Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352010
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK2decreases activityEXP 6480464CTDresveratrol results in decreased activity of CDK2 proteinPMID:12690110
CDK2decreases expressionEXP 6480464CTDresveratrol results in decreased expression of CDK2 mRNA; resveratrol results in decreased expression of CDK2 proteinPMID:11507064 PMID:12690110 PMID:18347188 PMID:23137833
CDK2increases expressionEXP 6480464CTDresveratrol results in increased expression of CDK2PMID:15583814
CDK2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with resveratrol] results in decreased expression of CDK2 mRNA; [Estradiol co-treated with resveratrol] results in decreased expression of CDK2 mRNA; [hexabromocyclododecane co-treated with resveratrol] results in decreased expression of CDK2 mRNA; [Methoxychlor co-treated with resveratrol] results in decreased expression of CDK2 mRNA; [nonylphenol co-treated with resveratrol] results in decreased expression of CDK2 mRNA; [octylphenol co-treated with resveratrol] results in decreased expression of CDK2 mRNA; resveratrol inhibits the reaction [TNF protein results in increased expression of and results in increased activity of CDK2 protein]; resveratrol promotes the reaction [TNF promotes the reaction [CDKN1A protein binds to CDK2 protein]]PMID:16317118 PMID:22552626
CDK2decreases expressionISOCdk2 (Rattus norvegicus)6480464CTDresveratrol results in decreased expression of CDK2 mRNA; resveratrol results in decreased expression of CDK2 proteinPMID:17588540 PMID:20972827
CDK2decreases expressionISOCdk2 (Mus musculus)6480464CTDresveratrol results in decreased expression of CDK2 proteinPMID:15122319 PMID:22935344
Go Back to source page   Continue to Ontology report