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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:28412
Term: eriodictyol
Definition: A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.
Chemical ID: MESH:C007619
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFdecreases activityISOTnf (Mus musculus)6480464CTDeriodictyol results in decreased activity of TNF proteinPMID:20438634
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTDeriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:11123379 PMID:21544733 PMID:31860763
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