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GENE - TERM ANNOTATION REPORT

RGD ID: 12514074
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Ide
Name: insulin degrading enzyme
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ide ISOIDE (Homo sapiens)9068941RGD PMID:28164769 REF_RGD_ID:13792824
Ide ISOIDE (Homo sapiens)9068941RGDprotein:decreased expression:cerebrospinal fluidPMID:26963025 REF_RGD_ID:13792798
Ide ISOIde (Mus musculus)9068941RGD PMID:12634421 REF_RGD_ID:737718
IdetreatmentISOIde (Rattus norvegicus)9068941RGD PMID:28157092 PMID:28553348 PMID:29948724 REF_RGD_ID:13792792 REF_RGD_ID:13792800 REF_RGD_ID:13792829
IdetreatmentISOIde (Rattus norvegicus)9068941RGDassociated with Insulin ResistancePMID:28447730 REF_RGD_ID:13792793
IdetreatmentISOIde (Mus musculus)9068941RGD PMID:30224067 REF_RGD_ID:13792790
Ide ISOIDE (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:17192785
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