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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344001
Species: Homo sapiens
RGD Object: Gene
Symbol: GDF15
Name: growth differentiation factor 15
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GDF15affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of GDF15 mRNAPMID:22298810
GDF15decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of GDF15 mRNAPMID:36370075
GDF15increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of GDF15 mRNAPMID:19619570 PMID:20106945 PMID:21632981 PMID:26159488 PMID:26238291
GDF15multiple interactionsEXP 6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GDF15 mRNA; pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA]PMID:19619570 PMID:20064835 PMID:26159488
GDF15affects expressionISOGdf15 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of GDF15 mRNAPMID:22298810
GDF15affects expressionISOGdf15 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of GDF15 mRNAPMID:21570461
GDF15increases expressionISOGdf15 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of GDF15 mRNAPMID:21215274 PMID:33387578
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