UTR: (rs4444903) (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:9029167 PMID:18167406 PMID:23790025 RGD:14695013 RGD:14695014 NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046 		JBrowse link
G EGFR epidermal growth factor receptor disease_progression ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9029167 PMID:11355950 RGD:126781769 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G EGR1 early growth response 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296 		JBrowse link
G EGR2 early growth response 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:66,280,665...66,291,308
Ensembl chr14:66,284,581...66,291,299 		JBrowse link
G EHD3 EH domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:108,103,631...108,135,161
Ensembl chr 3:108,100,401...108,134,906 		JBrowse link
G EIF3H eukaryotic translation initiation factor 3 subunit H ISO CTD Direct Evidence: marker/mechanism CTD PMID:14578863 NCBI chr 4:21,955,026...22,053,683
Ensembl chr 4:21,954,874...22,058,699 		JBrowse link
G ENAH ENAH actin regulator disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35030977 RGD:155791678 NCBI chr10:13,439,772...13,609,347
Ensembl chr10:13,446,426...13,609,303 		JBrowse link
G ENG endoglin ISO protein:increased expression:liver (rat) RGD PMID:20368095 RGD:7257538 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,309,400...268,343,783 		JBrowse link
G ENO1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 6:69,385,879...69,401,664
Ensembl chr 6:69,385,879...69,401,151 		JBrowse link
G EP300 E1A binding protein p300 ISO protein:increased expression:liver (rat) RGD PMID:17083329 RGD:2312274 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26735578 NCBI chr 3:94,167,759...94,253,662
Ensembl chr 3:94,165,816...94,254,079 		JBrowse link
G EPCAM epithelial cell adhesion molecule severity ISO protein:increased expression:liver RGD PMID:24616575 RGD:14695007 NCBI chr 3:93,169,800...93,185,221
Ensembl chr 3:93,168,852...93,185,653 		JBrowse link
G EPHB1 EPH receptor B1 ISO protein:increased phosphorylation:liver (mouse) RGD PMID:28100771 RGD:127285675 NCBI chr13:75,904,678...76,351,540
Ensembl chr13:75,905,676...76,345,534 		JBrowse link
G EPHX1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7892276 NCBI chr10:13,757,489...13,773,071
Ensembl chr10:13,751,881...13,773,072 		JBrowse link
G EPO erythropoietin disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936 		JBrowse link
G EPS8L3 EPS8 signaling adaptor L3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 4:110,311,533...110,326,999
Ensembl chr 4:110,311,519...110,326,994 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:11355950 RGD:126781769 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,474,475...21,495,038 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO DNA:insertion/deletion:3'UTR:rs6147150 (human) RGD PMID:22294845 RGD:126781763 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO mRNA, protein:increased expression:liver (human) RGD PMID:15922480 RGD:155598683 NCBI chr 6:51,783,537...51,808,898
Ensembl chr 6:51,783,478...51,798,984 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit susceptibility
disease_progression		 ISO DNA:SNPs:exon 23: p.K751Q (human)
DNA:SNP:cd: 312A>G (human)
DNA:SNPs:exon 23: p.K751Q (rs13181) (human)
DNA:SNPs:exon 23: p.K751Q (human)		 RGD PMID:19919686 PMID:25531380 PMID:28598207 PMID:28927037 RGD:150530503 RGD:25671459 RGD:25671460 RGD:25671461 NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553 		JBrowse link
G EREG epiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:35776891 NCBI chr 8:70,351,316...70,372,530
Ensembl chr 8:70,351,311...70,372,569 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 ISO DNA:hypomethylation: CpG islands: RGD PMID:20165882 RGD:14694974 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G ESM1 endothelial cell specific molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr16:34,184,255...34,193,877
Ensembl chr16:34,184,257...34,193,441 		JBrowse link
G ESR1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 PMID:28284560 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ETFA electron transfer flavoprotein subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 7:56,450,508...56,540,275
Ensembl chr 7:56,450,520...56,540,253 		JBrowse link
G EXO1 exonuclease 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr10:15,317,555...15,360,593
Ensembl chr10:15,317,581...15,359,839 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit susceptibility ISO mRNA:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple		 RGD
CTD		 PMID:24040354 PMID:24211739 PMID:25226601 PMID:26517514 PMID:28284560 More... RGD:10755339 RGD:11537550 RGD:126779595 RGD:126779608 NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO CTD Direct Evidence: marker/mechanism
associated with liver cirrhosis;protein:altered expression, altered processing:liver (human)		 CTD
RGD		 PMID:2821104 PMID:7620113 RGD:14975114 NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,455...15,819,137 		JBrowse link
G FABP5 fatty acid binding protein 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 4:55,277,831...55,282,585
Ensembl chr 4:55,275,205...55,282,908 		JBrowse link
G FAM111B FAM111 trypsin like peptidase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:12,268,692...12,279,386
Ensembl chr 2:12,268,695...12,279,559 		JBrowse link
G FAM180A family with sequence similarity 180 member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr18:13,574,024...13,589,117
Ensembl chr18:13,575,527...13,592,344 		JBrowse link
G FAM83D family with sequence similarity 83 member D ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:41,868,982...41,892,222
Ensembl chr17:41,868,976...41,892,220 		JBrowse link
G FANCD2 FA complementation group D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:66,241,951...66,308,601
Ensembl chr13:66,241,967...66,310,433 		JBrowse link
G FANCI FA complementation group I ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:54,811,024...54,889,992
Ensembl chr 7:54,811,027...54,889,998 		JBrowse link
G FAS Fas cell surface death receptor treatment ISO protein:increased expression:liver: RGD PMID:11274632 PMID:29634416 PMID:30737368 RGD:13792608 RGD:14700677 RGD:14700700 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G FASLG Fas ligand ISO protein:increased expression:liver: RGD PMID:11274632 RGD:14700677 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464 		JBrowse link
G FASN fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:14563831 PMID:15543204 PMID:21147110 NCBI chr12:922,405...937,560
Ensembl chr12:920,509...937,561 		JBrowse link
G FAT1 FAT atypical cadherin 1 disease_progression ISO mRNA,protein:increased expression:liver (human) RGD PMID:24590895 RGD:151347630 NCBI chr17:8,466,099...8,580,715
Ensembl chr17:8,457,187...8,580,715 		JBrowse link
G FATE1 fetal and adult testis expressed 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15580283 NCBI chr  X:123,106,086...123,113,178
Ensembl chr  X:123,099,746...123,113,171 		JBrowse link
G FBP1 fructose-bisphosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22039417 NCBI chr10:27,588,609...27,622,225
Ensembl chr10:27,588,570...27,622,674 		JBrowse link
G FBXL18 F-box and leucine rich repeat protein 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:4,031,784...4,079,605
Ensembl chr 3:4,033,580...4,079,549 		JBrowse link
G FBXO11 F-box protein 11 ameliorates
exacerbates		 ISO mRNA:increased expression:liver (human)
protein:increased expression:liver (human)		 RGD PMID:29518611 PMID:29603830 PMID:32657545 RGD:152025259 RGD:152025263 RGD:152025266 NCBI chr 3:92,696,402...92,792,623
Ensembl chr 3:92,696,441...92,792,616 		JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr14:14,976,259...15,010,701
Ensembl chr14:14,967,074...15,016,227 		JBrowse link
G FES FES proto-oncogene, tyrosine kinase exacerbates ISO DNA:hypermethylation:promoter (human) RGD PMID:31038805 RGD:153323297 NCBI chr 7:53,472,947...53,485,084
Ensembl chr 7:53,472,947...53,485,082 		JBrowse link
G FGF19 fibroblast growth factor 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25822088 NCBI chr 2:3,583,027...3,586,985
Ensembl chr 2:3,582,828...3,587,752 		JBrowse link
G FGF3 fibroblast growth factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25822088 NCBI chr 2:3,489,208...3,496,532
Ensembl chr 2:3,489,009...3,497,533 		JBrowse link
G FGF4 fibroblast growth factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25822088 NCBI chr 2:3,527,113...3,529,011
Ensembl chr 2:3,526,914...3,529,874 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 treatment ISO ClinVar Annotator: match by term: Hepatocellular carcinoma RGD
ClinVar		 PMID:21573021 PMID:25705862 PMID:26619011 PMID:26942290 PMID:33448156 RGD:25440476 NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 severity ISO associated with hepatitis B;DNA:SNPs: promoter, intron:rs308379, rs1219648 (human) RGD PMID:30952770 RGD:38501096 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425 		JBrowse link
G FGFR4 fibroblast growth factor receptor 4 treatment ISO RGD PMID:32677805 RGD:150520166 NCBI chr 2:80,841,536...80,853,791
Ensembl chr 2:80,841,536...80,853,796 		JBrowse link
G FH fumarate hydratase ISO ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar PMID:10896297 PMID:15221078 PMID:16876016 PMID:17182618 PMID:18313410 More... NCBI chr10:12,404,143...12,431,843
Ensembl chr10:12,404,176...12,431,824 		JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase ISO RGD PMID:12112319 RGD:632723 NCBI chr13:41,443,963...42,884,799
Ensembl chr13:41,443,965...42,392,817 		JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 ameliorates ISO human cells in mouse model RGD PMID:27511526 RGD:149735514 NCBI chr11:5,370,475...5,455,439
Ensembl chr11:5,370,496...5,455,358 		JBrowse link
G FLVCR1 FLVCR choline and heme transporter 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:130,543,911...130,570,486
Ensembl chr 9:130,541,660...130,570,702 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:9029167 PMID:28284560 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:51,836,780...51,844,531
Ensembl chr 6:51,837,719...51,844,529 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit ISO mRNA:increased expression:liver (human) RGD PMID:30086463 PMID:32048611 RGD:153344517 RGD:153344521 NCBI chr 3:110,820,403...110,842,903
Ensembl chr 3:110,823,666...110,843,068 		JBrowse link
G FOXA1 forkhead box A1 disease_progression
sexual_dimorphism
susceptibility		 ISO protein:decreased expression:liver
DNA:VNTR, SNPs, haplotypes:multiple:		 RGD PMID:25965836 PMID:29208003 PMID:31400761 RGD:11054501 RGD:151665752 RGD:151665820 NCBI chr 7:62,471,233...62,479,638
Ensembl chr 7:62,471,249...62,479,220 		JBrowse link
G FOXM1 forkhead box M1 ISO CTD Direct Evidence: marker/mechanism
OMIM:114550		 CTD
MouseDO		 PMID:15082532 PMID:17173139 PMID:28284560 NCBI chr 5:67,246,219...67,263,215
Ensembl chr 5:67,245,694...67,263,211
Ensembl chr 5:67,245,694...67,263,211 		JBrowse link
G FOXO1 forkhead box O1 ISO mRNA:decreased expression:liver RGD PMID:28972178 RGD:14401599 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473 		JBrowse link
G FOXP1 forkhead box P1 treatment ISO RGD PMID:25156538 RGD:9587823 NCBI chr13:52,346,844...52,974,358
Ensembl chr13:52,348,234...52,876,892 		JBrowse link
G FOXP3 forkhead box P3 ISO protein:increased expression:liver RGD PMID:21086571 RGD:38548919 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G FST follistatin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12203361 PMID:19363144 NCBI chr16:32,806,341...32,811,382
Ensembl chr16:32,805,932...32,811,421 		JBrowse link
G FTH1 ferritin heavy chain 1 ISO mRNA:increased expression:liver (rat) RGD PMID:9054589 RGD:632698 NCBI chr 2:9,535,051...9,537,979 JBrowse link
G FUBP1 far upstream element binding protein 1 ameliorates
exacerbates		 ISO human cell line in a mouse model
associated with Chronic Hepatitis C;mRNA:increased expression:liver (human)		 RGD PMID:19637194 PMID:25995247 PMID:31587040 RGD:151361188 RGD:151361194 RGD:151361196 NCBI chr 6:135,281,474...135,319,055
Ensembl chr 6:135,281,521...135,318,714 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 treatment ISO associated with Glycogen Storage Disease IA, human gene in a mouse model RGD PMID:28096054 RGD:14695537 NCBI chr12:19,965,885...19,975,783
Ensembl chr12:19,965,330...19,975,857 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:25473368 PMID:35693827 RGD:10449118 RGD:153344586 NCBI chr  X:125,029,147...125,041,040
Ensembl chr  X:125,029,150...125,041,040 		JBrowse link
G GABRD gamma-aminobutyric acid type A receptor subunit delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:64,049,665...64,059,644
Ensembl chr 6:64,049,675...64,059,640 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16767786 PMID:21472284 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991 		JBrowse link
G GBA3 glucosylceramidase beta 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:16,897,275...17,012,886
Ensembl chr 8:16,897,288...17,044,570 		JBrowse link
G GC GC vitamin D binding protein susceptibility ISO protein:increased expression:liver
associated with Hepatitis B, Chronic;DNA:SNP: :rs7041(human)		 RGD PMID:21683810 PMID:25541958 RGD:14402025 RGD:5509919 NCBI chr 8:68,326,293...68,360,262
Ensembl chr 8:68,326,299...68,360,262 		JBrowse link
G GDF15 growth differentiation factor 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20512989 NCBI chr 2:59,409,035...59,411,356
Ensembl chr 2:59,408,904...59,411,358 		JBrowse link
G GDF2 growth differentiation factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23936038 PMID:28284560 NCBI chr14:88,506,083...88,513,416
Ensembl chr14:88,507,399...88,513,375 		JBrowse link
G GHR growth hormone receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr16:27,126,300...27,422,618
Ensembl chr16:27,126,734...27,421,449 		JBrowse link
G GINS1 GINS complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:31,060,540...31,076,807
Ensembl chr17:31,060,650...31,080,314 		JBrowse link
G GJB1 gap junction protein beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17978847 NCBI chr  X:57,241,990...57,249,496
Ensembl chr  X:57,242,045...57,249,885 		JBrowse link
G GJB2 gap junction protein beta 2 ISO DNA, mRNA:promoter hypermethylation, decreased expression:liver RGD PMID:17295234 RGD:2289638 NCBI chr11:774,090...781,252
Ensembl chr11:775,166...775,846 		JBrowse link
G GLI1 GLI family zinc finger 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26189965 NCBI chr 5:22,736,325...22,747,421
Ensembl chr 5:22,739,900...22,747,421 		JBrowse link
G GLUL glutamate-ammonia ligase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr 9:123,751,551...123,762,575
Ensembl chr 9:123,751,548...123,762,547 		JBrowse link
G GMNN geminin DNA replication inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:19,585,968...19,595,346
Ensembl chr 7:19,586,002...19,595,344 		JBrowse link
G GMPS guanine monophosphate synthase ISO protein:increased activity:hepatoma (rat) RGD PMID:6861338 RGD:5135537 NCBI chr13:95,742,342...95,820,903
Ensembl chr13:95,738,659...95,819,759 		JBrowse link
G GNAO1 G protein subunit alpha o1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:29,416,574...29,592,874
Ensembl chr 6:29,416,708...29,592,516 		JBrowse link
G GNAS GNAS complex locus ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 PMID:3720010 More... NCBI chr17:58,985,580...59,053,022
Ensembl chr17:58,998,981...59,053,021 		JBrowse link
G GNAZ G protein subunit alpha z ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:49,132,012...49,174,114
Ensembl chr14:49,132,013...49,174,108 		JBrowse link
G GNMT glycine N-methyltransferase ISO CTD Direct Evidence: marker/mechanism
OMIM:114550		 CTD
MouseDO		 PMID:19146867 PMID:31086990 NCBI chr 7:38,038,359...38,041,218
Ensembl chr 7:38,038,358...38,041,217 		JBrowse link
G GOLM1 golgi membrane protein 1 severity ISO mRNA, protein:increased expression:liver
protein:increased expression:serum		 RGD PMID:21140449 PMID:21443671 RGD:401827118 RGD:401827119 NCBI chr10:29,117,578...29,219,024
Ensembl chr10:29,118,314...29,219,018 		JBrowse link
G GPC1 glypican 1 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr15:139,457,866...139,483,704
Ensembl chr15:139,457,669...139,484,670 		JBrowse link
G GPC3 glypican 3 disease_progression
exacerbates
severity
treatment		 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (human)
protein:increased expression:liver (human)
mRNA,protein:increased expression:peripheral blood mononuclear cell,blood serum, liver (human)
mRNA:increased expression:Peripheral Blood (human)
protein:increased expression:serum		 CTD
RGD		 PMID:16698587 PMID:19496787 PMID:21438004 PMID:22883669 PMID:23558072 More... RGD:14695019 RGD:14695020 RGD:243065125 RGD:243065131 RGD:243065134 RGD:243065135 RGD:243065139 NCBI chr  X:109,536,495...109,973,605
Ensembl chr  X:109,536,504...109,973,607 		JBrowse link
G GPM6A glycoprotein M6A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:38,258,496...38,555,129
Ensembl chr15:38,259,244...38,305,603 		JBrowse link
G GPR158 G protein-coupled receptor 158 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr10:49,862,312...50,202,748
Ensembl chr10:49,862,312...50,202,453 		JBrowse link
G GPR182 G protein-coupled receptor 182 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:22,303,466...22,309,652
Ensembl chr 5:22,304,588...22,311,028 		JBrowse link
G GPX1 glutathione peroxidase 1 severity
no_association
susceptibility		 ISO associated with hepatitis C;DNA:missense mutation:CDS:p.P198L (rs1050450) (human)
DNA:missense mutation:CDS:p.P198L (human)
associated with alcoholic liver cirrhosis;DNA:missense mutation:CDS:p.P198L (human)		 RGD PMID:16510607 PMID:19929244 PMID:25894370 PMID:26990426 RGD:11533013 RGD:151708729 RGD:152995483 RGD:152998906 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G GPX3 glutathione peroxidase 3 severity
disease_progression		 ISO mRNA,protein:decreased expression:liver, blood plasma (human)
DNA:hypermethylation		 RGD PMID:25333265 PMID:25445749 PMID:27570561 RGD:151665355 RGD:151665509 RGD:401827855 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026 		JBrowse link
G GRB7 growth factor receptor bound protein 7 exacerbates ISO protein:increased expression:liver (human) RGD PMID:17634422 RGD:151347655 NCBI chr12:22,574,579...22,583,386
Ensembl chr12:22,574,584...22,582,345 		JBrowse link
G GTSE1 G2 and S-phase expressed 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:3,227,813...3,246,679
Ensembl chr 5:3,227,816...3,242,789 		JBrowse link
G GYS2 glycogen synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:51,862,952...51,915,153
Ensembl chr 5:51,862,863...51,917,757 		JBrowse link
G HAMP hepcidin antimicrobial peptide ISO DNA:hypermethylation,hypomethylation:promoter
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:28284560 PMID:29235098 RGD:15042879 NCBI chr 6:44,785,863...44,787,303
Ensembl chr 6:44,784,160...44,787,305 		JBrowse link
G HAO2 hydroxyacid oxidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 4:101,588,510...101,787,818
Ensembl chr 4:101,588,861...101,732,304 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr16:66,162,318...66,208,868 JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 disease_progression ISO associated with hepatitis B;DNA:SNP: : ���1516 G>T (human) RGD PMID:27034168 RGD:40818257 NCBI chr16:66,138,157...66,160,568
Ensembl chr16:66,139,535...66,160,538 		JBrowse link
G HDAC2 histone deacetylase 2 disease_progression ISO mRNA:increased expression:liver: RGD PMID:24448241 RGD:9590206 NCBI chr 1:79,867,713...79,901,597
Ensembl chr 1:79,863,094...79,901,585 		JBrowse link
G HDAC4 histone deacetylase 4 ISO mRNA:increased expression:liver: RGD PMID:21837748 RGD:9681451 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,635...138,614,301 		JBrowse link
G HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28919514 NCBI chr 8:130,532,256...130,591,158
Ensembl chr 8:130,533,877...130,590,841 		JBrowse link
G HFE homeostatic iron regulator disease_progression ISO associated with Liver Cirrhosis;DNA:missense mutation:cds:p.C282Y (human) RGD PMID:20019189 PMID:29642405 RGD:14746967 RGD:2317357 NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,767,000 		JBrowse link
G HGF hepatocyte growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9932610 PMID:11896611 NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564 		JBrowse link
G HGFAC HGF activator ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr 8:2,077,164...2,084,506
Ensembl chr 8:2,077,176...2,084,507 		JBrowse link
G HHIP hedgehog interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18559595 NCBI chr 8:83,583,735...83,678,368
Ensembl chr 8:83,583,739...83,679,136 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha disease_progression
treatment		 ISO protein:increased expression:liver (human) RGD PMID:19335982 PMID:26078356 PMID:31321740 RGD:11526468 RGD:155882550 RGD:9068886 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G HILPDA hypoxia inducible lipid droplet associated disease_progression ISO mRNA, protein:increased expression:liver (human)
mRNA:increased expression:liver (human)
human cells in mouse model		 RGD PMID:30205391 PMID:31142329 PMID:35693827 RGD:153344574 RGD:153344577 RGD:153344586 NCBI chr18:19,944,929...19,947,080
Ensembl chr18:19,944,930...19,947,080 		JBrowse link
G HJURP Holliday junction recognition protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:134,106,561...134,123,163
Ensembl chr15:134,106,578...134,123,140 		JBrowse link
G HMGB2 high mobility group box 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20851854 NCBI chr14:16,709,966...16,712,288
Ensembl chr14:16,710,047...16,717,101 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:9207284 PMID:21147110 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,224...84,402,957 		JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 disease_progression ISO RGD PMID:28867541 RGD:14975299 NCBI chr 4:101,420,941...101,440,302
Ensembl chr 4:101,420,872...101,438,126 		JBrowse link
G HMMR hyaluronan mediated motility receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr16:60,290,684...60,332,411
Ensembl chr16:60,290,001...60,331,936 		JBrowse link
G HNF1A HNF1 homeobox A treatment ISO human cell line in mouse model RGD PMID:29466992 RGD:14700664 NCBI chr14:40,868,819...40,888,322
Ensembl chr14:40,868,676...40,888,328 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha ISO protein:decreased expression:liver: RGD PMID:20876809 RGD:12904747 NCBI chr17:46,783,772...46,847,505
Ensembl chr17:46,783,777...46,847,500 		JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 ISO protein:increased expression:liver (human) RGD PMID:23633480 RGD:9685423 NCBI chr 5:19,485,033...19,491,418
Ensembl chr 5:19,485,096...19,491,417 		JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 ISO mRNA:increased expression:liver (rat)
protein:increased expression:liver (human)		 RGD PMID:20604928 PMID:23633480 RGD:9685422 RGD:9685423 NCBI chr18:46,205,164...46,215,861
Ensembl chr18:46,205,418...46,215,856 		JBrowse link
G HNRNPAB heterogeneous nuclear ribonucleoprotein A/B severity ISO human gene in a mouse model RGD PMID:24638979 RGD:10059322 NCBI chr 2:80,186,998...80,194,155 JBrowse link
G HNRNPD heterogeneous nuclear ribonucleoprotein D ISO protein:increased expression:liver (human)
protein:increased expression:liver (rat)		 RGD PMID:20102719 PMID:22318685 RGD:10042969 RGD:10042977 NCBI chr 8:135,844,492...135,862,633
Ensembl chr 8:135,844,487...135,862,626 		JBrowse link
G HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 ISO protein:increased expression:liver (human) RGD PMID:23633480 RGD:9685423 NCBI chr 2:78,961,456...78,971,799
Ensembl chr 2:78,963,309...78,969,949 		JBrowse link
G HNRNPL heterogeneous nuclear ribonucleoprotein L ISO associated with Hepatitis B RGD PMID:24125732 RGD:9999429 NCBI chr 6:47,643,561...47,655,856
Ensembl chr 6:47,643,566...47,657,833 		JBrowse link
G HOXA10 homeobox A10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr18:45,393,525...45,403,259
Ensembl chr18:45,393,885...45,403,257 		JBrowse link
G HOXA13 homeobox A13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr18:45,373,340...45,379,046
Ensembl chr18:45,373,440...45,376,325 		JBrowse link
G HOXD9 homeobox D9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:81,910,415...81,926,276
Ensembl chr15:81,924,142...81,926,274 		JBrowse link
G HP haptoglobin ISO protein:increased expression:saliva
protein:decreased expression:liver (human)		 RGD PMID:24259486 PMID:31041878 RGD:152995276 RGD:27095881 NCBI chr 6:14,980,382...14,985,245 JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO protein:increased activity:hepatoma (rat) RGD PMID:6327016 RGD:5135035 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,204...110,357,894 		JBrowse link
G HRAS HRas proto-oncogene, GTPase treatment ISO human cells in a mouse model
ClinVar Annotator: match by term: Hepatocellular cancer		 RGD
ClinVar		 PMID:10791191 PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 More... RGD:14688055 NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 PMID:29698666 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 2:140,515,239...140,532,164
Ensembl chr 2:140,515,253...140,531,857 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,949...10,039,704 		JBrowse link
G HTATIP2 HIV-1 Tat interactive protein 2 ISO CTD Direct Evidence: therapeutic CTD PMID:16799960 NCBI chr 2:39,035,337...39,052,178
Ensembl chr 2:39,034,013...39,055,315 		JBrowse link
G HTRA1 HtrA serine peptidase 1 exacerbates
disease_progression		 ISO protein:decreased expression:liver (human)
mRNA:decreased expression:liver (human)		 RGD PMID:20943460 PMID:26403966 RGD:152985524 RGD:152985529 NCBI chr14:132,043,044...132,103,590
Ensembl chr14:132,041,934...132,103,595 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 severity ISO protein:increased expression:serum RGD PMID:26109813 RGD:11056752 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Hepatocellular cancer ClinVar PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More... NCBI chr15:111,341,153...111,362,330
Ensembl chr15:111,341,153...111,362,296 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 disease_progression ISO ClinVar Annotator: match by term: Hepatocellular cancer RGD
ClinVar		 PMID:20946881 PMID:21250968 PMID:21596855 PMID:21997850 PMID:22160010 More... RGD:14985249 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554 		JBrowse link
G IER2 immediate early response 2 ISO mRNA, protein:decreased expression:liver (human) RGD PMID:32009420 RGD:153323326 NCBI chr 2:65,909,638...65,912,491
Ensembl chr 2:65,909,651...65,912,445 		JBrowse link
G IFNA1 interferon, alpha 1 susceptibility ISO CTD Direct Evidence: therapeutic
associated with hepatitis B; DNA:SNP:: ( rs1831583) (human)		 CTD
RGD		 PMID:17088986 PMID:17971768 PMID:18665156 PMID:29080269 RGD:21406429 NCBI chr 1:201,515,835...201,516,477
Ensembl chr 1:201,515,809...201,516,488 		JBrowse link
G IFNG interferon gamma ISO mRNA:increased expression:liver (mouse) RGD PMID:26569409 RGD:11344640 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IGBP1 immunoglobulin binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21339737 NCBI chr  X:56,173,773...56,206,121 JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033 		JBrowse link
G IGF1R insulin like growth factor 1 receptor susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNPs, haplotype: :		 CTD
RGD		 PMID:17441810 PMID:23958494 PMID:24758241 RGD:14985227 NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058 		JBrowse link
G IGF2 insulin like growth factor 2 susceptibility ISO associated with hepatitis B;DNA:SNPs:intron, 3'utr:+2482A>C, +820A>G (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12532445 PMID:16092956 PMID:16750516 PMID:17554210 RGD:14401723 RGD:2311523 NCBI chr 2:1,469,183...1,496,417 JBrowse link
G IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:25,196,955...25,244,660
Ensembl chr12:25,197,058...25,243,272 		JBrowse link
G IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:92,104,786...92,272,264
Ensembl chr 9:92,104,848...92,272,211 		JBrowse link
G IGF2R insulin like growth factor 2 receptor disease_progression
no_association
treatment		 ISO ClinVar Annotator: match by term: Hepatocellular carcinoma
DNA:loss of heterozygosity:liver
DNA:loss of heterozygosity,mutations:liver:		 OMIM
ClinVar
RGD		 PMID:9722161 PMID:10347113 PMID:18322954 PMID:25741868 PMID:30720132 RGD:14985219 RGD:14985220 RGD:14985221 NCBI chr 1:7,369,485...7,472,480
Ensembl chr 1:7,368,103...7,472,548 		JBrowse link
G IGFALS insulin like growth factor binding protein acid labile subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:40,173,595...40,177,789
Ensembl chr 3:40,174,764...40,177,784 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma treatment ISO protein:decreased expression:liver (human) RGD PMID:17292824 PMID:22176836 PMID:22922425 PMID:24971483 PMID:25173965 More... RGD:11079569 RGD:153297807 RGD:153297813 RGD:153305943 RGD:153305945 RGD:153305947 NCBI chr  X:125,035,575...125,056,445
Ensembl chr  X:125,036,508...125,056,453 		JBrowse link
G IKZF1 IKAROS family zinc finger 1 ameliorates ISO protein:increased expression:liver (human) RGD PMID:25301737 RGD:150540326 NCBI chr 9:136,372,202...136,464,942
Ensembl chr 9:136,372,725...136,464,940 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:23822114 PMID:26890368 RGD:14975171 RGD:7365006 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL12A interleukin 12A susceptibility ISO associated with hepatitis B; DNA:SNP, haplotype:3′UTR :rs568408(human)
DNA:SNP:3'UTR: rs568408( G>A)(human)
associated with hepatitis C;DNA:SNP:3'UTR: rs568408( G>A)(human)		 RGD PMID:20521253 PMID:26631030 PMID:27819525 RGD:25440490 RGD:25440491 RGD:25440501 NCBI chr13:99,733,394...99,741,078
Ensembl chr13:99,733,394...99,741,078 		JBrowse link
G IL15RA interleukin 15 receptor subunit alpha disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr10:65,022,227...65,054,385 JBrowse link
G IL18 interleukin 18 disease_progression
susceptibility
severity		 ISO associated with hepatitis B, chronic;DNA:SNP:promoter:-607C>A(human)
DNA:SNP:promoter:-137G>C(rs187238)(human)
associated with hepatitis C;DNA:SNPs, haplotype:promoter:-607C>A, -137G>C(human)		 RGD PMID:26893476 PMID:27429592 PMID:27470888 PMID:29341496 RGD:11538094 RGD:14695526 RGD:14695540 RGD:14696663 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL18R1 interleukin 18 receptor 1 ISO mRNA:decreased expression:liver RGD PMID:26893476 RGD:11538094 NCBI chr 3:51,803,383...51,844,758
Ensembl chr 3:51,803,175...51,844,684 		JBrowse link
G IL1RAP interleukin 1 receptor accessory protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:127,933,239...128,071,984
Ensembl chr13:127,933,693...128,043,480 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560
G IL2 interleukin 2 treatment ISO RGD PMID:9449371 PMID:10933975 RGD:14747035 RGD:8693323 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL21 interleukin 21 ISO associated with hepatitis B;DNA:SNPS, haplotype:(rs13143866, rs2221903, rs907715) (human) RGD PMID:25892873 RGD:127285359 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,532,531...101,541,713 		JBrowse link
G IL29 interleukin 29 (interferon, lambda 1) ameliorates ISO human protein and cells in mouse model RGD PMID:24769671 RGD:126848750 NCBI chr17:51,484,658...51,485,233
Ensembl chr17:51,484,658...51,485,233 		JBrowse link
G IL6 interleukin 6 treatment
disease_progression		 ISO DNA:SNP: :rs2069852 (human)
mRNA,protein:increased expression:liver, blood serum (mouse)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17615358 PMID:20818158 PMID:26297436 PMID:26569409 PMID:27022031 More... RGD:11344640 RGD:14975289 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer ISO RGD PMID:15780071 RGD:1626706 NCBI chr16:35,101,304...35,151,832
Ensembl chr16:35,101,306...35,192,220 		JBrowse link
G ING3 inhibitor of growth family member 3 treatment ISO RGD PMID:25156538 RGD:9587823 NCBI chr18:25,946,529...25,976,528
Ensembl chr18:25,948,097...25,976,499 		JBrowse link
G INMT indolethylamine N-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr18:42,213,335...42,218,175
Ensembl chr18:42,209,352...42,218,174 		JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29415082 NCBI chr 8:84,812,041...85,555,200
Ensembl chr 8:85,084,133...85,514,516 		JBrowse link
G INS insulin ISO associated with Chronic Hepatitis C;mRNA:decreased expression:liver (human) RGD PMID:33132693 RGD:150340613 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G INSR insulin receptor ISO human cells in a mouse model
mRNA, protein:increased expression:liver (human, rat)		 RGD PMID:23633480 PMID:29610518 RGD:14700930 RGD:9685423 NCBI chr 2:71,797,209...71,939,923
Ensembl chr 2:71,797,204...71,936,104 		JBrowse link
G IQGAP2 IQ motif containing GTPase activating protein 2 ISO CTD Direct Evidence: marker/mechanism
OMIM:114550		 CTD
MouseDO		 PMID:20977743 NCBI chr 2:85,294,423...85,633,645
Ensembl chr 2:85,294,530...85,633,642 		JBrowse link
G IQGAP3 IQ motif containing GTPase activating protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 4:93,495,999...93,556,915
Ensembl chr 4:93,513,187...93,559,001 		JBrowse link
G IRF2 interferon regulatory factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22561517 NCBI chr15:45,546,779...45,693,241
Ensembl chr15:45,546,783...45,634,704 		JBrowse link
G IRS1 insulin receptor substrate 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1311924 PMID:23958494 NCBI chr15:128,245,846...128,307,321
Ensembl chr15:128,245,846...128,307,284 		JBrowse link
G IRS2 insulin receptor substrate 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16127164 NCBI chr11:76,626,158...76,654,639
Ensembl chr11:76,626,179...76,653,881 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier ISO CTD Direct Evidence: marker/mechanism CTD PMID:28919514 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208 		JBrowse link
G ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr13:34,911,104...34,924,881
Ensembl chr13:34,906,538...34,933,706 		JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 disease_progression ISO associated with hepatitis B;protein:decreased expression:serum RGD PMID:24836184 RGD:40903002 NCBI chr13:34,928,455...34,948,250
Ensembl chr13:34,928,439...34,948,229 		JBrowse link
G JAG1 jagged canonical Notch ligand 1 ISO protein:increased expression:liver RGD PMID:30660174 RGD:14694832 NCBI chr17:19,591,248...19,629,659
Ensembl chr17:19,591,259...19,629,641 		JBrowse link
G JAK1 Janus kinase 1 ISO RGD PMID:23788652 RGD:150524353 NCBI chr 6:147,320,288...147,567,188
Ensembl chr 6:147,429,056...147,567,182 		JBrowse link
G JAK2 Janus kinase 2 severity
treatment
ameliorates
exacerbates		 ISO mRNA:decreased expression:liver (human)
L-JAK2 KO
associated with Diseases of the Aged and non-alcoholic fatty liver disease
protein:increased phosphorylation:liver (mouse)
protein:increased phosphorylation:liver (human)		 RGD PMID:22392353 PMID:22821478 PMID:25420511 PMID:28100771 PMID:29486150 More... RGD:125097525 RGD:127285621 RGD:127285655 RGD:127285672 RGD:127285675 RGD:18182928 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G JDP2 Jun dimerization protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20214788 NCBI chr 7:98,574,386...98,616,480
Ensembl chr 7:98,575,667...98,616,474 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:20214788 NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit ISO associated with HBV;protein:increased expression:liver (human) RGD PMID:15927205 RGD:153297768 NCBI chr 2:59,530,991...59,532,846 JBrowse link
G KAT2B lysine acetyltransferase 2B severity ISO protein:decreased expression:liver (human) RGD PMID:23643089 RGD:9590314 NCBI chr13:6,985,151...7,099,771
Ensembl chr13:6,985,235...7,100,345 		JBrowse link
G KBTBD11 kelch repeat and BTB domain containing 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:33,487,439...33,501,274
Ensembl chr15:33,494,430...33,497,201 		JBrowse link
G KCNH1 potassium voltage-gated channel subfamily H member 1 ISO protein:increased expression:liver (human) RGD PMID:17022810 RGD:9693723 NCBI chr 9:131,960,566...132,336,029
Ensembl chr 9:131,960,480...132,334,953 		JBrowse link
G KCNN2 potassium calcium-activated channel subfamily N member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:118,439,328...118,882,299
Ensembl chr 2:118,439,403...118,882,295 		JBrowse link
G KDM1A lysine demethylase 1A severity ISO mRNA, protein:increased expression:liver (human) RGD PMID:23236241 RGD:9681002 NCBI chr 6:80,903,407...80,971,875
Ensembl chr 6:80,903,424...80,971,873 		JBrowse link
G KDM3A lysine demethylase 3A ISO mRNA:increased expression:liver (human) RGD PMID:21607773 RGD:9590222 NCBI chr 3:58,300,109...58,355,000
Ensembl chr 3:58,302,949...58,354,945 		JBrowse link
G KDM5C lysine demethylase 5C exacerbates ISO protein:increased expression:liver (human) RGD PMID:26503415 RGD:11530160 NCBI chr  X:45,968,812...46,003,215
Ensembl chr  X:45,968,814...46,003,215 		JBrowse link
G KDM6A lysine demethylase 6A ameliorates ISO human cells in a mouse model RGD PMID:32765772 RGD:150429729 NCBI chr  X:39,953,764...40,154,197
Ensembl chr  X:39,953,814...40,154,029 		JBrowse link
G KDM8 lysine demethylase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:19,653,396...19,676,207
Ensembl chr 3:19,653,402...19,676,148 		JBrowse link
G KDR kinase insert domain receptor disease_progression
treatment		 ISO protein:decreased expression:liver
associated with alcoholic liver cirrhosis;DNA:SNP: :1416A>T (human)
protein:increased expression:liver
DNA:SNPs: :rs1870377, rs2071559, rs2305948 (human)		 RGD PMID:19177438 PMID:23660204 PMID:24445728 PMID:25182707 PMID:25333267 RGD:126848806 RGD:126848810 RGD:126848812 RGD:126848813 RGD:126848814 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G KIF11 kinesin family member 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:104,125,839...104,177,381
Ensembl chr14:104,125,898...104,177,379 		JBrowse link
G KIF14 kinesin family member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr10:23,123,379...23,177,919
Ensembl chr10:23,123,480...23,174,273 		JBrowse link
G KIF15 kinesin family member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:27,966,586...28,041,121
Ensembl chr13:27,966,586...28,041,451 		JBrowse link
G KIF18A kinesin family member 18A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:32,244,073...32,331,392
Ensembl chr 2:32,244,137...32,335,736 		JBrowse link
G KIF18B kinesin family member 18B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:18,426,828...18,448,214
Ensembl chr12:18,426,835...18,448,208 		JBrowse link
G KIF1B kinesin family member 1B severity
susceptibility		 ISO mRNA, protein:decreased expression:liver (human)
DNA:snp:intron:c.2537+518A>G (rs17401966) (human)		 RGD PMID:26217094 PMID:27122668 RGD:11052488 RGD:12738461 NCBI chr 6:70,495,143...70,663,464
Ensembl chr 6:70,495,144...70,661,798 		JBrowse link
G KIF20A kinesin family member 20A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:140,202,316...140,213,144
Ensembl chr 2:140,202,015...140,211,155 		JBrowse link
G KIF23 kinesin family member 23 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:167,239,973...167,281,250
Ensembl chr 1:167,239,997...167,281,245 		JBrowse link
G KIF2C kinesin family member 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:166,556,765...166,577,904
Ensembl chr 6:166,556,776...166,577,904 		JBrowse link
G KIF4A kinesin family member 4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr  X:56,319,453...56,447,560
Ensembl chr  X:56,319,529...56,447,553 		JBrowse link
G KIFC1 kinesin family member C1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:29,692,775...29,713,716
Ensembl chr 7:29,694,778...29,713,712 		JBrowse link
G KLF4 KLF transcription factor 4 treatment
disease_progression		 ISO RGD PMID:22677193 RGD:14402023 NCBI chr 1:248,604,817...248,609,574
Ensembl chr 1:248,604,820...248,609,035 		JBrowse link
G KLRF1 killer cell lectin like receptor F1 disease_progression ISO mRNA:decreased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr 5:62,032,559...62,044,856
Ensembl chr 5:62,032,574...62,043,988 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22634756 NCBI chr 9:45,743,566...45,828,559
Ensembl chr 9:45,743,397...45,824,884 		JBrowse link
G KMT2B lysine methyltransferase 2B ISO DNA:insertions, translocations:intron:IVS3, multiple (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18320596 PMID:22634754 RGD:9588597 NCBI chr 6:45,146,863...45,166,854
Ensembl chr 6:45,147,566...45,166,852 		JBrowse link
G KMT2C lysine methyltransferase 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:22634756 NCBI chr18:4,993,213...5,279,668
Ensembl chr18:4,993,227...5,278,723 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase induced ISO aflatoxin B1 induced:DNA:transversion,transition mutations:cds:
ClinVar Annotator: match by term: Hepatocellular cancer		 RGD
ClinVar		 PMID:2278970 PMID:3122217 PMID:8446626 PMID:12460918 PMID:15696205 More... RGD:11568697 NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358 		JBrowse link
G KRT18 keratin 18 ISO OMIM:114550 MouseDO NCBI chr 5:18,217,686...18,221,432
Ensembl chr 5:18,217,691...18,221,429 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:28,550,356...28,553,561
Ensembl chr 6:28,550,358...28,553,566 		JBrowse link
G LECT2 leukocyte cell derived chemotaxin 2 ameliorates ISO human cells in mouse model
protein:increased expression:blood serum (human)
protein:increased expression:blood serum (mouse)		 RGD PMID:21394108 PMID:24892551 RGD:153323333 RGD:153323335 NCBI chr 2:138,109,537...138,120,285
Ensembl chr 2:138,109,351...138,124,464 		JBrowse link
G LEP leptin severity
susceptibility		 ISO protein:increased expression:liver (human)
DNA:SNP:enhancer:-2548G>A (rs7799039) (human)		 RGD PMID:18573568 PMID:28452232 RGD:15039399 RGD:25330348 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323 		JBrowse link
G LEPR leptin receptor susceptibility ISO associated with Hepatitis B, Chronic;DNA:missense mutations:cds:p.Q223R, p.K109R (human) RGD PMID:23090836 RGD:21079466 NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,801,954...146,895,995 		JBrowse link
G LETM1 leucine zipper and EF-hand containing transmembrane protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:23392203 NCBI chr 8:898,178...926,500
Ensembl chr 8:898,181...926,593 		JBrowse link
G LOC100153163 MHC class I polypeptide-related sequence B ISO CTD Direct Evidence: marker/mechanism CTD PMID:21499248 NCBI chr 7:23,596,900...23,610,431 JBrowse link
G LOC100157117 kallistatin ISO CTD Direct Evidence: therapeutic CTD PMID:19709125 NCBI chr 7:115,781,772...115,792,469
Ensembl chr 7:115,783,931...115,792,466 		JBrowse link
G LOC100511937 phosphatidylinositol 3-kinase regulatory subunit gamma treatment ISO RGD PMID:25999787 RGD:152177911 NCBI chr 6:165,268,260...165,402,668
Ensembl chr 6:165,268,568...165,402,649 		JBrowse link
G LOC100515114 serine/threonine-protein phosphatase 4 regulatory subunit 3B-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr  X:23,301,323...23,303,743 JBrowse link
G LOC100517408 cytochrome c oxidase subunit 7B2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:36,736,233...36,856,176
Ensembl chr 8:36,736,352...36,736,597 		JBrowse link
G LOC100737875 solute carrier family 22 member 10-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 PMID:30705370 NCBI chr 2:8,734,036...8,750,828 JBrowse link
G LOC100739508 glutathione S-transferase P-like ISO DNA:increased methylation:promoter
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:9029167 PMID:22536438 RGD:14401712 NCBI chr 2:5,005,498...5,009,247 JBrowse link
G LOC102167255 leukemia inhibitory factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr16:23,627,700...23,672,724
Ensembl chr16:23,634,298...23,804,854 		JBrowse link
G LOC110255234 liver carboxylesterase-like disease_progression ISO associated with tumor vascularization; protein:decreased expression:liver tumor (human)
protein:decreased expression:liver (human)
mRNA, protein:decreased expression:liver tumor (human)		 RGD PMID:19658107 PMID:24259486 PMID:30901224 RGD:152995276 RGD:152995279 RGD:152995286
G LOC110256483 carbonyl reductase [NADPH] 1-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:21056497 NCBI chr13:199,713,741...199,719,535 JBrowse link
G LOC110258578 interleukin-1 beta-like susceptibility ISO DNA:polymorphism:promoter:-31T>C (human) RGD PMID:21653279 RGD:7401222
G LOXL3 lysyl oxidase like 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35841383 NCBI chr 3:68,498,114...68,516,829
Ensembl chr 3:68,498,189...68,517,445 		JBrowse link
G LPAR1 lysophosphatidic acid receptor 1 ISO RGD PMID:19000703 RGD:2317680 NCBI chr 1:251,811,583...251,979,828
Ensembl chr 1:251,811,584...251,979,159 		JBrowse link
G LRAT lecithin retinol acyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:74,412,226...74,428,713
Ensembl chr 8:74,409,461...74,419,681 		JBrowse link
G LRP1B LDL receptor related protein 1B exacerbates ISO protein:increased expression:liver (human)
DNA:mutations:multiple: (human)		 RGD PMID:33324588 PMID:33391418 RGD:150429776 RGD:150429785 NCBI chr15:9,612,805...11,499,969
Ensembl chr15:9,613,238...11,499,530 		JBrowse link
G LRRC1 leucine rich repeat containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:26,860,138...26,989,664
Ensembl chr 7:26,860,140...26,989,698 		JBrowse link
G LRRC56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 More... NCBI chr 2:303,836...323,701
Ensembl chr 2:304,430...323,699 		JBrowse link
G LRRC59 leucine rich repeat containing 59 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30705370 NCBI chr12:26,678,207...26,694,277
Ensembl chr12:26,677,226...26,694,279 		JBrowse link
G LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:48,937,357...48,954,206
Ensembl chr 2:48,937,419...48,954,196 		JBrowse link
G LZTR1 leucine zipper like post translational regulator 1 ISO DNA:missense mutation:cds, liver (human) RGD PMID:28622513 RGD:151893487 NCBI chr14:50,576,413...50,590,397
Ensembl chr14:50,576,624...50,590,397 		JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:103,927,358...103,936,669
Ensembl chr 8:103,927,353...103,936,664 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 exacerbates ISO protein:increased expression:liver, cytosol (rat)
mRNA:increased expression:liver (human)		 RGD PMID:9397988 PMID:33553243 RGD:150530475 RGD:150530477 NCBI chr 2:74,626,739...74,651,352
Ensembl chr 2:74,626,783...74,651,348 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 ISO protein:decreased expression:liver (human) RGD PMID:32850377 RGD:150429765 NCBI chr12:56,402,029...56,516,217
Ensembl chr12:56,402,075...56,516,238 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 exacerbates ISO mRNA:decreased expression:liver (human) RGD PMID:31310010 RGD:150573714 NCBI chr16:35,872,301...35,947,097
Ensembl chr16:35,872,131...35,946,987 		JBrowse link
G MAP3K8 mitogen-activated protein kinase kinase kinase 8 ameliorates ISO RGD PMID:26560698 RGD:11342977 NCBI chr10:40,714,004...40,746,390
Ensembl chr10:40,713,847...40,742,462 		JBrowse link
G MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 ameliorates
treatment
severity		 ISO human cell line in a mouse model
human recombinant gene and cell line in a mouse model		 RGD PMID:21196414 PMID:27010469 PMID:31922225 RGD:151347673 RGD:151347674 RGD:151347839 NCBI chr 3:52,483,028...52,649,480
Ensembl chr 3:52,484,274...52,649,410 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO protein:increased expression:liver RGD PMID:27468214 RGD:401976278 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 exacerbates
treatment		 ISO RGD PMID:23271722 PMID:25216638 RGD:151665347 RGD:151665348 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ameliorates ISO protein:decreased phosphorylation:liver (human) RGD PMID:33875785 RGD:150340688 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G MAPT microtubule associated protein tau ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:17,098,259...17,211,483
Ensembl chr12:17,095,587...17,211,373 		JBrowse link
G MARCO macrophage receptor with collagenous structure ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:24,502,935...24,541,286
Ensembl chr15:24,503,108...24,541,283 		JBrowse link
G MAT1A methionine adenosyltransferase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12060674 NCBI chr14:82,109,405...82,126,487
Ensembl chr14:82,107,390...82,127,049 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility
no_association
severity		 ISO DNA:SNPs:promoter:rs7096206(human)
associated with hepatitis B;DNA:SNP:exon:
associated with hepatitis B-related cirrhosis;DNA:SNP: :rs11003123(G>A)(human)
associated with viral hepatitis;DNA:polymorphisms:exon:
associated with hepatitis C;DNA:SNP: :221C>G(rs709620)(human)
protein:decreased expression:plasma		 RGD PMID:18221301 PMID:21733090 PMID:25787238 PMID:26857650 PMID:27298104 More... RGD:14696813 RGD:14696814 RGD:14696829 RGD:14696833 RGD:14696835 RGD:14696836 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G MBTPS1 membrane bound transcription factor peptidase, site 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14563831 NCBI chr 6:4,503,530...4,558,601
Ensembl chr 6:4,503,565...4,558,609 		JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14563831 NCBI chr  X:18,013,360...18,054,250 JBrowse link
G MCM10 minichromosome maintenance 10 replication initiation factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr10:48,481,292...48,523,921
Ensembl chr10:48,480,705...48,538,952 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:72,630,378...72,651,270
Ensembl chr13:72,630,380...72,657,786 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 susceptibility ISO associated with hepatitis B;DNA:SNP:promoter: (rs999885) (human)
associated with hepatitis B;miRNA:increased expression:liver (human)		 RGD PMID:24416400 PMID:27298561 RGD:15042853 RGD:15042885 NCBI chr 3:8,005,890...8,014,047
Ensembl chr 3:8,005,900...8,014,053 		JBrowse link
G MCM9 minichromosome maintenance 9 homologous recombination repair factor ISO OMIM:114550 MouseDO NCBI chr 1:43,171,906...43,268,533 JBrowse link
G MDM2 MDM2 proto-oncogene susceptibility ISO DNA:transversion:promoter:g.-309T>G (human) RGD PMID:20019189 RGD:2317357 NCBI chr 5:33,105,717...33,137,602
Ensembl chr 5:33,105,759...33,137,739 		JBrowse link
G ME1 malic enzyme 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr 1:82,799,878...82,989,895
Ensembl chr 1:82,799,684...82,991,085 		JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver		 CTD
RGD		 PMID:11844796 PMID:26189965 RGD:2289670 NCBI chr  X:124,735,523...124,789,063
Ensembl chr  X:124,735,656...124,738,659 		JBrowse link
G MED1 mediator complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20007298 NCBI chr12:22,830,405...22,872,420
Ensembl chr12:22,841,205...22,872,409 		JBrowse link
G MELK maternal embryonic leucine zipper kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:237,317,161...237,431,522
Ensembl chr 1:237,317,191...237,431,589 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase severity ISO protein:increased expression:liver (human)
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma		 RGD
OMIM
ClinVar		 PMID:21774103 PMID:21970370 PMID:22703879 PMID:24728327 PMID:25741868 More... RGD:152995524 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512 		JBrowse link
G MFSD2A MFSD2 lysolipid transporter A, lysophospholipid ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:95,738,961...95,753,245
Ensembl chr 6:95,738,969...95,753,245 		JBrowse link
G MIR107 microRNA mir-107 onset
treatment		 ISO RNA:increased expression:liver:
RNA:decreased expression:liver:		 RGD PMID:26191213 PMID:27773820 PMID:28079796 PMID:30738047 RGD:11066920 RGD:14975277 RGD:14975278 RGD:14975300 NCBI chr14:101,420,743...101,420,829
Ensembl chr14:101,420,743...101,420,829 		JBrowse link
G MIR122 microRNA mir-122 severity ISO CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:blood (human)
protein:decreased expression:liver (human)
associated with hepatitis B; miRNA:decreased expression:liver		 CTD
RGD		 PMID:16924677 PMID:19584283 PMID:25269820 PMID:25422324 PMID:27528885 RGD:14394424 RGD:14401603 RGD:151356981 RGD:151361113 NCBI chr 1:162,329,776...162,329,860
Ensembl chr 1:162,329,767...162,329,860 		JBrowse link
G MIR125A microRNA mir-125a treatment
severity		 ISO RNA:increased expression:liver: RGD PMID:29951066 PMID:30257386 RGD:21403677 RGD:21403679 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645 		JBrowse link
G MIR127 microRNA mir-127 ISO miRNA:decreased expression:liver (human) RGD PMID:24854842 RGD:152995355 NCBI chr 7:121,709,636...121,709,715
Ensembl chr 7:121,709,640...121,709,720 		JBrowse link
G MIR133A-2 microRNA mir-133a-2 disease_progression ISO mRNA:decreased expression:liver (human)
human cells in mouse model		 RGD PMID:30086463 RGD:153344517 NCBI chr 6:106,998,899...106,998,971
Ensembl chr 6:106,998,896...106,998,982 		JBrowse link
G MIR133B microRNA mir-133b severity ISO mRNA:decreased expression:liver(human) RGD PMID:30391496 RGD:155804298 NCBI chr 7:45,980,138...45,980,217
Ensembl chr 7:45,980,138...45,980,217 		JBrowse link
G MIR136 microRNA mir-136 exacerbates ISO RNA:decreased expression:liver (human) RGD PMID:28849100 RGD:153345547 NCBI chr 7:121,711,328...121,711,409
Ensembl chr 7:121,711,325...121,711,414 		JBrowse link
G MIR139 microRNA mir-139 ISO RNA:decreased expression:liver (human) RGD PMID:30710422 RGD:153344549 NCBI chr 9:7,175,314...7,175,381
Ensembl chr 9:7,175,308...7,175,385 		JBrowse link
G MIR145 microRNA mir-145 severity ISO miRNA:decreased expression:liver (human) RGD PMID:30572504 RGD:15039395 NCBI chr 2:150,580,126...150,580,211
Ensembl chr 2:150,580,126...150,580,211 		JBrowse link
G MIR150-1 microRNA mir-150-1 ISO mRNA:decreased expression:liver (human) RGD PMID:30205391 RGD:153344577 NCBI chr 6:54,580,912...54,580,988
Ensembl chr 6:54,580,912...54,580,988 		JBrowse link
G MIR152 microRNA mir-152 disease_progression ISO miRNA:decreased expression:liver RGD PMID:26531720 PMID:30967300 RGD:19165146 RGD:21066331 NCBI chr12:24,292,249...24,292,328
Ensembl chr12:24,292,251...24,292,336 		JBrowse link
G MIR155 microRNA mir-155 disease_progression ISO miRNA:increased expression:serum
miRNA:decreased expression:peripheral blood mononuclear cell
associated with hepatitis C;DNA:SNP: :rs767649 (human)		 RGD PMID:27035278 PMID:27531892 PMID:28074870 PMID:29528577 PMID:30710754 RGD:21079433 RGD:21079477 RGD:21081523 RGD:24922222 RGD:25671465 NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902 		JBrowse link
G MIR181C microRNA mir-181c ISO miRNA:decreased expression:liver (human) RGD PMID:31114379 RGD:15042894 NCBI chr 2:65,279,950...65,280,036
Ensembl chr 2:65,279,944...65,280,040 		JBrowse link
G MIR18A microRNA mir-18a severity ISO associated with Hepatitis C, Chronic;miRNA:increased expression:serum (human)
associated with hepatitis B;miRNA:increased expression:liver (human)		 RGD PMID:19027010 PMID:24975878 PMID:29455432 PMID:30191950 PMID:30519035 RGD:15039389 RGD:15039398 RGD:15039400 RGD:15039401 RGD:15039404 NCBI chr11:60,734,791...60,734,882
Ensembl chr11:60,734,791...60,734,882 		JBrowse link
G MIR193A microRNA mir-193a disease_progression
exacerbates		 ISO RNA:decreased expression:liver (human)
miRNA:decreased expression:liver (human)
RNA:increased expression:blood serum (human)
DNA:hypomethylation		 RGD PMID:26263159 PMID:28036298 PMID:30710422 PMID:32960907 RGD:11070076 RGD:153344549 RGD:153344563 RGD:153344564 NCBI chr12:43,336,969...43,337,048
Ensembl chr12:43,336,969...43,337,048 		JBrowse link
G MIR195 microRNA mir-195 severity ISO miRNA:decreased expression:liver (mouse)
miRNA:decreased expression:liver (human)		 RGD PMID:25607636 RGD:15042896 NCBI chr12:52,422,039...52,422,118
Ensembl chr12:52,422,039...52,422,118 		JBrowse link
G MIR196A-2 microRNA mir-196a-2 susceptibility ISO associated with hepatitis B, chronic; DNA:SNP: : (rs12304647)
DNA:SNP: : (rs11614913)		 RGD PMID:21692953 PMID:24248733 RGD:14401594 RGD:14401595 NCBI chr 5:19,204,442...19,204,548
Ensembl chr 5:19,204,442...19,204,548 		JBrowse link
G MIR199B microRNA mir-199b disease_progression ISO miRNA:decreased expression:liver RGD PMID:30536310 RGD:14694833 NCBI chr 1:268,691,520...268,691,593
Ensembl chr 1:268,691,502...268,691,610 		JBrowse link
G MIR20A microRNA mir-20a ISO associated with Human Viral Hepatitis RGD PMID:30623908 RGD:25823145 NCBI chr11:60,735,109...60,735,179
Ensembl chr11:60,735,099...60,735,196 		JBrowse link
G MIR21 microRNA mir-21 treatment
severity		 ISO miRNA:increased expression:liver RGD PMID:20447717 PMID:21749846 PMID:24963487 RGD:14695022 RGD:40925952 RGD:41404642 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G MIR212 microRNA mir-212 disease_progression
ameliorates		 ISO RGD PMID:25965836 RGD:11054501 NCBI chr12:48,163,054...48,163,135
Ensembl chr12:48,163,046...48,163,145 		JBrowse link
G MIR221 microRNA mir-221 treatment
disease_progression		 ISO RGD PMID:22009537 PMID:25817558 PMID:28096271 PMID:29713162 PMID:31801250 RGD:11086123 RGD:151893509 RGD:18337267 RGD:18337273 RGD:18337275 NCBI chr  X:40,571,068...40,571,137
Ensembl chr  X:40,571,068...40,571,137 		JBrowse link
G MIR222 microRNA mir-222 disease_progression
severity		 ISO RGD PMID:20103675 PMID:24124720 RGD:151709003 RGD:151709004 NCBI chr  X:40,571,808...40,571,887
Ensembl chr  X:40,571,808...40,571,887 		JBrowse link
G MIR224 microRNA mir-224 severity ISO associated with hepatitis B;miRNA:increased expression:liver (human)
miRNA:increased expression:plasma (human)		 RGD PMID:22459148 PMID:23913306 PMID:23922662 PMID:24923856 PMID:27462777 RGD:18182921 RGD:18182922 RGD:18182923 RGD:18182924 RGD:18182926 NCBI chr  X:123,283,427...123,283,507
Ensembl chr  X:123,283,427...123,283,507 		JBrowse link
G MIR23A microRNA mir-23a ISO miRNA:increased expression:liver RGD PMID:22318941 RGD:14694846 NCBI chr 2:65,308,117...65,308,186
Ensembl chr 2:65,308,117...65,308,186 		JBrowse link
G MIR23B microRNA mir-23b ISO DNA:hypermethylation RGD PMID:28036298 RGD:153344564 NCBI chr10:27,080,197...27,080,276
Ensembl chr10:27,080,197...27,080,276 		JBrowse link
G MIR27A microRNA mir-27a severity
treatment		 ISO human cell line in a mouse model
human miRNA and cell line in a mouse model		 RGD PMID:29143999 PMID:30083261 RGD:14696659 RGD:14696660 NCBI chr 2:65,308,294...65,308,375
Ensembl chr 2:65,308,294...65,308,375 		JBrowse link
G MIR29A microRNA mir-29a severity ISO associated with hepatitis B;miRNA:increased expression:liver (human) RGD PMID:23285022 RGD:15042850 NCBI chr18:18,040,032...18,040,117
Ensembl chr18:18,040,032...18,040,118 		JBrowse link
G MIR31 microRNA mir-31 severity ISO RNA:decreased expression:liver (human)
miRNA:decreased expression:liver (human)
miRNA:decreased expression:liver (rat)		 RGD PMID:25797269 PMID:28623129 RGD:11085965 RGD:152998991 NCBI chr 1:201,198,732...201,198,809
Ensembl chr 1:201,198,732...201,198,809 		JBrowse link
G MIR432 microRNA mir-432 disease_progression ISO mRNA:decreased expression:liver (human)
human cells in mouse model		 RGD PMID:25797263 PMID:30086881 PMID:33675609 RGD:11087457 RGD:152999436 RGD:152999437 NCBI chr 7:121,711,137...121,711,216
Ensembl chr 7:121,711,137...121,711,216 		JBrowse link
G MIR455 microRNA mir-455 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35286011 NCBI chr 1:254,824,200...254,824,279
Ensembl chr 1:254,824,196...254,824,291 		JBrowse link
G MIR885 microRNA mir-885 ISO CTD Direct Evidence: therapeutic CTD PMID:27738331 NCBI chr13:66,597,531...66,597,610
Ensembl chr13:66,597,531...66,597,610 		JBrowse link
G MIR96 microRNA mir-96 severity ISO miRNA:increased expression:liver (human) RGD PMID:25813403 PMID:28892647 RGD:15042901 RGD:15042902 NCBI chr18:18,982,506...18,982,590
Ensembl chr18:18,982,506...18,982,590 		JBrowse link
G MIRLET7C microRNA let-7c ISO miRNA:decreased expression:liver RGD PMID:22289550 RGD:14695021 NCBI chr13:181,303,209...181,303,302
Ensembl chr13:181,303,209...181,303,302 		JBrowse link
G MKI67 marker of proliferation Ki-67 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:137,266,622...137,296,312 JBrowse link
G MLXIPL MLX interacting protein like ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr 3:10,898,675...10,934,257
Ensembl chr 3:10,898,670...10,934,048 		JBrowse link
G MME membrane metalloendopeptidase ISO RGD PMID:8302012 RGD:13801035 NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045 		JBrowse link
G MMP14 matrix metallopeptidase 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33010264 NCBI chr 7:76,174,502...76,185,931
Ensembl chr 7:76,172,971...76,185,928 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20084675 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20084675 PMID:21681821 RGD:8547864 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G MOGAT2 monoacylglycerol O-acyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:9,937,654...9,951,679
Ensembl chr 9:9,937,700...10,008,913 		JBrowse link
G MPL MPL proto-oncogene, thrombopoietin receptor ISO human cells in mouse model RGD PMID:23157389 RGD:126925755 NCBI chr 6:167,896,191...167,908,988
Ensembl chr 6:167,896,287...167,908,625 		JBrowse link
G MPO myeloperoxidase susceptibility
disease_progression		 ISO CTD Direct Evidence: marker/mechanism
associated with liver cirrhosis; DNA:SNP:promoter:-463G>A( rs2333227)(human)
associated with liver cirrhosis with Hepatitis C;DNA:SNP:promoter:-463G>A(human)		 CTD
RGD		 PMID:19731237 PMID:21907168 RGD:26923907 RGD:27095879 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G MRO maestro ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:100,342,040...100,368,355
Ensembl chr 1:100,343,462...100,368,354 		JBrowse link
G MSH3 mutS homolog 3 ISO ClinVar Annotator: match by term: Hepatocellular cancer ClinVar PMID:28492532 NCBI chr 2:89,255,647...89,456,102
Ensembl chr 2:89,250,003...89,453,936 		JBrowse link
G MSH5 mutS homolog 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:23,852,864...23,872,760
Ensembl chr 7:23,852,918...23,872,755 		JBrowse link
G MT-2B metallothionein-2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17363595 PMID:28284560 NCBI chr 6:18,645,125...18,646,034
Ensembl chr 6:18,645,153...18,646,033 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I ISO RGD PMID:2548155 RGD:2302301 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055 		JBrowse link
G MT-ND5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 ISO mRNA:increased expression:liver RGD PMID:2507335 RGD:2302316 NCBI chr MT:12,935...14,755
Ensembl chr MT:12,935...14,755 		JBrowse link
G MT1A metallothionein 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17363595 PMID:19363144 NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,672,001...18,673,672 		JBrowse link
G MTBP MDM2 binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:29765550 NCBI chr 4:18,533,201...18,608,702
Ensembl chr 4:18,532,041...18,608,602 		JBrowse link
G MTDH metadherin treatment ISO human cells in a mouse model RGD PMID:26351209 RGD:11096879 NCBI chr 4:39,052,895...39,113,380
Ensembl chr 4:39,051,537...39,113,385 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO mRNA:increased expression:liver RGD PMID:3878730 RGD:2302305 NCBI chr 3:68,819,171...68,833,641
Ensembl chr 3:68,818,119...68,833,600 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility
disease_progression
onset		 ISO DNA:SNP,haplotype: :677C>T, 1298A>C(human)
DNA:SNP: :677C>T(human)
DNA:SNPs: :677C>T, 1298A>C(human)
DNA:SNP: :1298A>C(human)		 RGD PMID:17503006 PMID:17659576 PMID:19035314 PMID:23996892 RGD:14696703 RGD:14696704 RGD:14696707 RGD:14696708 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTOR mechanistic target of rapamycin kinase severity ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver (human)		 CTD
RGD		 PMID:21147110 PMID:25371154 RGD:152995471 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase susceptibility ISO DNA:SNP: :66A>G(human) RGD PMID:19035314 RGD:14696707 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783 		JBrowse link
G MVK mevalonate kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr14:41,320,790...41,357,437
Ensembl chr14:41,281,673...41,357,368 		JBrowse link
G MYBL2 MYB proto-oncogene like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:46,256,245...46,287,929
Ensembl chr17:46,256,257...46,287,927 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor treatment
severity		 ISO mRNA:increased expression:liver (rat)
mRNA:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:9029167 PMID:12029619 PMID:15565109 PMID:21644509 PMID:22076107 More... RGD:6903288 RGD:7240567 RGD:7240695 RGD:7241004 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor exacerbates
treatment
ameliorates		 ISO mRNA:increased expression:liver (human)
human gene and cell in a mouse model
mouse cell line in a mouse model
human cell line in a mouse model
protein:increased expression:liver (human)
protein, mRNA:decreased expression:liver (human)		 RGD PMID:17615358 PMID:24603331 PMID:26985932 PMID:28370778 PMID:29022910 More... RGD:150520022 RGD:150520169 RGD:150521532 RGD:150521534 RGD:150524327 RGD:150524329 RGD:150524330 RGD:150524334 RGD:150530285 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NBN nibrin ISO ClinVar Annotator: match by term: Hepatocellular cancer ClinVar PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 More... NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,691...46,874,603 		JBrowse link
G NCAPG non-SMC condensin I complex subunit G ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:12,759,225...12,807,164
Ensembl chr 8:12,759,641...12,807,163 		JBrowse link
G NCAPH non-SMC condensin I complex subunit H ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:46,852,388...46,893,008
Ensembl chr 3:46,852,392...46,893,013 		JBrowse link
G NCOA2 nuclear receptor coactivator 2 exacerbates ISO RGD PMID:22556267 PMID:28273073 RGD:153002573 RGD:153002576 NCBI chr 4:64,888,029...65,245,757
Ensembl chr 4:64,954,238...65,246,572 		JBrowse link
G NDC80 NDC80 kinetochore complex component ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:104,000,794...104,055,785
Ensembl chr 6:103,999,034...104,055,760 		JBrowse link
G NEIL3 nei like DNA glycosylase 3 disease_progression ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)		 CTD
RGD		 PMID:28284560 PMID:35693827 RGD:153344586 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,308 		JBrowse link
G NEK2 NIMA related kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:131,547,044...131,560,527
Ensembl chr 9:131,547,069...131,561,095 		JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor disease_progression ISO DNA, protein:SNP, increased expression:intron, liver
protein:decreased expression:liver		 RGD PMID:26443326 PMID:27289045 PMID:29130106 RGD:11076529 RGD:150530489 RGD:150530504 NCBI chr14:46,653,869...46,726,421
Ensembl chr14:46,653,900...46,731,999 		JBrowse link
G NFE2L1 NFE2 like bZIP transcription factor 1 ISO OMIM:114550 MouseDO NCBI chr12:24,303,381...24,316,765
Ensembl chr12:24,303,399...24,316,763 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ISO ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar PMID:26619011 PMID:29018201 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 disease_progression
treatment		 ISO associated with Chronic Hepatitis B;DNA:insertion/deletion:3'utr: -94ins/delATTG (rs28720239) (human) RGD PMID:19797428 PMID:25999787 RGD:152177911 RGD:40400751 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691 		JBrowse link
G NFKBIA NFKB inhibitor alpha susceptibility
disease_progression		 ISO CTD Direct Evidence: therapeutic
associated with hepatitis B;DNA:SNP:promoter:-826C>T (rs2233406) (human)
associated with Chronic Hepatitis B;DNA:SNPs,haplotype:3'utr,promoter: 826C>T,881A>G (rs2233406,rs3138053) (human)		 CTD
RGD		 PMID:19797428 PMID:22022477 PMID:25223483 RGD:40400751 RGD:40902986 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NKX3-1 NK3 homeobox 1 treatment ISO mRNA:decreased expression:liver
human gene in a mouse model		 RGD PMID:28972178 RGD:14401599 NCBI chr14:7,783,296...7,787,036
Ensembl chr14:7,783,323...7,787,033 		JBrowse link
G NLRC3 NLR family CARD domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30081150 NCBI chr 3:38,673,590...38,719,188
Ensembl chr 3:38,687,967...38,710,938 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 ISO protein:increased expression:liver RGD PMID:27338800 RGD:15003194 NCBI chr 6:18,933,179...19,036,288
Ensembl chr 6:18,937,677...19,036,820 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140 		JBrowse link
G NNMT nicotinamide N-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:41,871,072...41,882,415
Ensembl chr 9:41,870,980...41,882,756 		JBrowse link
G NOS2 nitric oxide synthase 2 treatment ISO RGD PMID:25999787 RGD:152177911 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NOTCH3 notch receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:62,364,507...62,402,348
Ensembl chr 2:62,364,501...62,402,344 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23811326 NCBI chr 6:84,225,670...84,228,156
Ensembl chr 6:84,225,694...84,228,481 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr 6:55,238,536...55,245,457
Ensembl chr 6:55,239,500...55,245,456 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 ISO OMIM:114550
CTD Direct Evidence: marker/mechanism
intestinally expressed human gene in mouse model
mRNA:splice variant(s):liver (human)		 RGD
MouseDO
CTD		 PMID:23213087 PMID:23811326 PMID:24954587 PMID:25496033 RGD:14696796 RGD:14928330 RGD:14928334 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604 		JBrowse link
G NRAS NRAS proto-oncogene, GTPase severity
disease_progression		 ISO mRNA, protein:increased expression:liver (mouse, human)
ClinVar Annotator: match by term: Hepatocellular cancer
human gene in mouse model		 RGD
ClinVar		 PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More... RGD:14696775 RGD:14696793 NCBI chr 4:105,845,913...105,853,769
Ensembl chr 4:105,845,872...105,858,227 		JBrowse link
G NRG1 neuregulin 1 disease_progression ISO mRNA:increased expression:liver (human)
associated with hepatitis C;mRNA:altered expression:liver (human		 RGD PMID:17393520 PMID:27514687 RGD:39456104 RGD:39456110 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505 		JBrowse link
G NRP1 neuropilin 1 disease_progression ISO protein:decreased expression:liver RGD PMID:25333267 RGD:126848812 NCBI chr10:56,280,673...56,430,832
Ensembl chr10:56,280,665...56,430,777 		JBrowse link
G NUF2 NUF2 component of NDC80 kinetochore complex treatment
disease_progression		 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:28284560 PMID:30653265 PMID:31933938 RGD:28867240 RGD:28912742 NCBI chr 4:87,162,873...87,194,193
Ensembl chr 4:87,162,818...87,194,170 		JBrowse link
G NUSAP1 nucleolar and spindle associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:129,992,797...130,065,641
Ensembl chr 1:129,992,804...130,065,605 		JBrowse link
G OIT3 oncoprotein induced transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:75,726,353...75,753,461
Ensembl chr14:75,726,364...75,754,331 		JBrowse link
G OLFML2A olfactomedin like 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:265,577,250...265,604,365
Ensembl chr 1:265,577,704...265,604,502 		JBrowse link
G OLFML2B olfactomedin like 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 4:88,522,171...88,560,305
Ensembl chr 4:88,522,240...88,560,306 		JBrowse link
G ORC1 origin recognition complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:159,819,302...159,852,306
Ensembl chr 6:159,819,339...159,852,305 		JBrowse link
G OTC ornithine transcarbamylase severity ISO mRNA:altered expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr  X:34,322,398...34,391,711
Ensembl chr  X:34,322,298...34,391,821 		JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 disease_progression ISO mRNA,protein:decreased expression:liver: RGD PMID:21569763 RGD:12790589 NCBI chr12:48,567,329...48,735,836
Ensembl chr12:48,628,816...48,735,834 		JBrowse link
G PAMR1 peptidase domain containing associated with muscle regeneration 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:25,422,390...25,591,615
Ensembl chr 2:25,514,193...25,591,617 		JBrowse link
G PARK7 Parkinsonism associated deglycase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18695907 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G PBK PDZ binding kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:11,543,657...11,577,286
Ensembl chr14:11,543,603...11,566,702 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 PMID:28284560 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,936,522 		JBrowse link
G PCLAF PCNA clamp associated factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:107,659,509...107,669,477
Ensembl chr 1:107,659,509...107,670,954 		JBrowse link
G PCNA proliferating cell nuclear antigen treatment ISO protein:increased expression:liver: RGD PMID:23219601 PMID:25999787 RGD:10448993 RGD:152177911 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744 		JBrowse link
G PDCD1 programmed cell death 1 disease_progression ISO associated with hepatitis B;DNA:SNP: : +8669 A>G (human) RGD PMID:21912640 PMID:27034168 RGD:40818257 RGD:41410800 NCBI chr15:140,337,353...140,347,493
Ensembl chr15:140,336,258...140,347,478 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO CTD Direct Evidence: marker/mechanism CTD PMID:20506153 Ensembl chr 5:8,986,462...9,007,435 JBrowse link
G PDGFRL platelet derived growth factor receptor like ISO ClinVar Annotator: match by term: Hepatocellular carcinoma OMIM
ClinVar		 PMID:7898930 NCBI chr17:5,278,872...5,328,859
Ensembl chr17:5,279,004...5,329,511 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 1:127,786,174...127,814,096
Ensembl chr 1:127,785,772...127,814,196 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28003426 NCBI chr 9:75,246,956...75,260,134
Ensembl chr 9:75,246,002...75,260,134 		JBrowse link
G PFAS phosphoribosylformylglycinamidine synthase ISO protein:increased activity:hepatoma (rat)
protein:increased expression:liver		 RGD PMID:6722784 RGD:5135276 NCBI chr12:53,458,401...53,477,254 JBrowse link
G PFN2 profilin 2 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr13:90,177,534...90,185,978
Ensembl chr13:90,177,540...90,183,742 		JBrowse link
G PGD phosphogluconate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr 6:70,675,751...70,692,697
Ensembl chr 6:70,675,815...70,692,679 		JBrowse link
G PGK1 phosphoglycerate kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr  X:62,187,472...62,210,321
Ensembl chr  X:62,187,434...62,210,705 		JBrowse link
G PHB1 prohibitin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr12:25,596,520...25,609,693
Ensembl chr12:25,596,523...25,609,706 		JBrowse link
G PHF6 PHD finger protein 6 exacerbates ISO mRNA:increased expression:liver (human) RGD PMID:30888215 PMID:31329335 RGD:155260288 RGD:155260308 NCBI chr  X:110,249,010...110,311,503
Ensembl chr  X:110,249,010...110,303,017 		JBrowse link
G PHLDA1 pleckstrin homology like domain family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:39,309,701...39,319,313
Ensembl chr 5:39,291,560...39,315,615 		JBrowse link
G PIGE-108A11.3 leukocyte immunoglobulin-like receptor-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:59,042,881...59,046,646 JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha treatment
severity
no_association
susceptibility		 ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
DNA:mutations:exons:
DNA:mutation:exon:
DNA:SNPs: :rs17849071,rs17849079(human)		 OMIM
ClinVar
RGD		 PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... RGD:11556371 RGD:14402404 RGD:14402405 RGD:152177911 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta treatment ISO RGD PMID:25999787 RGD:152177911 NCBI chr13:79,427,033...79,610,840
Ensembl chr13:79,425,835...79,610,840 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 treatment ISO RGD PMID:25999787 PMID:31801250 RGD:151893509 RGD:152177911 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 treatment ISO RGD PMID:25999787 RGD:152177911 NCBI chr 2:59,637,363...59,652,075
Ensembl chr 2:59,637,371...59,652,073 		JBrowse link
G PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 disease_progression ISO associated with Chronic Hepatitis B; DNA:SNP::rs1469557(human) RGD PMID:27221889 RGD:152977752 NCBI chr14:13,965,733...14,041,841
Ensembl chr14:13,967,070...14,041,788 		JBrowse link
G PITPNM3 PITPNM family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:50,806,302...50,898,316
Ensembl chr12:50,742,773...50,898,331 		JBrowse link
G PITX1 paired like homeodomain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:137,200,424...137,212,500
Ensembl chr 2:137,200,423...137,206,979 		JBrowse link
G PKM pyruvate kinase M1/2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr 7:60,971,807...61,032,780
Ensembl chr 7:60,975,667...61,004,316
Ensembl chr 7:60,975,667...61,004,316 		JBrowse link
G PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:39,201,819...39,209,261
Ensembl chr 3:39,201,878...39,210,125 		JBrowse link
G PKP1 plakophilin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr10:23,689,394...23,735,457
Ensembl chr10:23,689,380...23,735,453 		JBrowse link
G PLAC8 placenta associated 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:135,250,761...135,279,091 JBrowse link
G PLCG1 phospholipase C gamma 1 ameliorates ISO human cell line in a mouse model RGD PMID:30623526 RGD:151356937 NCBI chr17:43,810,003...43,844,553
Ensembl chr17:43,810,048...43,844,554 		JBrowse link
G PLK1 polo like kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:22,537,814...22,550,901
Ensembl chr 3:22,537,831...22,552,380 		JBrowse link
G PLK4 polo like kinase 4 sexual_dimorphism ISO DNA:hypermethylation:promoter RGD PMID:21324136 RGD:27226690 NCBI chr 8:96,989,011...97,013,324
Ensembl chr 8:96,991,847...97,013,461 		JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 treatment ISO mRNA, protein:increased expression:liver (human) RGD PMID:29059470 RGD:155791679 NCBI chr 3:8,911,787...8,919,525
Ensembl chr 3:8,911,791...8,919,516 		JBrowse link
G PLVAP plasmalemma vesicle associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:60,324,565...60,344,450
Ensembl chr 2:60,324,560...60,344,443 		JBrowse link
G PLXDC1 plexin domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:23,073,292...23,142,529
Ensembl chr12:23,073,302...23,142,547 		JBrowse link
G PML PML nuclear body scaffold disease_progression
ameliorates
exacerbates		 ISO protein:increased expression:liver (human)
mRNA:increased expression:liver (mouse)
associated with hepatitis C		 RGD PMID:11511788 PMID:26118777 PMID:31144474 RGD:41404685 RGD:41404687 RGD:41404690 NCBI chr 7:59,405,044...59,450,155
Ensembl chr 7:59,405,053...59,450,105 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component ISO ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar NCBI chr 3:5,118,002...5,145,634
Ensembl chr 3:5,118,018...5,145,628 		JBrowse link
G PNPLA3 patatin like phospholipase domain containing 3 ISO associated with Hepatitis C, Chronic;DNA:SNP: :rs738409 (p.I148M) (human) RGD PMID:21319195 RGD:14981585 NCBI chr 5:5,075,608...5,092,599
Ensembl chr 5:5,075,622...5,092,515 		JBrowse link
G PNPT1 polyribonucleotide nucleotidyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 3:85,595,356...85,639,665
Ensembl chr 3:85,595,392...85,639,690 		JBrowse link
G POLG DNA polymerase gamma, catalytic subunit susceptibility ISO DNA:SNPs:introns: (rs1061316, rs758130) (human) RGD PMID:28457473 RGD:15039387 NCBI chr 7:54,889,150...54,907,167
Ensembl chr 7:54,889,157...54,906,844 		JBrowse link
G PON1 paraoxonase 1 disease_progression ISO mRNA:decreased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,723 		JBrowse link
G POT1 protection of telomeres 1 disease_progression ISO associated with hepatitis B;DNA:SNP: :rs7784168(human) RGD PMID:23907815 RGD:152975963 NCBI chr18:22,885,704...22,981,893
Ensembl chr18:22,885,749...22,981,890 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha susceptibility ISO associated with hepatitis B;DNA:missense mutation:cds:p.L162V (human) RGD PMID:19119483 RGD:15042881 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma severity ISO protein:decreased expression:liver
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:16374840 PMID:27451128 RGD:14694822 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO protein:increased activity:hepatoma (rat) RGD PMID:6327016 RGD:5135035 NCBI chr 8:55,652,194...55,701,077
Ensembl chr 8:55,654,377...55,701,077 		JBrowse link
G PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:15010824 NCBI chr 5:19,753,850...19,763,281
Ensembl chr 5:19,753,847...19,763,269 		JBrowse link
G PPP1R9A protein phosphatase 1 regulatory subunit 9A onset ISO protein:increased expression:liver (rat) RGD PMID:20935162 RGD:10002734 NCBI chr 9:74,635,285...74,944,050
Ensembl chr 9:74,635,403...74,940,362 		JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B severity ISO mRNA, protein:decreased expression:liver (human) RGD PMID:23591196 RGD:10043803 NCBI chr12:26,319,123...26,337,089
Ensembl chr12:26,319,124...26,336,562 		JBrowse link
G PRC1 protein regulator of cytokinesis 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:55,869,749...55,900,640
Ensembl chr 7:55,869,821...55,900,978 		JBrowse link
G PRDM1 PR/SET domain 1 disease_progression ISO associated with hepatitis B;
associated with hepatitis B;DNA:SNP: :rs1010273(human)		 RGD PMID:31100710 PMID:31376415 RGD:150530465 RGD:150530466 NCBI chr 1:72,309,096...72,335,474
Ensembl chr 1:72,311,880...72,335,466 		JBrowse link
G PRDX1 peroxiredoxin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27517622 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,395...165,861,442 		JBrowse link
G PRDX2 peroxiredoxin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,828...66,212,009 		JBrowse link
G PRDX6 peroxiredoxin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 9:115,857,629...115,868,898
Ensembl chr 9:115,857,644...115,868,892 		JBrowse link
G PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 exacerbates ISO mRNA:decreased expression:liver (human)
mRNA:increased expression:liver (human)
protein:increased expression:liver (human)		 RGD PMID:25151370 PMID:28000796 PMID:28205209 PMID:31776854 RGD:151665185 RGD:151665186 RGD:151665188 RGD:151665343 NCBI chr 4:66,712,412...66,996,258
Ensembl chr 4:66,715,237...66,996,044 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase severity ISO protein:decreased expression:liver (human) RGD PMID:28862485 RGD:13432206 NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872 		JBrowse link
G PRL prolactin onset ISO protein:increased expression:serum (human) RGD PMID:22392353 RGD:125097525 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G PROM1 prominin 1 ISO mRNA:increased expression:liver (mouse) RGD PMID:26569409 RGD:11344640 NCBI chr 8:11,215,659...11,331,442
Ensembl chr 8:11,215,663...11,317,312 		JBrowse link
G PTCH1 patched 1 severity
disease_progression		 ISO RGD PMID:18538319 PMID:22911366 RGD:150523837 RGD:150523842 NCBI chr10:26,627,165...26,703,225
Ensembl chr10:26,627,425...26,703,223 		JBrowse link
G PTEN phosphatase and tensin homolog severity
treatment
exacerbates		 ISO CTD Direct Evidence: marker/mechanism
OMIM:114550
protein:decreased expression:liver (human)
associated with hepatitis B;protein:decreased expression:liver (human)
associated with hepatitis C, liver cirrhosis;protein:decreased expression:liver (human)		 CTD
MouseDO
RGD		 PMID:12115563 PMID:12673720 PMID:27022031 PMID:29303510 PMID:30690477 More... RGD:127285591 RGD:127285603 RGD:127285610 RGD:151893509 RGD:152995524 NCBI chr14:99,929,590...100,021,619 JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 treatment
severity
susceptibility		 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver, cytosol
DNA:SNP:promoter:-1195A>G (rs689466) (human)
mRNA,protein:decreased expression:liver		 RGD
CTD		 PMID:11872629 PMID:12024111 PMID:14563831 PMID:15800977 PMID:16374840 More... RGD:14695010 RGD:14695011 RGD:14695012 RGD:152177911 RGD:2300283 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G PTH1R parathyroid hormone 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:29,749,940...29,775,361
Ensembl chr13:29,753,326...29,775,348 		JBrowse link
G PTK2 protein tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:14578863 PMID:17203219 RGD:2292584 NCBI chr 4:2,656,606...2,896,060
Ensembl chr 4:2,656,614...2,896,054 		JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 susceptibility
disease_progression		 ISO DNA:SNP: :p.Y2081D(human) RGD PMID:16489062 PMID:26801674 RGD:152176666 RGD:152599190 NCBI chr 8:132,035,170...132,200,425
Ensembl chr 8:132,035,151...132,249,411 		JBrowse link
G PTPRB protein tyrosine phosphatase receptor type B disease_progression ISO mRNA:decreased expression:liver (human) RGD PMID:30237408 RGD:151361293 NCBI chr 5:34,656,460...34,794,838
Ensembl chr 5:34,659,964...34,794,289 		JBrowse link
G PYCARD PYD and CARD domain containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:17471463 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786 		JBrowse link
G PYGL glycogen phosphorylase L ISO CTD Direct Evidence: marker/mechanism CTD PMID:2885971 NCBI chr 1:180,645,849...180,704,124
Ensembl chr 1:180,620,314...180,719,979 		JBrowse link
G RAC1 Rac family small GTPase 1 exacerbates ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)
mRNA:increased expression:liver (human)		 CTD
RGD		 PMID:18506888 PMID:20522449 PMID:33482578 RGD:153298967 RGD:153350129 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G RACGAP1 Rac GTPase activating protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:15,894,314...15,943,619
Ensembl chr 5:15,904,712...15,943,609 		JBrowse link
G RAD21 RAD21 cohesin complex component treatment
exacerbates
susceptibility		 ISO human cells in a mouse model
protein:increased expression:liver (human)
associated with hepatitis c, liver cirrhosis;mRNA:increased expression:liver (human)		 RGD PMID:28434945 PMID:30698808 PMID:32596342 PMID:33251678 RGD:150520026 RGD:150520029 RGD:150520030 RGD:150520035 NCBI chr 4:21,772,821...21,802,453
Ensembl chr 4:21,772,855...21,802,715 		JBrowse link
G RAD50 RAD50 double strand break repair protein ISO ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar PMID:16385572 PMID:18281469 PMID:19409520 PMID:24894818 PMID:25452441 More... NCBI chr 2:134,844,460...134,939,188
Ensembl chr 2:134,700,817...134,939,189 		JBrowse link
G RAD52 RAD52 homolog, DNA repair protein onset
susceptibility		 ISO mRNA,protein:increased expression:liver (human)
associated with hepatitis B;DNA:SNP:3'utr: (rs7963551) (human)		 RGD PMID:24729511 PMID:31719794 RGD:151361199 RGD:151361207 NCBI chr 5:68,140,846...68,223,587
Ensembl chr 5:68,143,646...68,169,670 		JBrowse link
G RAD54L RAD54 like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:165,156,833...165,184,641
Ensembl chr 6:165,152,978...165,184,776 		JBrowse link
G RARA retinoic acid receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18026104 NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,443...22,085,673 		JBrowse link
G RB1 RB transcriptional corepressor 1 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:12029619 PMID:14961299 PMID:33841550 RGD:152998960 NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,761...19,317,690 		JBrowse link
G RBM10 RNA binding motif protein 10 disease_progression ISO mRNA:decreased expression:liver RGD PMID:32572914 RGD:151356975 NCBI chr  X:41,773,232...41,803,656
Ensembl chr  X:41,773,232...41,803,653 		JBrowse link
G RCAN1 regulator of calcineurin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:198,106,256...198,205,727
Ensembl chr13:198,102,098...198,205,629 		JBrowse link
G RECQL RecQ like helicase disease_progression ISO protein:increased expression:liver RGD PMID:18422747 RGD:2317370 NCBI chr 5:51,953,460...51,995,619
Ensembl chr 5:51,953,451...52,003,740 		JBrowse link
G RET ret proto-oncogene severity ISO protein:increased expression:liver (human)
ClinVar Annotator: match by term: Hepatocellular carcinoma		 RGD
ClinVar		 PMID:7784092 PMID:7845675 PMID:7911697 PMID:9111992 PMID:9242375 More... RGD:150340602 NCBI chr14:61,305,818...61,361,416
Ensembl chr14:61,305,841...61,361,412 		JBrowse link
G RGN regucalcin ISO protein:decreased expression:liver RGD PMID:21683810 RGD:5509919 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 severity ISO mRNA, protein:increased expression:liver (human) RGD PMID:25371154 PMID:29303510 RGD:152995471 RGD:152995524 NCBI chr16:24,109,934...24,250,019
Ensembl chr16:24,109,939...24,311,132 		JBrowse link
G RIT1 Ras like without CAAX 1 ameliorates ISO human cells in mouse model RGD PMID:31247273 RGD:152999016 NCBI chr 4:94,117,721...94,127,882
Ensembl chr 4:94,117,882...94,127,384 		JBrowse link
G RND3 Rho family GTPase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:1,715,589...1,732,605
Ensembl chr15:1,715,207...1,734,414 		JBrowse link
G RNF157 ring finger protein 157 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:5,225,978...5,306,197
Ensembl chr12:5,225,849...5,304,458 		JBrowse link
G RNF43 ring finger protein 43 exacerbates ISO human cells in a mouse model RGD PMID:23136185 RGD:151361219 NCBI chr12:34,631,574...34,695,021
Ensembl chr12:34,635,228...34,694,378 		JBrowse link
G RNF6 ring finger protein 6 disease_progression ISO RGD PMID:30496760 RGD:151665757 NCBI chr11:4,020,752...4,033,040
Ensembl chr11:4,020,852...4,031,787 		JBrowse link
G ROBO1 roundabout guidance receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:175,348,223...176,479,482
Ensembl chr13:175,348,410...176,479,481 		JBrowse link
G RPS6 ribosomal protein S6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468 		JBrowse link
G RPS6KA3 ribosomal protein S6 kinase A3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22561517 NCBI chr  X:16,452,401...16,576,854
Ensembl chr  X:16,452,405...16,576,859 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18230555 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18230555 PMID:28284560 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644 		JBrowse link
G RSPO3 R-spondin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:35,985,985...36,066,432
Ensembl chr 1:35,984,950...36,067,077 		JBrowse link
G RTKN rhotekin ISO mRNA:increased expression:liver RGD PMID:27922690 RGD:19165144 NCBI chr 3:68,598,560...68,613,633
Ensembl chr 3:68,598,249...68,613,631 		JBrowse link
G RTP3 receptor transporter protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17693185 NCBI chr13:29,471,568...29,476,277 JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO mRNA:decreased expression:liver RGD PMID:17094378 RGD:126775147 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,837...198,638,189 		JBrowse link
G RUNX3 RUNX family transcription factor 3 ISO CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:liver		 CTD
RGD		 PMID:17094378 PMID:28458013 RGD:126775147 NCBI chr 6:82,531,203...82,595,044
Ensembl chr 6:82,531,559...82,595,026 		JBrowse link
G RXRA retinoid X receptor alpha ISO ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar PMID:26619011 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,505...273,797,620 		JBrowse link
G RYR3 ryanodine receptor 3 disease_progression ISO DNA:SNP:3'UTR:rs1044129(human) RGD PMID:26309413 RGD:155882454 NCBI chr 7:80,640,030...81,208,576
Ensembl chr 7:80,640,123...81,208,491 		JBrowse link
G S100A9 S100 calcium binding protein A9 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr 4:96,236,114...96,238,989 JBrowse link
G SARDH sarcosine dehydrogenase severity ISO mRNA:altered expression:liver tumor (human) RGD PMID:30901224 RGD:152995286 NCBI chr 1:273,230,357...273,295,170
Ensembl chr 1:273,230,375...273,294,621 		JBrowse link
G SAV1 salvador family WW domain containing protein 1 ISO OMIM:114550 MouseDO NCBI chr 1:180,404,871...180,434,458
Ensembl chr 1:180,406,162...180,434,196 		JBrowse link
G SCAP SREBF chaperone ISO CTD Direct Evidence: marker/mechanism CTD PMID:14563831 NCBI chr13:30,253,262...30,320,625
Ensembl chr13:30,253,268...30,320,526 		JBrowse link
G SCD stearoyl-CoA desaturase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,569...111,478,020 		JBrowse link
G SERPINA1 serpin family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:6258829 PMID:21472284 NCBI chr 7:115,604,282...115,616,915
Ensembl chr 7:115,583,043...115,614,645 		JBrowse link
G SERPINB5 serpin family B member 5 disease_progression ISO associated with hepatitis B; RGD PMID:26296971 RGD:11520929 NCBI chr 1:158,167,756...158,195,896
Ensembl chr 1:158,167,646...158,195,796 		JBrowse link
G SERPINF1 serpin family F member 1 ISO associated with Human Viral Hepatitis, liver cirrhosis;protein:increased expression:serum (human) RGD PMID:27748324 RGD:27226704 NCBI chr12:47,949,004...47,959,471
Ensembl chr12:47,948,510...47,959,470 		JBrowse link
G SET SET nuclear proto-oncogene ISO ClinVar Annotator: match by term: Hepatocellular carcinoma ClinVar PMID:26822237 NCBI chr 1:269,050,447...269,064,462 JBrowse link
G SF3B1 splicing factor 3b subunit 1 treatment
disease_progression		 ISO ClinVar Annotator: match by term: Hepatocellular carcinoma
mRNA, protein:increased expression:liver		 RGD
ClinVar		 PMID:23634996 PMID:26619011 PMID:33038489 RGD:126790494 NCBI chr15:101,274,968...101,338,018
Ensembl chr15:101,276,851...101,299,105 		JBrowse link
G SF3B2 splicing factor 3b subunit 2 ISO ClinVar Annotator: match by term: LIVER CELL CARCINOMA ClinVar PMID:26619011 NCBI chr 2:6,279,039...6,295,550
Ensembl chr 2:6,279,049...6,294,639 		JBrowse link
G SF3B4 splicing factor 3b subunit 4 treatment
severity		 ISO mRNA, protein:increased expression:liver(human)
human cells in mouse model
mRNA, protein:increased expression:liver (human)
mRNA, protein:increased expression:liver (rat)		 RGD PMID:29059470 PMID:30391496 RGD:155791679 RGD:155804298 NCBI chr 4:99,123,564...99,129,218
Ensembl chr 4:99,123,585...99,129,218 		JBrowse link
G SFN stratifin ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 6:84,188,521...84,189,824
Ensembl chr 6:84,188,445...84,189,827 		JBrowse link
G SFRP1 secreted frizzled related protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748 		JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33838155 NCBI chr 2:74,414,453...74,445,450
Ensembl chr 2:74,414,466...74,445,447 		JBrowse link
G SHC1 SHC adaptor protein 1 ISO protein:increased expression, increased phosphorylation:hepatocyte RGD PMID:15375560 RGD:1643188 NCBI chr 4:94,818,226...94,831,766
Ensembl chr 4:94,810,875...94,831,765 		JBrowse link
G SHH sonic hedgehog signaling molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:26189965 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484 		JBrowse link
G SIK2 salt inducible kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34491613 NCBI chr 9:39,368,555...39,483,519
Ensembl chr 9:39,368,599...39,483,515 		JBrowse link
G SIX1 SIX homeobox 1 severity ISO protein:increased expression:liver (human) RGD PMID:17008870 RGD:11561961 NCBI chr 1:189,620,430...189,624,652
Ensembl chr 1:189,619,855...189,624,651 		JBrowse link
G SKA1 spindle and kinetochore associated complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:99,976,354...99,993,492
Ensembl chr 1:99,976,485...99,993,462 		JBrowse link
G SKA3 spindle and kinetochore associated complex subunit 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr11:1,302,880...1,321,132
Ensembl chr11:1,302,886...1,320,981 		JBrowse link
G SKP2 S-phase kinase associated protein 2 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver		 CTD
RGD		 PMID:12717389 PMID:19533683 RGD:2315050 NCBI chr16:21,463,270...21,500,925
Ensembl chr16:21,463,012...21,509,310 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:7,340,442...7,365,543
Ensembl chr 1:7,340,126...7,365,520 		JBrowse link
G SLC25A47 solute carrier family 25 member 47 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:121,204,213...121,210,376
Ensembl chr 7:121,192,433...121,210,374 		JBrowse link
G SLC26A6 solute carrier family 26 member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:31,319,287...31,330,649
Ensembl chr13:31,317,877...31,330,580 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8364915 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8364915 NCBI chr13:109,592,595...109,614,105
Ensembl chr13:109,587,258...109,638,510 		JBrowse link
G SLC38A1 solute carrier family 38 member 1 ameliorates
disease_progression		 ISO RGD PMID:26389641 RGD:151361140 NCBI chr 5:77,009,840...77,076,723
Ensembl chr 5:77,009,862...77,058,427 		JBrowse link
G SLC5A5 solute carrier family 5 member 5 ISO CTD Direct Evidence: therapeutic CTD PMID:15347726 PMID:15520214 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 ameliorates
disease_progression		 ISO mRNA:increased expression:liver RGD PMID:7532544 PMID:23696029 PMID:26389641 RGD:151361140 RGD:151361280 RGD:634202 NCBI chr 6:1,545,940...1,574,298
Ensembl chr 6:1,545,944...1,574,285 		JBrowse link
G SLCO1B2 solute carrier organic anion transporter family member 1B2 exacerbates
disease_progression		 ISO mRNA,protein:decreased expression:liver (human) RGD PMID:21626360 PMID:32534581 RGD:152995417 RGD:152995423 NCBI chr 5:52,137,454...52,206,236 JBrowse link
G SLIT2 slit guidance ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19100240 NCBI chr 8:14,758,426...15,149,515
Ensembl chr 8:14,758,335...15,149,510 		JBrowse link
G SMAD2 SMAD family member 2 ISO RGD PMID:18971187 RGD:12880056 NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,357 		JBrowse link
G SMAD4 SMAD family member 4 disease_progression ISO protein:increased expression:liver:
protein:decreased expression:liver		 RGD PMID:18971187 PMID:22799322 PMID:23922662 PMID:29924446 RGD:12880056 RGD:18182921 RGD:21066341 RGD:21066342 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029 		JBrowse link
G SMAD7 SMAD family member 7 ISO mRNA:increased expression:liver (human) RGD PMID:25602745 RGD:14401589 NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,514,267...98,542,382 		JBrowse link
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ISO DNA:SNPs: :rs11879293, rs2072382 (human) RGD PMID:24556940 RGD:127285650 NCBI chr 2:69,717,175...69,810,301
Ensembl chr 2:69,662,238...69,810,295 		JBrowse link
G SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 disease_progression ISO mRNA:decreased expression:liver RGD PMID:27111394 RGD:127285647 NCBI chr14:49,874,981...49,906,043
Ensembl chr14:49,874,984...49,906,048 		JBrowse link
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 ameliorates ISO mRNA, protein:increased expression:liver (human) RGD PMID:32514535 RGD:151347860 NCBI chr13:30,409,979...30,576,270
Ensembl chr13:30,409,983...30,601,441 		JBrowse link
G SMC3 structural maintenance of chromosomes 3 exacerbates ISO mRNA:increased editing:cds:p.K96R,p.Q103R(human) RGD PMID:29996118 RGD:156430111 NCBI chr14:120,969,629...121,008,924
Ensembl chr14:120,969,631...121,021,497 		JBrowse link
G SMG9 SMG9 nonsense mediated mRNA decay factor severity ISO RGD PMID:34456727 RGD:155882446 NCBI chr 6:50,550,743...50,569,753
Ensembl chr 6:50,551,057...50,569,697 		JBrowse link
G SMO smoothened, frizzled class receptor disease_progression ISO DNA:SNP: :rs3824 (human) RGD PMID:25944162 RGD:150340548 NCBI chr18:19,450,730...19,478,796
Ensembl chr18:19,450,743...19,478,898 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35841383 NCBI chr17:51,546,446...51,552,498
Ensembl chr17:51,546,477...51,552,499 		JBrowse link
G SNRPE small nuclear ribonucleoprotein polypeptide E ISO human gene in a mouse model RGD PMID:21688285 RGD:10768833 NCBI chr 9:64,560,544...64,567,007
Ensembl chr 9:64,560,523...64,567,007 		JBrowse link
G SNW1 SNW domain containing 1 severity ISO protein:increased expression:liver (human) RGD PMID:23696020 RGD:11035253 NCBI chr 7:100,718,298...100,749,414
Ensembl chr 7:100,718,036...100,749,356 		JBrowse link
G SNX27 sorting nexin 27 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36029209 NCBI chr 4:97,533,643...97,620,816
Ensembl chr 4:97,525,181...97,620,788 		JBrowse link
G SOAT1 sterol O-acyltransferase 1 exacerbates ISO associated with hepatitis B;protein:increased expression:liver (human) RGD PMID:30814741 RGD:126925204 NCBI chr 9:121,045,211...121,112,393
Ensembl chr 9:121,045,234...121,113,692 		JBrowse link
G SOAT2 sterol O-acyltransferase 2 ISO RGD PMID:16274362 RGD:1581190 NCBI chr 5:18,358,941...18,371,262
Ensembl chr 5:18,358,673...18,371,264 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 treatment ISO DNA:hypermethylation:CpG island, 5'untranslated region:
associated with liver cirrhosis;DNA:altered methylation:liver:		 RGD PMID:14614012 PMID:15235874 PMID:18843197 PMID:22318090 RGD:150573687 RGD:150573689 RGD:150573700 RGD:150573703 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16831601 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,009 		JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33010264 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SOD2 superoxide dismutase 2 disease_progression
susceptibility		 ISO protein:increased expression:saliva
CTD Direct Evidence: marker/mechanism
associated with liver cirrhosis; DNA:SNP:cds:p.Ala16Val(rs1799725)(human)		 RGD
CTD		 PMID:15869407 PMID:16767786 PMID:18760346 PMID:19731237 PMID:21472284 More... RGD:1581242 RGD:26923907 RGD:26923955 RGD:27095881 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G SOX30 SRY-box transcription factor 30 disease_progression
exacerbates		 ISO RGD PMID:30312695 RGD:151660341 NCBI chr16:65,642,107...65,677,693
Ensembl chr16:65,642,223...65,678,047 		JBrowse link
G SPAG9 sperm associated antigen 9 ISO associated with Human Viral Hepatitis RGD PMID:29344208 RGD:30296654 NCBI chr12:27,225,377...27,370,337
Ensembl chr12:27,202,088...27,370,405 		JBrowse link
G SPC25 SPC25 component of NDC80 kinetochore complex ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr15:75,339,171...75,371,275
Ensembl chr15:75,336,514...75,371,277 		JBrowse link
G SPOCK1 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 ameliorates ISO human cells in mouse model RGD PMID:30710422 RGD:153344549 NCBI chr 2:139,018,177...139,523,601
Ensembl chr 2:139,018,179...139,522,593 		JBrowse link
G SPOP speckle type BTB/POZ protein exacerbates ISO human cells in mouse model
mRNA:decreased expression:liver (human) 		RGD PMID:26156804 PMID:33209975 RGD:11074965 RGD:153298924 NCBI chr12:25,792,621...25,860,630
Ensembl chr12:25,792,630...25,860,595 		JBrowse link
G SPP1 secreted phosphoprotein 1 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:16047475 PMID:35693827 RGD:153344586 RGD:1581375 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340 		JBrowse link
G SPRTN SprT-like N-terminal domain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25261934 NCBI chr14:59,177,801...59,192,221
Ensembl chr14:59,171,192...59,192,269 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase disease_progression ISO RGD PMID:9581679 RGD:150521543 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14563831 PMID:21147110 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,490...6,784,671 		JBrowse link
G SRF serum response factor ISO RGD PMID:9570363 RGD:1581428 NCBI chr 7:38,213,300...38,223,686
Ensembl chr 7:38,213,487...38,222,144 		JBrowse link
G SRPX sushi repeat containing protein X-linked ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr  X:34,075,577...34,198,462
Ensembl chr  X:34,075,579...34,198,467 		JBrowse link
G SRSF1 serine and arginine rich splicing factor 1 ISO mRNA:increased expression:liver (human) RGD PMID:23633480 RGD:9685423 NCBI chr12:34,278,363...34,282,164
Ensembl chr12:34,272,956...34,282,162 		JBrowse link
G SRSF2 serine and arginine rich splicing factor 2 treatment
disease_progression		 ISO RGD PMID:28082404 PMID:29278882 PMID:32372053 RGD:150429663 RGD:150429666 RGD:150429692 NCBI chr12:4,800,578...4,803,767
Ensembl chr12:4,800,624...4,801,675 		JBrowse link
G ST6GAL1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 ISO protein:increased activity:liver: RGD PMID:9331085 RGD:10043141 NCBI chr13:124,699,622...124,837,847
Ensembl chr13:124,791,751...124,837,841 		JBrowse link
G STAB2 stabilin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:80,692,459...80,863,221 JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22488367 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO protein:increased phosphorylation:liver (mouse) RGD PMID:28100771 RGD:127285675 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 susceptibility ISO CTD Direct Evidence: marker/mechanism
Hepatitis B, Chronic; DNA:SNP: intron 3: (rs7574865) (human)		 CTD
RGD		 PMID:23242368 PMID:26745093 RGD:11553302 NCBI chr15:95,656,206...95,764,099
Ensembl chr15:95,656,077...95,763,472 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A ameliorates ISO RGD PMID:28100771 RGD:127285675 NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B exacerbates
ameliorates		 ISO protein:increased expression:liver (human)
mRNA:increased expression:liver (human)		 RGD PMID:17047057 PMID:31485610 RGD:153298929 RGD:153298932 NCBI chr12:20,498,103...20,574,365
Ensembl chr12:20,508,404...20,574,266 		JBrowse link
G STC2 stanniocalcin 2 disease_progression ISO mRNA:increased expression:liver (human) RGD PMID:35693827 RGD:153344586 NCBI chr16:50,989,676...51,001,412
Ensembl chr16:50,989,433...51,004,481 		JBrowse link
G STIM1 stromal interaction molecule 1 ISO mRNA:increased expression:liver (human) RGD PMID:23211538 RGD:152995401 NCBI chr 9:6,066,612...6,270,090
Ensembl chr 9:6,066,617...6,270,575 		JBrowse link
G STMN1 stathmin 1 disease_progression ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:28284560 PMID:28982915 RGD:21408578 NCBI chr 6:83,356,404...83,362,546
Ensembl chr 6:83,356,412...83,362,500 		JBrowse link
G TACC3 transforming acidic coiled-coil containing protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 8:825,433...835,425
Ensembl chr 8:824,999...837,322 		JBrowse link
G TAGLN2 transgelin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 4:90,566,272...90,574,762 JBrowse link
G TALDO1 transaldolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19436114 NCBI chr 2:464,781...472,836
Ensembl chr 2:464,728...472,835 		JBrowse link
G TATDN1 TatD DNase domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 4:15,113,318...15,159,501
Ensembl chr 4:15,113,312...15,159,498 		JBrowse link
G TBX3 T-box transcription factor 3 disease_progression
severity
ameliorates		 ISO protein:increased expression:liver (human)
human cells in mouse model		 RGD PMID:22811581 PMID:26922018 PMID:29295731 PMID:30578408 PMID:33577921 RGD:151361112 RGD:151361114 RGD:151361122 RGD:151361123 RGD:151361132 NCBI chr14:37,582,704...37,596,767
Ensembl chr14:37,582,822...37,596,766 		JBrowse link
G TCF19 transcription factor 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:23,558,326...23,562,074
Ensembl chr 7:23,558,384...23,562,069 		JBrowse link
G TCIM transcriptional and immune response regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:9,441,488...9,443,053
Ensembl chr17:9,441,766...9,442,086 		JBrowse link
G TEDC2 tubulin epsilon and delta complex 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 3:39,580,181...39,584,414
Ensembl chr 3:39,580,199...39,584,380 		JBrowse link
G TEK TEK receptor tyrosine kinase ISO protein:increased expression RGD PMID:16951510 RGD:1601490 NCBI chr 1:195,938,177...196,052,294
Ensembl chr 1:195,937,432...196,051,980 		JBrowse link
G TEP1 telomerase associated protein 1 susceptibility
disease_progression		 ISO DNA:SNP:intron:rs1760893(human)
associated with hepatitis B;DNA:SNPs: :rs1713449,rs1760898, rs872072 (human)		 RGD PMID:23907815 PMID:27305982 RGD:152975963 RGD:152977750 NCBI chr 7:78,488,248...78,530,185
Ensembl chr 7:78,491,053...78,530,183 		JBrowse link
G TERT telomerase reverse transcriptase disease_progression
susceptibility
treatment
no_association		 ISO DNA:mutations:promoter:
associated with hepatitis B;DNA:SNP: :rs13167280 (human)
ClinVar Annotator: match by term: Hepatocellular carcinoma
DNA:SNPs::rs2736098(human)
DNA:SNP,mutations:promoter:rs2853669 (-245T >C), (-124C > T),(-146C > T)human
DNA:mutations, polymorphisms:promoter,intron, exon:rs2736100,rs2736098(human)		 RGD
ClinVar		 PMID:17175353 PMID:19184104 PMID:23000435 PMID:23907815 PMID:25123086 More... RGD:11564803 RGD:14696767 RGD:14696768 RGD:14696769 RGD:14696770 RGD:150530496 RGD:152975963 NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421 		JBrowse link
G TET1 tet methylcytosine dioxygenase 1 ISO protein:decreased expression:liver RGD PMID:23671639 RGD:9586747 NCBI chr14:71,675,671...71,812,732
Ensembl chr14:71,675,671...71,815,618 		JBrowse link
G TET2 tet methylcytosine dioxygenase 2 ameliorates
disease_progression
severity		 ISO human cells in mouse model
mRNA:decreased expression:liver (human)
mRNA, protein:increased expression:liver (human)
mRNA, protein:decreased expression:liver (human)		 RGD PMID:26366235 PMID:29331390 PMID:30070373 PMID:33097695 RGD:150429595 RGD:150429597 RGD:150429684 RGD:150429689 NCBI chr 8:116,413,253...116,546,976
Ensembl chr 8:116,415,267...116,545,299 		JBrowse link
G TFPI2 tissue factor pathway inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17464989 PMID:28284560 NCBI chr 9:73,684,236...73,694,663
Ensembl chr 9:73,673,535...73,689,095 		JBrowse link
G TFRC transferrin receptor ISO mRNA:increased expression:liver RGD PMID:16953838 RGD:2292036 NCBI chr13:133,976,765...133,997,554
Ensembl chr13:133,970,985...134,000,276 		JBrowse link
G TGFA transforming growth factor alpha ISO associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:9029167 PMID:9060843 PMID:15565109 RGD:2317471 NCBI chr 3:71,948,232...72,054,257
Ensembl chr 3:71,948,137...72,050,474 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (mouse)		 CTD
RGD		 PMID:9029167 PMID:28100771 RGD:127285675 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
G TGFB2 transforming growth factor beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33010264 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO mRNA, protein:decreased expression:liver RGD PMID:14585397 RGD:1601598 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160 		JBrowse link
G TGM3 transglutaminase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:33,191,901...33,236,065
Ensembl chr17:33,191,914...33,235,952 		JBrowse link
G TH tyrosine hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,620...1,506,170 		JBrowse link
G THY1 Thy-1 cell surface antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:46,607,022...46,612,691
Ensembl chr 9:46,607,494...46,612,269 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:55,142,957...55,200,259
Ensembl chr 7:55,143,240...55,200,640 		JBrowse link
G TIMD4 T cell immunoglobulin and mucin domain containing 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr16:66,253,572...66,292,963
Ensembl chr16:66,253,604...66,292,961 		JBrowse link
G TK1 thymidine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:3,785,997...3,794,824
Ensembl chr12:3,786,031...3,795,917 		JBrowse link
G TLR2 toll like receptor 2 susceptibility ISO DNA:deletion:promoter:-196 to -174(human)
associated with Hepatitis C, Chronic;DNA:deletion:promoter:-196 to -174(human)		 RGD PMID:21500195 PMID:22859216 PMID:27183918 RGD:15090813 RGD:15090815 RGD:18337266 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR3 toll like receptor 3 disease_progression ISO RGD PMID:23197495 RGD:21079421 NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291 		JBrowse link
G TLR4 toll like receptor 4 susceptibility ISO DNA:SNP: :rs1057317(human)
protein:increased expression:liver:
CTD Direct Evidence: marker/mechanism
DNA:SNPs, haplotype: :multiples		 RGD
CTD		 PMID:21559380 PMID:25179842 PMID:27022031 PMID:28578348 RGD:14700552 RGD:14700557 RGD:14700558 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR7 toll like receptor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24990399 NCBI chr  X:9,573,178...9,576,987 JBrowse link
G TLR9 toll like receptor 9 treatment ISO human cells in a mouse model
protein: increased expression:peripheral blood mononuclear cell (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18215354 PMID:24452201 PMID:24990399 RGD:18337468 RGD:18337472 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TMEM70 transmembrane protein 70 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27914986 NCBI chr 4:61,958,605...61,966,041
Ensembl chr 4:61,958,605...61,966,024 		JBrowse link
G TNF tumor necrosis factor disease_progression ISO mRNA, protein:increased expression:liver, blood serum (mouse)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:26569409 PMID:26890368 PMID:27022031 RGD:11344640 RGD:14975171 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 sexual_dimorphism
ameliorates		 ISO mRNA:decreased expression:liver (human)
protein:decreased expression:liver (human)
mRNA,protein:increased expression:liver (human)		 RGD PMID:26538215 PMID:27253414 PMID:29190981 PMID:32015333 RGD:151347600 RGD:151347604 RGD:151347618 RGD:151347622 NCBI chr 1:26,474,158...26,489,771
Ensembl chr 1:26,473,938...26,489,822 		JBrowse link
G TNFSF10 TNF superfamily member 10 ISO CTD Direct Evidence: therapeutic CTD PMID:17326159 NCBI chr13:111,021,952...111,103,060
Ensembl chr13:110,983,298...111,038,324 		JBrowse link
G TNFSF9 TNF superfamily member 9 ISO RGD PMID:17325342 RGD:2317348 NCBI chr 2:72,578,811...72,582,834
Ensembl chr 2:72,578,821...72,582,745 		JBrowse link
G TNIK TRAF2 and NCK interacting kinase disease_progression ISO protein:increased phosphorylation:liver, nucleus (human) RGD PMID:25160513 RGD:151347837 NCBI chr13:109,642,848...110,052,345
Ensembl chr13:109,643,895...110,052,236 		JBrowse link
G TONSL tonsoku like, DNA repair protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 4:349,992...361,749
Ensembl chr 4:350,060...362,167 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
G TP53 tumor protein p53 treatment ISO ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA RGD
ClinVar
OMIM		 PMID:253702 PMID:960674 PMID:1349102 PMID:1349175 PMID:1359493 More... RGD:152998960 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TP73 tumor protein p73 treatment
exacerbates		 ISO human cells in a mouse model
protein:decreased phosphorylation:liver (human)
mRNA:increased expression:liver (human)		 RGD PMID:14760085 PMID:19664633 PMID:25371988 PMID:27359056 PMID:31429776 RGD:151347579 RGD:151347592 RGD:151347593 RGD:151347594 RGD:151347596 NCBI chr 6:65,169,770...65,228,997
Ensembl chr 6:65,182,456...65,228,990 		JBrowse link
G TPX2 TPX2 microtubule nucleation factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:35,431,271...35,484,814
Ensembl chr17:35,431,395...35,485,065 		JBrowse link
G TRAF7 TNF receptor associated factor 7 treatment ISO mRNA:increased expression:liver RGD PMID:31730901 RGD:151356961 NCBI chr 3:39,811,803...39,828,450
Ensembl chr 3:39,810,606...39,828,395 		JBrowse link
G TRAIP TRAF interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:32,332,336...32,380,988
Ensembl chr13:32,345,599...32,379,766 		JBrowse link
G TRIM24 tripartite motif containing 24 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18026104 NCBI chr18:11,055,211...11,151,755
Ensembl chr18:11,055,213...11,151,404 		JBrowse link
G TRIP13 thyroid hormone receptor interactor 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr16:79,458,843...79,473,705
Ensembl chr16:79,458,847...79,473,712 		JBrowse link
G TROAP trophinin associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 5:15,300,688...15,307,681
Ensembl chr 5:15,300,687...15,307,679 		JBrowse link
G TSC1 TSC complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21499249 NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,951 		JBrowse link
G TSC2 TSC complex subunit 2 severity ISO protein:decreased expression:liver (human) RGD PMID:24119083 RGD:21079731 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,925...39,937,371 		JBrowse link
G TSLP thymic stromal lymphopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:115,832,152...115,837,572 JBrowse link
G TST thiosulfate sulfurtransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472284 NCBI chr 5:10,749,264...10,759,623
Ensembl chr 5:10,746,890...10,759,622 		JBrowse link
G TTC36 tetratricopeptide repeat domain 36 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 9:45,829,014...45,838,978
Ensembl chr 9:45,829,191...45,838,979 		JBrowse link
G TTK TTK protein kinase disease_progression ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)		 CTD
RGD		 PMID:28284560 PMID:35693827 RGD:153344586 NCBI chr 1:86,076,576...86,125,334
Ensembl chr 1:86,076,583...86,125,718 		JBrowse link
G TTR transthyretin disease_progression ISO protein:decreased expression:blood serum (human)
protein:increased expression:blood serum (human)
protein:increased expression:blood serum (rat)		 RGD PMID:16240287 PMID:28876464 PMID:29534342 RGD:151356736 RGD:151664602 RGD:151665161 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,326...115,503,977 		JBrowse link
G TXNIP thioredoxin interacting protein ISO OMIM:114550 MouseDO NCBI chr 4:99,348,589...99,351,760
Ensembl chr 4:99,348,490...99,352,755 		JBrowse link
G TYMS thymidylate synthetase susceptibility ISO DNA:deletion:3'UTR:1494del6(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17659576 PMID:18019677 PMID:18230555 RGD:14696708 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
G UACA uveal autoantigen with coiled-coil domains and ankyrin repeats ISO OMIM:114550 MouseDO NCBI chr 1:168,353,655...168,453,175
Ensembl chr 1:168,350,557...168,453,344 		JBrowse link
G UBD ubiquitin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:19363144 NCBI chr 7:22,501,130...22,502,883
Ensembl chr 7:22,501,130...22,503,094 		JBrowse link
G UBE2C ubiquitin conjugating enzyme E2 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr17:48,018,403...48,021,542
Ensembl chr17:48,018,400...48,021,534 		JBrowse link
G UBE2E2 ubiquitin conjugating enzyme E2 E2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27914986 NCBI chr13:9,998,097...10,380,564
Ensembl chr13:9,998,199...10,380,556 		JBrowse link
G UBE2T ubiquitin conjugating enzyme E2 T ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr10:24,454,492...24,459,085
Ensembl chr10:24,454,495...24,459,057 		JBrowse link
G UBR5 ubiquitin protein ligase E3 component n-recognin 5 treatment ISO RGD PMID:32087767 RGD:151665344 NCBI chr 4:34,645,794...34,794,510
Ensembl chr 4:34,645,809...34,793,940 		JBrowse link
G UCHL1 ubiquitin C-terminal hydrolase L1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18666234 NCBI chr 8:32,353,766...32,367,288
Ensembl chr 8:32,353,246...32,367,332 		JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 2:73,898,061...73,937,727
Ensembl chr 2:73,898,071...73,931,769 		JBrowse link
G UMPS uridine monophosphate synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18230555 NCBI chr13:135,611,857...135,650,656
Ensembl chr13:135,610,058...135,650,603 		JBrowse link
G UROC1 urocanate hydratase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 7:53,592,763...53,634,214
Ensembl chr 7:53,590,776...53,637,713 		JBrowse link
G USP2 ubiquitin specific peptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147110 NCBI chr 9:46,563,469...46,590,392
Ensembl chr 9:46,563,482...46,590,392 		JBrowse link
G USP4 ubiquitin specific peptidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35841383 NCBI chr13:31,844,780...31,904,418
Ensembl chr13:31,848,851...31,904,243 		JBrowse link
G VASN vasorin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25826090 NCBI chr 3:37,961,425...37,972,477
Ensembl chr 3:37,961,432...37,972,114 		JBrowse link
G VAV1 vav guanine nucleotide exchange factor 1 ISO mRNA:decreased expression:liver RGD PMID:2064726 RGD:2306008 NCBI chr 2:72,327,433...72,391,649
Ensembl chr 2:72,326,716...72,391,648 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22922871 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
G VDR vitamin D receptor susceptibility ISO associated with alcoholic liver cirrhosis;DNA:haplotype::
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
associated with Hepatitis B, Chronic;DNA:SNP: :rs2228570(human)		 RGD
ClinVar		 PMID:20572305 PMID:24033266 PMID:25541958 PMID:25741868 PMID:28492532 RGD:14402025 RGD:14402026 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
G VEGFA vascular endothelial growth factor A treatment
susceptibility
disease_progression		 ISO DNA:polymorphism:promoter:-2578C>A (rs699947)(human)
DNA:SNP: :2578C>A (human)
protein:increased expression:liver
protein:increased expression:serum:
associated with liver cirrhosis;
associated with liver cirrhosis; protein:increased expression:platelet, liver:		 RGD PMID:16835748 PMID:18392108 PMID:18544126 PMID:24445728 PMID:25999787 More... RGD:11527070 RGD:126848814 RGD:15003194 RGD:15003196 RGD:15003200 RGD:15014783 RGD:15036790 RGD:152177911 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
G VEGFC vascular endothelial growth factor C ISO associated with liver cirrhosis; protein:increased expression:liver: RGD PMID:18544126 RGD:15003200 NCBI chr15:39,037,764...39,136,234
Ensembl chr15:39,039,311...39,132,936 		JBrowse link
G VHL von Hippel-Lindau tumor suppressor disease_progression ISO RGD PMID:31321740 RGD:155882550 NCBI chr13:66,334,535...66,342,401
Ensembl chr13:66,334,591...66,342,654 		JBrowse link
G VIPR1 vasoactive intestinal peptide receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:26,036,610...26,073,168
Ensembl chr13:26,036,629...26,075,691 		JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr  X:52,175,601...52,198,635
Ensembl chr  X:52,175,607...52,198,566 		JBrowse link
G WDR62 WD repeat domain 62 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:45,418,966...45,477,619
Ensembl chr 6:45,419,015...45,474,050 		JBrowse link
G WDR76 WD repeat domain 76 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 1:127,651,765...127,741,357
Ensembl chr 1:127,654,178...127,741,354 		JBrowse link
G WNT2 Wnt family member 2 susceptibility ISO associated with hepatitis B;DNA:SNP: :rs4730775(human) RGD PMID:28328801 RGD:14402040 NCBI chr18:28,945,825...28,993,969
Ensembl chr18:28,946,326...28,993,961 		JBrowse link
G WRAP53 WD repeat containing antisense to TP53 ISO RNA:increased expression:liver: RGD PMID:26551349 RGD:11096781 NCBI chr12:52,954,674...52,968,371
Ensembl chr12:52,954,669...52,968,364 		JBrowse link
G XDH xanthine dehydrogenase ISO protein:decreased activity:tumor (rat) RGD PMID:179860 RGD:5135059 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
G XPO1 exportin 1 ameliorates
treatment
exacerbates		 ISO human cell line in a mouse model
mRNA:increased expression:liver (human)		 RGD PMID:25030088 PMID:27013579 PMID:31371628 RGD:151665796 RGD:151667433 RGD:151667441 NCBI chr 3:80,255,016...80,300,260
Ensembl chr 3:80,255,146...80,300,327 		JBrowse link
G XPO5 exportin 5 severity ISO DNA:snp, haplotype:3' utr:c.*659A>C (rs11077) (human) RGD PMID:24676133 RGD:11041737 NCBI chr 7:38,530,704...38,569,558
Ensembl chr 7:38,531,919...38,569,582 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 susceptibility
severity
disease_progression
no_association		 ISO DNA:missense mutation:cds:c.1804C>A (p.G506A) (human)
associated with Chronic Hepatitis C;DNA:SNP:exon 14: c.1517G>C, p.506G>A (human)
DNA:SNPs:exon 9, exon 15: c.910A>G, c.1686C>G (human)
DNA:SNP:exon 13: c.1471G>A, p.E491K (human)
DNA:SNPs:cds: 194C>T, 280A>G (human)
DNA:silent mutation, missense mutation:cds:c.1161G>A, c.1779C>G (p.L387L, p.S593R) (human)
DNA:missense mutations:cds:c.482C>T, c.1178G>A (p.P161L, p.R393H) (human)
associated with hepatitis B;DNA:missense mutation, haplotype:cds:p.R399Q (human)
DNA:missense mutation:cds:p.R399Q (rs25487) (human)
DNA:missense mutation:cds:p.R399Q (human)
DNA:missense mutations:cds:p.R194W, p.R280H, p.R399Q (human)
associated with Hepatitis C, Chronic;DNA:missense mutation:cds:p.R194W (human)
DNA:SNPs:exons:c.1254C>T, c.1517G>C (human)
associated with Hepatitis C, Chronic;DNA:missense mutation:cds:p.R399Q (human)
DNA:missense mutation:cds:p.R399Q (28152G>A) (rs25487) (human)		 RGD PMID:14519756 PMID:19194663 PMID:22502666 PMID:23454624 PMID:23493666 More... RGD:14696702 RGD:14696772 RGD:14696773 RGD:14985238 RGD:14985240 RGD:14985242 RGD:14985243 RGD:15014789 RGD:15014790 RGD:15014791 RGD:15014792 RGD:15036794 RGD:15036797 RGD:150530503 RGD:150530624 RGD:150540332 RGD:150540333 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729 		JBrowse link
G YAP1 Yes1 associated transcriptional regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:29698666 NCBI chr 9:32,811,629...32,924,926
Ensembl chr 9:32,811,416...32,925,603 		JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein F2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28104805 NCBI chr 6:85,717,147...85,756,750
Ensembl chr 6:85,716,983...85,726,473 		JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta severity ISO RGD PMID:27811373 RGD:14700875 NCBI chr 4:35,975,513...36,009,909
Ensembl chr 4:35,975,508...36,009,887 		JBrowse link
G ZC3H12D zinc finger CCCH-type containing 12D ISO CTD Direct Evidence: marker/mechanism CTD PMID:34545456 NCBI chr 1:16,463,532...16,498,974
Ensembl chr 1:16,465,252...16,498,971 		JBrowse link
G ZFHX3 zinc finger homeobox 3 severity
disease_progression		 ISO human cell line in a mouse model
associated with Chronic Hepatitis B;protein:decreased expression:blood serum (human)		 RGD PMID:20534899 PMID:32277050 RGD:151361162 RGD:151361169 NCBI chr 6:15,693,987...15,941,301
Ensembl chr 6:15,698,199...15,863,270 		JBrowse link
G ZFP36 ZFP36 ring finger protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr 6:48,063,732...48,066,235
Ensembl chr 6:48,063,677...48,066,250 		JBrowse link
G ZIC2 Zic family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr11:68,840,802...68,845,441
Ensembl chr11:68,840,631...68,845,378 		JBrowse link
G ZIC4 Zic family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr13:87,725,642...87,740,724
Ensembl chr13:87,722,146...87,740,921 		JBrowse link
G ZIC5 Zic family member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr11:68,821,733...68,830,472
Ensembl chr11:68,821,735...68,830,540 		JBrowse link
G ZNF23 zinc finger protein 23 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21965783 NCBI chr 6:14,463,135...14,480,783
Ensembl chr 6:14,463,304...14,480,863 		JBrowse link
G ZWINT ZW10 interacting kinetochore protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28284560 NCBI chr14:94,094,781...94,109,447
Ensembl chr14:94,094,894...94,102,060 		JBrowse link
aflatoxins-related hepatocellular carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPHX1 epoxide hydrolase 1 ISO associated with estrogen excess;protein:increased activity;liver (rat) RGD PMID:6133380 RGD:152998935 NCBI chr10:13,757,489...13,773,071
Ensembl chr10:13,751,881...13,773,072 		JBrowse link
childhood hepatocellular carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MET MET proto-oncogene, receptor tyrosine kinase ISO ClinVar Annotator: match by term: Pediatric hepatocellular carcinoma ClinVar PMID:9927037 PMID:17483355 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512 		JBrowse link
fibrolamellar carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CA12 carbonic anhydrase 12 ISO mRNA:increased expression:liver RGD PMID:28304380 RGD:153352326 NCBI chr 1:108,649,277...108,710,658
Ensembl chr 1:108,649,271...108,710,651 		JBrowse link
G CTNNB1 catenin beta 1 ISO protein:increased tyrosine phosphorylation:exon: RGD PMID:19101982 RGD:14402052 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 ISO protein:increased expression:liver: RGD PMID:24925055 RGD:11055933 NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha ISO mRNA,protein:increased expression:liver (human) RGD PMID:27027723 RGD:151347845 NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551 		JBrowse link
hepatocellular clear cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 disease_progression ISO DNA:polymorphism: :rs12478635(human)
DNA:misssense mutation:cds:p.Arg132Cys(human)		 RGD PMID:25355558 PMID:28403884 RGD:14974227 RGD:14974228 NCBI chr15:111,341,153...111,362,330
Ensembl chr15:111,341,153...111,362,296 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 disease_progression ISO DNA:polymorphism: :rs11632348(human) RGD PMID:25355558 RGD:14974228 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554 		JBrowse link
G LEP leptin ISO mRNA:increased expression:liver: RGD PMID:20723213 RGD:14696785 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323 		JBrowse link
G LEPR leptin receptor ISO mRNA:increased expression:liver RGD PMID:20723213 RGD:14696785 NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,801,954...146,895,995 		JBrowse link
G TERT telomerase reverse transcriptase disease_progression ISO mRNA:increased expression:liver: RGD PMID:20723213 PMID:28460432 RGD:14696783 RGD:14696785 NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421 		JBrowse link
mixed fibrolamellar hepatocellular carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKACA protein kinase cAMP-activated catalytic subunit alpha susceptibility ISO RGD PMID:28923495 RGD:151347843 NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551 		JBrowse link
Ruijs-Aalfs syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPRTN SprT-like N-terminal domain ISO ClinVar Annotator: match by term: Progeroid features-hepatocellular carcinoma predisposition syndrome | ClinVar Annotator: match by term: Ruijs-Aalfs syndrome OMIM
ClinVar		 PMID:12503110 PMID:25261934 PMID:25741868 NCBI chr14:59,177,801...59,192,221
Ensembl chr14:59,171,192...59,192,269 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17415
    disease of cellular proliferation 7153
      cancer 5187
        cell type cancer 3569
          carcinoma 3050
            adenocarcinoma 1605
              hepatocellular carcinoma 900
                Hepatoblastoma Caused By Somatic Mutation 0
                Ruijs-Aalfs syndrome 1
                adult hepatocellular carcinoma 0
                aflatoxins-related hepatocellular carcinoma 1
                childhood hepatocellular carcinoma 1
                fibrolamellar carcinoma + 4
                hepatocellular clear cell carcinoma 5
                sclerosing hepatic carcinoma 0
Path 2
Term Annotations click to browse term
  disease 17415
    disease of cellular proliferation 7153
      Neoplasms by Site 6636
        Digestive System Neoplasms 3667
          Gastrointestinal Neoplasms 3553
            gastrointestinal system cancer 2802
              hepatobiliary system cancer 1038
                liver cancer 958
                  liver carcinoma 902
                    hepatocellular carcinoma 900
                      Hepatoblastoma Caused By Somatic Mutation 0
                      Ruijs-Aalfs syndrome 1
                      adult hepatocellular carcinoma 0
                      aflatoxins-related hepatocellular carcinoma 1
                      childhood hepatocellular carcinoma 1
                      fibrolamellar carcinoma + 4
                      hepatocellular clear cell carcinoma 5
                      sclerosing hepatic carcinoma 0
paths to the root