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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306668
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fis1
Name: fission, mitochondrial 1
Acc ID: CHEBI:15756
Term: hexadecanoic acid
Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical ID: MESH:D019308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fis1increases expressionISOFis1 (Mus musculus)6480464CTDPalmitic Acid results in increased expression of FIS1 proteinPMID:34678374
Fis1multiple interactionsISOFIS1 (Homo sapiens)6480464CTD3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of FIS1 mRNA]; [Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein; [Palmitic Acid co-treated with Oleic Acid] results in increased expression of FIS1 mRNA; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein]PMID:32369900 PMID:32730863
Fis1multiple interactionsISOFis1 (Mus musculus)6480464CTDcarnosol inhibits the reaction [Palmitic Acid results in increased expression of FIS1 protein]; PRDX3 protein inhibits the reaction [Palmitic Acid results in increased expression of FIS1 protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of FIS1 protein]]PMID:34678374
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