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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:17775
Term: 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Definition: An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Chemical ID: MESH:D014527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAincreases phosphorylationISORela (Rattus norvegicus)6480464CTDUric Acid results in increased phosphorylation of RELA proteinPMID:33894285
RELAmultiple interactionsISORela (Mus musculus)6480464CTDUric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of RELA protein]PMID:33749747
RELAmultiple interactionsISORela (Rattus norvegicus)6480464CTDColchicine inhibits the reaction [Uric Acid results in increased phosphorylation of RELA protein]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased localization of and results in increased activity of RELA protein]; simiaowan inhibits the reaction [Uric Acid results in increased phosphorylation of RELA protein]; Uric Acid results in increased localization of and results in increased activity of RELA proteinPMID:19655406 PMID:33894285
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