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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309799
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac1
Name: histone deacetylase 1
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac1decreases activityISOHDAC1 (Homo sapiens)6480464CTDtrichostatin A results in decreased activity of HDAC1 proteinPMID:15103026 PMID:15927959 PMID:15930892 PMID:34973135
Hdac1decreases activityISOHdac1 (Mus musculus)6480464CTDtrichostatin A results in decreased activity of HDAC1 proteinPMID:32496642
Hdac1decreases expressionISOHDAC1 (Homo sapiens)6480464CTDtrichostatin A results in decreased expression of HDAC1 proteinPMID:23285096
Hdac1multiple interactionsISOHDAC1 (Homo sapiens)6480464CTDtrichostatin A inhibits the reaction [hydroquinone results in increased expression of HDAC1 mRNA]PMID:27220438
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