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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of pioglitazonePMID:15900286
CYP3A4decreases activityEXP 6480464CTDpioglitazone results in decreased activity of CYP3A4 proteinPMID:12642470 PMID:15860655
CYP3A4increases expressionEXP 6480464CTDPioglitazone results in increased expression of CYP3A4 mRNA; Pioglitazone results in increased expression of CYP3A4 proteinPMID:12642470 PMID:16837568 PMID:22524704 PMID:31233785
CYP3A4multiple interactionsEXP 6480464CTD[pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol; [pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; pioglitazone results in increased expression of and results in increased activity of CYP3A4 proteinPMID:12642470 PMID:22524704
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTDPioglitazone inhibits the reaction [Endotoxins results in decreased expression of CYP3A2 protein]PMID:15364003
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