GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Xbp1 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of XBP1 protein | PMID:17645694 PMID:17681577 | Xbp1 | multiple interactions | EXP | | 6480464 | CTD | Melatonin inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein] | PMID:17645694 | Xbp1 | affects localization | ISO | Xbp1 (Mus musculus) | 6480464 | CTD | sodium arsenite affects the localization of XBP1 protein | PMID:21911445 | Xbp1 | affects splicing | ISO | Xbp1 (Mus musculus) | 6480464 | CTD | sodium arsenite affects the splicing of XBP1 mRNA | PMID:21911445 | Xbp1 | decreases expression | ISO | Xbp1 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of XBP1 mRNA | PMID:19822182 | Xbp1 | decreases expression | ISO | XBP1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in decreased expression of XBP1 mRNA | PMID:28595984 PMID:34032870 | Xbp1 | increases expression | ISO | Xbp1 (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of XBP1 mRNA; sodium arsenite results in increased expression of XBP1 mRNA alternative form; sodium arsenite results in increased expression of XBP1 protein alternative form | PMID:21911445 PMID:23221991 | Xbp1 | increases expression | ISO | XBP1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of XBP1 mRNA | PMID:36586010 | Xbp1 | multiple interactions | ISO | Xbp1 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein alternative form] | PMID:21911445 | Xbp1 | multiple interactions | ISO | XBP1 (Homo sapiens) | 6480464 | CTD | sodium arsenite promotes the reaction [[XBP1 protein binds to HIF1A protein] which binds to ACE enhancer]; sodium arsenite promotes the reaction [[XBP1 protein binds to HIF1A protein] which binds to AGT enhancer]; sodium arsenite promotes the reaction [[XBP1 protein binds to HIF1A protein] which binds to AGTR1 enhancer]; sodium arsenite promotes the reaction [XBP1 protein binds to HIF1A protein]; sodium arsenite results in increased expression of and results in increased splicing of XBP1 mRNA; XBP1 affects the reaction [sodium arsenite results in increased expression of ACE mRNA]; XBP1 affects the reaction [sodium arsenite results in increased expression of AGT mRNA]; XBP1 affects the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]; XBP1 affects the reaction [sodium arsenite results in increased expression of and results in increased secretion of AGT protein modified form]; XBP1 affects the reaction [sodium arsenite results in increased expression of HIF1A protein]; XBP1 affects the reaction [sodium arsenite results in increased expression of SELE protein]; XBP1 affects the reaction [sodium arsenite results in increased secretion of CCL2 protein]; XBP1 affects the reaction [sodium arsenite results in increased secretion of CXCL8 protein]; XBP1 affects the reaction [sodium arsenite results in increased secretion of ICAM1 protein] | PMID:28973481 | | ||||||||||||||||||||||
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